<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>There have been studies on antibiotic use concerning lung cancer and its potential impact on carcinogenesis and microbiome. However, subsequent research has failed to support these associations consistently. In terms of the potential carcinogenic of antibiotics on lung cancer, the available evidence has not been sufficient to draw any definitive conclusions. Maintaining immune homeostasis and preventing pathogen invasion is critically dependent on the microbiome. The subtle balance of the body microbiota, including the lungs, is susceptible to disruption by antibiotic use. There is an association between disruptions of the lung microbiome and respiratory diseases, including lung cancer, and decreased efficacy of treatments. Patients with lung cancer are often indicated for antibiotic treatment due to respiratory infections or other comorbidities. Pulmonary infections in the area of undetected lung tumors are not uncommon. They can be an early sign of malignancy, which may explain the association between antibiotic use and lung cancer diagnosis. Antibiotic use can also affect the effectiveness of immune checkpoint inhibitor therapy. Studies suggest that antibiotic use can impair the efficacy of immune checkpoint inhibitor therapy in lung cancer patients, particularly around the time when treatment is initiated. These findings require further study, understanding underlying mechanisms, and identifying microbiota signatures associated with treatment response.</p>
</abstract>

There have been studies on antibiotic use concerning lung cancer and its potential impact on carcinogenesis and microbiome. However, subsequent research has failed to support these associations consistently. In terms of the potential carcinogenic of antibiotics on lung cancer, the available evidence has not been sufficient to draw any definitive conclusions. Maintaining immune homeostasis and preventing pathogen invasion is critically dependent on the microbiome. The subtle balance of the body microbiota, including the lungs, is susceptible to disruption by antibiotic use. There is an association between disruptions of the lung microbiome and respiratory diseases, including lung cancer, and decreased efficacy of treatments. Patients with lung cancer are often indicated for antibiotic treatment due to respiratory infections or other comorbidities. Pulmonary infections in the area of undetected lung tumors are not uncommon. They can be an early sign of malignancy, which may explain the association between antibiotic use and lung cancer diagnosis. Antibiotic use can also affect the effectiveness of immune checkpoint inhibitor therapy. Studies suggest that antibiotic use can impair the efficacy of immune checkpoint inhibitor therapy in lung cancer patients, particularly around the time when treatment is initiated. These findings require further study, understanding underlying mechanisms, and identifying microbiota signatures associated with treatment response.

The Effects of Antibiotics on the Development and Treatment of Non-Small Cell Lung Cancer

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

There have been studies on antibiotic use concerning lung cancer and its potential impact on carcinogenesis and microbiome. However, subsequent research has...

The Effects of Antibiotics on the Development and Treatment of Non-Small Cell Lung Cancer

Article Category: MINIREVIEW

Online veröffentlicht: 16. Dez. 2023

Seitenbereich: 365 - 375

Eingereicht: 15. Aug. 2023

Akzeptiert: 27. Okt. 2023

DOI: https://doi.org/10.33073/pjm-2023-047

Schlüsselwörter
lung, non-small-cell lung cancer, antibiotics, microbiome, immunotherapy

© 2023 Petra Švecová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Effects of Antibiotics on the Development and Treatment of Non-Small Cell Lung Cancer

Article Category: MINIREVIEW

Online veröffentlicht: 16. Dez. 2023

Seitenbereich: 365 - 375

Eingereicht: 15. Aug. 2023

Akzeptiert: 27. Okt. 2023

DOI: https://doi.org/10.33073/pjm-2023-047

Schlüsselwörterlung, non-small-cell lung cancer, antibiotics, microbiome, immunotherapy

© 2023 Petra Švecová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
lung, non-small-cell lung cancer, antibiotics, microbiome, immunotherapy