<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>We aimed to compare the clinical efficacy of fecal microbiota transplantation (FMT) from the same sex on ulcerative colitis (UC) patients. A total of 272 UC patients were selected in the prospective clinical study, which incorporated four distinct groups, each comprising male and female patients, who were either receiving FMT or placebo, respectively. FMT was performed by sending the gut microbiota of healthy female or male adolescents to the same gender patients via gastroscope three times (one time/three weeks), and a placebo was used with an equal volume of saline. Abdominal pain, diarrhea, thick bloody stool, intestinal mucosal lesion, and Mayo scores were measured. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated. The changes of intestinal flora were detected by the 16S rRNA sequencing. FMT reduced the scores of diarrhea, abdominal pain, mucosal lesion, and Mayo, SAS, and SDS in UC patients compared to the placebo group (<italic>p</italic> &lt; 0.05). Clostridiales and <italic>Desulfovibrionaceae</italic> were dominant in gut microbiota from male patients and were reduced after FMT. Meanwhile, the abundance of <italic>Prevotella</italic>, <italic>Lactobacillus</italic>, and <italic>Bifidobacterium</italic> was increased in the male group. Female patients had a higher abundance of <italic>Escherichia-Shigella</italic>, <italic>Desulfovibrionaceae</italic>, and <italic>Staphylococcaceae</italic> before FMT, and it was reduced after FMT. Meanwhile, the abundance of <italic>Porphyromonadaceae</italic>, <italic>Prevotella</italic>, <italic>Lactobacillus</italic>, and <italic>Bifidobacterium</italic> was increased in the female group. There were no significant changes for the species in the corresponding placebo groups. FMT improved the UC symptoms of male and female patients, which may be associated with different gut microbiota changes.</p>
</abstract>

We aimed to compare the clinical efficacy of fecal microbiota transplantation (FMT) from the same sex on ulcerative colitis (UC) patients. A total of 272 UC patients were selected in the prospective clinical study, which incorporated four distinct groups, each comprising male and female patients, who were either receiving FMT or placebo, respectively. FMT was performed by sending the gut microbiota of healthy female or male adolescents to the same gender patients via gastroscope three times (one time/three weeks), and a placebo was used with an equal volume of saline. Abdominal pain, diarrhea, thick bloody stool, intestinal mucosal lesion, and Mayo scores were measured. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated. The changes of intestinal flora were detected by the 16S rRNA sequencing. FMT reduced the scores of diarrhea, abdominal pain, mucosal lesion, and Mayo, SAS, and SDS in UC patients compared to the placebo group (p < 0.05). Clostridiales and Desulfovibrionaceae were dominant in gut microbiota from male patients and were reduced after FMT. Meanwhile, the abundance of Prevotella, Lactobacillus, and Bifidobacterium was increased in the male group. Female patients had a higher abundance of Escherichia-Shigella, Desulfovibrionaceae, and Staphylococcaceae before FMT, and it was reduced after FMT. Meanwhile, the abundance of Porphyromonadaceae, Prevotella, Lactobacillus, and Bifidobacterium was increased in the female group. There were no significant changes for the species in the corresponding placebo groups. FMT improved the UC symptoms of male and female patients, which may be associated with different gut microbiota changes.

The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients

Department of Endoscopic Diagnosis and Treatment Center

Zhuoyuan Health Human Microbiology Research Laboratory

University of Science and Technology of China

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

We aimed to compare the clinical efficacy of fecal microbiota transplantation (FMT) from the same sex on ulcerative colitis (UC) patients. A total of 272 UC...

The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients

Article Category: Original Paper

Online veröffentlicht: 20. Sept. 2023

Seitenbereich: 247 - 268

Eingereicht: 13. März 2023

Akzeptiert: 08. Juni 2023

DOI: https://doi.org/10.33073/pjm-2023-025

Schlüsselwörter
gut microbiota, fecal microbiota transplantation, ulcerative colitis, a prospective clinical study, sex differences

© 2023 Shu Shang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients

Article Category: Original Paper

Online veröffentlicht: 20. Sept. 2023

Seitenbereich: 247 - 268

Eingereicht: 13. März 2023

Akzeptiert: 08. Juni 2023

DOI: https://doi.org/10.33073/pjm-2023-025

Schlüsselwörtergut microbiota, fecal microbiota transplantation, ulcerative colitis, a prospective clinical study, sex differences

© 2023 Shu Shang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
gut microbiota, fecal microbiota transplantation, ulcerative colitis, a prospective clinical study, sex differences