<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Genotoxicology investigates the molecular basis of cellular responses to DNA damage. During more than three decades of genetic toxicology testing, a large number of tests with varying sensitivity and specificity have been developed.These genotoxicity tests can predict:the likelihood of a substance to be a (rodent) carcinogen,the mechanism of carcinogenic activity of different substances,if the results of genotoxicity studies only predict carcinogenicity or they are a distinct hazard endpoint (Nohynek, 2005).The current genetic toxicity testing batteries represent:Ames test which is a component of all genetic testing batteries.A mammalian cell mutagenicity assay which should confirm or complete the Ames test.Chromosomal aberrations tests which are based on a different endpoint than gene mutations.Positive <italic>in vitro</italic> results need to be confirmed by in vivo tests; results from test batteries have higher predictive value than results of a single test (Nohynek, 2005).</abstract>

Genotoxicology investigates the molecular basis of cellular responses to DNA damage. During more than three decades of genetic toxicology testing, a large number of tests with varying sensitivity and specificity have been developed.These genotoxicity tests can predict:the likelihood of a substance to be a (rodent) carcinogen,the mechanism of carcinogenic activity of different substances,if the results of genotoxicity studies only predict carcinogenicity or they are a distinct hazard endpoint (Nohynek, 2005).The current genetic toxicity testing batteries represent:Ames test which is a component of all genetic testing batteries.A mammalian cell mutagenicity assay which should confirm or complete the Ames test.Chromosomal aberrations tests which are based on a different endpoint than gene mutations.Positive in vitro results need to be confirmed by in vivo tests; results from test batteries have higher predictive value than results of a single test (Nohynek, 2005).

Trends in the study of genetic susceptibility

Cancer Research Institute, Slovak Academy of Sciences, SK-833 91 Bratislava, Slovakia

Interdisciplinary Toxicology

{"article-title":"Trends in the study of genetic susceptibility"}

Genotoxicology investigates the molecular basis of cellular responses to DNA damage. During more than three decades of genetic toxicology testing, a large...

Trends in the study of genetic susceptibility

Online veröffentlicht: 01. Nov. 2010

Seitenbereich: 13 - 14

DOI: https://doi.org/10.2478/v10102-010-0024-0

This content is open access.