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Isoflavonoids — an overview of their biological activities and potential health benefits

   | 06. Jan. 2010

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Akhter M, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S. (2008). Dietary soy isoflavone intake and risk of colorectal cancer in the Japan Public Health Cancer-based prospective study. Epidem Biomark Prev 17 (8): 2128-2135.Search in Google Scholar

Atkinson C, Warren RM, Sala E, Dowsett M, Dunning AM, Healey CS, Runswick S, Day NE, Bingham SA. (2004). Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial. Breast Can Res 6 (3): 170-179.Search in Google Scholar

Barnes S. (2004). Soy isoflavones - phytoestrogens and what else? J Nut 134: 1225S-1228S.10.1093/jn/134.5.1225S15113976Search in Google Scholar

Bezek S, Ujhazy E, Mach M, Navarova J, Dubovicky M. (2008). Developmental origin of chronic diseases: toxicological implication. Interdisc Toxicol 1 (1): 29-31.Search in Google Scholar

Birt DF, Hendrich S, Wang W. (2001). Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90 (2-3): 157-177.Search in Google Scholar

Boccia S, La Torre G, Gianfagna F, Mannocci A, Ricciardi G. (2005). N-Acetyltransferase 2 status and gastric cancer risk: a preliminary meta-analysis. Ital J Pub Health 2: 53-57.Search in Google Scholar

Cesarone MR, Grossi MG, Di Renzo, A, Errich S, Schönlau F, Wilmer JL, Lange M, Blimenfeld J. (2009). Accelerated antioxidant bioavailability of OPC-3® bioflavonoids administered as isotonic solution. Phytother Res 23 (6): 775-777.Search in Google Scholar

Chen Y, Gammon MD, Teitelbaum SL, Britton JA, Terry MB, Shantakumar S, Eng SM, Wang Q, Gurvich I, Neugut AI, Santella RM, Ahsan H. (2008). Estrogen-biosynthesis gene CYP17 and its interactions with reproductive hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project. Carcinogen 29 (4): 766-771.Search in Google Scholar

Cherdshewasart W, Sutjit W. (2008). Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria libata tubers. Phytomed 15 (1-2): 38-43.Search in Google Scholar

Chodon D, Ramamurty N, Sakthisekan D. (2007). Inhibition of cell proliferation and induction of apoptosis by genistein in hepatocellular carcinoma. Tox in Vitro 20 (5): 887-891.Search in Google Scholar

Chrzan BG, Bradford PG. (2007). Phytoestrogens activate estrogen receptor β1 and estrogenic responses in human breast and bone cancer cell lines. Mol Nutr Food Res 51: 171-177.Search in Google Scholar

Dixon RA, Summer LW. (2003.) Legume natural products: Understanding and manipulating complex pathways for human and animal health. Plant Physiol 131: 878-885.10.1104/pp.102.017319154028712644640Search in Google Scholar

Duffy C, Perez K, Partridge A. (2007). Implications of phytoestrogen intake for breast cancer. CA Can J Clin 57: 260-277.Search in Google Scholar

Eliassen AH, Missmer SA, Tworoger SS, Hankinson SE. (2008). Circulating 2-hydroxy and 16a-hydroxy estrone levels and risk of breast cancer among post-menopausal women. Can Epidem Biomark Prev 17 (8): 2029-2035.Search in Google Scholar

Fink BN, Steck SE, Wolff MS, Britton JA, Kabat GC, Gaudet MM, Abrahamson PE, Bell P, Schroeder JC, Teiltelbaum SL, Neugut AI, Gammon MD. (2007). Dietary flavonoid intake and breast cancer survival among women on Long Island. Can Epidem Biomark Prev 16: (11): 2285-2292.Search in Google Scholar

Goodman MT, Shvetsov YB, Wilkens LR, Franke AA, Marchand LL, Kazaku KK, Nomura AMY, Henderson BE, Kolonel LN. (2009). Urinary phytoestrogen excretion and postmenopausal breast cancer risk: the multiethnic cohort study. Can Prev Res 2: 887.Search in Google Scholar

Hirschberg AL, Edlund M, Svane G, Azavedo E, Skoog L, von Schoultz B. (2007). An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women. Menopause 14 (1): 89-96.Search in Google Scholar

Hedlund TE, van Bokhaven A, Johannes WU, Nordeen SK, Ogden LG. (2005) Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant epithelial cells in vitro.The Prost 66 (5): 557-566.Search in Google Scholar

Ito C, Murata T, Itoigawa M, Nakao K, Kumagai M, Kaneda N, Furukawa H. (2006). Induction of apoptosis by isoflavonoids from leaves of Milletia taiwaniana in human leukemia HL-60 cells. Planta Med 72 (5): 424-429.Search in Google Scholar

Iwasaki M, Inoue M, Otani T, Sasazuki S, Kurashi N, Miura T, Yamoto S, Tsugane S. (2008). Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from Japan Public Health Center-base prospective study group. J Clin Oncol 26 (10): 1677-1683.Search in Google Scholar

Ju IH, Allred KF, Allred CD, Helferich WG. (2006). Genistein stimulates growth of human breast cancer cells in a novel postmenopausal animal model, with low plasma estradiol concentrations. Carcinogen 27: 1292-1299.Search in Google Scholar

Kousidou OC, Tzanakakis GN, Karamanos NK. (2006). Effects of natural isoflavonoid genistein on growth, signaling pathway and gene expression of matrix macromolecules by breast cancer cells. Mini Rev Med Chem 6 (3): 331-337.Search in Google Scholar

Kralova J, Pekarova M, Drabikova K, Jancinova V, Nosal R, Ciz M, Lojek A. (2008). The effects of dithiaden on nitric oxide production by RAW 264.7 cells. Interdisc Toxicol 1 (3-4): 214-217.Search in Google Scholar

Lampe JW. (2009). Is equol the key to the efficacy of soy foods? Am J Clin Nutr 89: 1664S-1667S.10.3945/ajcn.2009.26736T267700919357217Search in Google Scholar

Lockwood B. (2008). The beneficial effects of soy isoflavones in osteoporosis of the elderly. Elderly Nutr AgroFood Ind Hi-tech 19 (5):38-41.Search in Google Scholar

Liu B, Edgerton S, Yang X. (2005). Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Can Res 65: 879-886.Search in Google Scholar

Maskarinec G, Williams AE, Carlin L. (2003). Mammographic densities in a oneyear isoflavone intervention. Eur J Can Prev 12 (2):165-169.Search in Google Scholar

Maskarinec G, Hebshi S, Custer L, Franke AA. (2008a). The relation of soy intake and isoflavone levels in nipple aspirate fluid. Eu J Can Prev 17(1): 67-70.10.1097/CEJ.0b013e328110810118090913Search in Google Scholar

Maskarinec G, Watts K, Kagihara J, Hebshi SM, Franke AA. (2008b) Urinary isoflavonoid is similar after consuming soya milk and miso soup in Japanese-American women. Brit J Nutr 100: 424-429.10.1017/S0007114508898686270691218275624Search in Google Scholar

Maskarinec G, Verheus M, Steinberg FM, Amato P, Cramer M, Lewis RD, Murray MJ, Yong RL, Wong WW. (2009). Various doses of isoflavones do not modify mammographic density in postmenopausal women. J Nutr 139 (5): 981-986.Search in Google Scholar

Messina M, Wood CE. (2008). Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. Nutr J 7(1): 17-28.Search in Google Scholar

Messina M, McCaskill-Stevens W, Lampe JW. (2006). Addressing the soy and breast cancer relatioship: review, commentary, and workshop proceedings. J Natl Can Inst 98 (18): 1275-1284.Search in Google Scholar

Miadokova E, Masterova I, Vlckova V, Duhova V, Toth J. (2002). Antimutagenic potential of homoisoflavonoids from Muscari racemosum.J Ethnopharmacol 18: 381-386.Search in Google Scholar

Murata IC, Itoigawa M, Nakao K, Kumagai M, Kaneda N, Furukawa H. (2006). Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells. Planta Med 72 (5): 424-429.Search in Google Scholar

Myasoedova VA, Sobenin IA. (2008). Background, rationale and design of clinical study of the effect of isoflavonoid-rich botanicals on natural history of atherosclerosis in women. Atheroscler Suppl. 9 (1): 171.Search in Google Scholar

Nagata C, Nakamura K, Fujii K, Kawachi T, Takatsuka N, Oba S, Shimizu H. (2008). Soy isoflavone intake is not associated with the development od cedar pollinosis in adults. J Nutr 138: 1372-1376Search in Google Scholar

Ørgaard A, Jensen L. (2008). The effects of soy isoflavones on obesity Exp Biol Med 233: 1066-1080.10.3181/0712-MR-34718535167Search in Google Scholar

Perry DL, Spedick JM, McCoy TP, Adams MR, Franke AA, Cline JM. (2007). Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).J Nutr 137: 1390-1394.Search in Google Scholar

Piller R, Chang-Claude J, Linseisen J. (2006). Plasma enterolactone and genistein and the risk of premenopausal breast cancer. Eu J Can Prev 15 (3): 225-232.Search in Google Scholar

Raju J, Bielecki A, Caldwell D, Lok E, Taylor M, Kapal K, Curran I, Cooke GM, Bird RP, Mehta R. (2009). Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells increasing the expression of estrogen receptor beta. Nutr 139 (3): 474-4781.Search in Google Scholar

Ralston L, Subramanian S, Matsuto M, Yu O. (2005). Partial reconstruction of flavoid and soflavoid biosynthesis in yeast using soybean Type I and Type II chalcone isomerases. Plant Physiol 137 (4): 1375-1388.Search in Google Scholar

Reiter RJ, Paredes SD, Kormaz A, Jou M-J, Tan D-X. (2008). Melatonin combats molecular terrorism at the mitochondrial level Interdisc Toxicol 1 (2): 137-149.10.2478/v10102-010-0030-2299348021218104Search in Google Scholar

Rice S, Mason HD, Whitehead SA. (2006). Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. J Ster Biochem Mol Biol 101 (4-5): 216-225.Search in Google Scholar

Ryan-Borchers TA, Park JS, Chew BP, McGuire MK, Fournier LR, Beerman KA. (2006). Soy isoflavones modulate immune function in healthy postmenopausal women. Am J Clin Nutr 83: 118-1125.Search in Google Scholar

Sabudak T, Guler N. (2009). Trifolium L.- A review on its phytochemical and pharmacological profile. Phytother Res 23: 439-446.Search in Google Scholar

Shen P, Liu MH, Ng TY, Chan YH, Long EL. (2006) Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPAR gamma, and adipocyte differentiation in vitro J Nutr 136: 899-905.10.1093/jn/136.4.89916549448Search in Google Scholar

Scarpato R, Paganucci L, Bertoli A, Fiore L, Pistelli L, Federico G. (2008). Licoflavone C attenuates the genotoxicity of cancer drugs in human peripheral lymphocytes. Phytother Res 22 (12): 1650-1654.Search in Google Scholar

Shen P, Liu MH, Ng TY, Chan YH, Yong EL. (2006). Differential effects of isoflavones, from Astragalus membranaceus and Puerarua thomsonii, on the activation of PPARalpha, PPAR gamma, and adipocyte differentiation in vitro.J Nutr 136: 899-905.Search in Google Scholar

Stienstra R, Duval C, Ller M, Kersten S. (2007). PPARs, obesity, and inflammation. PPAR Res. 2007: 95974.Search in Google Scholar

Su Y, Simmen RCM. (2009). Soy isoflavone genistein upregulates epithelian adhesion molecule E-cadherin expression and β-catenin signaling in mammary epithelial cells. Carcinogen 30 (2): 331-339.Search in Google Scholar

Talbott KE, Gammon MD, Kibriva MG, Chen Y, Teilbaum SL, Long CM, Gurvich I, Santella RM, Ahsan H. (2008). A Cyp 19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk. Breast Can Res Treat 111 (3): 481-487.Search in Google Scholar

Tamini RM, Hankinson SE, Coldiz GA, Byrne C. (2005). Endogenous sex hormone levels and mammographic density among postmenopausal women. Can Epidem Biomark Prev 14: 2641-2647.Search in Google Scholar

Thorp AA, Howe PR, Mori TA, Coates AM, Buckley JD, Hodgson J, Mansour J, Meyer BJ. (2008.) Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. Am J Clin Nutr 88 (2): 298-304.10.1093/ajcn/88.2.29818689364Search in Google Scholar

Verheus M, van Gils CH, Kreijkamp-Kaspers S, Kok L, Peeters PH, Grobbee DE, van der Schouw YT. (2008). Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women. Can Epidem Biomark Prev 17 (10): 2632-2638.Search in Google Scholar

Wang Y, Gho WM, Chan FL, Chen S, Leung LK. (2008). The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Brit J Nutr 99: 303-310.Search in Google Scholar

Wood CE, Appt S, Clarkson TB, Franke AA, Lees C, Doerge DR, Cline JM. (2006). Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Rep 75 (3): 477-486.Search in Google Scholar

Wood CE, Register TC, Cline JM. (2007). Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys. Carcinogen 28 (4): 801-808.Search in Google Scholar

Widyarini S, Domanski D, Painter N, Reeve VE. (2006). Estrogen receptor signaling protects against immune suppression by UV radiation exposure. Proc Nat Acad Sci 103 (34): 12837-12842.Search in Google Scholar

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