<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">In this work, the functional form similarity between the individual and fundamental population TCP models is investigated. Using the fact that both models can be expressed in terms of the geometric parameters γ50 and D50, we show that they have almost identical functional form for values of γ50 ≥ 1. The conceptual inadequacy of applying an individual model to clinical data is also discussed. A general individual response TCP expression is given, parameterized by Df and γf - the dose corresponding to a control level of f, and the normalized slope at that point. It is shown that the dose-response may be interpreted as an individual response only if γ50 is sufficiently high. Based on the functional form equivalency between the individual and the population TCP models, we discuss the possibility of applying the individual TCP model for the case of heterogeneous irradiations. Due to the fact that the fundamental population TCP model is derived for homogeneous irradiations only, we propose the use of the EUD, given by the generalized mean dose, when the fundamental population TCP model is used to fit clinical data.</abstract>

In this work, the functional form similarity between the individual and fundamental population TCP models is investigated. Using the fact that both models can be expressed in terms of the geometric parameters γ50 and D50, we show that they have almost identical functional form for values of γ50 ≥ 1. The conceptual inadequacy of applying an individual model to clinical data is also discussed. A general individual response TCP expression is given, parameterized by Df and γf - the dose corresponding to a control level of f, and the normalized slope at that point. It is shown that the dose-response may be interpreted as an individual response only if γ50 is sufficiently high. Based on the functional form equivalency between the individual and the population TCP models, we discuss the possibility of applying the individual TCP model for the case of heterogeneous irradiations. Due to the fact that the fundamental population TCP model is derived for homogeneous irradiations only, we propose the use of the EUD, given by the generalized mean dose, when the fundamental population TCP model is used to fit clinical data.

Functional form comparison between the population and the individual Poisson based TCP models

Department of Physics, University of Alberta

Department of Medical Physics, Cross Cancer Institute

Department of Oncology, University of Alberta, Edmonton, Alberta, Canada

Radiology and Oncology

In this work, the functional form similarity between the individual and fundamental population TCP models is investigated. Using the fact that both models can...

Functional form comparison between the population and the individual Poisson based TCP models

Online veröffentlicht: 06. Aug. 2007

Seitenbereich: 90 - 98

DOI: https://doi.org/10.2478/v10019-007-0016-7

Schlüsselwörter
radiotherapy dosage, Poisson distribution, dose-response relationship, models, statistical, TCP

This content is open access.

Functional form comparison between the population and the individual Poisson based TCP models

Online veröffentlicht: 06. Aug. 2007

Seitenbereich: 90 - 98

DOI: https://doi.org/10.2478/v10019-007-0016-7

Schlüsselwörterradiotherapy dosage, Poisson distribution, dose-response relationship, models, statistical, TCP

This content is open access.

Schlüsselwörter
radiotherapy dosage, Poisson distribution, dose-response relationship, models, statistical, TCP