<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>This brief review summarises recent observations which suggest a possible mechanism for organophosphate-induced delayed neuropathy (OPIDN). Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Raised levels of PtdCho are present in the brains of swiss cheese/NTE mutant <italic>Drosophila</italic> together with abnormal membrane structures, axonal and dendritic degeneration and neural cell loss. Similar vacuolated pathology is found in the brains of mice with brain-specific deletion of the NTE gene and, in old age, these mice show clinical and histopathological features of neuropathy resembling those in wild-type mice chronically dosed with tri-ortho-cresylphosphate. It is suggested that OPIDN results from the loss of NTE's phospholipase activity which in turn causes ER malfunction and perturbation of axonal transport and glial-axonal interactions.</p></abstract>

This brief review summarises recent observations which suggest a possible mechanism for organophosphate-induced delayed neuropathy (OPIDN). Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Raised levels of PtdCho are present in the brains of swiss cheese/NTE mutant Drosophila together with abnormal membrane structures, axonal and dendritic degeneration and neural cell loss. Similar vacuolated pathology is found in the brains of mice with brain-specific deletion of the NTE gene and, in old age, these mice show clinical and histopathological features of neuropathy resembling those in wild-type mice chronically dosed with tri-ortho-cresylphosphate. It is suggested that OPIDN results from the loss of NTE's phospholipase activity which in turn causes ER malfunction and perturbation of axonal transport and glial-axonal interactions.

Axonal Degeneration and Neuropathy Target Esterase

MRC Toxicology Unit, University of Leicester, United Kingdom

Archives of Industrial Hygiene and Toxicology

{"article-title":"Axonal Degeneration and Neuropathy Target Esterase"}

This brief review summarises recent observations which suggest a possible mechanism for organophosphate-induced delayed neuropathy (OPIDN). Neuropathy target...

Axonal Degeneration and Neuropathy Target Esterase

Online veröffentlicht: 09. Okt. 2007

Seitenbereich: 355 - 358

DOI: https://doi.org/10.2478/v10004-007-0029-z

Schlüsselwörter
endoplazmatski retikulum, fosfolipid, karbamat, mozak, organofosfat

This content is open access.

Axonal Degeneration and Neuropathy Target Esterase

Online veröffentlicht: 09. Okt. 2007

Seitenbereich: 355 - 358

DOI: https://doi.org/10.2478/v10004-007-0029-z

Schlüsselwörterendoplazmatski retikulum, fosfolipid, karbamat, mozak, organofosfat

This content is open access.

Schlüsselwörter
endoplazmatski retikulum, fosfolipid, karbamat, mozak, organofosfat