<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Vitamin D is known to affect the functions of pancreatic beta cells, but the effects of vitamin D deficiency on glucoregulatory mechanisms are still inconclusive. The aim of this study was to link vitamin D levels with parameters of insulin resistance and insulin secretion. The study included 70 male and female participants, 40 newly diagnosed patients with type 2 diabetes mellitus (T2DM) and 30 healthy controls. All participants were tested for fasting glucose, hemoglobin A1c, fasting insulin, vitamin D levels, and the HOMA indexes were calculated using HOMA2 calculator. Fasting glucose levels, insulinemia, hemoglobin A1c levels and HOMA IR were all significantly higher in the diabetic group (p&lt;0.001), while vitamin D levels and HOMA S index were significantly lower (p&lt;0.001). HOMA-B values did not differ between the two groups (p=0.31). Vitamin D levels moderately correlated with HOMA S and HOMA B indexes (r=0.466, p&lt;0.001; r=0.394, p&lt;0.001, respectively), whereas a negative correlation was found between vitamin D levels and HOMA IR (r=−0.285; p&lt;0.001). Multiple regression analysis showed that vitamin D levels significantly predicted the values of HOMA B index (p=0.001), but they had no predictive value on HOMA IR (p=0.26). In conclusion, the group of newly diagnosed patients with T2DM showed significantly lower vitamin D values compared to the healthy control group. The connection between vitamin D, glucose levels, hemoglobin A1c and insulin secretion index underlines the role of this vitamin in glucoregulation.</p>
</abstract>

Vitamin D is known to affect the functions of pancreatic beta cells, but the effects of vitamin D deficiency on glucoregulatory mechanisms are still inconclusive. The aim of this study was to link vitamin D levels with parameters of insulin resistance and insulin secretion. The study included 70 male and female participants, 40 newly diagnosed patients with type 2 diabetes mellitus (T2DM) and 30 healthy controls. All participants were tested for fasting glucose, hemoglobin A1c, fasting insulin, vitamin D levels, and the HOMA indexes were calculated using HOMA2 calculator. Fasting glucose levels, insulinemia, hemoglobin A1c levels and HOMA IR were all significantly higher in the diabetic group (p<0.001), while vitamin D levels and HOMA S index were significantly lower (p<0.001). HOMA-B values did not differ between the two groups (p=0.31). Vitamin D levels moderately correlated with HOMA S and HOMA B indexes (r=0.466, p<0.001; r=0.394, p<0.001, respectively), whereas a negative correlation was found between vitamin D levels and HOMA IR (r=−0.285; p<0.001). Multiple regression analysis showed that vitamin D levels significantly predicted the values of HOMA B index (p=0.001), but they had no predictive value on HOMA IR (p=0.26). In conclusion, the group of newly diagnosed patients with T2DM showed significantly lower vitamin D values compared to the healthy control group. The connection between vitamin D, glucose levels, hemoglobin A1c and insulin secretion index underlines the role of this vitamin in glucoregulation.

Associations of Vitamin D Level and Glucoregulatory Parameters in Type 2 Diabetes Mellitus

Institute for Child and Youth Health Care of Vojvodina

Clinical Center of Vojvodina Center of laboratory medicine

Clinic for endocrinology, Diabetes and metabolic disorders

Center for gastroenterology and hepatology

Department of Physiology, Faculty of Medicine

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Vitamin D is known to affect the functions of pancreatic beta cells, but the effects of vitamin D deficiency on glucoregulatory mechanisms are still...

Associations of Vitamin D Level and Glucoregulatory Parameters in Type 2 Diabetes Mellitus

Online veröffentlicht: 11. Juli 2022

Seitenbereich: 141 - 146

Eingereicht: 24. Aug. 2019

Akzeptiert: 17. Okt. 2019

DOI: https://doi.org/10.2478/sjecr-2019-0054

Schlüsselwörter
vitamin D, insulin resistance, insulin secretion, HOMA index, glucose metabolism

© 2019 Andrea Zubnar et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Associations of Vitamin D Level and Glucoregulatory Parameters in Type 2 Diabetes Mellitus

Online veröffentlicht: 11. Juli 2022

Seitenbereich: 141 - 146

Eingereicht: 24. Aug. 2019

Akzeptiert: 17. Okt. 2019

DOI: https://doi.org/10.2478/sjecr-2019-0054

Schlüsselwörtervitamin D, insulin resistance, insulin secretion, HOMA index, glucose metabolism

© 2019 Andrea Zubnar et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
vitamin D, insulin resistance, insulin secretion, HOMA index, glucose metabolism