[1. Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75(1):7-23.10.1111/prd.1222128758294]Search in Google Scholar
[2. Pihlstrom, BL. Periodontal risk assessment, diagnosis and treatment planning. Periodontology 2000. 2001;25:37-58.10.1034/j.1600-0757.2001.22250104.x11155181]Search in Google Scholar
[3. Grenier, G, Gagnon, G, Grenier, D. Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment. Oral Microbiology and Immunology 2009;24:506-9.10.1111/j.1399-302X.2009.00542.x19832804]Search in Google Scholar
[4. Järvensivu, A, Hietanen, J, Rautemaa, R, Sorsa, T, Richardson, M. Candida yeasts in chronic periodontitis tissues and subgingival microbial biofilms in vivo. Oral Diseases 2004;10:106-12.10.1046/j.1354-523X.2003.00978.x14996281]Search in Google Scholar
[5. Hajishengallis, G, Lamont, RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Molecular oral microbiology 2012;27:409-19.10.1111/j.2041-1014.2012.00663.x365331723134607]Search in Google Scholar
[6. Mahajan, A, Singh, B, Kashyap, D, Kumar, A, Mahajan, P. Interspecies communication and periodontal disease. The Scientific World Journal 2013;2013:10.1155/2013/765434387430924396307]Search in Google Scholar
[7. Gupta S, Maharjan A, Dhami B, Amgain P, Katwal S, Adhikari B, Shukla A. Status of Tobacco Smoking and Diabetes with Periodontal Disease. JNMA J Nepal Med Assoc. 2018;56(213):818-824.10.31729/jnma.3610]Search in Google Scholar
[8. Preshaw, PM, Taylor, JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? Journal of clinical periodontology 2011;38:60-84.]Search in Google Scholar
[9. Kinane, DF, Preshaw, PM, Loos, BG, on Behalf of Working Group 2 of the Seventh European Workshop on, P. Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions – Consensus of the Seventh European Workshop on Periodontology. Journal of Clinical Periodontology 2011;38:44-8.10.1111/j.1600-051X.2010.01682.x21323703]Search in Google Scholar
[10. Garlet, G. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. Journal of dental research 2010;89:1349-63.10.1177/002203451037640220739705]Search in Google Scholar
[11. McInnes, IB, Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nature Reviews Immunology 2007;7:429-42.10.1038/nri209417525752]Search in Google Scholar
[12. Page, RC. The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Annals of periodontology 1998;3:108-20.10.1902/annals.1998.3.1.1089722695]Search in Google Scholar
[13. Lamster, IB, Lalla, E, Borgnakke, WS, Taylor, GW. The relationship between oral health and diabetes mellitus. The Journal of the American Dental Association 2008;139:19S-24S.10.14219/jada.archive.2008.036318809650]Search in Google Scholar
[14. Murrah, V, Crosson, J, Sauk, J. Parotid gland basement membrane variation in diabetes mellitus. Journal of Oral Pathology & Medicine 1985;14:236-46.10.1111/j.1600-0714.1985.tb00487.x3921679]Search in Google Scholar
[15. Ship, JA. Diabetes and oral health: an overview. The Journal of the American Dental Association 2003;134:4S-10S.10.14219/jada.archive.2003.036718196667]Search in Google Scholar
[16. Löe, H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes care 1993;16:329-34.10.2337/diacare.16.1.329]Search in Google Scholar
[17. Tsai, C, Hayes, C, Taylor, GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community dentistry and oral epidemiology 2002;30:182-92.10.1034/j.1600-0528.2002.300304.x12000341]Search in Google Scholar
[18. Lalla, E, Cheng, B, Lal, S, Kaplan, S, Softness, B, Greenberg, E, et al. Diabetes mellitus promotes periodontal destruction in children. Journal of clinical periodontology 2007;34:294-8.10.1111/j.1600-051X.2007.01054.x17378885]Search in Google Scholar
[19. Yoshida, T, Flegler, A, Kozlov, A, Stern, PH. Direct inhibitory and indirect stimulatory effects of RAGE ligand S100 on sRANKL-induced osteoclastogenesis. Journal of cellular biochemistry 2009;107:917-25.10.1002/jcb.2219219415676]Search in Google Scholar
[20. Nishimura, F, Takahashi, K, Kurihara, M, Takashiba, S, Murayama, Y. Periodontal Disease as a Complication of Diabetes Mellitus*. Annals of periodontology 1998;3:20-9.10.1902/annals.1998.3.1.209722687]Search in Google Scholar
[21. Esposito, K, Nappo, F, Marfella, R, Giugliano, G, Giugliano, F, Ciotola, M, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress. Circulation 2002;106:2067-72.10.1161/01.CIR.0000034509.14906.AE12379575]Search in Google Scholar
[22. Kobayashi, K, Takahashi, N, Jimi, E, Udagawa, N, Takami, M, Kotake, S, et al. Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL–RANK interaction. The Journal of experimental medicine 2000;191:275-86.10.1084/jem.191.2.275219574610637272]Search in Google Scholar
[23. Pan Z, Guzeldemir E, Toygar HU, Bal N, Bulut S. Nitric oxide synthase in gingival tissues of patients with chronic periodontitis and with and without diabetes. J Periodontol. 2010;81(1):109-20.10.1902/jop.2009.09045420059423]Search in Google Scholar
[24. Collin, H-L, Uusitupa, M, Niskanen, L, Kontturi-Närhi, V, Markkanen, H, Koivisto, A-M, et al. Periodontal Findings in Elderly Patients with Non-Insulin Dependent Diabetes Mellitus. Journal of Periodontology 1998;69:962-6.10.1902/jop.1998.69.9.9629776023]Search in Google Scholar
[25. Taylor, GW, Burt, BA, Becker, MP, Genco, RJ, Shlossman, M, Knowler, WC, et al. Severe Periodontitis and Risk for Poor Glycemic Control in Patients with Non-Insulin-Dependent Diabetes Mellitus. Journal of Periodontology 1996;67:1085-93.10.1902/jop.1996.67.10s.10858910827]Search in Google Scholar
[26. Kıran, M, Arpak, N, Ünsal, E, Erdoğan, MF. The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. Journal of Clinical Periodontology 2005;32:266-72.10.1111/j.1600-051X.2005.00658.x15766369]Search in Google Scholar
[27. Singh, S, Kumar, V, Kumar, S, Subbappa, A. The effect of periodontal therapy on the improvement of glycemic control in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. International Journal of Diabetes in Developing Countries 2008;28:38-44.10.4103/0973-3930.43097277201019902046]Search in Google Scholar
[28. Katagiri, S, Nitta, H, Nagasawa, T, Uchimura, I, Izumiyama, H, Inagaki, K, et al. Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease. Diabetes Research and Clinical Practice 2009;83:308-15.10.1016/j.diabres.2008.10.01619168253]Search in Google Scholar
[29. Koromantzos, PA, Makrilakis, K, Dereka, X, Katsilambros, N, Vrotsos, IA, Madianos, PN. A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes. Part I: effect on periodontal status and glycaemic control. Journal of Clinical Periodontology 2011;38:142-7.10.1111/j.1600-051X.2010.01652.x21114680]Search in Google Scholar
[30. Moeintaghavi, A, Arab, HR, Bozorgnia, Y, Kianoush, K, Alizadeh, M. Non-surgical periodontal therapy affects metabolic control in diabetics: a randomized controlled clinical trial. Australian Dental Journal 2012;57:31-7.10.1111/j.1834-7819.2011.01652.x22369555]Search in Google Scholar
[31. Wang, X, Han, X, Guo, X, Luo, X, Wang, D. The Effect of Periodontal Treatment on Hemoglobin A1c Levels of Diabetic Patients: A Systematic Review and Meta-Analysis. PLoS ONE 2014;9:e108412.10.1371/journal.pone.0108412417791425255331]Search in Google Scholar
[32. Southerland JH, Taylor GW, Moss K, Beck JD, Offenbacher S. Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease. Periodontol 2000. 2006;40:130-43.10.1111/j.1600-0757.2005.00138.x]Search in Google Scholar
[33. Chen, L, Luo, G, Xuan, D, Wei, B, Liu, F, Li, J, et al. Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control in patients with type 2 diabetes: a randomized study. Journal of periodontology 2012;83:435-43.10.1902/jop.2011.110327]Search in Google Scholar
[34. Rodrigues, DC, Taba, M, Novaes, AB, Souza, SLS, Grisi, MFM. Effect of Non-Surgical Periodontal Therapy on Glycemic Control in Patients with Type 2 Diabetes Mellitus. Journal of Periodontology 2003;74:1361-7.10.1902/jop.2003.74.9.1361]Search in Google Scholar
[35. Nishimura, F, Iwamoto, Y, Mineshiba, J, Shimizu, A, Soga, Y, Murayama, Y. Periodontal Disease and Diabetes Mellitus: The Role of Tumor Necrosis Factor-α in a 2-Way Relationship. Journal of Periodontology 2003;74:97-102.10.1902/jop.2003.74.1.97]Search in Google Scholar
[36. Baud, V, Karin, M. Signal transduction by tumor necrosis factor and its relatives. Trends in cell biology 2001;11:372-7.10.1016/S0962-8924(01)02064-5]Search in Google Scholar
[37. Aderka, D. The potential biological and clinical significance of the soluble tumor necrosis factor receptors. Cytokine & growth factor reviews 1996;7:231-40.10.1016/S1359-6101(96)00026-3]Search in Google Scholar
[38. Franco C, Patricia H, Timo S, Claudia B, Marcela H. Matrix Metalloproteinases as Regulators of Periodontal Inflammation. Int J Mol Sci. 2017;18(2).10.3390/ijms18020440534397428218665]Search in Google Scholar
[39. Romanelli, R, Mancini, S, Laschinger, C, Overall, CM, Sodek, J, McCulloch, CA. Activation of neutrophil collagenase in periodontitis. Infection and immunity 1999;67:2319-26.10.1128/IAI.67.5.2319-2326.199911597310225890]Search in Google Scholar
[40. Bhavsar, A.P.; Guttman, J.A.; Finlay, B.B. Manipulation of host-cell pathways by bacterial pathogens. Nature. 2007, 449, 827–834.10.1038/nature06247]Search in Google Scholar
[41. Graves, D. Cytokines that promote periodontal tissue destruction. J. Periodontol. 2008, 79, 1585–1591.10.1902/jop.2008.080183]Search in Google Scholar
[42. Houri-Haddad, Y.; Wilensky, A.; Shapira, L. T-cell phenotype as a risk factor for periodontal disease. Periodontol. 2000 2007, 45, 67–75.10.1111/j.1600-0757.2007.00227.x]Search in Google Scholar
[43. Nitta, H.; Katagiri, S.; Nagasawa, T.; Izumi, Y.; Ishikawa, I.; Izumiyama, H.; Uchimura, I.; Kanazawa, M.; Chiba, H.; Matsuo, A.; et al. The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetic patients: Results of a multicenter hospital-based cross-sectional 1. study. J. Diabetes Investig. 2017;8(5):677-68610.1111/jdi.12633558395828129466]Search in Google Scholar
[44. Leppilahti, J, Ahonen, MM, Hernández, M, Munjal, S, Netuschil, L, Uitto, VJ, et al. Oral rinse MMP-8 point-of-care immuno test identifies patients with strong periodontal inflammatory burden. Oral diseases 2011;17:115-22.10.1111/j.1601-0825.2010.01716.x20659259]Search in Google Scholar
[45. Sorsa, T.; Gursoy, U.K.; Nwhator, S.; Hernandez, M.; Tervahartiala, T.; Leppilahti, J.; Gursoy, M.; Könönen, E.; Emingil, G.; Pussinen, P.J.; et al. Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol. 2000. 2016; 70(1):142-63.10.1111/prd.12101]Search in Google Scholar
[46. Luo, K.W.; Wei, C.; Lung, W.Y.; Wei, X.Y.; Cheng, B.H.; Cai, Z.M.; Huang, W.R. EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-_B and MMP-9. J. Nutr. Biochem. 2016, 41, 56–64.10.1016/j.jnutbio.2016.12.004]Search in Google Scholar
[47. Stawowczyk, M.;Wellenstein, M.D.; Lee, S.B.; Yomtoubian, S.; Durrans, A.; Choi, H.; Huang,W.R. Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. Neoplasia 2017; 19(2):55-64.10.1016/j.neo.2016.11.005519872828013056]Search in Google Scholar
[48. Shintani, T.; Kusuhara, Y.; Daizumoto, K.; Dondoo, T.O.; Yamamoto, H.; Mori, H.; Fukawa, T.; Nakatsuji, H.; Fukumori, T.; Takahashi, M.; et al. The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells. Urology. 2017; 101:169.e7-169.e13.10.1016/j.urology.2016.12.00628013036]Search in Google Scholar
[49. Butler, G.S.; Overall, C.M. Updated biological roles for matrix metalloproteinases and new “intracellular” substrates revealed by degradomics. Biochemistry. 2009; 48(46):10830-45.10.1021/bi901656f19817485]Search in Google Scholar
[50. Morrison CJ, Butler GS, Rodríguez D, Overall CM. Matrix metalloproteinase proteomics: substrates, targets, and therapy. Curr Opin Cell Biol. 2009;21(5):645-53.10.1016/j.ceb.2009.06.00619616423]Search in Google Scholar
[51. Heikkinen, A.M.; Sorsa, T.; Pitkaniemi, J.; Tervahartiala, T.; Kari, K.; Broms, U.; Koskenvuo, M.; Meurman, J.H. Smoking affects diagnostic salivary periodontal disease biomarker levels in adolescents. J. Periodontol. 2010; 81(9):1299-30710.1902/jop.2010.09060820450405]Search in Google Scholar
[52. Hernandez, M.; Valenzuela, M.A.; Lopez-Otin, C.; Alvarez, J.; Lopez, J.M.; Vernal, R.; Gamonal, J. Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity. J. Periodontol. 2006; 77(11):1863-70.10.1902/jop.2006.05046117076612]Search in Google Scholar
[53. Folgueras, A.R.; Pendas, A.M.; Sanchez, L.M.; Lopez-Otin, C. Matrix metalloproteinases in cancer: From new functions to improved inhibition strategies. Int. J. Dev. Biol. 2004; 48(5-6):411-24.10.1387/ijdb.041811af15349816]Search in Google Scholar
[54. Overall, C.M. Molecular determinants of metalloproteinase substrate specificity: Matrix metalloproteinase substrate binding domains, modules, and exosites. Mol. Biotechnol. 2002; 22(1):51-86.10.1385/MB:22:1:051]Search in Google Scholar
[55. Leppilahti, J.M.; Hernandez-Rios, P.A.; Gamonal, J.A.; Tervahartiala, T.; Brignardello-Petersen, R.; Mantyla, P.; Sorsa, T.; Hernández, M. Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis. J. Clin. Periodontol. 2014, 41, 348–356.10.1111/jcpe.12223]Search in Google Scholar
[56. Mori, K.; Shibanuma, M.; Nose, K. Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res. 2004, 64, 7464–7472.10.1158/0008-5472.CAN-04-1725]Search in Google Scholar
[57. Yoon, S.O.; Park, S.J.; Yoon, S.Y.; Yun, C.H.; Chung, A.S. Sustained production of H2O2 activates pro-matrix metalloproteinase-2 through receptor tyrosine kinases/phosphatidylinositol 3-kinase/NF-_B pathway. J. Biol. Chem. 2002, 277, 30271–30282.10.1074/jbc.M202647200]Search in Google Scholar
[58. Siwik, D.A.; Pagano, P.J.; Colucci, W.S. Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am. J. Physiol. Cell Physiol. 2001, 280, C53–C60.10.1152/ajpcell.2001.280.1.C53]Search in Google Scholar
[59. Tiranathanagul, S.; Yongchaitrakul, T.; Pattamapun, K.; Pavasant, P. Actinobacillus actinomycetemcomitans lipopolysaccharide activates matrix metalloproteinase-2 and increases receptor activator of nuclear factor-_B ligand expression in human periodontal ligament cells. J. Periodontol. 2004, 75, 1647–1654.10.1902/jop.2004.75.12.1647]Search in Google Scholar
[60. Osorio, C.; Cavalla, F.; Paula-Lima, A.; Diaz-Araya, G.; Vernal, R.; Ahumada, P.; Gamonal, J.; Hernández, M. H2O2 activates matrix metalloproteinases through the nuclear factor _B pathway and Ca2+ signals in human periodontal fibroblasts. J. Periodontal Res. 2015, 50, 798–806.10.1111/jre.12267]Search in Google Scholar
[61. Astrom, P.; Pirila, E.; Lithovius, R.; Heikkola, H.; Korpi, J.T.; Hernandez, M.; Sorsa, T.; Salo, T. Matrix metalloproteinase-8 regulates transforming growth factor-_1 levels in mouse tongue wounds and fibroblasts in vitro. Exp. Cell Res. 2014, 328, 217–227.10.1016/j.yexcr.2014.07.010]Search in Google Scholar
[62. Eguchi, T.; Kubota, S.; Kawata, K.; Mukudai, Y.; Uehara, J.; Ohgawara, T.; Ibaragi, S.; Sasaki, A.; Kuboki, T.; Takigawa, M. Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol. Cell. Biol. 2008, 28, 2391–2413.10.1128/MCB.01288-07]Search in Google Scholar
[63. Goncxalves FM, Jacob-Ferreira AL, Gomes VA, et al. Increased circulating levels of matrix metalloproteinase (MMP)-8, MMP-9, and pro-inflammatory markersin patients with metabolic syndrome. Clinica Chimica Acta.2009;403:173-177.10.1016/j.cca.2009.02.01319254704]Search in Google Scholar
[64. Kadoglou NP, Daskalopoulou SS, Perrea D, Liapis CD.Matrix metalloproteinases and diabetic vascular complications. Angiology. 2005;56:173-189.10.1177/00033197050560020815793607]Search in Google Scholar
[65. Thrailkill KM, Clay Bunn R, Fowlkes JL. Matrix metal-loproteinases: Their potential role in the pathogenesisof diabetic nephropathy. International Journal of Basic and Clinical Endocrinology. 2009;35:1-10.10.1007/s12020-008-9114-6]Search in Google Scholar
[66. Koromantzos PA, Makrilakis K, Dereka X, Offenbacher S, Katsilambros N, Vrotsos IA, Madianos PN.Effect of non-surgical periodontal therapy on C-reactive protein, oxidative stress, and matrix metalloproteinase (MMP)-9 and MMP-2 levels in patients with type 2 diabetes: a randomized controlled study. Journal of Periodontology. 2012;83(1):3-10.10.1902/jop.2011.11014821627458]Search in Google Scholar
[67. Kumar MS, Vamsi G, Sripriya R, Sehgal PK.Expression of matrix metalloproteinases (MMP-8 and -9) in chronic periodontitis patients with and without diabetes mellitus. Journal of Periodontology. 2006;77(11):1803-8.10.1902/jop.2006.050293]Search in Google Scholar
[68. Halliwell B. Free radicals, antioxidants and human disease: Curiosity, cause or consequence. Lancet. 1994; 344:721-724.10.1016/S0140-6736(94)92211-X]Search in Google Scholar
[69. Page RC, Kornman K. The pathogenesis of human periodontitis:an introduction. Periodontol 2000 1997;14:9-11.10.1111/j.1600-0757.1997.tb00189.x]Search in Google Scholar
[70. Cesaratto L, Vascotto C, Calligaris S, Tell G. The importance of redox state in liver damage. Ann Hepatol 2004;3:86-92.10.1016/S1665-2681(19)32099-X]Search in Google Scholar
[71. Jozanov-Stankov О, Dobutović DB, Djuric J, Isenović ER. Okidativni stres kao činilac kod oboljevanja i patoloških poremećaja ljudi. Apoll Med Aescul 2007;5:31-6.]Search in Google Scholar
[72. Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell cultures: how should you do it and what do the results mean? Brit J Pharmacol 2004;142:231-55.10.1038/sj.bjp.0705776]Search in Google Scholar
[73. Canakci CF, Ciceki Y, Canakci V. Reactive oxygen species and human inflammatory periodontal diseases. Biochem (Mosc) 2005;70:619-28.10.1007/s10541-005-0161-916038603]Search in Google Scholar
[74. Waddington RJ, Moseley R, Embery G. Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis 2000;6:138-51.10.1111/j.1601-0825.2000.tb00325.x10822357]Search in Google Scholar
[75. Giannobile WV. C-telopeptide pyridinolone cross-links. Sensitive indicators of periodontal tissue destruction. Ann NY Acad Sci 1999;30:404–12.10.1111/j.1749-6632.1999.tb07698.x258693010415744]Search in Google Scholar
[76. Mahajan, A, Singh, B, Kashyap, D, Kumar, A, Mahajan, P. Interspecies communication and periodontal disease. The Scientific World Journal 2013;2013:10.1155/2013/765434387430924396307]Search in Google Scholar
[77. Johnson, GK, Slach, NA. Impact of tobacco use on periodontal status. Journal of Dental Education 2001;65:313-21.10.1002/j.0022-0337.2001.65.4.tb03401.x]Search in Google Scholar
[78. Preshaw, PM, Taylor, JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? Journal of clinical periodontology 2011;38:60-84.10.1111/j.1600-051X.2010.01671.x]Search in Google Scholar
[79. Mukhopadhyay CK, Chatterjee IB. Free metal iondependent oxidative damage of collagen. Protection by ascorbic acid. J Biol Chem 1994;269:30200–5.10.1016/S0021-9258(18)43797-0]Search in Google Scholar
[80. Garrett IR, Boyce BF, Oreffo ROC, Bonewald L, Poser J, Mundy GR. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990;85:632–9.10.1172/JCI1144852964762312718]Search in Google Scholar
[81. Bax BE, Alam AS, Banerji B, Bax CM, Bevis PJ, Stevens CR et al. Stimulation of osteoclastic bone resorption by hydrogen peroxide. Biochem Biophys Res Commun 1992;183:1153–8.10.1016/S0006-291X(05)80311-0]Search in Google Scholar
[82. Hall TJ, Schaeublin M, Jeker H, Fuller K, Chambers TJ. The role of reactive oxygen intermediates in osteoclastic bone resorption. Biochem Biophys Res Commun 1995;207:280–7.10.1006/bbrc.1995.11847857277]Search in Google Scholar
[83. Moseley R, Waddington RJ, Embery G. The modification of alveolar bone proteoglycans by reactive species in vitro. Connect Tissue Res 1998;37:13–28.10.3109/030082098090288979643644]Search in Google Scholar
[84. Chapple ILC, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000. 2007;43:160-232.10.1111/j.1600-0757.2006.00178.x17214840]Search in Google Scholar
[85. Tamaki N, Tomofuji T, Ekuni D, Yamanaka R, Yamamoto T, Morita M. Short-term effects on non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis. J Periodontol 2009;80:901-6.10.1902/jop.2009.08064019485819]Search in Google Scholar
[86. Ekuni D, Tomofuji T, Tamaki N, Sanbe T, Azuma T, Yamanaka R, et al. Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis. Arch Oral Biol 2008;53:324-9.10.1016/j.archoralbio.2007.10.00518031711]Search in Google Scholar
[87. Tomofuji T, Sanbe T, Ekuni D, Azuma T, Irie K, Maruyama T, et al. Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Arch Oral Biol 2008;53:1113-8.10.1016/j.archoralbio.2008.05.01518603227]Search in Google Scholar
[88. Palasciano G, Moshetta A, Palmieri VO, Grattagliano I, Iacobellis G, Portincasa P. Non-alcoholic fatty liver disease in the metabolic syndrome. Curr Pharm Design 2007;13:2193-8.10.2174/13816120778103965217627552]Search in Google Scholar
[89. Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 2008;29:9-16.10.1016/j.mam.2007.09.00418045675]Search in Google Scholar
[90. Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, et al. Periodontitis-induced lipid peroxidation in rat descending aorta is involvedin initiation of atherosclerosis. J Periodontal Res 2009;44:434–4210.1111/j.1600-0765.2008.01122.x19210335]Search in Google Scholar
[91. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology. 2007; 39(1):44–87.10.1016/j.biocel.2006.07.00116978905]Search in Google Scholar
[92. Yamamoto Y, Hirose H, saito I, Nishikai K, Saruta T. Adiponectin, an adipocytederived protein, predicts future insulin resistance: two – year follow – up study in Japanese population. The Journal of Clinical Endocrinology and Metabolism. 2004; 89(1):87-90.10.1210/jc.2003-03116314715832]Search in Google Scholar
[93. Liu Y, Zhang Q. Periodontitis aggravated pancreatic β-cell dysfunction in diabetic mice through interleukin-12 regulation on Klotho. J Diabetes Investig. 2016;7(3):303-11.10.1111/jdi.12410484788327330715]Search in Google Scholar
[94. Monea A, Mezei T, Popsor S, Monea M. Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease. International Journal of Endocrinology. 2014; 1–4.10.1155/2014/917631426569225525432]Search in Google Scholar
[95. Vincent RR, Appukuttan D, Dhayanand JV, Balasundaram A. Oxidative stress in chronic periodontitis patients with type II diabetes mellitus. European Journal of Dentistry. 2018; 12(2): 225–231.10.4103/ejd.ejd_244_17600479329988233]Search in Google Scholar
[96. Arana C, Moreno-Fernández AM, Gómez-Moreno G, Morales-Portillo C, Serrano-Olmedo I, de la Cuesta Mayor MC, Martín Hernández T. Increased salivary oxidative stress parameters in patients with type 2 diabetes: Relation with periodontal disease. Еndocrinologia, diabetes y nutricion. 2017;64(5):258-264.10.1016/j.endinu.2017.03.00528495321]Search in Google Scholar
[97. Patil VS, Patil VP, Gokhale N, Acharya A, Kangokar P. Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury. Јournal of clinical and diagnostic research. 2016; 10(4):12-16.10.7860/JCDR/2016/17350.7542486608827190790]Search in Google Scholar
[98. Blasco-Baque V, Garidou L, Pomié C, Escoula Q, Loubieres P, Le Gall-David S, Lemaitre M, Nicolas S, Klopp P, Waget A, Azalbert V, Colom A, Bonnaure-Mallet M, Kemoun P, Serino M, Burcelin R. Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut. 2017;66(5):872-885.10.1136/gutjnl-2015-309897553122726838600]Search in Google Scholar