<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of 42 patients with rheumatoid arthritis and 48 age- and sex-matched controls were included in the study. Clinical examination was performed and assessed disease activity. Peripheral blood samples were used for all the assays. The markers of oxidative stress were assessed, including plasma levels of index of lipid peroxidation – thiobarbituric acid reactive substances, hydrogen peroxide, superoxide anion radical, nitrites and activity of superoxide dismutase, catalase and reduced glutathione levels as anti-oxidant parameters. In the patients group, levels of hydrogen peroxide and index of lipid peroxidation were higher than in controls. Patients with rheumatoid arthritis had decreased su-peroxide dismutase and catalase activity compared to healthy subjects. Interestingly, controls had higher levels of nitrites compared to patients. Patients showed a marked increase in reactive oxygen species formation and lipid peroxidation as well as decrease in the activity of antioxidant defense system leading to oxidative stress which may contribute to tissue and cartilage damage and hence to the chronicity of the disease.</p>
</abstract>

The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of 42 patients with rheumatoid arthritis and 48 age- and sex-matched controls were included in the study. Clinical examination was performed and assessed disease activity. Peripheral blood samples were used for all the assays. The markers of oxidative stress were assessed, including plasma levels of index of lipid peroxidation – thiobarbituric acid reactive substances, hydrogen peroxide, superoxide anion radical, nitrites and activity of superoxide dismutase, catalase and reduced glutathione levels as anti-oxidant parameters. In the patients group, levels of hydrogen peroxide and index of lipid peroxidation were higher than in controls. Patients with rheumatoid arthritis had decreased su-peroxide dismutase and catalase activity compared to healthy subjects. Interestingly, controls had higher levels of nitrites compared to patients. Patients showed a marked increase in reactive oxygen species formation and lipid peroxidation as well as decrease in the activity of antioxidant defense system leading to oxidative stress which may contribute to tissue and cartilage damage and hence to the chronicity of the disease.

Redox Status in Women with Rheumathoid Arthritis

Department of Pharmacy, Faculty of Medical Sciences

Department of Physiology, Faculty of Medical Sciences

1st Moscow State Medical University IM Sechenov

Department of Internal medicine, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Redox Status in Women with Rheumathoid Arthritis"}

The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of...

Redox Status in Women with Rheumathoid Arthritis

Online veröffentlicht: 29. Mai 2021

Seitenbereich: 29 - 36

Eingereicht: 19. Okt. 2018

Akzeptiert: 26. Okt. 2018

DOI: https://doi.org/10.2478/sjecr-2018-0047

Schlüsselwörter
rheumatoid arthritis, oxidative stress, reactive oxygen species, women

© 2020 Aleksandra Vranic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Redox Status in Women with Rheumathoid Arthritis

Online veröffentlicht: 29. Mai 2021

Seitenbereich: 29 - 36

Eingereicht: 19. Okt. 2018

Akzeptiert: 26. Okt. 2018

DOI: https://doi.org/10.2478/sjecr-2018-0047

Schlüsselwörterrheumatoid arthritis, oxidative stress, reactive oxygen species, women

© 2020 Aleksandra Vranic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
rheumatoid arthritis, oxidative stress, reactive oxygen species, women