<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives:</bold> There is increasing evidence that metabolic syndrome (MetS) may be associated with increased uric acid levels. Previous studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disorders. We sought to determine the association of serum uric acid (SUA) with MetS components and other cardiovascular risk factors among middle aged Lithuanians with MetS.<bold>Design and methods:</bold> A cross-sectional study was conducted in 2018. A total of 705 subjects aged 40 to 65 years with MetS diagnosed using NCEP ATP III criteria were included. None of the participants had previously diagnosed cardiovascular, cerebrovascular, peripheral artery or end-stage oncological disease. Blood tests and all anthropometric measurements were obtained using standard methods. Subjects were divided into 2 groups: with hyperuricaemia and without hyperuricaemia.<bold>Results:</bold> Hyperuricaemia was found in 33.3% of subjects. Mean serum uric acid level increased as the number of metabolic factors increased. Participants with hyperuricaemia had abnormal waist circumference (p &lt; 0.001), higher systolic (p = 0.001) and diastolic blood pressure (p = 0.003), higher levels of triglycerides and, lower levels of high-density lipoprotein cholesterol (p &lt; 0.001). Subjects in hyperuricaemia group were more likely to be alcohol users (p = 0.034), to have diabetes (p = 0.02) and higher body mass index (p &lt; 0.001). Their creatinine levels were statistically significantly higher (p &lt; 0.001).<bold>Conclusions:</bold> Our analysis showed that serum uric acid is associated with MetS and other cardiovascular risk factors. The study found a statistically significant association with the four out of five components of the MetS (excluding plasma glucose) as well as with alcohol consumption, and renal function indicators (creatinine, eGFR).</abstract>

Objectives: There is increasing evidence that metabolic syndrome (MetS) may be associated with increased uric acid levels. Previous studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disorders. We sought to determine the association of serum uric acid (SUA) with MetS components and other cardiovascular risk factors among middle aged Lithuanians with MetS.Design and methods: A cross-sectional study was conducted in 2018. A total of 705 subjects aged 40 to 65 years with MetS diagnosed using NCEP ATP III criteria were included. None of the participants had previously diagnosed cardiovascular, cerebrovascular, peripheral artery or end-stage oncological disease. Blood tests and all anthropometric measurements were obtained using standard methods. Subjects were divided into 2 groups: with hyperuricaemia and without hyperuricaemia.Results: Hyperuricaemia was found in 33.3% of subjects. Mean serum uric acid level increased as the number of metabolic factors increased. Participants with hyperuricaemia had abnormal waist circumference (p < 0.001), higher systolic (p = 0.001) and diastolic blood pressure (p = 0.003), higher levels of triglycerides and, lower levels of high-density lipoprotein cholesterol (p < 0.001). Subjects in hyperuricaemia group were more likely to be alcohol users (p = 0.034), to have diabetes (p = 0.02) and higher body mass index (p < 0.001). Their creatinine levels were statistically significantly higher (p < 0.001).Conclusions: Our analysis showed that serum uric acid is associated with MetS and other cardiovascular risk factors. The study found a statistically significant association with the four out of five components of the MetS (excluding plasma glucose) as well as with alcohol consumption, and renal function indicators (creatinine, eGFR).

Is the increase of uric acid associated with the components of the metabolic syndrome?

State Research Institute Centre for Innovative Medicine

Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Institute of Clinical Medicine

Vilnius University Hospital Santaros Klinikos

Vilnius University Faculty of Mathematics and Informatics

Institute of Data Science and Digital Technologies

Seminars in Cardiovascular Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objectives: There is increasing evidence that metabolic syndrome (MetS) may be associated with increased uric acid levels. Previous studies indicate that...

Is the increase of uric acid associated with the components of the metabolic syndrome?

Online veröffentlicht: 24. Juni 2020

Seitenbereich: 7 - 13

Eingereicht: 29. Apr. 2020

Akzeptiert: 18. Mai 2020

DOI: https://doi.org/10.2478/semcard-2020-0002

Schlüsselwörter
metabolic syndrome, cardiovascular risk factors, hyperuricaemia, uric acid

© 2020 Vaida Sudmantaitė et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Is the increase of uric acid associated with the components of the metabolic syndrome?

Online veröffentlicht: 24. Juni 2020

Seitenbereich: 7 - 13

Eingereicht: 29. Apr. 2020

Akzeptiert: 18. Mai 2020

DOI: https://doi.org/10.2478/semcard-2020-0002

Schlüsselwörtermetabolic syndrome, cardiovascular risk factors, hyperuricaemia, uric acid

© 2020 Vaida Sudmantaitė et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
metabolic syndrome, cardiovascular risk factors, hyperuricaemia, uric acid