Incidence rate of postoperative cognitive dysfunction at different anesthetic depths and its correlation with serum levels of RAGE, NR2B, CREB, and NFL
Online veröffentlicht: 15. Mai 2025
Seitenbereich: 87 - 94
Eingereicht: 18. Sept. 2024
Akzeptiert: 26. Feb. 2025
DOI: https://doi.org/10.2478/rrlm-2025-0009
Schlüsselwörter
© 2025 Xuegang Yang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
Anesthetic depth may affect cognitive function, which is reflected by serum biomarker levels. We aimed to investigate the incidence rate of postoperative cognitive dysfunction (POCD) at different anesthetic depths and its correlations with levels of serum receptor for advanced glycation end product (RAGE), N-methyl-D-aspartate receptor 2B subunit (NR2B), cAMP response element-binding protein (CREB) and neurofilament light chain (NFL).
Methods
Elderly patients (n=273) undergoing general anesthesia from January 2022 to February 2024 were selected and assigned to a light anesthesia group [bispectral index (BIS): 60-70, n=98)], a moderate anesthesia group (BIS: 50-60, n=85) and a deep anesthesia group (BIS: 40-50, n=90). The serum levels of RAGE, NR2B, CREB and NFL were detected. Cognitive function was assessed by the Mini-mental State Examination to determine the occurrence of POCD. The correlations of POCD with RAGE, NR2B, CREB and NFL levels were explored by Spearman analysis. Their predictive efficiencies for POCD were evaluated using receiver operating characteristic curves.
Results
The levels of serum RAGE, NR2B, CREB and NFL had significant differences among groups, at each time point and at each interaction (
Conclusions
The levels of serum RAGE, NR2B, CREB and NFL are closely correlated with the incidence rate of POCD.