This work is licensed under the Creative Commons Attribution 4.0 International License.
Centers for Disease Control and Prevention. “Strengthening Clinical Laboratories”. Retrieved from https://www.cdc.gov/csels/dls/strengthening-clinical-labs.html [accessed May 2024]Search in Google Scholar
Horn PS, Pesce AJ. Reference intervals: an update. Clin Chim Acta. 2003;334(1-2):5-23. DOI: 10.1016/S0009-8981(03)00133-5Search in Google Scholar
CLSI and IFCC. C28-A3 document; Defining, establishing and verifying reference intervals in the clinical laboratory: approved guideline-third edition, 2008;28:1-76Search in Google Scholar
Ozarda Y, Sikaris K, Streichert T, Macri J. IFCC Committee on Reference intervals and Decision Limits (C-RIDL). Distinguishing reference intervals and clinical decision limits - A review by the IFCC Committee on Reference Intervals and Decision Limits. Crit Rev Clin Lab Sci. 2018;55(6):420-431. DOI: 10.1080/10408363.2018.1482256Search in Google Scholar
Chuah TY, Lim CY, Tan RZ, Pratumvinit B, Loh TP, Vasikaran S, Markus C; APFCB Harmonization of Reference Intervals Working Group. Functional Reference Limits: Describing Physiological Relationships and Determination of Physiological Limits for Enhanced Interpretation of Laboratory Results. Ann Lab Med. 2023 Sep 1;43(5):408-417. DOI: 10.3343/alm.2023.43.5.408Search in Google Scholar
Emancipator K. Critical values: ASCP practice parameter. American Society of Clinical Pathologists. Am J Clin Pathol. 1997 Sep;108(3):247-53. DOI: 10.1093/ajcp/108.3.247Search in Google Scholar
Marginean O. Cresterea si Dezvoltarea. Tratat de Pediatrie.Ed. I. MEDICHUB MEDIA; Bucuresti, Romania, 202.Search in Google Scholar
Centers for Disease Control and Prevention. Growth charts. Retrieved from https://www.cdc.gov/growthcharts/index.htm [accessed May 2024].Search in Google Scholar
Coffin CM, Hamilton MS, Pysher TJ, Bach P, Ashwood E, Schweiger J et al. Pediatric laboratory medicine: current challenges and future opportunities. Am J Clin Pathol. 2002 May;117(5):683-90. DOI: 10.1309/C52D-BY0U-VXXU-R360Search in Google Scholar
Santos RP, Tristram D. A practical guide to the diagnosis, treatment, and prevention of neonatal infections. Pediatr Clin North Am. 2015 Apr;62(2):491-508. DOI: 10.1016/j. pcl.2014.11.010Search in Google Scholar
Centers for Disease Control and Prevention. Congenital syphilis. Retrieved from https://www.cdc.gov/std/treatment-guidelines/congenital-syphilis.htm [accessed June 2024]Search in Google Scholar
Read JS; Committee on Pediatric AIDS, American Academy of Pediatrics. Diagnosis of HIV-1 infection in children younger than 18 months in the United States. Pediatrics. 2007 Dec;120(6):e1547-62. DOI: 10.1542/peds.2007-2951Search in Google Scholar
Schnabl K, Chan MK, Gong Y, Adeli K. Closing the gaps in paediatric reference intervals: the CALIPER initiative. Clin Biochem Rev. 2008 Aug;29(3):89-96.Search in Google Scholar
Jones P. M. Pediatric Clinical Biochemistry: Why Is It Different? Biochemical and Molecular Basis of Pediatric Disease 4th Edition. AACC Press, USA, 2010.Search in Google Scholar
Lepage N, Li D, Kavsak PA, Bamforth F, Callahan J, Dooley K, Potter M. Incomplete pediatric reference intervals for the management of patients with inborn errors of metabolism. Clin Biochem. 2006 Jun;39(6):595-9. DOI: 10.1016/j.clinbiochem.2006.02.011Search in Google Scholar
Rahman M, George C, Monagle P. Hot topics in coagulation testing: Important considerations for testing children for bleeding/thrombotic disorders. Int J Lab Hematol. 2020 Jun;42 Suppl 1:68-74. DOI: 10.1111/ijlh.13198Search in Google Scholar
Jung B, Adeli K. Clinical laboratory reference intervals in pediatrics: the CALIPER initiative. Clin Biochem 2009;42:1589-1595 DOI: 10.1016/j.clinbiochem.2009.06.025Search in Google Scholar
Soldin OP, Soldin SJ. Review: therapeutic drug monitoring in pediatrics. Ther Drug Monit. 2002 Feb;24(1):1-8. DOI: 10.1097/00007691-200202000-00001Search in Google Scholar
Aricò MO, Valletta E, Caselli D. Appropriate Use of Antibiotic and Principles of Antimicrobial Stewardship in Children. Children (Basel). 2023 Apr 17;10(4):740. DOI: 10.3390/children10040740Search in Google Scholar
Christensen B, Glueck C, Kwiterovich P, Degroot I, Chase G, Heiss G et al. Plasma cholesterol and triglyceride distributions in 13,665 children and adolescents: the Prevalence Study of the Lipid Research Clinics Program. Pediatr Res. 1980 Mar;14(3):194-202. DOI: 10.1203/00006450-198003000-00004Search in Google Scholar
Fiorentino R, Chiarelli F. Treatment of Dyslipidaemia in Children. Biomedicines. 2021 Aug 24;9(9):1078. DOI: 10.3390/biomedicines9091078Search in Google Scholar
Roth-Cline M, Gerson J, Bright P, Lee CS, Nelson RM. Ethical considerations in conducting pediatric research. Handb Exp Pharmacol. 2011;205:219-44. DOI: 10.1007/978-3-642-20195-0_11Search in Google Scholar
Shaw JL, Binesh Marvasti T, Colantonio D, Adeli K. Pediatric reference intervals: challenges and recent initiatives. Crit Rev Clin Lab Sci. 2013 Feb-Apr;50(2):37-50. DOI: 10.3109/10408363.2013.786673Search in Google Scholar
Ceriotti F. Establishing pediatric reference intervals: a challenging task. Clin Chem. 2012 May;58(5):808-10. DOI: 10.1373/clinchem.2012.183483Search in Google Scholar
Lyle AN, Pokuah F, Dietzen DJ, Wong ECC, Pyle-Eilola AL, Fuqua JS et al. Current State of Pediatric Reference Intervals and the Importance of Correctly Describing the Biochemistry of Child Development: A Review. JAMA Pediatr. 2022 Jul 1;176(7):699-714. DOI: 10.1001/jamapediatrics.2022.0794Search in Google Scholar
Madsen LP, Rasmussen MK, Bjerregaard LL, Nøhr SB, Ebbesen F. Impact of blood sampling in very preterm infants. Scand J Clin Lab Invest. 2000 Apr;60(2):125-32. DOI: 10.1080/00365510050184949Search in Google Scholar
Broder-Fingert S, Crowley WF, Jr, Boepple PA. Safety of frequent venous blood sampling in a pediatric research population. J Pediatr. 2009;154:578-81 DOI: 10.1016/j.jpeds.2008.10.007Search in Google Scholar
Cole M, Boddy AV, Kearns P, Teh KH, Price L, Parry A, et al.UKCCSG Pharmacology group Potential clinical impact of taking multiple blood samples for research studies in paediatric oncology: how much do we really know? Pediatr Blood Cancer. 2006;46:723-7 DOI: 10.1002/pbc.20463Search in Google Scholar
Aytekin M, Emerk K. Accurate Reference Intervals are Required for Accurate Diagnosis and Monitoring of Patients. EJIFCC. 2008 Oct 16;19(2):137-41.Search in Google Scholar
Ozarda Y. Establishing and using reference intervals. Turkish Journal of Biochemistry. 2020;45(1): 1-10. DOI: 10.1515/tjb-2017-0299Search in Google Scholar
Ceriotti F, Hinzmann R, Panteghini M. Reference intervals: the way forward. Ann Clin Biochem. 2009 Jan;46(Pt 1):8-17. DOI: 10.1258/acb.2008.008170Search in Google Scholar
Loh T, Cooke B, Markus C, Zakaria R, Tran M, Ho C, Greaves R, On behalf of the IFCC Working Group on Method Evaluation Protocols. Method evaluation in the clinical laboratory. Clinical Chemistry and Laboratory Medicine (CCLM). 2023;61(5): 751-758. DOI: 10.1515/cclm-2022-0878Search in Google Scholar
Plebani M. Harmonization in laboratory medicine: the complete picture. Clinical Chemistry and Laboratory Medicine (CCLM). 2013;51(4): 741-751 DOI: 10.1515/cclm-2013-0075Search in Google Scholar
Smellie WS; Association for Clinical Biochemistry’s Clinical Practice Section. Time to harmonise common laboratory test profiles. BMJ. 2012 Mar 20;344:e1169. DOI: 10.1136/bmj.e1169Search in Google Scholar
Plebani M. Harmonization in laboratory medicine: Requests, samples, measurements and reports. Crit Rev Clin Lab Sci. 2016;53(3):184-96. DOI: 10.3109/10408363.2015.1116851Search in Google Scholar
Katayev A, Balciza C, Seccombe DW. Establishing reference intervals for clinical laboratory test results: is there a better way? Am J Clin Pathol. 2010 Feb;133(2):180-6. DOI: 10.1309/AJCPN5BMTSF1CDYPSearch in Google Scholar
Tate JR, Yen T, Jones GR. Transference and validation of reference intervals. Clin Chem. 2015 Aug;61(8):1012-5. DOI: 10.1373/clinchem.2015.243055Search in Google Scholar
Zierk J, Metzler M, Rauh M. Data mining of pediatric reference intervals. Journal of Laboratory Medicine. 2021;45(6): 311-317. DOI: 10.1515/labmed-2021-0120Search in Google Scholar
Haeckel R, Wosniok W, Arzideh F, Zierk J, Gurr E, Streichert T. Critical comments to a recent EFLM recommendation for the review of reference intervals. Clin Chem Lab Med. 2017 Mar 1;55(3):341-347. DOI: 10.1515/cclm-2016-1112Search in Google Scholar
Farrell CL, Nguyen L. Indirect Reference Intervals: Harnessing the Power of Stored Laboratory Data. Clin Biochem Rev. 2019 May;40(2):99-111. DOI: 10.33176/AACB-19-00022Search in Google Scholar
Jones G, Haeckel R, Loh T, Sikaris K, Streichert T, Katayev A et al on behalf of the IFCC Committee on Reference Intervals and Decision Limits. Indirect methods for reference interval determination - review and recommendations. Clinical Chemistry and Laboratory Medicine (CCLM). 2019;57(1): 20-29. DOI: 10.1515/cclm-2018-0073Search in Google Scholar
Doyle K, Bunch DR. Reference intervals: past, present, and future. Crit Rev Clin Lab Sci. 2023 Sep;60(6):466-482. DOI: 10.1080/10408363.2023.2196746Search in Google Scholar
Haeckel R, Wosniok W, Streichert T, Members of the Section Guide Limits of the DGKL. Review of potentials and limitations of indirect approaches for estimating reference limits/intervals of quantitative procedures in laboratory medicine. Journal of Laboratory Medicine. 2021;45(2): 35-53. DOI: 10.1515/labmed-2020-0131Search in Google Scholar
Haeckel R. Indirect approaches to estimate reference intervals. Journal of Laboratory Medicine. 2021;45(2): 31-33. DOI: 10.1515/labmed-2021-0003Search in Google Scholar
Ammer T, Schützenmeister A, Prokosch HU, Rauh M, Rank CM, Zierk J. refineR: A Novel Algorithm for Reference Interval Estimation from Real-World Data. Sci Rep. 2021 Aug 6;11(1):16023. DOI: 10.1038/s41598-021-95301-2Search in Google Scholar
Mrosewski I, Dähn T, Hehde J, Kalinowski E, Lindner I, Meyer TM et al. Indirectly determined hematology reference intervals for pediatric patients in Berlin and Brandenburg. Clin Chem Lab Med. 2021 Dec 14;60(3):408-432. DOI: 10.1515/cclm-2021-0853Search in Google Scholar
Zierk J, Arzideh F, Haeckel R, Rascher W, Rauh M, Metzler M. Indirect determination of pediatric blood count reference intervals. Clin Chem Lab Med. 2013 Apr;51(4):863-72. DOI: 10.1515/cclm-2012-0684Search in Google Scholar
Shaw JL, Cohen A, Konforte D, Binesh-Marvasti T, Colantonio DA, Adeli K. Validity of establishing pediatric reference intervals based on hospital patient data: a comparison of the modified Hoffmann approach to CALIPER reference intervals obtained in healthy children. Clin Biochem. 2014 Feb;47(3):166-72. DOI: 10.1016/j.clinbiochem.2013.11.008Search in Google Scholar
IFCC Global Reference Interval Database. Reference Interval Studies. Retrieved from https://grid.ifcc.org/studies/ [accessed June 2024]Search in Google Scholar
Flanders MM, Crist RA, Roberts WL, Rodgers GM. Pediatric reference intervals for seven common coagulation assays. Clin Chem 2005;51:1738-1742. DOI: 10.1373/clinchem.2005.050211Search in Google Scholar
Kushnir MM, Rockwood AL, Roberts WL, Pattison EG, Owen WE, Bunker AM, Meikle AW. Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids. Clin Chem 2006;52:1559-1567. DOI: 10.1373/clinchem.2006.068445Search in Google Scholar
Clifford SM, Bunker AM, Jacobsen JR, Roberts WL. Age and gender specific pediatric reference intervals for aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin, and uric acid. Clin Chim Acta 2011;412:788-790. DOI: 10.1016/j.cca.2011.01.011Search in Google Scholar
Johnson-Davis KL, Moore SJ, Owen WE, Cutler JM, Frank EL. A rapid HPLC method used to establish pediatric reference intervals for vitamins A and E. Clin Chim Acta 2009;405:35-38. DOI: 10.1016/j.cca.2009.03.058Search in Google Scholar
Meikle AW, Kushnir MM, Rockwood AL, Pattison EG, Terry AH, Sandrock T, Bunker AM, Phanslkar AR, Owen WE, Roberts WL. Adrenal steroid concentrations in children seven to seventeen years of age. J Pediatr Endocrinol Metab 2007;20:1281-1291. DOI: 10.1515/JPEM.2007.20.12.1281Search in Google Scholar
Wyness SP, Roberts WL, Straseski JA. Pediatric reference intervals for four serum bone markers using two automated immunoassays. Clin Chim Acta 2013;415:169-172. DOI: 10.1016/j.cca.2012.10.036Search in Google Scholar
Southcott EK, Kerrigan JL, Potter JM, Telford RD, Waring P, Reynolds GJ, Lafferty AR, Hickman PE. Establishment of pediatric reference intervals on a large cohort of healthy children. Clin Chim Acta 2010;411:1421-1427. DOI: 10.1016/j.cca.2010.06.018Search in Google Scholar
Koerbin G, Abhayaratna WP, Potter JM, Apostoloska S, Telford RD, Hickman PE. NTproBNP concentrations in healthy children. Clin Biochem 2012;45:1158-1160. DOI: 10.1016/j. clinbiochem.2012.05.008Search in Google Scholar
Hoq M, Matthews S, Karlaftis V, Burgess J, Cowley J, Donath S, Carlin J, Yen T, Ignjatovic V, Monagle P; HAPPI Kids study team. Reference Values for 30 Common Biochemistry Analytes Across 5 Different Analyzers in Neonates and Children 30 Days to 18 Years of Age. Clin Chem. 2019 Oct;65(10):1317-1326. DOI: 10.1373/clinchem.2019.306431Search in Google Scholar
Cai T, Karlaftis V, Hearps S, Matthews S, Burgess J, Monagle P, Ignjatovic V; HAPPI Kids study team. Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old. Pediatr Nephrol. 2020 Oct;35(10):1959-1966. DOI: 10.1007/s00467-020-04612-5Search in Google Scholar
Tate JR, Sikaris KA, Jones GR, Yen T, Koerbin G, Ryan J, Reed M, Gill J, Koumantakis G, Hickman P, Graham P. Harmonising adult and paediatric reference intervals in Australia and New Zeeland: an evidence-based approach for establishing a first panel of chemistry analytes. Clin Biochem Rev. 2014 Nov;35(4):213-35.Search in Google Scholar
CALIPER. CALIPER Project Achievements. Retrieved from https://caliperproject.ca/ [accessed June 2024]Search in Google Scholar
Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci. 2017 Sep;54(6):358-413. DOI: 10.1080/10408363.2017.1379945Search in Google Scholar
Bohn MK, Higgins V, Tahmasebi H, Hall A, Liu E, Adeli K et al. Complex biological patterns of hematology parameters in childhood necessitating age- and sex-specific reference intervals for evidence-based clinical interpretation. Int J Lab Hematol. 2020 Dec;42(6):750-760. DOI: 10.1111/ijlh.13306Search in Google Scholar
Tahmasebi H, Higgins V, Bohn MK, Hall A, Adeli K. CALIPER Hematology Reference Standards (I). Am J Clin Pathol. 2020 Aug 5;154(3):330-341. DOI: 10.1093/ajcp/aqaa059Search in Google Scholar
Higgins V, Tahmasebi H, Bohn MK, Hall A, Adeli K. CALIPER Hematology Reference Standards (II). Am J Clin Pathol. 2020 Aug 5;154(3):342-352. DOI: 10.1093/ajcp/aqaa057Search in Google Scholar
Bohn MK, Higgins V, Asgari S, Leung F, Hoffman B et al. Paediatric reference intervals for 17 Roche cobas 8000 e602 immunoassays in the CALIPER cohort of healthy children and adolescents. Clin Chem Lab Med. 2019 Nov 26;57(12):1968-1979. DOI: 10.1515/cclm-2019-0707Search in Google Scholar
Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc D, Venner AA et al. Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May;58(5):854-68. DOI: 10.1373/clinchem.2011.177741Search in Google Scholar
Teodoro-Morrison T, Kyriakopoulou L, Chen YK, Raizman JE, Bevilacqua V, Chan MK et al. Dynamic biological changes in metabolic disease biomarkers in childhood and adolescence: A CALIPER study of healthy community children. Clin Biochem. 2015 Sep;48(13-14):828-36. DOI: 10.1016/j.clinbiochem.2015.05.005Search in Google Scholar
Raizman JE, Quinn F, Armbruster DA, Adeli K. Pediatric reference intervals for calculated free testosterone, bioavailable testosterone and free androgen index in the CALIPER cohort. Clin Chem Lab Med. 2015 Sep 1;53(10):e239-43. DOI: 10.1515/cclm-2015-0027Search in Google Scholar
Konforte D, Shea JL, Kyriakopoulou L, Colantonio D, Cohen AH, Shaw J et al. Complex biological pattern of fertility hormones in children and adolescents: a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals. Clin Chem. 2013 Aug;59(8):1215-27. DOI: 10.1373/clinchem.2013.204123Search in Google Scholar
Bailey D, Colantonio D, Kyriakopoulou L, Cohen AH, Chan MK, Armbruster D et al. Marked biological variance in endocrine and biochemical markers in childhood: establishment of pediatric reference intervals using healthy community children from the CALIPER cohort. Clin Chem. 2013 Sep;59(9):1393-405. DOI: 10.1373/clinchem.2013.204222Search in Google Scholar
Pasic MD, Colantonio DA, Chan MK, Venner AA, Brinc D, Adeli K. Influence of fasting and sample collection time on 38 biochemical markers in healthy children: a CALIPER substudy. Clin Biochem 2012;45:1125-1130. DOI: 10.1016/j.clinbiochem.2012.07.089Search in Google Scholar
Bevilacqua V, Chan MK, Chen Y, Armbruster D, Schodin B, Adeli K. Pediatric population reference value distributions for cancer biomarkers and covariate-stratified reference intervals in the CALIPER cohort. Clin Chem 2014;60:1532-1542. DOI: 10.1373/clinchem.2014.229799Search in Google Scholar
Bohn MK, Hall A, Wilson S, Henderson T, Adeli K. Pediatric Reference Intervals for Critical Point-of-Care Whole Blood Assays in the CALIPER Cohort of Healthy Children and Adolescents. Am J Clin Pathol. 2021 Nov 8;156(6):1030-1037. DOI: 10.1093/ajcp/aqab064Search in Google Scholar
Ni X, Song W, Peng X, Shen Y, Peng Y, Li Q et al; study group of Pediatric Reference Intervals in China (PRINCE). Pediatric reference intervals in China (PRINCE): design and rationale for a large, multicenter collaborative cross-sectional study. Sci Bull (Beijing). 2018 Dec 30;63(24):1626-1634. DOI: 10.1016/j. scib.2018.11.024Search in Google Scholar
Song W, Yan R, Peng M, Jiang H, Li G, Cao S, Jiang Y, Guo Z, Chen D, Yang H, Xu J, Chang Y, Xiang Y, Zhao M, Li C, Shen Y, Jin F, Li Q, Wang Y, Peng Y, Hu L, Liu Y, Zhang X, Chen W, Peng X, Ni X. Age and sex specific reference intervals of 13 hematological analytes in Chinese children and adolescents aged from 28 days up to 20 years: the PRINCE study. Clin Chem Lab Med. 2022 May 24;60(8):1250-1260. DOI: 10.1515/cclm-2022-0304Search in Google Scholar
Peng X, Peng Y, Zhang C, Zhao M, Yang H, Cao S et al; Study Group of Pediatric Reference Intervals in China (PRINCE). Reference intervals of 14 biochemical markers for children and adolescence in China: the PRINCE study. Clin Chem Lab Med. 2022 Aug 8;60(10):1627-1639. DOI: 10.1515/cclm-2022-0299Search in Google Scholar
Yan R, Peng Y, Hu L, Zhang W, Li Q, Wang Y et al. Continuous reference intervals for 21 biochemical and hematological analytes in healthy Chinese children and adolescents: The PRINCE study. Clin Biochem. 2022 Apr;102:9-18. DOI: 10.1016/j. clinbiochem.2022.01.004Search in Google Scholar
Rustad P, Felding P, Franzson L, Kairisto V, Lahti A, Mårtensson A, Hyltoft Petersen P, Simonsson P, Steensland H, Uldall A. The Nordic Reference Interval Project 2000: recommended reference intervals for 25 common biochemical properties. Scand J Clin Lab Invest. 2004;64(4):271-84. DOI: 10.1080/00365510410006324Search in Google Scholar
Nordin G, Mårtensson A, Swolin B, Sandberg S, Christensen NJ, Thorsteinsson V, Franzson L, Kairisto V, Savolainen ER. A multicentre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries. Scand J Clin Lab Invest. 2004;64(4):385-98. DOI: 10.1080/00365510410002797Search in Google Scholar
Kohse KP. KiGGS - the German survey on children’s health as data base for reference intervals and beyond. Clin Biochem 2014;47:742-743. DOI: 10.1016/j.clinbiochem.2014.05.039Search in Google Scholar
Schaffrath Rosario A, Schlaud M, Kamtsiuris P; KiGGS Study Group. The first KiGGS follow-up (KiGGS Wave 1): study conduct, sample design, and response. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Jul;57(7):747-61. DOI: 10.1007/s00103-014-1973-9Search in Google Scholar
Hoffmann R, Lange M, Butschalowsky H, Houben R, Schmich P, Allen J, Kuhnert R, Rosario AS, Gößwald A. KiGGS Wave 2 cross-sectional study - participant acquisition, response rates and representativeness. J Health Monit. 2018 Mar 15;3(1):78-91.Search in Google Scholar
Mauz E, Lange M, Houben R, Hoffmann R, Allen J, Gößwald A, Hölling H, Lampert T, Lange C, Poethko-Müller C, Richter A, Rosario AS, von Schenck U, Ziese T, Kurth BM; KiGGS Cohort Research Team. Cohort profile: KiGGS cohort longitudinal study on the health of children, adolescents and young adults in Germany. Int J Epidemiol. 2020 Apr 1;49(2):375-375k. DOI: 10.1093/ije/dyz231Search in Google Scholar
Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H. Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth. J Clin Endocrinol Metab. 2015 May;100(5):2090-7. DOI: 10.1210/jc.2014-4466Search in Google Scholar
Thierfelder W, Dortschy R, Hintzpeter B, Kahl H, Scheidt-Nave C. Biochemical measures in the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2007 May-Jun;50(5-6):757-70. DOI: 10.1007/s00103-007-0238-2Search in Google Scholar
Zierk J, Arzideh F, Rechenauer T, Haeckel R, Rascher W, Metzler M, Rauh M. Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence. Clin Chem. 2015 Jul;61(7):964-73. DOI: 10.1373/clinchem.2015.239731Search in Google Scholar
Zierk J, Hirschmann J, Toddenroth D, Arzideh F, Haeckel R, Bertram A et al. Next-generation reference intervals for pediatric hematology. Clin Chem Lab Med. 2019 Sep 25;57(10):1595-1607. DOI: 10.1515/cclm-2018-1236Search in Google Scholar
Zierk J, Arzideh F, Haeckel R, Cario H, Frühwald MC, Groß HJ et al. Pediatric reference intervals for alkaline phosphatase. Clin Chem Lab Med. 2017 Jan 1;55(1):102-110. DOI: 10.1515/cclm-2016-0318Search in Google Scholar
Kansra AR, Lakkunarajah S, Jay MS. Childhood and Adolescent Obesity: A Review. Front Pediatr. 2021 Jan 12;8:581461. DOI: 10.3389/fped.2020.581461Search in Google Scholar
Vuong J, Qiu Y, La M, Clarke G, Swinkels DW, Cembrowski G. Reference intervals of complete blood count constituents are highly correlated to waist circumference: should obese patients have their own “normal values?”. Am J Hematol. 2014 Jul;89(7):671-7. DOI: 10.1002/ajh.23713Search in Google Scholar
Tomer Ziv-Baran, Asaf Wasserman, Ilana Goldiner, Moshe Stark, Shani Shenhar-Tsarfaty et al. The association between elevated body mass index and wide blood chemistry panel results in apparently healthy individuals. Am J Med Sci . 2023. 365(2):152-61. DOI: 10.1016/j.amjms.2022.07.019Search in Google Scholar
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K. Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents. J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1781-97. DOI: 10.1210/clinem/dgz161Search in Google Scholar
Deutschbein T, Mann K, Petersenn S. Total Testosterone and Calculated Estimates for Free and Bioavailable Testosterone: Influence of Age and Body Mass Index and Establishment of Sex-Specific Reference Ranges. Horm Metab Res. 2015 Oct;47(11):846-54. DOI: 10.1055/s-0034-1395569Search in Google Scholar
Jørgensen RM, Bøttger B, Vestergaard ET, Kremke B, Bahnsen RF, Nielsen BW et al. Uric Acid Is Elevated in Children With Obesity and Decreases After Weight Loss. Front Pediatr. 2022 Jan 4;9:814166. DOI: 10.3389/fped.2021.814166Search in Google Scholar
Tahmasebi H, Asgari S, Hall A, Higgins V, Chowdhury A, Thompson R et al. Influence of ethnicity on biochemical markers of health and disease in the CALIPER cohort of healthy children and adolescents. Clin Chem Lab Med. 2020 Mar 26;58(4):605-617. DOI: 10.1515/cclm-2019-0876Search in Google Scholar
Quintó L, Aponte JJ, Sacarlal J, Espasa M, Aide P, Mandomando I. Haematological and biochemical indices in young African children: in search of reference intervals. Trop Med Int Health. 2006 Nov;11(11):1741-8. DOI: 10.1111/j.1365-3156.2006.01764.xSearch in Google Scholar
Gitaka J, Ogwang C, Ngari M, Akoo P, Olotu A, Kerubo C et al. Clinical laboratory reference values amongst children aged 4 weeks to 17 months in Kilifi, Kenya: A cross sectional observational study. PLoS One. 2017 May 11;12(5):e0177382. DOI: 10.1371/journal.pone.0177382Search in Google Scholar
Kibaya RS, Bautista CT, Sawe FK, Shaffer DN, Sateren WB, Scott PT, Michael NL, Robb ML, Birx DL, de Souza MS. Reference ranges for the clinical laboratory derived from a rural population in Kericho, Kenya. PLoS One. 2008 Oct 3;3(10):e3327. DOI: 10.1371/journal.pone.0003327Search in Google Scholar
Davies PS, Bates CJ, Cole TJ, Prentice A, Clarke PC. Vitamin D: seasonal and regional differences in preschool children in Great Britain. Eur J Clin Nutr. 1999 Mar;53(3):195-8. DOI: 10.1038/sj.ejcn.1600697Search in Google Scholar
Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016 Apr;103(4):1033-44. DOI: 10.3945/ajcn.115.120873Search in Google Scholar
Völzke H, Alte D, Kohlmann T, Lüdemann J, Nauck M, John U et al. Reference intervals of serum thyroid function tests in a previously iodine-deficient area. Thyroid. 2005 Mar;15(3):279-85. DOI: 10.1089/thy.2005.15.279Search in Google Scholar
Lauridsen KM, Kristiansen HP, Winther-Larsen A. Pediatric reference intervals of the hemoglobin fractions HbA2, HbF and HbA0 using high-performance liquid chromatography and capillary electrophoresis. Clin Chim Acta. 2023 Sep 1;549:117557. DOI: 10.1016/j.cca.2023.117557Search in Google Scholar
Colah R, Gorakshakar A, Nadkarni A. Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders. Expert Rev Hematol. 2010;3:103-117. DOI: 10.1586/ehm.09.74Search in Google Scholar
Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S et al; Coeliac EU Cluster, Project Epidemiology. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med. 2010 Dec;42(8):587-95. DOI: 10.3109/07853890.2010.505931Search in Google Scholar
Cronin CC, Shanahan F. Why is celiac disease so common in Ireland? Perspect Biol Med. 2001 Summer;44(3):342-52. DOI: 10.1353/pbm.2001.0045Search in Google Scholar
Coskun A, Zarepour A, Zarrabi A. Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine. Int J Mol Sci. 2023 Mar 27;24(7):6275. DOI: 10.3390/ijms24076275Search in Google Scholar
Fraser CG. Inherent biological variation and reference values. Clin Chem Lab Med. 2004;42(7):758-64. DOI: 10.1515/CCLM.2004.128Search in Google Scholar
Fraser, CG. Biological variation: from principles to practice. Washington DC: AACC Press; 2001.Search in Google Scholar
Whyte MB, Kelly P. The normal range: it is not normal and it is not a range. Postgrad Med J. 2018 Nov;94(1117):613-616. DOI: 10.1136/postgradmedj-2018-135983Search in Google Scholar
Miller WG, Horowitz GL, Ceriotti F, Fleming JK, Greenberg N, Katayev A, Jones GR, Rosner W, Young IS. Reference Intervals: Strengths, Weaknesses, and Challenges. Clin Chem. 2016 DOI: 10.1373/clinchem.2016.256511Search in Google Scholar
Timbrell NE. The Role and Limitations of the Reference Interval Within Clinical Chemistry and Its Reliability for Disease Detection. Br J Biomed Sci. 2024 Feb 28;81:12339. DOI: 10.3389/bjbs.2024.12339Search in Google Scholar
Fraser CG. Reference change values. Clin Chem Lab Med. 2011;50(5):807-812 DOI: 10.1007/978-1-4419-1695-2_147Search in Google Scholar
Aarsand, AK, Webster, C, Coskun, A, Gonzales-Lao, E, Diaz-Garzon, J, Roraas, T, et al. EFLM biological variation database https://biologicalvariation.eu [Accessed June 2024]Search in Google Scholar
Randell EW, Yenice S. Delta Checks in the clinical laboratory. Crit Rev Clin Lab Sci. 2019 Mar;56(2):75-97. DOI: 10.1080/10408363.2018.1540536Search in Google Scholar
CLSI. Use of delta checks in the medical laboratory; Approved Guideline - First Edition. CLSI Document EP33. Wayne, PA: Clinical and Laboratory Standards Institute; 2016.Search in Google Scholar
Hong J, Cho EJ, Kim HK, Lee W, Chun S, Min WK. Application and optimization of reference change values for Delta Checks in clinical laboratory. J Clin Lab Anal. 2020 Dec;34(12):e23550. DOI: 10.1002/jcla.23550Search in Google Scholar
Plebani M. Harmonization of Clinical Laboratory Information - Current and Future Strategies. EJIFCC. 2016 Feb 9;27(1):15-22.Search in Google Scholar
Panteghini M. Implementation of standardization in clinical practice: not always an easy task. Clin Chem Lab Med. 2012 Feb 29;50(7):1237-41. DOI: 10.1515/cclm.2011.791Search in Google Scholar
Tate JR, Johnson R, Barth JH, Panteghini M. Harmonization of laboratory testing - a global activity. Clin Chim Acta 2014;432: 1-3. DOI: 10.1016/j.cca.2014.02.006Search in Google Scholar
Gruson D. Big Data, artificial intelligence and laboratory medicine: time for integration. Adv Lab Med. 2021 Feb 10;2(1):1-7. DOI: 10.1515/almed-2021-0003Search in Google Scholar
Martinez-Sanchez L, Marques-Garcia F, Ozarda Y, Blanco A, Brouwer N, Canalias F et al. Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio. 2021;2(1): 9-16. DOI: 10.1515/almed-2020-0034Search in Google Scholar
Ngiam KY, Khor IW. Big data and machine learning algorithms for health-care delivery. Lancet Oncol. 2019 May;20(5):e262-e273. doi: 10.1016/S1470-2045(19)30149-4. Erratum in: Lancet Oncol. 2019 Jun;20(6):293. DOI: 10.1016/S1470-2045(19)30149-4Search in Google Scholar
Gruson D, Helleputte T, Rousseau P, Gruson D. Data science, artificial intelligence, and machine learning: Opportunities for laboratory medicine and the value of positive regulation. Clin Biochem. 2019 Jul;69:1-7. DOI: 10.1016/j. clinbiochem.2019.04.013Search in Google Scholar
Prodan Žitnik I, Černe D, Mancini I, Simi L, Pazzagli M, Di Resta C et al; behalf of EFLM/ESPT working group of Personalised Laboratory Medicine on. Personalized laboratory medicine: a patient-centered future approach. Clin Chem Lab Med. 2018 Nov 27;56(12):1981-1991. DOI: 10.1515/cclm-2018-0181Search in Google Scholar
Coskun A, Sandberg S, Unsal I, Yavuz FG, Cavusoglu C, Serteser M, Kilercik M, Aarsand AK. Personalized reference intervals -statistical approaches and considerations. Clin Chem Lab Med. 2021 Dec 13;60(4):629-635. DOI: 10.1515/cclm-2021-1066Search in Google Scholar
Coskun A, Sandberg S, Unsal I, Serteser M, Aarsand AK. Personalized reference intervals: from theory to practice. Crit Rev Clin Lab Sci. 2022 Nov;59(7):501-516. DOI: 10.1080/10408363.2022.2070905Search in Google Scholar
Coşkun A, Sandberg S, Unsal I, Cavusoglu C, Serteser M, Kilercik M, Aarsand AK. Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation. Clin Chem. 2021 Jan 30;67(2):374-384. DOI: 10.1093/clinchem/hvaa233Search in Google Scholar