Comparative Efficacy of Microwave versus Radiofrequency Ablation in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis of Randomized-Controlled Trials

1 CHIDAMBARANATHAN-REGHUPATY S., FISHER PB., SARKAR D. Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification. Adv Cancer Res. 2021;149:1–61. Search in Google Scholar

2 HAN J., FAN Y., WANG K. Radiofrequency ablation versus microwave ablation for early stage hepatocellular carcinoma. Medicine (Baltimore). 2020 Oct 23;99(43):e22703. Search in Google Scholar

3 POULOU LS., BOTSA E., THANOU I., ZIAKAS PD., THANOS L. Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma. World J Hepatol. 2015;7(8):1054–63. Search in Google Scholar

4 GLASSBERG MB., GHOSH S., CLYMER JW., QADEER RA., FERKO NC., SADEGHIRAD B., et al. Microwave ablation compared with radiofrequency ablation for treatment of hepatocellular carcinoma and liver metastases: a systematic review and meta-analysis. Onco Targets Ther. 2019 Aug;12:6407–38. Search in Google Scholar

5 PAGE MJ., MCKENZIE JE., BOSSUYT PM., BOUTRON I., HOFFMANN TC., MULROW CD., et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. PLoS Med. 2021;18(3). Search in Google Scholar

6 STERNE J., SAVOVIC J., PAGE M., ELBERS R., BLENCOWE N., BOUTRON I. RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366. Search in Google Scholar

7 ABDELAZIZ A., ELBAZ T., SHOUSHA HI., MAHMOUD S., IBRAHIM M., ABDELMAKSOUD A., et al. Efficacy and survival analysis of percutaneous radiofrequency versus microwave ablation for hepatocellular carcinoma: an egyptian multidisciplinary clinic experience. Surg Endosc. 2014;28(12):3429–34. Search in Google Scholar

8 CHONG CCN., LEE KF., CHEUNG SYS., CHU CCM., FONG AKW., WONG J., et al. Prospective double-blinded randomized controlled trial of Microwave versus RadioFrequency Ablation for hepatocellular carcinoma (McRFA trial). Hpb. 2020;22(8):1121–7. Search in Google Scholar

9 DI VECE F., TOMBESI P., ERMILI F., MARALDI C., SARTORI S. Coagulation areas produced by cool-tip radiofrequency ablation and microwave ablation using a device to decrease back-heating effects: A prospective pilot study. Cardiovasc Intervent Radiol. 2014;37(3):723–9. Search in Google Scholar

10 KAMAL A., ELMOETY AAA., ROSTOM YAM., SHATER MS., LASHEN SA. Percutaneous radiofrequency versus microwave ablation for management of hepatocellular carcinoma: A randomized controlled trial. J Gastrointest Oncol. 2019;10(3):562–71. Search in Google Scholar

11 MAHMOUD HS., ARAFAT S., ZAKY S., BAZEED SES. Microwave ablation versus Radiofrequency ablation in the management of Hepatocellular carcinoma. SVU-International J Med Sci. 2021;4(2):286–92. Search in Google Scholar

12 QIAN GJ., WANG N., SHEN Q., SHENG YH., ZHAO JQ., KUANG M., et al. Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: Experimental and clinical studies. Eur Radiol. 2012;22(9):1983–90. Search in Google Scholar

13 RADOSEVIC A., QUESADA R., SERLAVOS C., SANCHEZ J., ZUGAZAGA A., SIERRA A., et al. Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial. Sci Rep. 2022;12(1):1–10. Search in Google Scholar

14 VIETTI VIOLI N., DURAN R., GUIU B., CERCUEIL JP., AUBE C., DIGKLIA A., et al. Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial. Lancet Gastroenterol Hepatol. 2018;3(5):317–25. Search in Google Scholar

15 SHIBATA T., IIMURO Y., YAMAMOTO Y., MAETANI Y., AMETANI F., ITOH K., et al. Small hepatocellular carcinoma: Comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Radiology. 2002;223(2):331–7. Search in Google Scholar

16 FACCIORUSSO A., ABD EL AZIZ MA., TARTAGLIA N., RAMAI D., MOHAN BP., COTSOGLOU C., et al. Microwave Ablation Versus Radiofrequency Ablation for Treatment of Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials. Cancers (Basel). 2020 Dec 16;12(12):3796. Search in Google Scholar

17 POGGI G. Microwave ablation of hepatocellular carcinoma. World J Hepatol. 2015;7(25):2578. Search in Google Scholar

18 IZZO F., GRANATA V., GRASSI R., FUSCO R., PALAIA R., DELRIO P., et al. Radiofrequency Ablation and Microwave Ablation in Liver Tumors: An Update. Oncologist. 2019 Oct 1;24(10):e990–1005. Search in Google Scholar

19 CURLEY SA. Radiofrequency Ablation of Malignant Liver Tumors. Oncologist. 2001;6(1):14–23. Search in Google Scholar

20 LEHMANN KS., POCH FGM., RIEDER C., SCHENK A., STROUX A., FRERICKS BB., et al. Minimal vascular flows cause strong heat sink effects in hepatic radiofrequency ablation ex vivo. J Hepatobiliary Pancreat Sci. 2016;23(8):508–16. Search in Google Scholar

21 TAMAI H., OKAMURA J. New next-generation microwave thermosphere ablation for small hepatocellular carcinoma. Clin Mol Hepatol. 2021;27(4):564–74. Search in Google Scholar

22 YANG W. Radiofrequency ablation of hepatocellular carcinoma in difficult locations: Strategies and long-term outcomes. World J Gastroenterol. 2015;21(5):1554. Search in Google Scholar