<abstract xmlns="http://www.w3.org/1999/xhtml">
<p>Clopidogrel is a widely prescribed prodrug with antithrombotic activity that functions by irreversibly inhibiting the P2Y12 receptors on platelets; nevertheless, drug-induced eosinophilia from this drug is rarely reported. An 81-year-old man was diagnosed with cerebral infarction 2 months earlier and was admitted to our hospital with rash, fever, wheezing, and stomach discomfort after being initiated with clopidogrel treatment. Based on his medical history, chest CT, and gastroscopy, we diagnosed him with clopidogrel-induced hypereosinophilic syndrome. After discontinuation of clopidogrel, the eosinophilia and symptoms improved. In cases of drug-induced eosinophilia, it is important to obtain a detailed medical history.</p>
</abstract>

Clopidogrel is a widely prescribed prodrug with antithrombotic activity that functions by irreversibly inhibiting the P2Y12 receptors on platelets; nevertheless, drug-induced eosinophilia from this drug is rarely reported. An 81-year-old man was diagnosed with cerebral infarction 2 months earlier and was admitted to our hospital with rash, fever, wheezing, and stomach discomfort after being initiated with clopidogrel treatment. Based on his medical history, chest CT, and gastroscopy, we diagnosed him with clopidogrel-induced hypereosinophilic syndrome. After discontinuation of clopidogrel, the eosinophilia and symptoms improved. In cases of drug-induced eosinophilia, it is important to obtain a detailed medical history.

Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis exacerbated by clopidogrel bisulphate

Metabolism and Nephrology Kochi Medical School

Department of Haematology and Respiratory Medicine Kochi Medical School

Department of Otolaryngology, Kochi Medical School

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Clopidogrel is a widely prescribed prodrug with antithrombotic activity that functions by irreversibly inhibiting the P2Y12 receptors on platelets;...

Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis exacerbated by clopidogrel bisulphate

Online veröffentlicht: 05. Sept. 2023

Seitenbereich: 216 - 221

Eingereicht: 12. Mai 2023

DOI: https://doi.org/10.2478/rjim-2023-0022

Schlüsselwörter
eosinophilic gastroenteritis, eosinophilic pneumonitis, computed tomography, hypereosinophilic syndrome, gastroscopy

© 2023 Taro Horino et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis exacerbated by clopidogrel bisulphate

Online veröffentlicht: 05. Sept. 2023

Seitenbereich: 216 - 221

Eingereicht: 12. Mai 2023

DOI: https://doi.org/10.2478/rjim-2023-0022

Schlüsselwörtereosinophilic gastroenteritis, eosinophilic pneumonitis, computed tomography, hypereosinophilic syndrome, gastroscopy

© 2023 Taro Horino et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
eosinophilic gastroenteritis, eosinophilic pneumonitis, computed tomography, hypereosinophilic syndrome, gastroscopy