Could ferritin, vitamin B₁₂, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?

1. TUZCU A., BAYKARA RA., ALIŞIK M., OMMA A., ACET GK., DOGAN E., et al. Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome. Acta Medica (Hradec Kralove). 2019;62(1):12–8.10.14712/18059694.2019.4030931891 Search in Google Scholar

2. RIERA R. Selective serotonin reuptake inhibitors for fibromyalgia syndrome. Sao Paulo Med J. 2015;133(5):454.10.1590/1516-3180.20151335T126648437 Search in Google Scholar

3. BINKIEWICZ-GLIŃSKA A., BAKUŁA S., TOMCZAK H., LANDOWSKI J., RUCKEMANN-DZIURDZIŃSKA K., ZABOROWSKA-SAPETA K., et al. Fibromyalgia Syndrome – a multidisciplinary approach. Psychiatr Pol. 2015;49(4):801–10. Search in Google Scholar

4. BORCHERS AT., GERSHWIN ME. Fibromyalgia: A Critical and Comprehensive Review. Clin Rev Allergy Immunol. 2015;49(2):100–51.10.1007/s12016-015-8509-426445775 Search in Google Scholar

5. ASSUMPÇÃO A., CAVALCANTE AB., CAPELA CE., SAUER JF., CHALOT SD., PEREIRA CA., et al. Prevalence of fibromyalgia in a low socioeconomic status population. BMC Musculoskelet Disord. 2009;10:64.10.1186/1471-2474-10-64270621619505321 Search in Google Scholar

6. EKAIDEM IS., AKPANABIATU MI., UBOH FE., EKA OU. Effect of folic acid and vitamin B(12) administration on phenytoin induced toxicity in rats. Indian J Clin Biochem. 2007;22(2):36–40.10.1007/BF02913310345380023105679 Search in Google Scholar

7. HUIJTS M., VAN OOSTENBRUGGE RJ., ROUHL RP., MENHEERE P., DUITS A. Effects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar stroke. Int Psychogeriatr. 2013;25(3):508–10.10.1017/S104161021200192523158866 Search in Google Scholar

8. VAN DYCK CH., LYNESS JM., ROHRBAUGH RM., SIEGAL AP. Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study. Int Psychogeriatr. 2009;21(1):138–47.10.1017/S1041610208007904352321218925978 Search in Google Scholar

9. OH R., BROWN DL. Vitamin B12 deficiency. Am Fam Physician. 2003;67(5):979–86. Search in Google Scholar

10. DEN ELZEN WP., VAN DER WEELE GM., GUSSEKLOO J., WESTENDORP RG., ASSENDELFT WJ. Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review. BMC Geriatr. 2010;10:42.10.1186/1471-2318-10-42290026120573208 Search in Google Scholar

11. DE CARVALHO JF., SILVA DN. Serum levels of vitamin B12 (cobalamin) in fibromyalgia. Rheumatol Int. 2016;36(5):741–2.10.1007/s00296-016-3454-y26972987 Search in Google Scholar

12. ORTANCIL O., SANLI A., ERYUKSEL R., BASARAN A., ANKARALI H. Association between serum ferritin level and fibromyalgia syndrome. Eur J Clin Nutr. 2010;64(3):308–12.10.1038/ejcn.2009.14920087382 Search in Google Scholar

13. ROY S., SHERMAN A., MONARI-SPARKS MJ., SCHWEIKER O., HUNTER K. Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study). N Am J Med Sci. 2014;6(8):396–402.10.4103/1947-2714.139291 Search in Google Scholar

14. PEREDA CA., NISHISHINYA MB. Is there really a relationship between serum vitamin D (25OHD) levels and the musculoskeletal pain associated with statin intake? A systematic review. Reumatol Clin. 2016;12(6):331–35. Search in Google Scholar

15. MAAFI AA., GHAVIDEL-PARSA B., HAGHDOOST A., AARABI Y., HAJIABBASI A., SHENAVAR MASOOLEH I., et al. Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation. Korean J Pai.n 2016;29(3):172–78. Search in Google Scholar

16. DOGRU A., BALKARLI A., COBANKARA V., TUNC SE., SAHIN M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia. Eurasian J Med. 2017;49(2):113–17.10.5152/eurasianjmed.2017.16283 Search in Google Scholar

17. DELOUGHERY TG. Iron Deficiency Anemia. Med Clin North Am. 2017;101(2):319–32.10.1016/j.mcna.2016.09.004 Search in Google Scholar

18. SPENCER BR., KLEINMAN S., WRIGHT DJ., GLYNN SA., RYE DB., KISS JE., et al. REDS-II RISE Analysis Group. Restless legs syndrome, pica, and iron status in blood donors. Transfusion. 2013;53(8):1645–52.10.1111/trf.12260 Search in Google Scholar

19. JONES GT., ATZENI F., BEASLEY M., FLÜB E., SARZI-PUTTINI P., MACFARLANE GJ. The prevalence of fibromyalgia in the general population: a comparison of the American College of Rheumatology 1990, 2010, and modified 2010 classification criteria. Arthritis Rheumatol. 2015;67(2):568–75.10.1002/art.38905 Search in Google Scholar

20. WOLFE F., SMYTHE HA., YUNUS MB., BENNETT RM., BOMBARDIER C., GOLDENBERG DL., et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33(2):160–72.10.1002/art.1780330203 Search in Google Scholar

21. WEWERS ME., LOWE NK.. A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health. 1990;13(4):227–36.10.1002/nur.4770130405 Search in Google Scholar

22. BURCKHARDT CS., CLARK SR., BENNETT RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol. 1991;18(5):728–33. Search in Google Scholar

23. BUYSSE DJ., REYNOLDS CF 3^RD., MONK TH., BERMAN SR., KUPFER DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213.10.1016/0165-1781(89)90047-4 Search in Google Scholar

24. WARE JE JR., SHERBOURNE CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473–83. Search in Google Scholar

25. FISK JD., RITVO PG., ROSS L., HAASE DA., MARRIE TJ., SCHLECH WF. Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18:79–83.10.1093/clinids/18.Supplement_1.S798148458 Search in Google Scholar

26. SCHMIDT-WILCKE T., CLAUW DJ. Fibromyalgia: from pathophysiology to therapy. Nat Rev Rheumatol. 2011;7(9):518–27.10.1038/nrrheum.2011.9821769128 Search in Google Scholar

27. PAMUK GE., PAMUK ON., SET T., HARMANDAR O., YEŞIL N. An increased prevalence of fibromyalgia in iron deficiency anemia and thalassemia minor and associated factors. Clin Rheumatol. 2008;27(9):1103–8.10.1007/s10067-008-0871-718404239 Search in Google Scholar

28. WOOD PB. Role of central dopamine in pain and analgesia. Expert Rev Neurother. 2008;8(5):781–97.10.1586/14737175.8.5.78118457535 Search in Google Scholar

29. DAUBIAN-NOSÉ P., FRANK MK., ESTEVES AM. Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism. Sleep Sci. 2014;7(4):234–7.10.1016/j.slsci.2014.10.002460889126483934 Search in Google Scholar

30. BOOMERSHINE CS., KOCH TA., MORRIS D. A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia. Rheumatol Ther. 2018;5(1):271–81.10.1007/s40744-017-0088-9593560829149437 Search in Google Scholar

31. KIM J., WESSLING-RESNICK M. Iron and mechanisms of emotional behavior. J Nutr Biochem. 2014;25(11):1101–7.10.1016/j.jnutbio.2014.07.003425390125154570 Search in Google Scholar

32. MADER R., KOTON Y., BUSKILA D., HERER P., ELIAS M. Serum iron and iron stores in non-anemic patients with fibromyalgia. Clin Rheumatol. 2012;31(4):595–9.10.1007/s10067-011-1888-x22095117 Search in Google Scholar

33. PAGANA KD., PAGANA, TJ., PAGANA TN. Mosby’s diagnostic and laboratory test reference. 14th ed. St. Loust, Elsevier, 2019. Search in Google Scholar

34. OKAN S, CAGLIYAN TURK A, SIVGIN H, OZSOY F, OKAN F. Association of ferritin levels with depression, anxiety, sleep quality, and physical functioning in patients with fibromyalgia syndrome: a cross-sectional study. Croat Med J. 2019;60(6):515–20.10.3325/cmj.2019.60.515 Search in Google Scholar

35. TOOHEY JI. Vitamin B12 and methionine synthesis: a critical review. Is nature’s most beautiful cofactor misunderstood? Biofactors. 2006;26(1):45–57.10.1002/biof.552026010516614482 Search in Google Scholar

36. MILLER A., KOREM M., ALMOG R., GALBOIZ Y. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci. 2005;233(1-2):93–7.10.1016/j.jns.2005.03.00915896807 Search in Google Scholar

37. REGLAND B., FORSMARK S., HALAOUATE L., MATOUSEK M., PEILOT B., ZACHRISSON O., et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10(4):e0124648.10.1371/journal.pone.0124648440644825902009 Search in Google Scholar

38. CUMHUR CURE M., CURE E., YUCE S., YAZICI T., KARAKOYUN I., EFE H. Mean platelet volume and vitamin D level. Ann Lab Med. 2014;34(2):98–103.10.3343/alm.2014.34.2.98394884024624344 Search in Google Scholar

39. DE OLIVEIRA DL., HIROTSU C., TUFIK S., ANDERSEN ML. The interfaces between vitamin D, sleep and pain. J Endocrinol. 2017;234(1):23–36.10.1530/JOE-16-051428536294 Search in Google Scholar

40. YILMAZ R., SALLI A., CINGOZ HT., KUCUKSEN S., UGURLU H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis. 2016;19(12):1255–62.10.1111/1756-185X.1296027860257 Search in Google Scholar

41. MCCABE PS., PYE SR., BETH JM., LEE DM., TAJAR A., BARTFAI G., et al. EMAS Study Group. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study. BMC Musculoskelet Disord. 2016;17:32.10.1186/s12891-016-0881-6471535926774507 Search in Google Scholar

42. KASAPOĞLU AKSOY M., ALTAN L., ÖKMEN METIN B. The relationship between balance and vitamin 25(OH)D in fibromyalgia patients. Mod Rheumatol. 2017;27(5):868–74.10.1080/14397595.2016.125960327846770 Search in Google Scholar

43. OLAMA SM., SENNA MK., ELARMAN MM., ELHAWARY G. Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia. Rheumatol Int. 2013;33(1):185–92.10.1007/s00296-012-2361-022311432 Search in Google Scholar

44. MATEOS F., VALERO C., OLMOS JM., CASANUEVA B., CASTILLO J., MARTÍNEZ J., et al. Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia. Osteoporos Int. 2014;25(2):525–33.10.1007/s00198-013-2434-224008400 Search in Google Scholar

45. WEPNER F., SCHEUER R., SCHUETZ-WIESER B., MACHACEK P., PIELER-BRUHA E., CROSS HS., et al. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain. 2014;155(2):261–8.10.1016/j.pain.2013.10.00224438771 Search in Google Scholar

46. YONG WC., SANGUANKEO A., UPALA S. Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis. Clin Rheumatol. 2017;36(12):2825–33.10.1007/s10067-017-3754-y28812209 Search in Google Scholar

47. KERSTEN P., WHITE PJ., TENNANT A. Is the pain visual analogue scale linear and responsive to change? An exploration using Rasch analysis. PLoS One 2014;9(6):e99485.10.1371/journal.pone.0099485405572424921952 Search in Google Scholar

48. GHAI B., BANSAL D., KANUKULA R.,GUDALA K., SACHDEVA N., DHATT SS., et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20(1):E99-E105.10.36076/ppj.2017.1.E99 Search in Google Scholar