<abstract xmlns="http://www.w3.org/1999/xhtml">

<italic>Background:</italic> Data regarding cardiac damage in Romanian hypertensive adults are scarce. Our aim was to assess hypertension-mediated subclinical and clinical cardiac damage using a post-hoc echocardiographic analysis of a national epidemiological survey.
<italic>Methods:</italic> A representative sample of 1477 subjects was included in the SEPHAR IV (Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in an Adult Population in Romania) survey. We retrieved echocardiographic data for 976 subjects, who formed our study group. Cardiac damage included left ventricular (LV) hypertrophy (defined as an LV mass > 95 g/m2 in females and > 115 g/m2 in males), coronary artery disease (CAD), and LV diastolic and systolic dysfunction.
<italic>Results:</italic> Hypertension prevalence was 46.0% in SEPHAR IV and 45.3% in our study subgroup. Hypertensives had a higher prevalence of LV hypertrophy, CAD, diastolic dysfunction (p&lt;0.001 for all) and systolic dysfunction (p=0.03) than normotensives. Age (OR=1.05;95% CI,1.03–1.08;p&lt;0.001), female sex (OR=2.07;95% CI,1.24–3.45;p=0.006), and systolic blood pressure (OR=1.02;95% CI,1.01−1.04;p=0.026) were independent predictors of LVH in hypertensives. Age was a predictor of diastolic dysfunction (OR=1.04;95% CI,1.02−1.06;p&lt;0.001), and female sex was a protective factor against systolic dysfunction (OR=0.26;95% CI,0.10–0.71;p=0.009). Age (OR=1.05;95% CI,1.02−1.07;p&lt;0.001) and dyslipidemia (OR=1.89;95% CI,1.20–3.00;p=0.007) were independent determinants of CAD in hypertensives.
<italic>Conclusion:</italic> The prevalence of cardiac damage in Romanian hypertensives is high. Both non-modifiable risk factors (such as age and gender) and modifiable (such as dyslipidemia and systolic blood pressure) risk factors are independent predictors of cardiac damage in hypertensives.
</abstract>

Background: Data regarding cardiac damage in Romanian hypertensive adults are scarce. Our aim was to assess hypertension-mediated subclinical and clinical cardiac damage using a post-hoc echocardiographic analysis of a national epidemiological survey.
Methods: A representative sample of 1477 subjects was included in the SEPHAR IV (Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in an Adult Population in Romania) survey. We retrieved echocardiographic data for 976 subjects, who formed our study group. Cardiac damage included left ventricular (LV) hypertrophy (defined as an LV mass > 95 g/m2 in females and > 115 g/m2 in males), coronary artery disease (CAD), and LV diastolic and systolic dysfunction.
Results: Hypertension prevalence was 46.0% in SEPHAR IV and 45.3% in our study subgroup. Hypertensives had a higher prevalence of LV hypertrophy, CAD, diastolic dysfunction (p<0.001 for all) and systolic dysfunction (p=0.03) than normotensives. Age (OR=1.05;95% CI,1.03–1.08;p<0.001), female sex (OR=2.07;95% CI,1.24–3.45;p=0.006), and systolic blood pressure (OR=1.02;95% CI,1.01−1.04;p=0.026) were independent predictors of LVH in hypertensives. Age was a predictor of diastolic dysfunction (OR=1.04;95% CI,1.02−1.06;p<0.001), and female sex was a protective factor against systolic dysfunction (OR=0.26;95% CI,0.10–0.71;p=0.009). Age (OR=1.05;95% CI,1.02−1.07;p<0.001) and dyslipidemia (OR=1.89;95% CI,1.20–3.00;p=0.007) were independent determinants of CAD in hypertensives.
Conclusion: The prevalence of cardiac damage in Romanian hypertensives is high. Both non-modifiable risk factors (such as age and gender) and modifiable (such as dyslipidemia and systolic blood pressure) risk factors are independent predictors of cardiac damage in hypertensives.

Hypertension-mediated Cardiac Damage Among Romanian Adult Hypertensive Patients: A Post-hoc Echocardiographic Analysis of the SEPHAR IV Epidemiological Survey

<trans-abstract xml:lang="fr" xmlns="http://www.w3.org/1999/xhtml">

<italic>Context:</italic> Există puţine date privind afectarea cardiacă în rândul populaţiei hipertensive a României. Scopul studiului a fost evaluarea afectării cardiace clinice şi subclinice printr-o analiză ecocardiografică post-hoc a unui studiu epidemiologic naţional.
<italic>Metode:</italic> Un eşantion reprezentativ de 1477 subiecţi au fost incluşi în studiul SEPHAR. Au fost prelucrate date ecocardiografice de la 976 subiecţi, care au format lotul de studiu. Afectarea cardiacă a inclus hipertrofia de ventricul stâng (VS) (definită ca un index de masă al VS > 95 g/m2 la femei şi > 115 g/m2 la bărbaţi), boala coronariană, disfuncţia sistolică şi diastolică de VS.
<italic>Rezultate:</italic> Prevalenţa hipertensiunii a fost 46.0% în SEPHAR IV şi 45.3% în subgrupul de studiu. Hipertensivii au avut o prevalenţă mai mare a hipertrofiei VS, bolii coronariene, disfuncţiei diastolice (p&lt;0.001) şi disfuncţiei sistolice (p=0.03). Vârsta (OR=1.05;95% CI,1.03−1.08;p&lt;0.001), sexul feminin (OR=2.07;95% CI,1.24−3.45;p=0.006) şi tensiunea arterială sistolică (OR=1.02;95% CI,1.01–1.04;p=0.026) sunt predictori independenţi ai hipertrofiei VS la hipertensivi. Vârsta a fost un predictor al disfuncţiei diastolice (OR=1.04;95% CI,1.02−1.06;p&lt;0.001) iar sexul feminin un factor protector împotriva disfuncţiei sistolice (OR=0.26;95% CI,0.10–0.71;p=0.009). Vârsta (OR=1.05;95% CI,1.02−1.07;p&lt;0.001) şi dislipidemia (OR=1.89;95% CI,1.20−3.00;p=0.007) au fost determinanţi independenţi ai bolii coronariene la hipertensivi.
<italic>Concluzii:</italic> Prevalenţa afectării cardiace la hipertensivii români e ridicată. Atât factori de risc nemodificabili (vârsta şi sexul), cât şi modificabili (dislipidemia şi tensiunea arterială sistolică) sunt predictori independenţi ai afectării cardiace la hipertensivi.
</trans-abstract>

Context: Există puţine date privind afectarea cardiacă în rândul populaţiei hipertensive a României. Scopul studiului a fost evaluarea afectării cardiace clinice şi subclinice printr-o analiză ecocardiografică post-hoc a unui studiu epidemiologic naţional.
Metode: Un eşantion reprezentativ de 1477 subiecţi au fost incluşi în studiul SEPHAR. Au fost prelucrate date ecocardiografice de la 976 subiecţi, care au format lotul de studiu. Afectarea cardiacă a inclus hipertrofia de ventricul stâng (VS) (definită ca un index de masă al VS > 95 g/m2 la femei şi > 115 g/m2 la bărbaţi), boala coronariană, disfuncţia sistolică şi diastolică de VS.
Rezultate: Prevalenţa hipertensiunii a fost 46.0% în SEPHAR IV şi 45.3% în subgrupul de studiu. Hipertensivii au avut o prevalenţă mai mare a hipertrofiei VS, bolii coronariene, disfuncţiei diastolice (p<0.001) şi disfuncţiei sistolice (p=0.03). Vârsta (OR=1.05;95% CI,1.03−1.08;p<0.001), sexul feminin (OR=2.07;95% CI,1.24−3.45;p=0.006) şi tensiunea arterială sistolică (OR=1.02;95% CI,1.01–1.04;p=0.026) sunt predictori independenţi ai hipertrofiei VS la hipertensivi. Vârsta a fost un predictor al disfuncţiei diastolice (OR=1.04;95% CI,1.02−1.06;p<0.001) iar sexul feminin un factor protector împotriva disfuncţiei sistolice (OR=0.26;95% CI,0.10–0.71;p=0.009). Vârsta (OR=1.05;95% CI,1.02−1.07;p<0.001) şi dislipidemia (OR=1.89;95% CI,1.20−3.00;p=0.007) au fost determinanţi independenţi ai bolii coronariene la hipertensivi.
Concluzii: Prevalenţa afectării cardiace la hipertensivii români e ridicată. Atât factori de risc nemodificabili (vârsta şi sexul), cât şi modificabili (dislipidemia şi tensiunea arterială sistolică) sunt predictori independenţi ai afectării cardiace la hipertensivi.

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background: Data regarding cardiac damage in Romanian hypertensive adults are scarce. Our aim was to assess hypertension-mediated subclinical and clinical...

Hypertension-mediated Cardiac Damage Among Romanian Adult Hypertensive Patients: A Post-hoc Echocardiographic Analysis of the SEPHAR IV Epidemiological Survey

Article Category: Original Article

Online veröffentlicht: 18. März 2023

Seitenbereich: 6 - 13

DOI: https://doi.org/10.2478/rjc-2023-0001

Schlüsselwörter
cardiac damage, hypertension, SEPHAR survey

© 2023 Aura Vîjîiac et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Hypertension-mediated Cardiac Damage Among Romanian Adult Hypertensive Patients: A Post-hoc Echocardiographic Analysis of the SEPHAR IV Epidemiological Survey

Article Category: Original Article

Online veröffentlicht: 18. März 2023

Seitenbereich: 6 - 13

DOI: https://doi.org/10.2478/rjc-2023-0001

Schlüsselwörtercardiac damage, hypertension, SEPHAR survey

© 2023 Aura Vîjîiac et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
cardiac damage, hypertension, SEPHAR survey