[18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency
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Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism. Lancet 2018; 391: 168–178. doi: 10.1016/S0140-6736(17)31430-7BilezikianJPBandeiraLKhanACusanoNEHyperparathyroidismLancet201839116817810.1016/S0140-6736(17)31430-7Open DOISearch in Google Scholar
Minisola S, Cipriani C, Diacinti D, Tartaglia F, Scillitani A, Pepe J, et al. Imaging of the parathyroid glands in primary hyperparathyroidism. Eur J Endocrinol 2016; 174: D1–8. doi: 10.1530/EJE-15-0565MinisolaSCiprianiCDiacintiDTartagliaFScillitaniAPepeJImaging of the parathyroid glands in primary hyperparathyroidismEur J Endocrinol2016174D1810.1530/EJE-15-0565Open DOISearch in Google Scholar
Hocevar M, Lezaic L, Rep S, Zaletel K, Kocjan T, Sever MJ, et al. Focused parathyroidectomy without intraoperative parathormone testing is safe after pre-operative localization with 18F-fluorocholine PET/CT. Eur J Surg Oncol 2017; 43: 133–7. doi: 10.1016/j.ejso.2016.09.016HocevarMLezaicLRepSZaletelKKocjanTSeverMJFocused parathyroidectomy without intraoperative parathormone testing is safe after pre-operative localization with 18F-fluorocholine PET/CTEur J Surg Oncol201743133710.1016/j.ejso.2016.09.016Open DOISearch in Google Scholar
Wong KK, Fig LM, Gross MD, Dwamena BA. Parathyroid adenoma localization with 99mTc-sestamibi SPECT/CT: a meta-analysis. Nucl Med Commun 2015; 36: 363–75. doi: 10.1097/MNM.0000000000000262WongKKFigLMGrossMDDwamenaBAParathyroid adenoma localization with 99mTc-sestamibi SPECT/CT: a meta-analysisNucl Med Commun2015363637510.1097/MNM.0000000000000262Open DOISearch in Google Scholar
Treglia G, Trimboli P, Huellner M, Giovanella L. Imaging in primary hyperparathyroidism: focus on the evidence-based diagnostic performance of different methods. Minerva Endocrinol 2018; 43: 133–43, doi: 10.23736/S0391-1977.17.02685-2TregliaGTrimboliPHuellnerMGiovanellaLImaging in primary hyperparathyroidism: focus on the evidence-based diagnostic performance of different methodsMinerva Endocrinol2018431334310.23736/S0391-1977.17.02685-2Open DOISearch in Google Scholar
Petranović Ovčariček P, Giovanella L, Carrió Gasset I, Hindié E, Huellner MW, Luster M, et al. The EANM practice guidelines for parathyroid imaging. Eur J Nucl Med Mol Imaging 2021; 48: 2801–22. doi: 10.1007/s00259-021-05334-yPetranović OvčaričekPGiovanellaLCarrió GassetIHindiéEHuellnerMWLusterMThe EANM practice guidelines for parathyroid imagingEur J Nucl Med Mol Imaging20214828012210.1007/s00259-021-05334-yOpen DOISearch in Google Scholar
Lee SW, Shim SR, Jeong SY, Kim SJ. Direct comparison of preoperative imaging modalities for localization of primary hyperparathyroidism: a systematic review and network meta-analysis. JAMA Otolaryngol Head Neck Surg 2021; 147: 692–706. doi: 10.1001/jamaoto.2021.0915LeeSWShimSRJeongSYKimSJDirect comparison of preoperative imaging modalities for localization of primary hyperparathyroidism: a systematic review and network meta-analysisJAMA Otolaryngol Head Neck Surg202114769270610.1001/jamaoto.2021.0915Open DOISearch in Google Scholar
Lezaic L, Rep S, Sever MJ, Kocjan T, Hocevar M, Fettich J. 18F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study. Eur J Nucl Med Mol Imaging 2014; 41: 2083–9. doi: 10.1007/s00259-014-2837-0LezaicLRepSSeverMJKocjanTHocevarMFettichJ18F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot studyEur J Nucl Med Mol Imaging2014412083910.1007/s00259-014-2837-0Open DOISearch in Google Scholar
Michaud L, Balogova S, Burgess A, Ohnona J, Huchet V, Kerrou K, et al. A pilot comparison of 18F-fluorocholine PET/CT, ultrasonography and 123I/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: influence of thyroid anomalies. Medicine 2015; 94: e1701. doi: 10.1097/MD.0000000000001701MichaudLBalogovaSBurgessAOhnonaJHuchetVKerrouKA pilot comparison of 18F-fluorocholine PET/CT, ultrasonography and 123I/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: influence of thyroid anomaliesMedicine201594e170110.1097/MD.0000000000001701Open DOISearch in Google Scholar
Thanseer N, Bhadada SK, Sood A, Mittal BR, Behera A, Gorla AKR, et al. Comparative effectiveness of ultrasonography, 99mTc-sestamibi, and 18F-fluorocholine PET/CT in detecting parathyroid adenomas in patients with primary hyperparathyroidism. Clin Nucl Med 2017; 42: e491–7. doi: 10.1097/RLU.0000000000001845ThanseerNBhadadaSKSoodAMittalBRBeheraAGorlaAKRComparative effectiveness of ultrasonography, 99mTc-sestamibi, and 18F-fluorocholine PET/CT in detecting parathyroid adenomas in patients with primary hyperparathyroidismClin Nucl Med201742e491710.1097/RLU.0000000000001845Open DOISearch in Google Scholar
Beheshti M, Hehenwarter L, Paymani Z, Rendl G, Imamovic L, Rettenbacher R, et al. (18)F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with (99m)Tc-MIBI or (99m)Tc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patients. Eur J Nucl Med Mol Imaging 2018; 45: 1762–71. doi: 10.1007/s00259-018-3980-9BeheshtiMHehenwarterLPaymaniZRendlGImamovicLRettenbacherR(18)F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with (99m)Tc-MIBI or (99m)Tc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patientsEur J Nucl Med Mol Imaging20184517627110.1007/s00259-018-3980-9Open DOISearch in Google Scholar
Cuderman A, Senica K, Rep S, Hocevar M, Kocjan T, Sever MJ, et al. 18F-fluorocholine PET/CT in primary hyperparathyroidism: superior diagnostic performance to conventional scintigraphic imaging for localization of hyperfunctioning parathyroid glands. J Nucl Med 2020; 61: 577–83. doi: 10.2967/jnumed.119.229914CudermanASenicaKRepSHocevarMKocjanTSeverMJ18F-fluorocholine PET/CT in primary hyperparathyroidism: superior diagnostic performance to conventional scintigraphic imaging for localization of hyperfunctioning parathyroid glandsJ Nucl Med2020615778310.2967/jnumed.119.229914Open DOISearch in Google Scholar
Imperiale A, Bani J, Bottoni G, Latgé A, Heimburger C, Catrambone U, et al. Does (18)F-Fluorocholine PET/CT add value to positive parathyroid scintigraphy in the presurgical assessment of primary hyperparathyroidism? Front Med 2023; 10: 1148287. doi: 10.3389/fmed.2023.1148287ImperialeABaniJBottoniGLatgéAHeimburgerCCatramboneUDoes (18)F-Fluorocholine PET/CT add value to positive parathyroid scintigraphy in the presurgical assessment of primary hyperparathyroidism?Front Med202310114828710.3389/fmed.2023.1148287Open DOISearch in Google Scholar
Rep S, Hocevar M, Vaupotic J, Zdesar U, Zaletel K, Lezaic L. 18F-choline PET/CT for parathyroid scintigraphy: significantly lower radiation exposure of patients in comparison to conventional nuclear medicine imaging approaches. J Radiol Prot 2018; 38: 343–56. doi: 10.1088/1361-6498/aaa86fRepSHocevarMVaupoticJZdesarUZaletelKLezaicL18F-choline PET/CT for parathyroid scintigraphy: significantly lower radiation exposure of patients in comparison to conventional nuclear medicine imaging approachesJ Radiol Prot2018383435610.1088/1361-6498/aaa86fOpen DOISearch in Google Scholar
Ahuja AT, Wong KT, Ching AS, Fung MK, Lau JY, Yuen EH, et al. Imaging for primary hyperparathyroidism--what beginners should know. Clin Radiol 2004; 59: 967–76. doi: 10.1016/j.crad.2004.04.005AhujaATWongKTChingASFungMKLauJYYuenEHImaging for primary hyperparathyroidism--what beginners should knowClin Radiol2004599677610.1016/j.crad.2004.04.005Open DOISearch in Google Scholar
Díaz-Aguirregoitia FJ, Emparan C, Gaztambide S, Aniel-Quiroga MA, Busturia MA, Vázquez JA, et al. Intraoperative monitoring of kinetic total serum calcium levels in primary hyperparathyroidism surgery. J Am Coll Surg 2004; 198: 519–24. doi: 10.1016/j.jamcollsurg.2003.12.006Díaz-AguirregoitiaFJEmparanCGaztambideSAniel-QuirogaMABusturiaMAVázquezJAIntraoperative monitoring of kinetic total serum calcium levels in primary hyperparathyroidism surgeryJ Am Coll Surg20041985192410.1016/j.jamcollsurg.2003.12.006Open DOISearch in Google Scholar
Bergenfelz A, Lindblom P, Tibblin S, Westerdahl J. Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial. Ann Surg 2002; 236: 543–51. doi: 10.1097/00000658-200211000-00001BergenfelzALindblomPTibblinSWesterdahlJUnilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trialAnn Surg20022365435110.1097/00000658-200211000-00001Open DOISearch in Google Scholar
Inabnet WB 3rd, Dakin GF, Haber RS, Rubino F, Diamond EJ, Gagner M. Targeted parathyroidectomy in the era of intraoperative parathormone monitoring. World J Surg 2002; 26: 921–5. doi: 10.1007/s00268-002-6619-7InabnetWB3rdDakinGFHaberRSRubinoFDiamondEJGagnerMTargeted parathyroidectomy in the era of intraoperative parathormone monitoringWorld J Surg200226921510.1007/s00268-002-6619-7Open DOISearch in Google Scholar
Dillavou ED, Cohn HE. Minimally invasive parathyroidectomy: 101 consecutive cases from a single surgeon. J Am Coll Surg 2003; 197: 1–7. doi: 10.1016/S1072-7515(03)00113-3DillavouEDCohnHEMinimally invasive parathyroidectomy: 101 consecutive cases from a single surgeonJ Am Coll Surg20031971710.1016/S1072-7515(03)00113-3Open DOISearch in Google Scholar
Treglia G, Piccardo A, Imperiale A, Strobel K, Kaufmann PA, Prior JO, et al. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 2019; 46: 751–65. doi: 10.1007/s00259-018-4123-zTregliaGPiccardoAImperialeAStrobelKKaufmannPAPriorJODiagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysisEur J Nucl Med Mol Imaging2019467516510.1007/s00259-018-4123-zOpen DOISearch in Google Scholar
Jansen FP, Vanderheyden JL. The future of SPECT in a time of PET. Nucl Med Biol 2007; 34: 733–5. doi: 10.1016/j.nucmedbio.2007.06.013.JansenFPVanderheydenJLThe future of SPECT in a time of PETNucl Med Biol200734733510.1016/j.nucmedbio.2007.06.013Open DOISearch in Google Scholar
Nichols KJ, Tomas MB, Tronco GG, Rini JN, Kunjummen BD, Heller KS, et al. Preoperative parathyroid scintigraphic lesion localization: accuracy of various types of readings. Radiology 2008; 248: 221–32. doi: 10.1148/radiol.2481071066NicholsKJTomasMBTroncoGGRiniJNKunjummenBDHellerKSPreoperative parathyroid scintigraphic lesion localization: accuracy of various types of readingsRadiology20082482213210.1148/radiol.2481071066Open DOISearch in Google Scholar
Broos WAM, Wondergem M, Knol RJJ, van der Zant FM. Parathyroid imaging with 18F-fluorocholine PET/CT as a first-line imaging modality in primary hyperparathyroidism: a retrospective cohort study. EJNMMI Res 2019; 9: 72. doi: 10.1186/s13550-019-0544-3BroosWAMWondergemMKnolRJJvan der ZantFMParathyroid imaging with 18F-fluorocholine PET/CT as a first-line imaging modality in primary hyperparathyroidism: a retrospective cohort studyEJNMMI Res201997210.1186/s13550-019-0544-3Open DOISearch in Google Scholar
Imperiale A, Taïeb D, Hindié E. 18F-fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidism. Eur J Nucl Med Mol Imaging 2018; 45: 654–7. doi: 10.1007/s00259-017-3920-0ImperialeATaïebDHindiéE18F-fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidismEur J Nucl Med Mol Imaging201845654710.1007/s00259-017-3920-0Open DOISearch in Google Scholar
Evangelista L, Ravelli I, Magnani F, Iacobone M, Giraudo C, Camozzi V, et al. 18F-choline PET/CT and PET/MRI in primary and recurrent hyperparathyroidism: a systematic review of the literature. Ann Nucl Med 2020; 34: 601–19. doi: 10.1007/s12149-020-01507-1EvangelistaLRavelliIMagnaniFIacoboneMGiraudoCCamozziV18F-choline PET/CT and PET/MRI in primary and recurrent hyperparathyroidism: a systematic review of the literatureAnn Nucl Med2020346011910.1007/s12149-020-01507-1Open DOISearch in Google Scholar
Hindié E, Zanotti-Fregonara P, Tabarin A, Rubello D, Morelec I, Wagner T, et al. The role of radionuclide imaging in the surgical management of primary hyperparathyroidism. J Nucl Med 2015; 56: 737–44. doi: 10.2967/jnumed.115.156018HindiéEZanotti-FregonaraPTabarinARubelloDMorelecIWagnerTThe role of radionuclide imaging in the surgical management of primary hyperparathyroidismJ Nucl Med2015567374410.2967/jnumed.115.156018Open DOISearch in Google Scholar
Quak E, Lasne-Cardon A, Cavarec M, Lireux B, Bastit V, Roudaut N, et al. F18-Choline PET/CT or MIBI SPECT/CT in the surgical management of primary hyperparathyroidism: a diagnostic randomized clinical trial. JAMA Otolaryngol Head Neck Surg 2024; 150: 658–65. doi: 10.1001/jamaoto.2024.1421QuakELasne-CardonACavarecMLireuxBBastitVRoudautNF18-Choline PET/CT or MIBI SPECT/CT in the surgical management of primary hyperparathyroidism: a diagnostic randomized clinical trialJAMA Otolaryngol Head Neck Surg20241506586510.1001/jamaoto.2024.1421Open DOISearch in Google Scholar
Quak E, Lasne Cardon A, Ciappuccini R, Lasnon C, Bastit V, Le Henaff V, et al. Upfront F18-choline PET/CT versus Tc99m-sestaMIBI SPECT/CT guided surgery in primary hyperparathyroidism: the randomized phase III diagnostic trial APACH2. BMC Endocr Disord 2021; 21: 3. doi: 10.1186/s12902-020-00667-5QuakELasne CardonACiappucciniRLasnonCBastitVLe HenaffVUpfront F18-choline PET/CT versus Tc99m-sestaMIBI SPECT/CT guided surgery in primary hyperparathyroidism: the randomized phase III diagnostic trial APACH2BMC Endocr Disord202121310.1186/s12902-020-00667-5Open DOISearch in Google Scholar
Yap A, Hope TA, Graves CE, Kluijfhout W, Shen WT, Gosnell JE, et al. A costutility analysis of 18F-fluorocholine-positron emission tomography imaging for localizing primary hyperparathyroidism in the United States. Surgery 2022; 171: 55–62. doi: 10.1016/j.surg.2021.03.075YapAHopeTAGravesCEKluijfhoutWShenWTGosnellJEA costutility analysis of 18F-fluorocholine-positron emission tomography imaging for localizing primary hyperparathyroidism in the United StatesSurgery2022171556210.1016/j.surg.2021.03.075Open DOISearch in Google Scholar
van Mossel S, Saing S, Appelman-Dijkstra N, Quak E, Schepers A, Smit F, et al. Cost-effectiveness of one-stop-shop [(18)F]fluorocholine PET/CT to localise parathyroid adenomas in patients suffering from primary hyperparathyroidism. Eur J Nucl Med Mol Imaging 2024. 51: 3585–95. doi: 10.1007/s00259-024-06771-1.van MosselSSaingSAppelman-DijkstraNQuakESchepersASmitFCost-effectiveness of one-stop-shop [(18)F]fluorocholine PET/CT to localise parathyroid adenomas in patients suffering from primary hyperparathyroidismEur J Nucl Med Mol Imaging20245135859510.1007/s00259-024-06771-1Open DOISearch in Google Scholar