This work is licensed under the Creative Commons Attribution 4.0 International License.
Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, Piñeros M, et al. Global Cancer Observatory: cancer today. Lyon, France: International Agency for Research on Cancer; 2024. [cited 2024 Feb 1]. Available at: https://gco.iarc.who.int/todayFerlayJErvikMLamFLaversanneMColombetMMeryLPiñerosMGlobal Cancer Observatory: cancer todayLyon, FranceInternational Agency for Research on Cancer2024[cited 2024 Feb 1]. Available at: https://gco.iarc.who.int/todaySearch in Google Scholar
Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet 2022; 400: 1345–62. doi: 10.1016/S0140-6736(22)01200-4VogelAMeyerTSapisochinGSalemRSaborowskiAHepatocellular carcinomaLancet202240013456210.1016/S0140-6736(22)01200-4Open DOISearch in Google Scholar
European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatocellular carcinoma. J Hepatol 2018; 69: 182–236. doi: 10.1016/j.jhep.2018.03.019European Association for the Study of the LiverEASL Clinical Practice Guidelines: management of hepatocellular carcinomaJ Hepatol20186918223610.1016/j.jhep.2018.03.019Open DOISearch in Google Scholar
Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol 2022; 76: 681–93. doi: 10.1016/j.jhep.2021.11.018ReigMFornerARimolaJFerrer-FàbregaJBurrelMGarcia-CriadoÁBCLC strategy for prognosis prediction and treatment recommendation: The 2022 updateJ Hepatol2022766819310.1016/j.jhep.2021.11.018Open DOISearch in Google Scholar
Ducreux M, Abou-Alfa GK, Bekaii-Saab T, Berlin J, Cervantes A, de Baere T, et al. The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022. ESMO Open 2023; 8: 101567. doi: 10.1016/j.esmoop.2023.101567DucreuxMAbou-AlfaGKBekaii-SaabTBerlinJCervantesAde BaereTThe management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022ESMO Open2023810156710.1016/j.esmoop.2023.101567Open DOISearch in Google Scholar
Raoul JL, Forner A, Bolondi L, Cheung TT, Kloeckner R, de Baere T. Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence. Cancer Treat Rev 2019; 72: 28–36. doi: 10.1016/j.ctrv.2018.11.002RaoulJLFornerABolondiLCheungTTKloecknerRde BaereTUpdated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidenceCancer Treat Rev201972283610.1016/j.ctrv.2018.11.002Open DOISearch in Google Scholar
Varela M, Real MI, Burrel M, Forner A, Sala M, Brunet M, et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 2007; 46: 474–81. doi: 10.1016/j.jhep.2006.10.020VarelaMRealMIBurrelMFornerASalaMBrunetMChemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokineticsJ Hepatol2007464748110.1016/j.jhep.2006.10.020Open DOISearch in Google Scholar
Lammer J, Malagari K, Vogl T, Pilleul F, Denys A, Watkinon A, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Interv Radiol 2010; 33: 41–52. doi: 10.1007/s00270-009-9711-7LammerJMalagariKVoglTPilleulFDenysAWatkinonAProspective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V studyCardiovasc Interv Radiol201033415210.1007/s00270-009-9711-7Open DOISearch in Google Scholar
Boulin M, Guiu S, Chauffert B, Delhom E, Schmitt A, Hillon P, et al. Screening of anticancer drugs for chemoembolization of hepatocellular carcinoma. Anticancer Drugs 2011; 22: 741–8. doi: 10.1111/apt.12746BoulinMGuiuSChauffertBDelhomESchmittAHillonPScreening of anticancer drugs for chemoembolization of hepatocellular carcinomaAnticancer Drugs201122741810.1111/apt.12746Open DOISearch in Google Scholar
Robert J. Clinical pharmacokinetics of idarubicin. Clin Pharmacokinet 1993; 24: 275–88. doi: 10.2165/00003088-199324040-00002RobertJClinical pharmacokinetics of idarubicinClin Pharmacokinet1993242758810.2165/00003088-199324040-00002Open DOISearch in Google Scholar
Guiu B, Hincapie G, Thompson L, Wu Y, Boulin M, Cassinotto C, et al. An in vitro evaluation of four types of drug-eluting embolics joaded with idarubicin. J Vasc Interv Radiol 2019: 30: 1303–9. doi: 10.1016/j.jvir.2018.12.022GuiuBHincapieGThompsonLWuYBoulinMCassinottoCAn in vitro evaluation of four types of drug-eluting embolics joaded with idarubicinJ Vasc Interv Radiol2019301303910.1016/j.jvir.2018.12.022Open DOISearch in Google Scholar
Favelier S, Boulin M, Hamza S, Cercueil JP, Cherblanc V, Lepage C, et al. Lipiodol trans-arterial chemoembolization of hepatocellular carcinoma with idarubicin: First experience. Cardiovasc Intervent Radiol 2013; 36: 1039–46. doi: 10.1007/s00270-012-0532-8FavelierSBoulinMHamzaSCercueilJPCherblancVLepageCLipiodol trans-arterial chemoembolization of hepatocellular carcinoma with idarubicin: First experienceCardiovasc Intervent Radiol20133610394610.1007/s00270-012-0532-8Open DOISearch in Google Scholar
Guiu B, Schmitt A, Reinhardt S, Deltenre P, Denys A, Lepida A, et al. Idarubicin-loaded ONCOZENE drug-eluting embolic agents for chemoembolization of hepatocellular carcinoma: in vitro loading and release and in vivo pharmacokinetics. J Vasc Interv Radiol 2015; 26: 262–70. doi: 10.1016/j.jvir.2014.08.021GuiuBSchmittAReinhardtSDeltenrePDenysALepidaAIdarubicin-loaded ONCOZENE drug-eluting embolic agents for chemoembolization of hepatocellular carcinoma: in vitro loading and release and in vivo pharmacokineticsJ Vasc Interv Radiol2015262627010.1016/j.jvir.2014.08.021Open DOISearch in Google Scholar
Boulin M, Hillon P, Cercueil JP, Raoul JL, Lepage C, Barbare JC, et al. Idarubicin-loaded beads for chemoembolisation of hepatocellular carcinoma: results of the IDASPHERE phase I trial. Aliment Pharmacol Ther 2014; 39: 1301–13. doi: 10.1111/apt.12776BoulinMHillonPCercueilJPRaoulJLLepageCBarbareJCIdarubicin-loaded beads for chemoembolisation of hepatocellular carcinoma: results of the IDASPHERE phase I trialAliment Pharmacol Ther20143913011310.1111/apt.12776Open DOISearch in Google Scholar
Guiu B, Chevallier P, Assenat E, Barbier E, Merle P, Bouvier A, et al. Idarubicin-loaded beads for chemoembolization of hepatocellular carcinoma: the IDASPHERE II single-arm phase II trial 2019; 291: 801–8. doi: 0.1148/radiol.2019182399GuiuBChevallierPAssenatEBarbierEMerlePBouvierAIdarubicin-loaded beads for chemoembolization of hepatocellular carcinoma: the IDASPHERE II single-arm phase II trial20192918018doi: 0.1148/radiol.2019182399Search in Google Scholar
Guiu B, Jouve JL, Schmitt A, Minello A, Bonnetain F, Cassinotto C, et al. Intra-arterial idarubicin_lipiodol without embolisation in hepatocellular carcinoma: the LIDA-B phase I trial. J Hepatol 2018; 68: 1163–71. doi: 10.1016/j.jhep.2018.01.022.GuiuBJouveJLSchmittAMinelloABonnetainFCassinottoCIntra-arterial idarubicin_lipiodol without embolisation in hepatocellular carcinoma: the LIDA-B phase I trialJ Hepatol20186811637110.1016/j.jhep.2018.01.022.Open DOISearch in Google Scholar
Common Terminology Criteria for Adverse Events v. 5.0 [internet]. [cited 2024 Jan 3]. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcae_v5_quick_reference_5x7.pdfCommon Terminology Criteria for Adverse Events v. 5.0 [internet]. [cited 2024 Jan 3]. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcae_v5_quick_reference_5x7.pdfSearch in Google Scholar
Lencioni R, Llovet J. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis 2010; 30: 52–60. doi: 10.1055/s-0030-1247132LencioniRLlovetJModified RECIST (mRECIST) assessment for hepatocellular carcinomaSemin Liver Dis201030526010.1055/s-0030-1247132Open DOISearch in Google Scholar
Guiu B, Hincapie G, Thompson L, Wu Y, Boulin M, Cassinotto C, et al. An in vitro evaluation of four types of drug-eluting embolics loaded with idarubicin. J Vasc Interv Radiol 2019; 30: 1303–9. doi: 10.1016/j.jvir.2018.12.022.GuiuBHincapieGThompsonLWuYBoulinMCassinottoCAn in vitro evaluation of four types of drug-eluting embolics loaded with idarubicinJ Vasc Interv Radiol2019301303910.1016/j.jvir.2018.12.022.Open DOISearch in Google Scholar
de Baere T, Guiu B, Ronot M, Chevallier P, Sergent G, Tancredi I, et al. Real life prospective evaluation of new drug-eluting platform for chemoembolization of patients with hepatocellular carcinoma: PARIS registry. Cancers 2020; 12: 3405. doi: 10.3390/cancers12113405de BaereTGuiuBRonotMChevallierPSergentGTancrediIReal life prospective evaluation of new drug-eluting platform for chemoembolization of patients with hepatocellular carcinoma: PARIS registryCancers202012340510.3390/cancers12113405Open DOISearch in Google Scholar
Guiu B, Colombat S, Piron L, Hermida M, Allimant C, Pierredon-Foulongne MA, et al. Transarterial chemoembolization of hepatocellular carcinoma with idarubicin-loaded tandem drug-eluting embolics. Cancers 2019; 11: 987. doi: 10.3390/cancers11070987GuiuBColombatSPironLHermidaMAllimantCPierredon-FoulongneMATransarterial chemoembolization of hepatocellular carcinoma with idarubicin-loaded tandem drug-eluting embolicsCancers20191198710.3390/cancers11070987Open DOISearch in Google Scholar
Anderlini P, Benjamin RS, Wong FC, Kantarjian HM, Andreeff M, Kornblau SM, et al. Idarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myelodysplasia. J Clin Oncol 1995; 13: 2827–34. doi: 10.1200/JCO.1995.13.11.2827AnderliniPBenjaminRSWongFCKantarjianHMAndreeffMKornblauSMIdarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myelodysplasiaJ Clin Oncol19951328273410.1200/JCO.1995.13.11.2827Open DOISearch in Google Scholar
Guiu B, Deschamps F, Aho S, Munck F, Dromain C, Boige V, et al. Liver/biliary injuries following chemoembolisation of endocrine tumours and hepatocellular carcinoma: Lipiodol vs. drug-eluting beads. J Hepatol 2012; 56: 609–17. doi: 10.1016/j.jhep.2011.09.012GuiuBDeschampsFAhoSMunckFDromainCBoigeVLiver/biliary injuries following chemoembolisation of endocrine tumours and hepatocellular carcinoma: Lipiodol vs. drug-eluting beadsJ Hepatol2012566091710.1016/j.jhep.2011.09.012Open DOISearch in Google Scholar
Shi Z, Wang D, Jiang H, Kang T, Yi R, Cui L. Comparison of CalliSpheres® microspheres drug-eluting beads and conventional transarterial chemoembolization in hepatocellular carcinoma patients: a randomized controlled trial. Radiol Oncol 2023; 57: 70–9. doi: 10.2478/raon-2023-0001ShiZWangDJiangHKangTYiRCuiLComparison of CalliSpheres® microspheres drug-eluting beads and conventional transarterial chemoembolization in hepatocellular carcinoma patients: a randomized controlled trialRadiol Oncol20235770910.2478/raon-2023-0001Open DOISearch in Google Scholar
Korsic S, Levasic N, Dezman R, Zupan LAL, Trotovsek B, Jansa R, et al. Safety and efficacy of drug-eluting microspheres chemoembolization under cone beam computed tomography control in patients with early and intermediate stage hepatocellular carcinoma. Radiol Oncol 2022; 56: 311–8. doi: 10.2478/raon-2022-0019KorsicSLevasicNDezmanRZupanLALTrotovsekBJansaRSafety and efficacy of drug-eluting microspheres chemoembolization under cone beam computed tomography control in patients with early and intermediate stage hepatocellular carcinomaRadiol Oncol202256311810.2478/raon-2022-0019Open DOISearch in Google Scholar
Gomes FV, Oliveira JA, Correia MT, Costa NV, Abrantes J, Torres D, et al. Chemoembolization of hepatocellular carcinoma with drug-eluting polyethylene glycol embolic agents: single-center retrospective analysis in 302 patients. J Vasc Interv Radiol 2018; 29: 841–9. doi: 10.1016/j.jvir.2018.02.004GomesFVOliveiraJACorreiaMTCostaNVAbrantesJTorresDChemoembolization of hepatocellular carcinoma with drug-eluting polyethylene glycol embolic agents: single-center retrospective analysis in 302 patientsJ Vasc Interv Radiol201829841910.1016/j.jvir.2018.02.004Open DOISearch in Google Scholar
Lucatelli P, Ginnani Corradini L, De Rubeis G, Corona M, Saba L, Catalano C, et al. Balloon-occluded transcatheter arterial chemoembolization (b-TACE) for hepatocellular carcinoma performed with polyethylene-glycol epirubicin-loaded drug-eluting embolics: safety and preliminary results. Cardiovasc Intervent Radiol 2019; 42: 853–62. doi: 10.1007/s00270-019-02192-yLucatelliPGinnani CorradiniLDe RubeisGCoronaMSabaLCatalanoCBalloon-occluded transcatheter arterial chemoembolization (b-TACE) for hepatocellular carcinoma performed with polyethylene-glycol epirubicin-loaded drug-eluting embolics: safety and preliminary resultsCardiovasc Intervent Radiol2019428536210.1007/s00270-019-02192-yOpen DOISearch in Google Scholar
Aliberti C, Carandina R, Sarti D, Mulazzani L, Pizzirani E, Guadagni S, et al. Chemoembolization adopting polyethylene glycol drug-eluting embolics loaded with doxorubicin for the treatment of hepatocellular carcinoma. AJR Am J Roentgenol 2017; 209: 430–4. doi: 10.2214/AJR.16.17477AlibertiCCarandinaRSartiDMulazzaniLPizziraniEGuadagniSChemoembolization adopting polyethylene glycol drug-eluting embolics loaded with doxorubicin for the treatment of hepatocellular carcinomaAJR Am J Roentgenol2017209430410.2214/AJR.16.17477Open DOISearch in Google Scholar
Fiorentini G, Sarti D, Carandina R, Mincarelli C, Candelari R, Argirò R, et al. A review discussing the use of polyethylene glycol microspheres in the treatment of hepatocellular carcinoma. Future Oncol 2019; 15: 695–703. doi: 10.2217/fon-2018-0425FiorentiniGSartiDCarandinaRMincarelliCCandelariRArgiròRA review discussing the use of polyethylene glycol microspheres in the treatment of hepatocellular carcinomaFuture Oncol20191569570310.2217/fon-2018-0425Open DOISearch in Google Scholar
Veloso Gomes F, de Baère T, Verset G, Coimbra É, Tovar-Felice G, Malagari K, et al. Transarterial chemoembolization with anthracyclines-loaded polyethylene glycol drug eluting microspheres for the treatment of hepatocellular carcinoma: a pooled multicentric analysis of survival in 580 patients. Cardiovasc Intervent Radiol 2023; 46: 436–46. doi: 10.1007/s00270-023-03362-9Veloso GomesFde BaèreTVersetGCoimbraÉTovar-FeliceGMalagariKTransarterial chemoembolization with anthracyclines-loaded polyethylene glycol drug eluting microspheres for the treatment of hepatocellular carcinoma: a pooled multicentric analysis of survival in 580 patientsCardiovasc Intervent Radiol2023464364610.1007/s00270-023-03362-9Open DOISearch in Google Scholar
Popovic P, Stabuc B, Jansa R, Garbajs M. Survival of patients with intermediate stage hepatocellular carcinoma treated with superselective transarterial chemoembolization using doxorubicin-loaded DC Bead under conebeam computed tomography control. Radiol Oncol 2016; 50: 418–26. doi: 10.1515/raon-2015-0045PopovicPStabucBJansaRGarbajsMSurvival of patients with intermediate stage hepatocellular carcinoma treated with superselective transarterial chemoembolization using doxorubicin-loaded DC Bead under conebeam computed tomography controlRadiol Oncol2016504182610.1515/raon-2015-0045Open DOISearch in Google Scholar
Vogel A, Cervantes A, Chau I, Daniele B, Llovet JM, Meyer T, et al. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2018; 29: iv238–55. doi: 10.1093/annonc/mdy308VogelACervantesAChauIDanieleBLlovetJMMeyerTHepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upAnn Oncol201829iv2385510.1093/annonc/mdy308Open DOISearch in Google Scholar
Bruix J, Reig M, Rimola J, Vilana R, Burrel M, Llovet JM, et al. Clinical decision making and research in hepatocellular carcinoma: pivotal role of imaging techniques. Hepatology 2011; 54: 2238–44. doi: 10.1002/hep.24670BruixJReigMRimolaJVilanaRBurrelMLlovetJMClinical decision making and research in hepatocellular carcinoma: pivotal role of imaging techniquesHepatology20115422384410.1002/hep.24670Open DOISearch in Google Scholar
Wang H, Li B, Wang Y, Zhang J, Wu Y, Fan W, Li J. Time to untreatable progression is an appropriate surrogate endpoint for overall survival in patients with hepatocellular carcinoma after transarterial chemoembolization. J Cancer Res Ther 2020; 16: 301–8. doi: 10.4103/jcrt.JCRT_898_19WangHLiBWangYZhangJWuYFanWLiJTime to untreatable progression is an appropriate surrogate endpoint for overall survival in patients with hepatocellular carcinoma after transarterial chemoembolizationJ Cancer Res Ther202016301810.4103/jcrt.JCRT_898_19Open DOISearch in Google Scholar