<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>Retroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS.</p></sec>
<sec><h3>Patients and methods</h3><p>We retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative skeletal muscle area (SMA), visceral and subcutaneous adipose tissue area (VAT and SAT) and muscle radiation attenuation (MRA) were calculated using computed tomography scans at the level of third lumbar vertebra. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were applied to define myopenia. Using maximum log-rank statistic method we determined the optimal cut-off values of body composition parameters. Myosteatosis was defined based on determined MRA cut-offs.</p></sec>
<sec><h3>Results</h3><p>In total 58 patient were eligible for the study. With a median follow-up of 116 months, the estimated 5-year overall survival (OS) and local-recurrence free survival (LRFS) were 66.8% and 77.6%, respectively. Patients with myopenia had significantly lower 5-year OS compared to non-myopenic (p = 0.009). Skeletal muscle index and subcutaneous adipose tissue index predicted LRFS on univariate analysis (p = 0.052 and p = 0.039, respectively). In multivariate analysis high visceral-to-subcutaneous adipose tissue area ratio (VSR) independently predicted higher postoperative complication rate (89.2% <italic>vs</italic>. 10.8%, p = 0.008). Myosteatosis was associated with higher postoperative morbidity.</p></sec>
<sec><h3>Conclusions</h3><p>Myopenia affected survival, but not postoperative outcome in RPS. Visceral obesity, VSR (> 0.26) and myosteatosis were associated with higher postoperative morbidity. VSR was better prognostic factor than VAT in RPS.</p></sec>
</abstract>

BackgroundRetroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS.
Patients and methodsWe retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative skeletal muscle area (SMA), visceral and subcutaneous adipose tissue area (VAT and SAT) and muscle radiation attenuation (MRA) were calculated using computed tomography scans at the level of third lumbar vertebra. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were applied to define myopenia. Using maximum log-rank statistic method we determined the optimal cut-off values of body composition parameters. Myosteatosis was defined based on determined MRA cut-offs.
ResultsIn total 58 patient were eligible for the study. With a median follow-up of 116 months, the estimated 5-year overall survival (OS) and local-recurrence free survival (LRFS) were 66.8% and 77.6%, respectively. Patients with myopenia had significantly lower 5-year OS compared to non-myopenic (p = 0.009). Skeletal muscle index and subcutaneous adipose tissue index predicted LRFS on univariate analysis (p = 0.052 and p = 0.039, respectively). In multivariate analysis high visceral-to-subcutaneous adipose tissue area ratio (VSR) independently predicted higher postoperative complication rate (89.2% vs. 10.8%, p = 0.008). Myosteatosis was associated with higher postoperative morbidity.
ConclusionsMyopenia affected survival, but not postoperative outcome in RPS. Visceral obesity, VSR (> 0.26) and myosteatosis were associated with higher postoperative morbidity. VSR was better prognostic factor than VAT in RPS.

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Biotechnical Faculty, University of Ljubljana

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

BackgroundRetroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We...

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Article Category: Research Article

Online veröffentlicht: 21. Feb. 2024

Seitenbereich: 110 - 123

Eingereicht: 26. Juli 2023

Akzeptiert: 03. Nov. 2023

DOI: https://doi.org/10.2478/raon-2024-0013

Schlüsselwörter
body composition, myopenia, cancer cachexia, myosteatosis, obesity, retroperitoneal sarcoma

© 2024 Manuel Ramanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Details zum Zusatzmaterial

Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma

Article Category: Research Article

Online veröffentlicht: 21. Feb. 2024

Seitenbereich: 110 - 123

Eingereicht: 26. Juli 2023

Akzeptiert: 03. Nov. 2023

DOI: https://doi.org/10.2478/raon-2024-0013

Schlüsselwörterbody composition, myopenia, cancer cachexia, myosteatosis, obesity, retroperitoneal sarcoma

© 2024 Manuel Ramanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Details zum Zusatzmaterial

Schlüsselwörter
body composition, myopenia, cancer cachexia, myosteatosis, obesity, retroperitoneal sarcoma