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Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis

Jelena Kostic Peric

Jelena Kostic Peric

Institute for Molecular Genetics and Genetic Engineering, University of BelgradeBelgrade, Serbia
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Kostic Peric, Jelena
, 
Andja Cirkovic

Andja Cirkovic

Department for Medical Statistics and Informatics, Faculty of Medicine, University of BelgradeBelgrade, Serbia
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Cirkovic, Andja
, 
Sanja Srzentic Drazilov

Sanja Srzentic Drazilov

Institute for Molecular Genetics and Genetic Engineering, University of BelgradeBelgrade, Serbia
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Srzentic Drazilov, Sanja
, 
Natalija Samardzic

Natalija Samardzic

University Hospital of Pulmonology, Clinical Centre of SerbiaBelgrade, Serbia
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Samardzic, Natalija
, 
Vesna Skodric Trifunovic

Vesna Skodric Trifunovic

  • University Hospital of Pulmonology, Clinical Centre of SerbiaBelgrade, Serbia
  • Faculty of Medicine, University of BelgradeBelgrade, Serbia
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Skodric Trifunovic, Vesna
, 
Dragana Jovanovic

Dragana Jovanovic

Internal Medicine Clinic “Akta Medica”Belgrade, Serbia
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Jovanovic, Dragana
 und 
Sonja Pavlovic

Sonja Pavlovic

Institute for Molecular Genetics and Genetic Engineering, University of BelgradeBelgrade, Serbia
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Pavlovic, Sonja
  
22. März 2023
Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis's Cover Image
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Artikel-Kategorie: Review
Online veröffentlicht: 22. März 2023
Seitenbereich: 12 - 19
Eingereicht: 21. Okt. 2022
Akzeptiert: 31. Jan. 2023
DOI: https://doi.org/10.2478/raon-2023-0013
Schlüsselwörter
© 2023 Jelena Kostic Peric, Andja Cirkovic, Sanja Srzentic Drazilov, Natalija Samardzic, Vesna Skodric Trifunovic, Dragana Jovanovic, Sonja Pavlovic, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure

Flow chart to illustrate the process by which articles were selected or rejected for inclusion in the study.
Flow chart to illustrate the process by which articles were selected or rejected for inclusion in the study.

Figure

Forest plot of GTH2I gene in thymoma.
Forest plot of GTH2I gene in thymoma.

Figure

Forest plot of TP53 gene in thymoma.
Forest plot of TP53 gene in thymoma.

Figure

Forest plot of HRAS gene in thymoma.
Forest plot of HRAS gene in thymoma.

Figure

Funnel plot of GTF2I gene in thymoma.
Funnel plot of GTF2I gene in thymoma.

Figure

Funnel plot of TP53 gene in thymoma.
Funnel plot of TP53 gene in thymoma.

Figure

Funnel plot of HRAS gene in thymoma.
Funnel plot of HRAS gene in thymoma.

Characteristics of 12 selected studies

Author Year Study design Thymoma Gene (SNV) Number of cases number Total of cases NGS genomics
APC 23
TP53 12
ATM 22
Chen K, China 2020 Cross-sectional Type A, AB, B1, B2, B3 AKT1 5 50 TS
SMAD4 12
ALK 19
KRAS 2
NRAS 2
HRAS 3
Enkner F, Austria 2017 Cross-sectional Type A, B SMARCB1 1 19 TS
STK11 1
Higuchi R, Japan 2020 Cross-sectional Type A, AB, B GTF2I 14 22 TS
Petrini I, Italia 2014 Cross-sectional Type A, AB GTF2I 119 270 ES
GTF2I 44
Radovich M, USA 2017 Case-control Type A, AB HRAS 10 105 MOPA
TP53 2
HRAS 1
PIK3CA 2 SNaPshot
Sakane T, Japan 2020 Cross-sectional Type A, B2, B3, B4, B5 AKT1 1 33
RAS pathway 1 Multiplex
EGFR pathway 3
Song ZB, China 2016 Type B2, B3 PIK3CA 1 37 TS
EGFR 1 IonAmpliSeq
SMAD4 27
APC 27
Peric J, Serbia 2020 Case-control Type A, B1, B2, B3 ATM 26 35 TSACP
ERBB4 24
TP53 26
Xu S, China 2021 Cross-sectional Type A, AB B1, B2, B3 TP53 9 17 ES
HRAS 2
Liang N, China 2021 Cross-sectional Type A, AB, B1, B2, B3 GTF2I 15 24 SureSelectXT TS
Szpechcinski A, Poland 2022 Cross-sectional Type B2B3 ERBBKIT 2 11 19 TS
KIT 1
Girard N, France 2022 Cross-sectional Type A, B1, B2, B3 TPHRAS 53 81 90 WES
Other genes 80
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