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Treatment of vulvar cancer recurrences with electrochemotherapy – a detailed analysis of possible causes for unsuccessful treatment

Gregor Vivod

Gregor Vivod

  • Department of Gynecological Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Medical Faculty Ljubljana, University of LjubljanaLjubljana, Slovenia
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Vivod, Gregor
, 
Tanja Jesenko

Tanja Jesenko

  • Medical Faculty Ljubljana, University of LjubljanaLjubljana, Slovenia
  • Department of Experimental Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
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Jesenko, Tanja
, 
Gorana Gasljevic

Gorana Gasljevic

Department Pathology, Institute of Oncology LjubljanaLjubljana, Slovenia
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Gasljevic, Gorana
, 
Nina Kovacevic

Nina Kovacevic

  • Department of Gynecological Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Medical Faculty Ljubljana, University of LjubljanaLjubljana, Slovenia
  • Faculty of Health Care Angela BoškinJesenice, Slovenia
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Kovacevic, Nina
, 
Masa Bosnjak

Masa Bosnjak

  • Department of Experimental Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Pharmacy, University of LjubljanaLjubljana, Slovenia
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Bosnjak, Masa
, 
Gregor Sersa

Gregor Sersa

  • Department of Experimental Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Health Sciences, University of LjubljanaLjubljana, Slovenia
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Sersa, Gregor
, 
Sebastjan Merlo

Sebastjan Merlo

  • Department of Gynecological Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Medical Faculty Ljubljana, University of LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of MariborMaribor, Slovenia
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Merlo, Sebastjan
 und 
Maja Cemazar

Maja Cemazar

  • Department of Experimental Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Health Sciences, University of PrimorskaIzola, Slovenia
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Cemazar, Maja
  
17. Feb. 2023
Treatment of vulvar cancer recurrences with electrochemotherapy – a detailed analysis of possible causes for unsuccessful treatment's Cover Image
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Artikel-Kategorie: Research Article
Online veröffentlicht: 17. Feb. 2023
Seitenbereich: 121 - 126
Eingereicht: 21. Dez. 2022
Akzeptiert: 11. Jan. 2023
DOI: https://doi.org/10.2478/raon-2023-0010
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© 2023 Gregor Vivod, Tanja Jesenko, Gorana Gasljevic, Nina Kovacevic, Masa Bosnjak, Gregor Sersa, Sebastjan Merlo, Maja Cemazar, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

(A) Local recurrence of vulvar cancer. (B) No response to treatment two months after electrochemotherapy.
(A) Local recurrence of vulvar cancer. (B) No response to treatment two months after electrochemotherapy.

Figure 2

Hematoxylin and eosin stained sections of primary (A) and post-electrochemotherapy (B) biopsy. Scale bar represents 50 μm.
Hematoxylin and eosin stained sections of primary (A) and post-electrochemotherapy (B) biopsy. Scale bar represents 50 μm.

Figure 3

Immunohistologically stained sections for lymphocytes CD3 (A), macrophages CD68 PMG1 (B) and CD163 (C), and blood vessels ERG (D), from primary biopsy (Primary Bx) and post-electrochemotherapy biopsy (post-ECT Bx) samples. Scale bar represents 50 μm. The number of positively stained regions ± standard error of the mean (SEM) is presented.
Immunohistologically stained sections for lymphocytes CD3 (A), macrophages CD68 PMG1 (B) and CD163 (C), and blood vessels ERG (D), from primary biopsy (Primary Bx) and post-electrochemotherapy biopsy (post-ECT Bx) samples. Scale bar represents 50 μm. The number of positively stained regions ± standard error of the mean (SEM) is presented.

Review of studies evaluating electrochemotherapy in vulvar cancer

First author, year published Included no. of patients Average age Histology Response of vulvar cancer
OR NR
Perrone, 201320 8 84y 8 SCC 6/8 (75%) 2/8 (25%)
Perrone, 201521 25 85y 25 SCC 20/25 (80%) 5/20 (20%)
Pellegrino, 201618 10 68y 1 9 Paget’s SCC 6/10 (60%) 4/10 (40%)
Perrone, 201913 55 79y 57 SCC 3 Paget’s 1 melanoma 46/55 (84%) 9/55 (16%)
Corrado, 202016 15 83y 14 1 SCC CS 12/15 (80%) 3/15 (20%)
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