Advances in diagnostics and management of gestational trophoblastic disease

1Lok C, Frijstein M, van Trommel N. Clinical presentation and diagnosis of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol 2020; 74: 42-52. doi: 10.1016/j.bpobgyn.2020.12.001 Lok C Frijstein M van Trommel N Clinical presentation and diagnosis of gestational trophoblastic disease Best Pract Res Clin Obstet Gynaecol 2020 74 42 52 10.1016/j.bpobgyn.2020.12.00133422446Open DOISearch in Google Scholar

2Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, et al. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet 2018; 143(Suppl 2): 79-85. doi: 10.1002/ ijgo.12615 Ngan HYS Seckl MJ Berkowitz RS Xiang Y Golfier F Sekharan PK et al Update on the diagnosis and management of gestational trophoblastic disease Int J Gynaecol Obstet 2018 143Suppl 2 79 85 10.1002/ijgo.1261530306586Open DOISearch in Google Scholar

3Fehlmann A, Benkortbi K, Rosseel G, Meyer-Hamme U, Tille JC, Sloan-Bena F, et al. Gestational trophoblastic disease in Switzerland: retrospective study of the impact of a regional reference centre. Swiss Med Wkly 2021; 151: w20406. doi: 10.4414/smw.2021.20406 Fehlmann A Benkortbi K Rosseel G Meyer-Hamme U Tille JC Sloan-Bena F et al Gestational trophoblastic disease in Switzerland: retrospective study of the impact of a regional reference centre Swiss Med Wkly 2021 151 w20406 10.4414/smw.2021.2040633578430Open DOISearch in Google Scholar

4Capobianco G, Tinacci E, Saderi L, Dessole F, Petrillo M, Madonia M, et al. High incidence of gestational trophoblastic disease in a third-level university-hospital, Italy: a retrospective cohort study. Front Oncol 2021; 11: 684700. doi: 10.3389/fonc.2021.684700 Capobianco G Tinacci E Saderi L Dessole F Petrillo M Madonia M et al High incidence of gestational trophoblastic disease in a third-level university-hospital, Italy: a retrospective cohort study Front Oncol 2021 11 684700 10.3389/fonc.2021.684700813579534026657Open DOISearch in Google Scholar

5Eysbouts YK, Bulten J, Ottevanger PB, Thomas CMG, ten Kate-Booij MJ, van Herwaarden AE, et al. Trends in incidence for gestational trophoblastic disease over the last 20 years in a population-based study. Gynecol Oncol 2016; 140: 70-5. doi: 10.1016/j.ygyno.2015.11.014 Eysbouts YK Bulten J Ottevanger PB Thomas CMG ten Kate-Booij MJ van Herwaarden AE et al Trends in incidence for gestational trophoblastic disease over the last 20 years in a population-based study Gynecol Oncol 2016 140 70 5 10.1016/j.ygyno.2015.11.01426586414Open DOISearch in Google Scholar

6Hancock BW, Seckl MJ, Berkowitz RS. Gestational trophoblastic disease. London: Hodder Education Publishers; 2022. Hancock BW Seckl MJ Berkowitz RS Gestational trophoblastic disease. London: Hodder Education Publishers; 2022Search in Google Scholar

7Soper JT. Gestational trophoblastic disease: current evaluation and management. Obstet Gynecol 2021; 137: 355-70. doi: 10.1097/ AOG.0000000000004240 Soper JT Gestational trophoblastic disease: current evaluation and management Obstet Gynecol 2021 137 355 70 10.1097/AOG.0000000000004240781344533416290Open DOISearch in Google Scholar

8Fisher RA, Maher GJ. Genetics of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol 2021; 74: 29-41. doi: 10.1016/j.bpob-gyn.2021.01.004 Fisher RA Maher GJ Genetics of gestational trophoblastic disease Best Pract Res Clin Obstet Gynaecol 2021 74 29 41 10.1016/j.bpob-gyn.2021.01.004Open DOISearch in Google Scholar

9Kaur B. Pathology of gestational trophoblastic disease (GTD). Best Pract Res Clin Obstet Gynaecol 2021; 74: 3-28. doi: 10.1016/j.bpobgyn.2021.02.005 Kaur B Pathology of gestational trophoblastic disease (GTD) Best Pract Res Clin Obstet Gynaecol 2021 74 3 28 10.1016/j.bpobgyn.2021.02.00534219021Open DOISearch in Google Scholar

10Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet 2010; 376: 717-29. doi: 10.1016/S0140-6736(10)60280-2 Seckl MJ Sebire NJ Berkowitz RS Gestational trophoblastic disease Lancet 2010 376 717 29 10.1016/S0140-6736(10)60280-220673583Open DOISearch in Google Scholar

11Abu-Rustum NR, Yashar CM, Bean S, Bradley K, Campos SM, Sook Chon H, et al. Gestational trophoblastic neoplasia, version 2.2019. J Natl Compr Canc Netw 2019; 17: 1374-91. doi: 10.6004/jnccn.2019.0053 Abu-Rustum NR Yashar CM Bean S Bradley K Campos SM Sook Chon H et al Gestational trophoblastic neoplasia, version 2.2019 J Natl Compr Canc Netw 2019 17 1374 91 10.6004/jnccn.2019.005331693991Open DOISearch in Google Scholar

12Lok C, van Trommel N, Massuger L, Golfier F, Seckl M. Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease. Eur J Cancer 2020; 130: 228-40. doi: 10.1016/j.ejca.2020.02.011 Lok C van Trommel N Massuger L Golfier F Seckl M Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease Eur J Cancer 2020 130 228 40 10.1016/j.ejca.2020.02.01132247260Open DOISearch in Google Scholar

13Cavoretto P, Cioffi R, Mangili G, Petrone M, Bergamini A, Rabaiotti E, et al. A pictorial ultrasound essay of gestational trophoblastic disease. J Ultrasound Med 2020; 39: 597-613. doi: 10.1002/jum.15119 Cavoretto P Cioffi R Mangili G Petrone M Bergamini A Rabaiotti E et al A pictorial ultrasound essay of gestational trophoblastic disease J Ultrasound Med 2020 39 597 613 10.1002/jum.1511931468566Open DOISearch in Google Scholar

14Memtsa M, Johns J, Jurkovic D, Ross JA, Sebire NJ, Jauniaux E. Diagnosis and outcome of hydatidiform moles in missed-miscarriage: a cohort-study, systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2020; 253: 206-12. doi: 10.1016/j.ejogrb.2020.07.030 Memtsa M Johns J Jurkovic D Ross JA Sebire NJ Jauniaux E Diagnosis and outcome of hydatidiform moles in missed-miscarriage: a cohort-study, systematic review and meta-analysis Eur J Obstet Gynecol Reprod Biol 2020 253 206 12 10.1016/j.ejogrb.2020.07.03032877774Open DOISearch in Google Scholar

15Jauniaux E, Memtsa M, Johns J, Ross JA, Sebire NJ, Jurkovic D. Ultrasound diagnosis of complete and partial hydatidiform moles in early pregnancy failure: an inter-observer study. Placenta 2020; 97: 65-7. doi: 10.1016/j. placenta.2020.06.013 Jauniaux E Memtsa M Johns J Ross JA Sebire NJ Jurkovic D Ultrasound diagnosis of complete and partial hydatidiform moles in early pregnancy failure: an inter-observer study Placenta 2020 97 65 7 10.1016/j.placenta.2020.06.01332792066Open DOISearch in Google Scholar

16Kirk E, Papageorghiou AT, Condous G, Bottomley C, Bourne T. The accuracy of first trimester ultrasound in the diagnosis of hydatidiform mole. Ultrasound Obstet Gynecol 2007; 29: 70-5. doi: 10.1002/uog.3875 Kirk E Papageorghiou AT Condous G Bottomley C Bourne T The accuracy of first trimester ultrasound in the diagnosis of hydatidiform mole Ultrasound Obstet Gynecol 2007 29 70 5 10.1002/uog.387517201012Open DOISearch in Google Scholar

17Shaaban AM, Rezvani M, Haroun RR, Kennedy AM, Elsayes KM, Olpin JD, et al. Gestational trophoblastic disease: clinical and imaging features. Radiographics 2017; 37: 681-700. doi: 10.1148/rg.2017160140 Shaaban AM Rezvani M Haroun RR Kennedy AM Elsayes KM Olpin JD et al Gestational trophoblastic disease: clinical and imaging features Radiographics 2017 37 681 700 10.1148/rg.201716014028287945Open DOISearch in Google Scholar

18Jauniaux E, Memtsa M, Johns J, Ross JA, Jurkovic D. New insights in the pathophysiology of complete hydatidiform mole. Placenta 2018; 62: 28-33. doi: 10.1016/j.placenta.2017.12.008 Jauniaux E Memtsa M Johns J Ross JA Jurkovic D New insights in the pathophysiology of complete hydatidiform mole Placenta 2018 62 28 33 10.1016/j.placenta.2017.12.00829405964Open DOISearch in Google Scholar

19Knez J, Day A, Jurkovic D. Ultrasound imaging in the management of bleeding and pain in early pregnancy. Best Pract Res Clin Obstet Gynaecol 2014; 28: 621-36. doi: 10.1016/j.bpobgyn.2014.04.003 Knez J Day A Jurkovic D Ultrasound imaging in the management of bleeding and pain in early pregnancy Best Pract Res Clin Obstet Gynaecol 2014 28 621 36 10.1016/j.bpobgyn.2014.04.00324841987Open DOISearch in Google Scholar

20Lin LH, Bernardes LS, Hase EA, Fushida K, Francisco RPV. Is Doppler ultrasound useful for evaluating gestational trophoblastic disease? Clinics 2015; 70: 810. doi: 10.6061/clinics/2015(12)08 Lin LH Bernardes LS Hase EA Fushida K Francisco RPV Is Doppler ultrasound useful for evaluating gestational trophoblastic disease? Clinics 2015 70 810 10.6061/clinics/2015(12)08467632426735221Open DOISearch in Google Scholar

21Taylor HS, Pal L, Seli E. Speroff’s clinical gynecologic endocrinology and infertility. Philadelphia: Wolters Kluwer; 2020. Taylor HS Pal L Seli E Speroff’s clinical gynecologic endocrinology and infertility Philadelphia Wolters Kluwer 2020Search in Google Scholar

22McMahon LM, Stewart WW, Cuthill L. Human chorionic gonadotrophin assays to monitor GTD. Best Pract Res Clin Obstet Gynaecol 2021; 74: 109-21. doi: 10.1016/j.bpobgyn.2021.05.001 McMahon LM Stewart WW Cuthill L Human chorionic gonadotrophin assays to monitor GTD Best Pract Res Clin Obstet Gynaecol 2021 74 109 21 10.1016/j.bpobgyn.2021.05.00134074603Open DOISearch in Google Scholar

23Sato A, Usui H, Shozu M. Comparison between vacuum aspiration and forceps plus blunt curettage for the evacuation of complete hydatidi-form moles. Taiwan J Obstet Gynecol 2019; 58: 650-5. doi: 10.1016/j. tjog.2019.07.012 Sato A Usui H Shozu M Comparison between vacuum aspiration and forceps plus blunt curettage for the evacuation of complete hydatidi-form moles Taiwan J Obstet Gynecol 2019 58 650 5 10.1016/j.tjog.2019.07.01231542087Open DOISearch in Google Scholar

24Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, et al. Diagnosis and management of gestational trophoblastic disease: 2021 update. Int J Gynaecol Obstet 2021; 155: 86-93. doi: 10.1002/ijgo.13877 Ngan HYS Seckl MJ Berkowitz RS Xiang Y Golfier F Sekharan PK et al Diagnosis and management of gestational trophoblastic disease: 2021 update Int J Gynaecol Obstet 2021 155 86 93 10.1002/ijgo.13877929823034669197Open DOISearch in Google Scholar

25Tidy J, Seckl M, Hancock BW, on behalf of the Royal College of Obstetricians and Gynaecologists. Management of gestational trophoblastic disease. BJOG 2021; 128: e1-27. doi: 10.1111/1471-0528.16266 Tidy J Seckl M Hancock BW on behalf of the Royal College of Obstetricians and Gynaecologists Management of gestational trophoblastic disease BJOG 2021 128 e1 27 10.1111/1471-0528.1626632996207Open DOISearch in Google Scholar

26Horowitz NS, Eskander RN, Adelman MR, Burke W. Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: a society of gynecologic oncology evidenced-based review and recommendation. Gynecol Oncol 2021; 163: 605-13. doi: 10.1016/j.ygyno.2021.10.003 Horowitz NS Eskander RN Adelman MR Burke W Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: a society of gynecologic oncology evidenced-based review and recommendation Gynecol Oncol 2021 163 605 13 10.1016/j.ygyno.2021.10.00334686354Open DOISearch in Google Scholar

27Ngu SF, Ngan HYS. Surgery including fertility-sparing treatment of GTD. Best Pract Res Clin Obstet Gynaecol 2021; 74: 97-108. doi: 10.1016/j. bpobgyn.2020.10.005 Ngu SF Ngan HYS Surgery including fertility-sparing treatment of GTD Best Pract Res Clin Obstet Gynaecol 2021 74 97 108 10.1016/j.bpobgyn.2020.10.005754782633127305Open DOISearch in Google Scholar

28Zhao P, Lu Y, Huang W, Tong B, Lu W. Total hysterectomy versus uterine evacuation for preventing post-molar gestational trophoblastic neoplasia in patients who are at least 40 years old: a systematic review and meta-analysis. BMC Cancer 2019; 19: 13. doi: 10.1186/s12885-018-5168 Zhao P Lu Y Huang W Tong B Lu W Total hysterectomy versus uterine evacuation for preventing post-molar gestational trophoblastic neoplasia in patients who are at least 40 years old: a systematic review and meta-analysis BMC Cancer 2019 19 13 10.1186/s12885-018-5168Open DOISearch in Google Scholar

29Gockley AA, Lin LH, Davis M, Melamed A, Rizzo A, Sun SY, et al. Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy. Clinics 2021; 76: e2830. doi: 10.6061/clinics/2021/e2830 Gockley AA Lin LH Davis M Melamed A Rizzo A Sun SY et al Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy Clinics 2021 76 e2830 10.6061/clinics/2021/e2830836690134468539Open DOISearch in Google Scholar

30Eysbouts Y, Brouwer R, Ottevanger P, Massuger L, Sweep F, Thomas C, et al. Serum human chorionic gonadotropin normogram for the detection of gestational trophoblastic neoplasia. Int J Gynecol Cancer 2017; 27: 1035-41. doi: 10.1097/IGC.0000000000000966 Eysbouts Y Brouwer R Ottevanger P Massuger L Sweep F Thomas C et al Serum human chorionic gonadotropin normogram for the detection of gestational trophoblastic neoplasia Int J Gynecol Cancer 2017 27 1035 41 10.1097/IGC.000000000000096628498241Open DOISearch in Google Scholar

31Snyman LC. Gestational trophoblastic disease: an overview. S Afr J Gynaecol Oncol 2009; 1: 32-7. doi: 10.1080/20742835.2009.11441132 Snyman LC Gestational trophoblastic disease: an overview S Afr J Gynaecol Oncol 2009 1 32 7 10.1080/20742835.2009.11441132Open DOISearch in Google Scholar

32Lurain JR. Gestational trophoblastic tumors. Semin Surg Oncol 1990; 6: 347-53. doi: 10.1002/SSU.2980060610 Lurain JR Gestational trophoblastic tumors Semin Surg Oncol 1990 6 347-53 10.1002/SSU.29800606102175931Open DOISearch in Google Scholar

33FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee. Int J Gynaecol Obstet 2002; 77: 285-7. doi: 10.1016/S0020-7292(02)00063-2 FIGO Oncology Committee FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee Int J Gynaecol Obstet 2002 77 285 7 10.1016/S0020-7292(02)00063-212065144Open DOISearch in Google Scholar

34Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol 2010; 203: 531-9. doi: 10.1016/j.ajog.2010.06.073 Lurain JR Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole Am J Obstet Gynecol 2010 203 531 9 10.1016/j.ajog.2010.06.07320728069Open DOISearch in Google Scholar

35Hancock BW, Tidy J. Placental site trophoblastic tumour and epithelioid trophoblastic tumour. Best Pract Res Clin Obstet Gynaecol 2021; 74: 131-48. doi: 10.1016/j.bpobgyn.2020.10.004 Hancock BW Tidy J Placental site trophoblastic tumour and epithelioid trophoblastic tumour Best Pract Res Clin Obstet Gynaecol 2021 74 131 48 10.1016/j.bpobgyn.2020.10.00433139212Open DOISearch in Google Scholar

36Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C. Gestational trophoblastic disease: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013; 24(Suppl 6): 39-50. doi: 10.1093/ annonc/mdt345 Seckl MJ Sebire NJ Fisher RA Golfier F Massuger L Sessa C Gestational trophoblastic disease: ESMO clinical practice guidelines for diagnosis, treatment and follow-up Ann Oncol 2013 24Suppl 6 39 50 10.1093/annonc/mdt34523999759Open DOISearch in Google Scholar

37Biscaro A, Braga A, Berkowitz RS. Diagnosis, classification and treatment of gestational trophoblastic neoplasia. Rev Bras Ginecol Obstet 2015; 37: 42-51. doi: 10.1590/SO100-720320140005198 Biscaro A Braga A Berkowitz RS Diagnosis, classification and treatment of gestational trophoblastic neoplasia Rev Bras Ginecol Obstet 2015 37 42-51 10.1590/SO100-72032014000519825607129Open DOISearch in Google Scholar

38Winter MC. Treatment of low-risk gestational trophoblastic neoplasia. Best Pract Res Clin Obstet Gynaecol 2021; 74: 67-80. doi: 10.1016/j.bpob-gyn.2021.01.006 Winter MC Treatment of low-risk gestational trophoblastic neoplasia Best Pract Res Clin Obstet Gynaecol 2021 74 67 80 10.1016/j.bpob-gyn.2021.01.006Open DOISearch in Google Scholar

39Berkowitz RS, Goldstein DP. Current management of gestational trophoblastic diseases. Gynecol Oncol 2009; 112: 654-62. doi: 10.1016/j.ygy-no.2008.09.005 Berkowitz RS Goldstein DP Current management of gestational trophoblastic diseases Gynecol Oncol 2009 112 654 62 10.1016/j.ygy-no.2008.09.005Open DOISearch in Google Scholar

40Braga A, Mora P, Melo AC de, Nogueira-Rodrigues A, Amim-Junior J, Rezende-Filho J, et al. Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide. World J Clin Oncol 2019; 10: 28-37. doi: 10.5306/wjco.v10.i2.28 Braga A Mora P Melo AC de Nogueira-Rodrigues A Amim-Junior J Rezende-Filho J et al Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide World J Clin Oncol 2019 10 28 37 10.5306/wjco.v10.i2.28639011930815369Open DOISearch in Google Scholar

41Clark JJ, Slater S, Seckl MJ. Treatment of gestational trophoblastic disease in the 2020s. Curr Opin Obstet Gynecol 2021; 33: 7-12. doi: 10.1097/ GCO.0000000000000674 Clark JJ Slater S Seckl MJ Treatment of gestational trophoblastic disease in the 2020s Curr Opin Obstet Gynecol 2021 33 7 12 10.1097/GCO.0000000000000674711687233337613Open DOISearch in Google Scholar

42Clair KH, Gallegos N, Bristow RE. Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: a case for immune checkpoint salvage therapy in trophoblastic tumors. Gynecol Oncol Rep 2020; 34: 100625. doi: 10.1016/j.gore.2020.100625 Clair KH Gallegos N Bristow RE Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: a case for immune checkpoint salvage therapy in trophoblastic tumors Gynecol Oncol Rep 2020 34 100625 10.1016/j.gore.2020.100625749098232964090Open DOISearch in Google Scholar

43Choi MC, Oh J, Lee C. Effective anti-programmed cell death 1 treatment for chemoresistant gestational trophoblastic neoplasia. Eur J Cancer 2019; 121: 94-7. doi: 10.1016/j.ejca.2019.08.024 Choi MC Oh J Lee C Effective anti-programmed cell death 1 treatment for chemoresistant gestational trophoblastic neoplasia Eur J Cancer 2019 121 94 7 10.1016/j.ejca.2019.08.02431569067Open DOISearch in Google Scholar

44Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, et al. Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia. Lancet 2017; 390: 2343-5. doi: 10.1016/S0140-6736(17)32894-5 Ghorani E Kaur B Fisher RA Short D Joneborg U Carlson JW et al Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia Lancet 2017 390 2343 5 10.1016/S0140-6736(17)32894-529185430Open DOISearch in Google Scholar

45Lurain JR. Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol 2011; 204: 11-8. doi: 10.1016/j.ajog.2010.06.072 Lurain JR Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia Am J Obstet Gynecol 2011 204 11 8 10.1016/j.ajog.2010.06.07220739008Open DOISearch in Google Scholar

46di Mattei V, Mazzetti M, Perego G, Rottoli S, Mangili G, Bergamini A, et al. Psychological aspects and fertility issues of GTD. Best Pract Res Clin Obstet Gynaecol 2021; 74: 53-66. doi: 10.1016/j.bpobgyn.2020.10.007 di Mattei V Mazzetti M Perego G Rottoli S Mangili G Bergamini A et al Psychological aspects and fertility issues of GTD Best Pract Res Clin Obstet Gynaecol 2021 74 53 66 10.1016/j.bpobgyn.2020.10.00733176992Open DOISearch in Google Scholar