Deep inspiration breath hold reduces the mean heart dose in left breast cancer radiotherapy
Artikel-Kategorie: Research Article
Online veröffentlicht: 29. Jan. 2021
Seitenbereich: 212 - 220
Eingereicht: 07. Okt. 2020
Akzeptiert: 18. Nov. 2020
DOI: https://doi.org/10.2478/raon-2021-0008
Schlüsselwörter
© 2021 Michał Falco, Bartłomiej Masojć, Agnieszka Macała, Magdalena Łukowiak, Piotr Woźniak, Julian Malicki, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Background
Patients with left breast cancer who undergo radiotherapy have a non-negligible risk of developing radiation-induced cardiovascular disease (CVD). Cardioprotection can be achieved through better treatment planning protocols and through respiratory gating techniques, including deep inspiration breath hold (DIBH). Several dosimetric studies have shown that DIBH reduces the cardiac dose, but clinical data confirming this effect is limited. The aim of the study was to compare the mean heart dose (MHD) in patients with left breast cancer who underwent radiotherapy at our institution as we transitioned from non-gated free-breathing (FB) radiotherapy to gated radiotherapy (FB-GRT), and finally to DIBH.
Patients and methods
Retrospective study involving 2022 breast cancer patients who underwent radiotherapy at West Pomeranian Oncology Center in Szczecin from January 1, 2014 through December 31, 2017. We compared the MHD in these patients according to year of treatment and technique.
Results
Overall, the MHD for patients with left breast cancer in our cohort was 3.37 Gy. MHD values in the patients treated with DIBH were significantly lower than in patients treated with non-gated FB (2.1
Conclusions
Compared to free-breathing techniques (both gated and non-gated), DIBH reduces the mean radiation dose to the heart in patients with left breast cancer. These findings support the use of DIBH in patients with left breast cancer treated with radiotherapy.