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Long term results of follow-up after HPV self-sampling with devices Qvintip and HerSwab in women non-attending cervical screening programme

Teodora Bokan

Teodora Bokan

Mistelbach-Gänserndorf Regional HospitalMistelbach, Austria
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Bokan, Teodora
, 
Urska Ivanus

Urska Ivanus

  • Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
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Ivanus, Urska
, 
Tine Jerman

Tine Jerman

Institute of Oncology LjubljanaLjubljana, Slovenia
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Jerman, Tine
, 
Iztok Takac

Iztok Takac

  • University Medical Centre MariborMaribor, Slovenia
  • Faculty of Medicine, University of MariborMaribor, Slovenia
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Takac, Iztok
 und 
Darja Arko

Darja Arko

  • University Medical Centre MariborMaribor, Slovenia
  • Faculty of Medicine, University of MariborMaribor, Slovenia
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Arko, Darja
  
06. Jan. 2021
Long term results of follow-up after HPV self-sampling with devices Qvintip and HerSwab in women non-attending cervical screening programme's Cover Image
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Artikel-Kategorie: Research Article
Online veröffentlicht: 06. Jan. 2021
Seitenbereich: 187 - 195
Eingereicht: 01. Okt. 2020
Akzeptiert: 09. Dez. 2020
DOI: https://doi.org/10.2478/raon-2021-0001
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© 2021 Teodora Bokan, Urska Ivanus, Tine Jerman, Iztok Takac, Darja Arko, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Flow chart of women enrolled in the study with results of human papillomaviruses (HPV) self-sampling and histological cervical intraepithelial neoplasia grade 2 or more (CIN2+) results after one and four-year follow-up.
Flow chart of women enrolled in the study with results of human papillomaviruses (HPV) self-sampling and histological cervical intraepithelial neoplasia grade 2 or more (CIN2+) results after one and four-year follow-up.

Figure 2

Sensitivity and specificity for cervical intraepithelial neoplasia grade 2 or more (CIN2+) by test (cytology, human papillomaviruses [HPV]), testing modality (self, clinician) and self-sampling device (Qvintip, HerSwab) after four years of follow-up following enrolment.ASC-US+ = atypical squamous cells of undetermined significance or more
Sensitivity and specificity for cervical intraepithelial neoplasia grade 2 or more (CIN2+) by test (cytology, human papillomaviruses [HPV]), testing modality (self, clinician) and self-sampling device (Qvintip, HerSwab) after four years of follow-up following enrolment.ASC-US+ = atypical squamous cells of undetermined significance or more

Figure 3

Positive predictive value and negative predictive value for cervical intraepithelial neoplasia grade 2 or more (CIN2+) by test (cytology, human papillomaviruses [HPV]), testing modality (self, clinician) and self-sampling device (Qvintip, HerSwab).ASC-US+ = atypical squamous cells of undetermined significance or more
Positive predictive value and negative predictive value for cervical intraepithelial neoplasia grade 2 or more (CIN2+) by test (cytology, human papillomaviruses [HPV]), testing modality (self, clinician) and self-sampling device (Qvintip, HerSwab).ASC-US+ = atypical squamous cells of undetermined significance or more

Figure 4A

Cumulative incidence of cervical intraepithelial neoplasia grade 2 or more (CIN2+) according to human papillomaviruses (HPV) test result in Qvintip group
Cumulative incidence of cervical intraepithelial neoplasia grade 2 or more (CIN2+) according to human papillomaviruses (HPV) test result in Qvintip group

Figure 4B

Cumulative incidence of cervical intraepithelial neoplasia grade 2 or more (CIN2+) according to human papillomaviruses (HPV) test result in HerSwab group.
Cumulative incidence of cervical intraepithelial neoplasia grade 2 or more (CIN2+) according to human papillomaviruses (HPV) test result in HerSwab group.

Concordance of human papillomavirus (HPV) test results (among devices) and cytology (among laboratories)

HPV testCytology
OPA (%)kappa (95% CI)OPAa (%)kappa (95% CI)
Qvintip group81.80.534 (0.349–0.718)74.80.471 (0.3029–0.641)
HerSwab group77.10.456 (0.2569–0.655)74.50.406 (0.2059–0.607)
Total79.60.495 (0.3599–0.632)74.60.444 (0.3159–0.574)
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