CMS subtype | CMS1 -MSI immune | CMS2 - Canonical | CMS3 – Metabolic | CMS4 - Mesenchymal |
---|---|---|---|---|
Frequency | 14% | 37% | 13% | 23% |
MSI, CIMP high, hypermutation | SCNA high | Mixed MSI CIMP status, low SCNA low, | SCNA high | |
BRAF mutation | KRAS mutation | |||
Characteristics | Immune infiltration and activation | WNT and MYC activation | Metabolic deregulation | Stromal infiltration, TGF-β activation, angiogenesis |
Worse survival after relapse | Worse relapse- free and overall survival |