<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2019-0017_s_006_w2aab3b7b4b1b6b1aab1c18b1Aa"><h3>Background</h3><p>The aim of the study was investigate the impact of body-mass factors (BMF) on setup displacement during pelvic radiotherapy in patients with lower abdominal cancers.</p></sec><sec id="j_raon-2019-0017_s_007_w2aab3b7b4b1b6b1aab1c18b2Aa"><h3>Patients and methods</h3><p>The clinical data of a training cohort composed of 60 patients with gynecological, rectal, or prostate cancer were analyzed. The daily alignment data from image-guided radiotherapy (IGRT) were retrieved. Setup errors for were assessed by systematic error (SE) and random error (RE) through the superior-inferior (SI), anterior-posterior (AP), and medial-lateral (ML) directions. Several BMFs and patient-related parameters were analyzed with binary logistic regression and receiver-operating characteristic curves. A scoring system was proposed to identify those with greater setup displacement during daily treatment. The results were validated by another cohort.</p></sec><sec id="j_raon-2019-0017_s_008_w2aab3b7b4b1b6b1aab1c18b3Aa"><h3>Results</h3><p>A large hip lateral diameter correlated with a greater SI-SE and AP-SE, whereas a large umbilical AP diameter correlated with a greater ML-SE and ML-RE. A higher SI-RE was associated with a large hip circumference. The positive predictors for setup uncertainty were chosen to dichotomize patients into groups at high risk and low risk for setup displacement. Based on the scoring system, the adequate treatment margins for the SI direction in the high-and low-risk groups were 5.4 mm and 3.8 mm, whereas those for the ML direction were 8.2 mm and 4.2 mm, respectively. The validated cohort showed a similar trend.</p></sec><sec id="j_raon-2019-0017_s_009_w2aab3b7b4b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Large BMFs including hip lateral diameter, hip circumference, and umbilical AP diameter are associated with greater setup uncertainty. Based on the scores, IGRT or required treatment margins can be adapted for patients with high risk features.</p></sec></abstract>

BackgroundThe aim of the study was investigate the impact of body-mass factors (BMF) on setup displacement during pelvic radiotherapy in patients with lower abdominal cancers.Patients and methodsThe clinical data of a training cohort composed of 60 patients with gynecological, rectal, or prostate cancer were analyzed. The daily alignment data from image-guided radiotherapy (IGRT) were retrieved. Setup errors for were assessed by systematic error (SE) and random error (RE) through the superior-inferior (SI), anterior-posterior (AP), and medial-lateral (ML) directions. Several BMFs and patient-related parameters were analyzed with binary logistic regression and receiver-operating characteristic curves. A scoring system was proposed to identify those with greater setup displacement during daily treatment. The results were validated by another cohort.ResultsA large hip lateral diameter correlated with a greater SI-SE and AP-SE, whereas a large umbilical AP diameter correlated with a greater ML-SE and ML-RE. A higher SI-RE was associated with a large hip circumference. The positive predictors for setup uncertainty were chosen to dichotomize patients into groups at high risk and low risk for setup displacement. Based on the scoring system, the adequate treatment margins for the SI direction in the high-and low-risk groups were 5.4 mm and 3.8 mm, whereas those for the ML direction were 8.2 mm and 4.2 mm, respectively. The validated cohort showed a similar trend.ConclusionsLarge BMFs including hip lateral diameter, hip circumference, and umbilical AP diameter are associated with greater setup uncertainty. Based on the scores, IGRT or required treatment margins can be adapted for patients with high risk features.

Impact of body-mass factors on setup displacement during pelvic irradiation in patients with lower abdominal cancer

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundThe aim of the study was investigate the impact of body-mass factors (BMF) on setup displacement during pelvic radiotherapy in patients with lower...

Impact of body-mass factors on setup displacement during pelvic irradiation in patients with lower abdominal cancer

Article Category: Research Article

Online veröffentlicht: 05. Apr. 2019

Seitenbereich: 256 - 264

Eingereicht: 04. Sept. 2018

Akzeptiert: 03. März 2019

DOI: https://doi.org/10.2478/raon-2019-0017

© 2019 Wei-Chieh Wu, Yi-Ru Chang, Yo-Liang Lai, An-Cheng Shiau, Ji-An Liang, Chun-Ru Chien, Yu-Cheng Kuo, Shang-Wen Chen, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.