[Anonymous (2001). Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of Good Clinical Practice in the conduct of clinical trials on medicinal products for human use. OJ EC, L121, 34–41. http://ec.europa.eu/health/files/eudralex/vol-1/dir_2001_20/dir_2001_20_en.pdf (accessed 12 September 2014).]Search in Google Scholar
[Anonymous (1964). WMA Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects Adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964 and amended by the: 29th WMA General Assembly, Tokyo, Japan, October 1975; 35th WMA General Assembly, Venice, Italy, October 1983; 41st WMA General Assembly, Hong Kong, September 1989; 64th WMA General Assembly, Fortaleza, Brazil, October 2013. http://www.wma.net/en/30publications/10policies/b3/ (accessed 12 September 2014).]Search in Google Scholar
[Bai, H., Chen, X., Zhang, L., Dou, X. (2012). The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates inflammation and fibrosis in a mouse model of chronic pancreatitis. BMC Gastroenterol., 24 (12), 115.10.1186/1471-230X-12-115]Search in Google Scholar
[Brown, A., Hughes, M., Tenner, S., Banks, P. (1997). Does pancreatic enzyme supplementation reduce pain in patients with chronic pancreatitis: A meta-analysis. Amer. J. Gastroenterol., 92 (11), 2032–2035.]Search in Google Scholar
[Capurso, G., Cocomello, L., Benedetto, U., Cammà, C., Delle Fave, G.. (2012). Meta-analysis: The placebo rate of abdominal pain remission in clinical trials of chronic pancreatitis. Pancreas, 41 (7), 1125–1131.10.1097/MPA.0b013e318249ce93]Search in Google Scholar
[Drummey, G., Benson, J., Jones, C. (1961). Microscopical examination of the stool for steatorrhea. New Engl. J. Med., 264, 85–87.10.1056/NEJM196101122640207]Search in Google Scholar
[Frulloni, L., Falconi, M., Gabbrielli, A., et al. (2010). Italian consensus guidelines for chronic pancreatitis. Dig. Liver. Dis., 42 (6), S381–S406.10.1016/S1590-8658(10)60682-2]Search in Google Scholar
[Gigante, A., Tagarro, I. (2012). Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: A focus on ketoprofen/omeprazole. Clin. Drug Investig., 32 (4), 221–233.10.2165/11596670-000000000-00000]Search in Google Scholar
[Grady, T., Liang, P., Ernst, S., Logsdon, C. (1997). Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology,113, 1966–1975.10.1016/S0016-5085(97)70017-9]Search in Google Scholar
[Halgreen, H., Pedersen, N., Worning, H. (1986). Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis. Scand. J. Gastroenterol., 21 (1), 104–8.10.3109/003655286090346313633631]Search in Google Scholar
[Isaksson, G., Ihse, I. (1983). Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig. Dis. Sci., 28 (2), 97–102.10.1007/BF013151376825540]Search in Google Scholar
[Jonasson, C., Hatlebakk, J., Lundell, L., Kouri, J. P., Andersen, M., Granath, F. (2013). Association between adherence to concomitant proton pump inhibitor therapy in current NSAID users and upper gastrointestinal complications. Eur. J. Gastroenterol. Hepatol., 25 (5), 531–538.10.1097/MEG.0b013e32835d5acd23269097]Search in Google Scholar
[Larvin, M., McMahon, M., Thomas, W., Puntis, M. C. A. (1991). Creon (enteric coated pancreatin microspheres) for the treatment of pain in chronic pancreatitis: A double-blind randomized placebo-controlled crossover study. Gastroenterology, 100, A283.]Search in Google Scholar
[Lin, Y., Tamakoshi, A., Matsuno, S., Takeda, K., Hayakawa, T., Kitagawa, M., Naruse, S., Kawamura, T., Wakai, K., Aoki, R., Kojima, M., Ohno, Y. (2000). Nationwide epidemiological survey of chronic pancreatitis in Japan. J. Gastroenterol., 35 (2), 136–141.10.1007/s00535005002610680669]Search in Google Scholar
[de-Madaria, E., Abad-González, A., Aparicio, J., Aparisi, L., Boadas, J., Boix, E., de-Las-Heras, G., Domínguez-Muñoz, E., Farré, A., Fernández-Cruz, L., Gómez, L., Iglesias-García, J., García-Malpartida, K., Guarner, L., Lariño-Noia, J., Lluís, F., López, A., Molero, X., Moreno-Pérez, O., Navarro, S., Palazón, J. M., Pérez-Mateo, M., Sabater, L., Sastre, Y., Vaquero, E. C., Martínez, J. (2013). The Spanish Pancreatic Club's recommendations for the diagnosis and treatment of chronic pancreatitis: Part 2 (treatment). Pancreatology,13 (1), 18–28.10.1016/j.pan.2012.11.310]Search in Google Scholar
[Malesci, A., Gaia, E., Fioretta, A., Bocchia, P., Ciravegna, G., Cantor, P., Vantini, I. (1995). No effect of long-term treatment with pancreatic extract on recurrent abdominal pain in patients with chronic pancreatitis. Scand. J. Gastroenterol., 30 (4), 392–398.10.3109/00365529509093296]Search in Google Scholar
[di Mola, F. F., di Sebastiano, P. (2008). Pain mechanisms in chronic pancreatitis. In: Beger, H. G., Buchler, M., Kozarek, R., Lerch, M., Neoptolemos, J., Warshaw, A., Whitcomb, D., Shiratori, K. (eds). The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, 2nd edn. (pp. 375–563). Oxford: Wiley-Blackwell.]Search in Google Scholar
[Mössner, J., Secknus, R., Meyer, J., Niederau, C., Adler, G. (1992). Treatment of pain with pancreatic extracts in chronic pancreatitis: Results of a prospective placebo-controlled multicenter trial. Digestion,53 (1–2), 54–66.10.1159/000200971]Search in Google Scholar
[Mössner, J., Stange, J., Ewald, M., Kestel, W., Fischbach, W. (1991). Influence of exogenous application of pancreatic extracts on endogenous pancreatic enzyme secretion. Pancreas, 6 (6), 637–44.10.1097/00006676-199111000-00004]Search in Google Scholar
[Mössner, J., Wresky, H. P., Kestel, W., Zeeh, J., Regner, U., Fischbach, W. (1989). Influence of treatment with pancreatic extracts on pancreatic enzyme secretion. Gut,30 (8), 1143–1149.10.1136/gut.30.8.1143]Search in Google Scholar
[Novak, I., Wang, J., Henriksen, K., Haanes, K. A., Krabbe, S., Nitschke, R., Hede, S. E. (2011). Pancreatic bicarbonate secretion involves two proton pumps. J. Biol. Chem., 286 (1), 280–9.10.1074/jbc.M110.136382]Search in Google Scholar
[Orļikovs, G., Pļaviņa, I., Selezņovs, J., Pokrotnieks, J., Karpovs, J., Voicehovska, J. (2007). Pancreatic index: A new approach to chronic pancreatitis estimation. Proc. Latvian Acad. Sci., Section B, 61 (1/2), 43–46.]Search in Google Scholar
[Schneider, A., Löhr, J. M., Singer, M. V. (2007). The M-ANNHEIM classification of chronic pancreatitis: Introduction of a unifying classification system based on a review of previous classifications of the disease. J. Gastroenterol., 42 (2), 101–119.10.1007/s00535-006-1945-4]Search in Google Scholar
[Slaff, J., Jacobson, D., Tillman, C., Curington, C., Toskes, P. (1984). Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology,87, 44–52.10.1016/0016-5085(84)90124-0]Search in Google Scholar
[Song, A., Bhagat, L., Singh, V., et al. (2002). Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Amer. J. Physiol., 283, G1166–G1174.10.1152/ajpgi.00370.200112381531]Search in Google Scholar
[Trelle, S., Reichenbach, S., Wandel, S., Hildebrand, P., Tschannen, B., Villiger, P. M., Egger, M., Jüni, P. (2011) Cardiovascular safety of non-steroidal anti-inflammatory drugs: Network meta-analysis. BMJ (British Medical Journal), 342, c7086.10.1136/bmj.c7086301923821224324]Search in Google Scholar
[Warshaw, A., Banks, P., Fernández-Del Castillo, C. (1998). AGA technical review: Treatment of pain in chronic pancreatitis. Gastroenterology,115 (3), 765–76.10.1016/S0016-5085(98)70157-X]Search in Google Scholar
[Yadav, D., Timmons, L., Benson, J., Dierkhising, R. A., Chari, S. T. (2011). Incidence, prevalence, and survival of chronic pancreatitis: A population-based study. Amer. J. Gastroenterol., 106 (12), 2192–2199.10.1038/ajg.2011.32821946280]Search in Google Scholar