ALPPS Procedure for the Treatment of Bilobar Multiple Liver Metastasis from Colorectal Cancer: First Case in RN Macedonia

1 Wen XD, Xiao L. Associating liver partition and portal vein ligation for staged hepatectomy in the treatment of colorectal cancer liver metastases. World J Gastrointest Surg 2021 August 27; 13(8): 814-821. doi: 10.4240/wjgs.v13.i8.814. Search in Google Scholar

2 Dekker E, Tanis PJ, Vleugels JLA, et al. Colorectal cancer. Lancet. 2019;394:1467–1480. Search in Google Scholar

3 Popescu GA, Alexandrescu ST, Grigorie RT, et al. GOOD TO KNOW: The ALPPS Procedure - Embracing a New Technique. Chirurgia (Bucur). 2017 May-Jun;112(3):332-341. doi: 10.21614/chirurgia.112.3.332. Search in Google Scholar

4 de Jong MC, Pulitano C, Ribero D, et al. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg 2009; 250:440–448. Search in Google Scholar

5 Schlitt HJ, Hackl C, Lang SA. ‘In-Situ Split’ Liver Resection/ALPPS – Historical Development and Current Practice. Visc Med. 2017 Dec; 33(6): 408–412. doi: 10.1159/000479850 Search in Google Scholar

6 Truant S, Baillet C, Millet G, et al. ALPPS: a new technique of major liver resection for non resectable colorectal liver metastases. Hépato-Gastro & Oncologie Digestive. 2015;22(6):506-512. doi:10.1684/hpg.2015.1169. Search in Google Scholar

7 Guglielmi A, Ruzzenente A, Conci S, et al. How Much Remnant Is Enough in Liver Re-section? Dig Surg 2012; 29:6–17. https://doi.org/10.1159/000335713. Search in Google Scholar

8 Makuuchi M, Thai BL, Takayasu K et al. Pre-operative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery 1990; 107:521–7. Search in Google Scholar

9 Adam R, Laurent A, Azoulay D et al. Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg 2000; 232:777–85. Search in Google Scholar

10 Schadde E, Ardiles V, Slankamenac K, et al. ALPPS offers a better chance of complete resection in patients with primarily unresectable liver tumors compared with conventional-staged hepatectomies: results of a multicenter analysis. World J Surg. 2014 Jun;38(6):1510-9. doi: 10.1007/s00268-014-2513-3. PMID: 24748319. Search in Google Scholar

11 Yang C, Rahbari NN, Mees ST, et al. Staged resection of bilobar colorectal liver metastases: surgical strategies. Langenbecks Arch Surg. 2015; 400:633–640. doi: 10.1007/s00423-015-1310-2. Search in Google Scholar

12 de Santibanes E, Clavien PA. Playing Play-Doh to prevent postoperative liver failure: the “ALPPS” approach. Ann Surg 2012; 255:415-7. Search in Google Scholar

13 Liu Y, Yang Y, Gu S, Tang K. A systematic review and meta-analysis of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) versus traditional staged hepatectomy. Medicine (2019) 98:15. Search in Google Scholar

14 Schlitt HJ, Hackl C, Lang SA. ‘In-Situ Split’ Liver Resection/ALPPS – Historical Development and Current Practice. Visc Med. 2017 Dec; 33(6): 408–412. doi: 10.1159/000479850 Search in Google Scholar

15 Baumgart J, Lang S, Lang H. A new method for induction of liver hypertrophy prior to right trisectionectomy: a report of three cases. HPB (Oxford) 2011; 13:71–72. Search in Google Scholar

16 Schnitzbauer AA, Lang SA, Goessmann H, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012; 255:405–414. Search in Google Scholar

17 Lang H, de Santibanes E, Schlitt HJ, Malago M, et al. 10th anniversary of ALPPS-lessons learned and quo Vadis. Ann Surg. 2019; 269:114–9. Search in Google Scholar

18 Alvarez FA, Ardiles V, de Santibañes M, et al. Associating liver partition and portal vein ligation for staged hepatectomy offers high onco-logical feasibility with adequate patient safety: a prospective study at a single center. Ann Surg. 2015 Apr;261(4):723-32. doi: 10.1097/SLA.0000000000001046. PMID: 25493362. Search in Google Scholar

19 de Santibañes E, Alvarez FA, Ardiles V, et al. Inverting the ALPPS paradigm by minimizing first stage impact: the Mini-ALPPS technique. Langenbecks Arch Surg. 2016 Jun;401(4):557-63. doi: 10.1007/s00423-016-1424-1. Epub 2016 Apr 15. PMID: 27084508. Search in Google Scholar

20 Robles R, Parrilla P, López-Conesa A, et al. Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure. Br J Surg. 2014; 101:1129–1134; discussion 1134. doi: 10.1002/bjs.9547. Search in Google Scholar

21 Gall TM, Sodergren MH, Frampton AE, et al. Radio-frequency-assisted Liver Partition with Portal vein ligation (RALPP) for liver regeneration. Ann Surg. 2015;261: e45–e46. doi: 10.1097/SLA.0000000000000607. Search in Google Scholar

22 Gringeri E, Boetto R, D’Amico FE, et al. Laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS): a minimally invasive first-step approach. Ann Surg. 2015;261: e42–e43. doi: 10.1097/SLA.0000000000000606. Search in Google Scholar

23 Xiao L, Li JW, Zheng SG. Totally laparoscopic ALPPS in the treatment of cirrhotic hepatocellular carcinoma. Surg Endosc. 2015 Sep;29(9):2800-1. doi: 10.1007/s00464-014-4000-1. Epub 2014 Dec 17. PMID: 25515978. Search in Google Scholar

24 Vicente E, Quijano Y, Ielpo B, Fabra I. First ALPPS procedure using a total robotic approach. Surg Oncol. 2016 Dec;25(4):457. doi: 10.1016/j.suronc.2015.10.001. Epub 2015 Nov 14. PMID: 26856770. Search in Google Scholar

25 Wen XD, Xiao L. Associating liver partition and portal vein ligation for staged hepatectomy in the treatment of colorectal cancer liver metastases. World J Gastrointest Surg. 2021 Aug 27;13(8):814-821. doi: 10.4240/wjgs. v13.i8.814. PMID: 34512905; PMCID: PMC8394386. Search in Google Scholar

26 Vennarecci G, Grazi GL, Sperduti I, et al. ALPPS for primary and secondary liver tumors. Int J Surg, 30 (2016), pp. 38-44 http://dx.doi.org/10.1016/j.ijsu.2016.04.031. Search in Google Scholar

27 Liu Y, Yang Y, Gu S, Tang K. A systematic review and meta-analysis of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) versus traditional staged hepatectomy. Medicine (Baltimore). 2019 Apr;98(15): e15229. doi: 10.1097/MD.0000000000015229. PMID: 30985727; PMCID: PMC6485722. Search in Google Scholar

28 Sandström P, Røsok BI, Sparrelid E, et al. ALPPS Improves Resectability Compared with Conventional Two-stage Hepatectomy in Patients With Advanced Colorectal Liver Metastasis: Results From a Scandinavian Multi-center Randomized Controlled Trial (LIGRO Trial). Ann Surg. 2018 May;267(5):833-840. doi: 10.1097/SLA.0000000000002511. PMID: 28902669; PMCID: PMC5916470. Search in Google Scholar

29 Joechle K, Moser C, Ruemmele P, et al. ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases. World J Surg Oncol. 2017 Mar 7;15(1):57. doi: 10.1186/s12957-017-1121-8. PMID: 28270160; PMCID: PMC5341393. Search in Google Scholar

30 Huang HC, Bian J, Bai Y, et al. Complete or partial split in associating liver partition and portal vein ligation for staged hepatectomy: A systematic review and meta-analysis. World J Gastroenterol. 2019 Oct 21;25(39):6016-6024. doi: 10.3748/wjg. v25.i39.6016. PMID: 31660037; PMCID: PMC6815793. Search in Google Scholar

31 Chan ACY, Chok K, Dai JWC, Lo CM. Impact of split completeness on future liver remnant hypertrophy in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in hepatocellular carcinoma: Complete-ALPPS versus partial-ALPPS. Surgery. 2017 Feb;161(2):357-364. doi: 10.1016/j. surg.2016.07.029. Epub 2016 Sep 3. PMID: 27596751. Search in Google Scholar

32 Wu X, Rao J, Zhou X, Deng R, Ma Y. Partial ALPPS versus complete ALPPS for staged hepatectomy.BMC Gastroenterology (2019) 19:170. doi.org/10.1186/s12876-019-1090-1 Search in Google Scholar

33 Hernandez-Alejandro R, Bertens KA, Pine-da-Solis K, Croome KP. Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases? Surgery. 2015 Feb;157(2):194-201. doi: 10.1016/j.surg.2014.08.041. Search in Google Scholar

34 Schadde E, Raptis DA, Schnitzbauer AA, et al. Prediction of Mortality After ALPPS Stage-1: An Analysis of 320 Patients from the International ALPPS Registry. Ann Surg. 2015 Nov;262(5):780-5; discussion 785-6. doi: 10.1097/SLA.0000000000001450. PMID: 26583666. Search in Google Scholar

35 Ray S, Mehta NN, Golhar A, Nundy S. Post hepatectomy liver failure - A comprehensive review of current concepts and controversies. Ann Med Surg (Lond). 2018 Aug 23; 34:4-10. doi: 10.1016/j.amsu.2018.08.012. PMID: 30181871; PMCID: PMC6120608. Search in Google Scholar

36 Hotineanu A, Burgoci S, Bortă E. ALPPS Procedure. The New Frontier in Advanced Liver Surgery. Single Centre Experience and Literature Review. Chirurgia (Bucur). 2021 Aug;116(4):409-423. doi: 10.21614/chirurgia.116.4.409. PMID: 34498568. Search in Google Scholar

37 Cieslak KP, Bennink RJ, de Graaf W, et al. Measurement of liver function using hepatobiliary scintigraphy improves risk assessment in patients undergoing major liver resection. HPB (Oxford). 2016 Sep;18(9):773-80. doi: 10.1016/j.hpb.2016.06.006. Epub 2016 Jul 25. PMID: 27593595; PMCID: PMC5011085. Search in Google Scholar

38 Truant S, Baillet C, Deshorgue AC, et al. Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing. Updates Surg. 2017 Sep;69(3):411-419. doi: 10.1007/s13304-017-0481-5. Epub 2017 Aug 9. PMID: 28795384. Search in Google Scholar

39 Schadde E, Ardiles V, Robles-Campos R, et al; ALPPS Registry Group. Early survival and safety of ALPPS: first report of the International ALPPS Registry. Ann Surg. 2014 Nov;260(5):829-36; discussion 836-8. doi: 10.1097/SLA.0000000000000947. PMID: 25379854. Search in Google Scholar

40 Chan ACY, Lo CM. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)-pushing the envelope in modulation of future liver remnant before major hepatectomy. Hepatobiliary Surg Nutr. 2020 Feb;9(1):80-82. doi: 10.21037/hbsn.2019.10.28. PMID: 32140485; PMCID: PMC7026787. Search in Google Scholar

41 Linecker M, Björnsson B, Stavrou GA, et al. Risk Adjustment in ALPPS Is Associated with a Dramatic Decrease in Early Mortality and Morbidity. Ann Surg. 2017 Nov;266(5):779-786. doi: 10.1097/SLA.0000000000002446. PMID: 28806301. Search in Google Scholar

42 Clavien PA, Petrowsky H, DeOliveira ML, Graf R. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007; 356:1545–59. Search in Google Scholar

43 Vivarelli M, Vincenzi P, Montalti R, et al. ALPPS Procedure for Extended Liver Resections: A Single Centre Experience and a Systematic Review. PLoS One. 2015; 10(12): e0144019. doi: 10.1371/journal.pone.0144019. PMCID: PMC4689524. PMID: 26700646/ Search in Google Scholar

44 Baili E, Tsilimigras DI, Moris D, et al. Technical modifications and outcomes after Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) for primary liver malignancies: A systematic review. Surgical Oncology. Volume 33, June 2020, Pages 70-80. Search in Google Scholar