<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The main objective of this study was to determine the relationship between the pro- and anti-inflammatory response based on the interleukin 1α and interleukin 10 levels in the serum of patients with acquired bronchiectasis and healthy controls. This study was conducted on 77 subjects, divided into two lots: one lot comprising 57 patients with the aforementioned bronchiectasis and the second one comprising 20 healthy control subjects. The enzyme-linked immunosorbent assay method was used to perform the spectrophotometry test for the serum to detect and measure interleukin 1α and interleukin 10 levels. The results were significant from a statistical point on view but only in terms of the mean value of interleukin 10 that was much higher in the anti-inflammatory cytokine. Therefore, we can assume that there is a systemic anti-inflammatory reaction to the inflammation caused by bronchiectasis. Interleukin 1α is unspecific, and the values were similar in both groups; therefore, this interleukin should not be researched further in this direction. Future research is open in this field for the analysis of interleukin levels in bronchoalveolar lavage compared to serum levels.</p></abstract>

The main objective of this study was to determine the relationship between the pro- and anti-inflammatory response based on the interleukin 1α and interleukin 10 levels in the serum of patients with acquired bronchiectasis and healthy controls. This study was conducted on 77 subjects, divided into two lots: one lot comprising 57 patients with the aforementioned bronchiectasis and the second one comprising 20 healthy control subjects. The enzyme-linked immunosorbent assay method was used to perform the spectrophotometry test for the serum to detect and measure interleukin 1α and interleukin 10 levels. The results were significant from a statistical point on view but only in terms of the mean value of interleukin 10 that was much higher in the anti-inflammatory cytokine. Therefore, we can assume that there is a systemic anti-inflammatory reaction to the inflammation caused by bronchiectasis. Interleukin 1α is unspecific, and the values were similar in both groups; therefore, this interleukin should not be researched further in this direction. Future research is open in this field for the analysis of interleukin levels in bronchoalveolar lavage compared to serum levels.

Inflammatory reaction in patients with acquired bronchiectasis based on the interleukin 1α and interleukin 10 levels measured using the ELISA method

Iuliu Haţieganu University of Medicine and Pharmacy

Pneumologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Răspunsul inflamator la pacienţii cu bronsiectazii bazat pe nivelurile interleukinelor 1α şi 10 măsurate prin metoda ELISA

The main objective of this study was to determine the relationship between the pro- and anti-inflammatory response based on the interleukin 1α and interleukin...

	Group 1 – patients with bronchiectasis	Group 2 – healthy control subjects
Average IL1a value (pg/ml)	51.31	52.82
Standard deviation	7.328	5.240

Variable	Frequency
Gender (F)	21 (36.8%)
Age less than 60 years	21 (36.8%)
Leukocytosis	7 (12.3%)
Anaemia	11 (19.3%)
Isolated microorganism
Gram negative	13 (22.8%)
Oropharyngeal biocenosis	35 (61.4%)
Mycobacterium tuberculosis	1 (1.8%)
Multiple germs	4 (7%)
Gram positive	1 (1.8%)
Cause of bronchiectasis
Other causes	4 (7.02%)
Asthma	3 (5.26%)
COPD	10 (17.54%)
Bronchitis	10 (17.54%)
Pulmonary fibrosis	25 (43.86%)
Tuberculosis	2 (3.51%)

Inflammatory reaction in patients with acquired bronchiectasis based on the interleukin 1α and interleukin 10 levels measured using the ELISA method

Online veröffentlicht: 09. Dez. 2019

Seitenbereich: 120 - 125

DOI: https://doi.org/10.2478/pneum-2019-0022

Schlüsselwörter
bronchiectasis, interleukins 1α and 10, proinflammatory

© 2019 Andrei Lesan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chart 1

Figure 1

Chart 2

Average IL1α values and standard deviation.

Isolated microorganisms.

Average IL10 values and standard deviation.

Inflammatory reaction in patients with acquired bronchiectasis based on the interleukin 1α and interleukin 10 levels measured using the ELISA method

Online veröffentlicht: 09. Dez. 2019

Seitenbereich: 120 - 125

DOI: https://doi.org/10.2478/pneum-2019-0022

Schlüsselwörterbronchiectasis, interleukins 1α and 10, proinflammatory

© 2019 Andrei Lesan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chart 1

Figure 1

Chart 2

Average IL1α values and standard deviation.

Isolated microorganisms.

Average IL10 values and standard deviation.

Schlüsselwörter
bronchiectasis, interleukins 1α and 10, proinflammatory