<abstract xmlns="http://www.w3.org/1999/xhtml">

The aim of our study was to develop a multimodal experimental protocol for <italic>in vivo</italic> imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/1H MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric “bio-markers” were generated in the brain for the D-galactose model of “age-related dementia”. The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated “neurodegeneration”, even in response to the applied Huperzine A therapy.
</abstract>

The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/1H MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric “bio-markers” were generated in the brain for the D-galactose model of “age-related dementia”. The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated “neurodegeneration”, even in response to the applied Huperzine A therapy.

<italic>In vivo</italic> Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Slovak University of Technology in Bratislava

Faculty of Medicine of Comenius University in Bratislava, Slovak Medical University and University Hospital Bratislava

Faculty of Medicine of Comenius University in Bratislava

Measurement Science Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 Volumetric, DTI and H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of...

In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Online veröffentlicht: 17. Okt. 2023

Seitenbereich: 237 - 247

Eingereicht: 17. Juli 2023

Akzeptiert: 25. Sept. 2023

DOI: https://doi.org/10.2478/msr-2023-0030

Schlüsselwörter
Animals, multimodal imaging, diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS)

© 2023 Tomáš Tvrdík et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Online veröffentlicht: 17. Okt. 2023

Seitenbereich: 237 - 247

Eingereicht: 17. Juli 2023

Akzeptiert: 25. Sept. 2023

DOI: https://doi.org/10.2478/msr-2023-0030

SchlüsselwörterAnimals, multimodal imaging, diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS)

© 2023 Tomáš Tvrdík et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In vivo Volumetric, DTI and ¹H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

Schlüsselwörter
Animals, multimodal imaging, diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS)