Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies
Artikel-Kategorie: Research Article
Online veröffentlicht: 30. Juni 2025
Seitenbereich: 40 - 51
Eingereicht: 18. Apr. 2024
Akzeptiert: 10. Feb. 2025
DOI: https://doi.org/10.2478/msp-2025-0006
Schlüsselwörter
© 2025 Huanli Hu and Xueyang Zheng, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Diabetic foot ulcers (DFUs) are a frequent and severe complication of diabetes, leading to chronic wounds, infections, and even amputations. The treatment of DFUs poses a significant challenge to healthcare professionals, and therefore new therapeutic approaches are necessary. In the current research, nicaraven was loaded into gelatin nanofibers using the electrospinning method. Then, these fibers were crushed and dispersed in the matrix of a collagen hydrogel to prepare a nanocomposite sponge for diabetic wound healing applications. The produced scaffolds protected skin cells against oxidative stress and increased their migration activity. An