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Evaluation of regular treadmill exercise plan combined with electrospun scaffolds loaded with green tea extract and bone marrow-derived mesenchymal stem cells for spinal cord injury repair in a rat model

Jianjun Wang

Jianjun Wang

Institute of Physical Education, Xi’an Shiyou UniversityXi’an 710065, China
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Wang, Jianjun
, 
Tao Zhang

Tao Zhang

School of Pharmacy, Xi’an Jiaotong UniversityYanta West Road, Xi’an 710061, China
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Zhang, Tao
, 
Yingqi Jiang

Yingqi Jiang

Sport Arts College, Guangzhou Sport UniversityGuangzhou 510610, Guangdong, China
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Jiang, Yingqi
, 
Wei Han

Wei Han

Automotive College, Guangdong City Technician CollegeGuangzhou 510520, Guangdong, China
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Han, Wei
, 
Shimeng Huang

Shimeng Huang

School of Physical Education, Guangzhou Sport UniversityGuangzhou 510500, Guangdong, China
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Huang, Shimeng
, 
Jihong Zhao

Jihong Zhao

Sport Arts College, Guangzhou Sport UniversityGuangzhou 510610, Guangdong, China
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Zhao, Jihong
 und 
Xiru Du

Xiru Du

Sport Arts College, Guangzhou Sport UniversityGuangzhou 510610, Guangdong, China
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Du, Xiru
  
31. Dez. 2024
Evaluation of regular treadmill exercise plan combined with electrospun scaffolds loaded with green tea extract and bone marrow-derived mesenchymal stem cells for spinal cord injury repair in a rat model's Cover Image
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Artikel-Kategorie: Research Article
Online veröffentlicht: 31. Dez. 2024
Seitenbereich: 79 - 91
Eingereicht: 29. Apr. 2024
Akzeptiert: 22. Okt. 2024
DOI: https://doi.org/10.2478/msp-2024-0038
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© 2024 the Jianjun Wang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

MTT assay with PC-12 cultured on GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.
MTT assay with PC-12 cultured on GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.

Figure 2

MTT assay under 1% H2O2 with PC-12 cells cultured with GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.
MTT assay under 1% H2O2 with PC-12 cells cultured with GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.

Figure 3

DPPH assay with GTEPCLGEL and PCLGEL scaffolds compared with ascorbic acid as the control group. * shows p-value <0.05.
DPPH assay with GTEPCLGEL and PCLGEL scaffolds compared with ascorbic acid as the control group. * shows p-value <0.05.

Figure 4

Stress–strain curve for GTEPCLGEL and PCLGEL scaffolds.
Stress–strain curve for GTEPCLGEL and PCLGEL scaffolds.

Figure 5

Hemolysis activity of GTEPCLGEL and PCLGEL scaffolds compared with normal saline and triton x-100 as the negative and positive control groups, respectively. * shows p-value <0.05.
Hemolysis activity of GTEPCLGEL and PCLGEL scaffolds compared with normal saline and triton x-100 as the negative and positive control groups, respectively. * shows p-value <0.05.

Figure 6

Anti-inflammatory assay with GTEPCLGEL and PCLGEL scaffolds compared with the macrophage cells cultured on the tissue culture plate as the control group. * shows p-value <0.05.
Anti-inflammatory assay with GTEPCLGEL and PCLGEL scaffolds compared with the macrophage cells cultured on the tissue culture plate as the control group. * shows p-value <0.05.

Figure 7

SEM images and size distribution of (a) GTEPCLGEL and (b) PCLGEL scaffolds.
SEM images and size distribution of (a) GTEPCLGEL and (b) PCLGEL scaffolds.

Figure 8

H&E staining images of spinal cord tissues in animals treated with (a) GTEPCLGELBM-MSCsPH, (b) GTEPCLGELBM-MSCs, (c) PCLGELPH, (d) PCLGEL, and (e) negative control. Arrows indicate vacuolation, asterisks denote edema, and axonal disintegration is indicated by arrowheads.
H&E staining images of spinal cord tissues in animals treated with (a) GTEPCLGELBM-MSCsPH, (b) GTEPCLGELBM-MSCs, (c) PCLGELPH, (d) PCLGEL, and (e) negative control. Arrows indicate vacuolation, asterisks denote edema, and axonal disintegration is indicated by arrowheads.

Figure 9

BBB scores in rats treated with different strategies on weeks 2, 4, and 8 after surgery. * shows p-value <0.05.
BBB scores in rats treated with different strategies on weeks 2, 4, and 8 after surgery. * shows p-value <0.05.

Figure 10

Hotplate latency test results in animals treated with different strategies, * shows p-value <0.05.
Hotplate latency test results in animals treated with different strategies, * shows p-value <0.05.

Figure 11

Tissue concentrations of BDNF, NGF, TNF-α, and IL-6 in spinal cord tissues treated with different strategies. * shows p-value <0.05.
Tissue concentrations of BDNF, NGF, TNF-α, and IL-6 in spinal cord tissues treated with different strategies. * shows p-value <0.05.
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