<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The nucleolus is the cell organelle responsible for ribosome synthesis and, hence, for protein synthesis. In the mammalian oocyte, the nucleolus compacts into a dense sphere with no ribosome synthesis well in advance of ovulation. It seems, that this body is of utmost importance for the development of the embryo. It is unknown, however, how it exerts this essential function. During the last two decades, great attention has been paid to the study of nucleogenesis in oocytes and early embryos, with transcription of ribosomal DNA being evaluated as one of the criteria of normal development. In this review, we summarize some aspects of nucleolus transformation during oocyte growth, as well as during early embryonic development with possible impact on the quality of the embryos used in biomedical research. This knowledge in connection with further observations will substantially contribute to the development of new criteria suitable for evaluation of oocytes and embryos used in biomedical application.</p></abstract>

The nucleolus is the cell organelle responsible for ribosome synthesis and, hence, for protein synthesis. In the mammalian oocyte, the nucleolus compacts into a dense sphere with no ribosome synthesis well in advance of ovulation. It seems, that this body is of utmost importance for the development of the embryo. It is unknown, however, how it exerts this essential function. During the last two decades, great attention has been paid to the study of nucleogenesis in oocytes and early embryos, with transcription of ribosomal DNA being evaluated as one of the criteria of normal development. In this review, we summarize some aspects of nucleolus transformation during oocyte growth, as well as during early embryonic development with possible impact on the quality of the embryos used in biomedical research. This knowledge in connection with further observations will substantially contribute to the development of new criteria suitable for evaluation of oocytes and embryos used in biomedical application.

The Oocyte’s Nucleolus Precursor Body: The Globe for Life

Department of Zoology and Anthropology, Faculty of Natural Sciences

Constantine the Philosopher University in Nitra

Ss. Cyril and Methodius University in Skopje

Department of Botany and Genetics, Faculty of Natural Sciences

The Czech Academy of Sciences, Institute of Animal Physiology and Genetics

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"The Oocyte\u2019s Nucleolus Precursor Body: The Globe for Life"}

The nucleolus is the cell organelle responsible for ribosome synthesis and, hence, for protein synthesis. In the mammalian oocyte, the nucleolus compacts into...

The Oocyte’s Nucleolus Precursor Body: The Globe for Life

Online veröffentlicht: 29. Okt. 2018

Seitenbereich: 115 - 122

Eingereicht: 28. Nov. 2017

Akzeptiert: 12. Feb. 2018

DOI: https://doi.org/10.2478/macvetrev-2018-0013

Schlüsselwörter
nucleolus precursor body, oocyte, embryo, transcriptomics, epigenetics

© 2018 Michal Benc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Oocyte’s Nucleolus Precursor Body: The Globe for Life

Online veröffentlicht: 29. Okt. 2018

Seitenbereich: 115 - 122

Eingereicht: 28. Nov. 2017

Akzeptiert: 12. Feb. 2018

DOI: https://doi.org/10.2478/macvetrev-2018-0013

Schlüsselwörternucleolus precursor body, oocyte, embryo, transcriptomics, epigenetics

© 2018 Michal Benc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
nucleolus precursor body, oocyte, embryo, transcriptomics, epigenetics