In vivo efficacy of macrocyclic lactones on goat farms – pour-on vs injectable application
Michal Babják
Orcid-Profil, Alžbeta Königová
Orcid-Profil, Tetiana A. Kuzmina
- Laboratory of Therapy of Parasitic Infections, Institute of Parasitology of the Slovak Academy of ScienceKošice, Slovak Republic
- I. I. Schmalhausen Institute of Zoology of the National Academy of Sciences of UkraineKyiv, Ukraine
Orcid-Profil und Marián Várady
Orcid-Profil 
Online veröffentlicht: 19. Apr. 2025
Seitenbereich: 293 - 298
Eingereicht: 19. Dez. 2024
Akzeptiert: 09. Apr. 2025
DOI: https://doi.org/10.2478/jvetres-2025-0025
Schlüsselwörter
© 2025 Michal Babják et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Introduction
Pour-on eprinomectin (EPN) is the only anthelmintic currently available that is approved for use in lactating goats with a zero-day milk withdrawal period. The aim of this study was to compare the efficacy of the pour-on form of EPN with the efficacy of the injectable version of ivermectin (IVM) on goat farms in Slovakia.
Material and Methods
The study was conducted from September to December 2023 on eight dairy-goat farms. The goats on six farms were divided into two groups of 10 animals each. The first group was administered pour-on EPN at the recommended dose for sheep and goats, and the second group was treated with injectable IVM at a dose 1.5-fold higher than the recommended dose for sheep. The goats on the remaining two farms were treated only with EPN. Efficacy was determined using the
Results
The percent reductions for IVM and EPN ranged from 80.8 to 93.6 and 51.0 to 96.6, respectively. A substantially higher egg reduction on the 14th day post treatment of 20 to 30% was noted in the groups on three farms treated with injectable IVM. The reduction differed little between the drugs on the other three farms (1–3%). Infectious L3 larvae in the LDT were observed at concentrations equal to or higher than the minimum inhibitory concentration of 21.6 ng/mL on all farms.
Conclusion
This study is the first to report reduced efficacy of the pour-on form of EPN in goat herds in Slovakia.