Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

1. Aksakal F.I., Ciltas A.: Developmental toxicity of penconazole in Zebrfish (Danio rerio) embryos. Chemosphere 2018, 200, 8–15, doi: 10.1016/j.chemosphere.2018.02.094. Aksakal F.I. Ciltas A. : Developmental toxicity of penconazole in Zebrfish (Danio rerio) embryos . Chemosphere 2018 , 200 , 8 – 15 , doi: 10.1016/j.chemosphere.2018.02.094 . Open DOISearch in Google Scholar

2. Badr A.M., Al-Kharashi L.A., Attia H., Alshehri S., Alajami H.N., Ali R.A., Mahran, Y.F.: TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity. Pharmaceuticals 2023, 16, 337, doi: 10.3390/ph16030337. Badr A.M. Al-Kharashi L.A. Attia H. Alshehri S. Alajami H.N. Ali R.A. Mahran Y.F. : TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity . Pharmaceuticals 2023 , 16 , 337 , doi: 10.3390/ph16030337 . Open DOISearch in Google Scholar

3. Bancroft J., Stevens A., Turner D.: Theory and Practice of Histological Techniques, Fourth Edition, Churchill Living Stone, New York 1996, 20. Bancroft J. Stevens A. Turner D. : Theory and Practice of Histological Techniques , Fourth Edition , Churchill Living Stone , New York 1996 , 20 . Search in Google Scholar

4. Bartosz G.: Total antioxidant capacity. Advances in Clinical Chemistry 2003, 37, 219–292, doi: 10.1016/S0065-2423(03)37010-6. Bartosz G. : Total antioxidant capacity . Advances in Clinical Chemistry 2003 , 37 , 219 – 292 , doi: 10.1016/S0065-2423(03)37010-6 . Open DOISearch in Google Scholar

5. Basile D.P, Yoder M.C.: Renal endothelial dysfunction in acute kidney ischemia reperfusion injury. Cardiovasc Hematol Disord Drug Targets 2014, 14, 3–14, doi: 10.2174/1871529x1401140724093505. Basile D.P Yoder M.C. : Renal endothelial dysfunction in acute kidney ischemia reperfusion injury . Cardiovasc Hematol Disord Drug Targets 2014 , 14 , 3 – 14 , doi: 10.2174/1871529x1401140724093505 . Open DOISearch in Google Scholar

6. Bellezza I., Giambanco I., Minelli A., Donato R.: Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta (BBA)-Molecular Cell Res 2018, 1865, 721–733, doi: 10.1016/j.bbamcr.2018.02.010. Bellezza I. Giambanco I. Minelli A. Donato R. : Nrf2-Keap1 signaling in oxidative and reductive stress . Biochim Biophys Acta (BBA)-Molecular Cell Res 2018 , 1865 , 721 – 733 , doi: 10.1016/j.bbamcr.2018.02.010 . Open DOISearch in Google Scholar

7. Cai Z., Lou Q., Wang F., Li E., Sun J., Fang H., Xi J., Ju L.: N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway. Int J Clin Exp Pathol 2015, 8, 8655–8662. Cai Z. Lou Q. Wang F. Li E. Sun J. Fang H. Xi J. Ju L. : N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway . Int J Clin Exp Pathol 2015 , 8 , 8655 – 8662 . Search in Google Scholar

8. Chaâbane M., Elwej A., Ghorbel I., Chelly S., Mnif H., Boudawara T., Chaabouni S.E., Zeghal N., Soudani N.: Penconazole alters redox status, cholinergic function and lung’s histoarchitecture of adult rats: Reversal effect of vitamin E. Biomed Pharmacother 2018, 102, 645–652, doi: 10.1016/j.biopha.2018.03.113. Chaâbane M. Elwej A. Ghorbel I. Chelly S. Mnif H. Boudawara T. Chaabouni S.E. Zeghal N. Soudani N. : Penconazole alters redox status, cholinergic function and lung’s histoarchitecture of adult rats: Reversal effect of vitamin E . Biomed Pharmacother 2018 , 102 , 645 – 652 , doi: 10.1016/j.biopha.2018.03.113 . Open DOISearch in Google Scholar

9. Chaâbane M., Ghorbel I., Elwej A., Mnif H., Boudawara T., Chaâbouni S.E., Zeghal N., Soudani N.: Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol 2017, 36, 854–866, doi: 10.1177/0960327116672911. Chaâbane M. Ghorbel I. Elwej A. Mnif H. Boudawara T. Chaâbouni S.E. Zeghal N. Soudani N. : Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats . Hum Exp Toxicol 2017 , 36 , 854 – 866 , doi: 10.1177/0960327116672911 . Open DOISearch in Google Scholar

10. Chaâbane M., Koubaa M., Soudani N., Elwej A., Grati M., Jamoussi K., Boudawara T., Ellouze Chaabouni S., Zeghal N.: Nitraria retusa fruit prevents penconazole-induced kidney injury in adult rats through modulation of oxidative stress and histopathological changes. Pharm Biol 2017, 55, 1061–1073, doi: 10.1080/13880209.2016.1278455. Chaâbane M. Koubaa M. Soudani N. Elwej A. Grati M. Jamoussi K. Boudawara T. Ellouze Chaabouni S. Zeghal N. : Nitraria retusa fruit prevents penconazole-induced kidney injury in adult rats through modulation of oxidative stress and histopathological changes . Pharm Biol 2017 , 55 , 1061 – 1073 , doi: 10.1080/13880209.2016.1278455 . Open DOISearch in Google Scholar

11. Chaâbane M., Soudani N., Benjeddou K., Turki M., Ayadi Makni F., Boudawara T., Zeghal N., Ellouze Ghorbel R.: The protective potential of Nitraria retusa on penconazole-induced hepatic injury in adult rats. Toxicol Environ Chem 2015, 97, 1253–1264, doi: 10.1080/02772248.2015.1093633. Chaâbane M. Soudani N. Benjeddou K. Turki M. Ayadi Makni F. Boudawara T. Zeghal N. Ellouze Ghorbel R. : The protective potential of Nitraria retusa on penconazole-induced hepatic injury in adult rats . Toxicol Environ Chem 2015 , 97 , 1253 – 1264 , doi: 10.1080/02772248.2015.1093633 . Open DOISearch in Google Scholar

12. Dodd S., Dean O., Copolov D.L., Malhi G.S., Berk M.: N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther 2008, 8, 1955–1962, doi: 10.1517/14728220802517901. Dodd S. Dean O. Copolov D.L. Malhi G.S. Berk M. : N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility . Expert Opin Biol Ther 2008 , 8 , 1955 – 1962 , doi: 10.1517/14728220802517901 . Open DOISearch in Google Scholar

13. Elsayed A., Elkomy A., Elkammar R., Youssef G., Abdelhiee E.Y., Abdo W., Fadl S.E., Soliman A., Aboubakr M.: Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats. Sci Rep 2021, 11, 1–10, doi: 10.1038/s41598-021-93196-7. Elsayed A. Elkomy A. Elkammar R. Youssef G. Abdelhiee E.Y. Abdo W. Fadl S.E. Soliman A. Aboubakr M. : Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats . Sci Rep 2021 , 11 , 1 – 10 , doi: 10.1038/s41598-021-93196-7 . Open DOISearch in Google Scholar

14. El-Sharkawy E.E., El-Nisr N.A.: Testicular dysfunction induced by penconazole fungicide on male albino rats. Comp Clin Path 2013, 22, 475–480, doi: 10.1007/s00580-012-1435-4. El-Sharkawy E.E. El-Nisr N.A. : Testicular dysfunction induced by penconazole fungicide on male albino rats . Comp Clin Path 2013 , 22 , 475 – 480 , doi: 10.1007/s00580-012-1435-4 . Open DOISearch in Google Scholar

15. Forman H.J., Zhang H., Rinna A.: Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 2009, 30, 1–12, doi: 10.1016/j.mam.2008.08.006. Forman H.J. Zhang H. Rinna A. : Glutathione: overview of its protective roles, measurement, and biosynthesis . Mol Aspects Med 2009 , 30 , 1 – 12 , doi: 10.1016/j.mam.2008.08.006 . Open DOISearch in Google Scholar

16. Gaschler M.M., Stockwell B.R.: Lipid peroxidation in cell death. Biochem Biophys Res Commun 2017, 482, 419–425, doi: 10.1016/j.bbrc.2016.10.086. Gaschler M.M. Stockwell B.R. : Lipid peroxidation in cell death . Biochem Biophys Res Commun 2017 , 482 , 419 – 425 , doi: 10.1016/j.bbrc.2016.10.086 . Open DOISearch in Google Scholar

17. Hang W, Shu H, Wen Z, Liu J, Jin Z, Shi Z, Chen C, Wang D.W.: N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function. Front Pharmacol 2021, 12, 636204, doi: 10.3389/fphar.2021.636204. Hang W Shu H Wen Z Liu J Jin Z Shi Z Chen C Wang D.W. : N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function . Front Pharmacol 2021 , 12 , 636204 , doi: 10.3389/fphar.2021.636204 . Open DOISearch in Google Scholar

18. Hassanen E.I., Korany R.M.S., Bakeer A.M.: Cisplatin-conjugated gold nanoparticles-based drug delivery system for targeting hepatic tumors. J Biochem Mol Toxicol 2021, 35, e22722, doi: 10.1002/jbt.22722. Hassanen E.I. Korany R.M.S. Bakeer A.M. : Cisplatin-conjugated gold nanoparticles-based drug delivery system for targeting hepatic tumors . J Biochem Mol Toxicol 2021 , 35 , e22722 , doi: 10.1002/jbt.22722 . Open DOISearch in Google Scholar

19. Husak V.V., Mosiichuk N.M., Storey J.M., Storey K.B., Lushchak V.I.: Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol 2017, 193, 1–8, doi: 10.1016/j.cbpc.2016.12.003. Husak V.V. Mosiichuk N.M. Storey J.M. Storey K.B. Lushchak V.I. : Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues . Comp Biochem Physiol C Toxicol Pharmacol 2017 , 193 , 1 – 8 , doi: 10.1016/j.cbpc.2016.12.003 . Open DOISearch in Google Scholar

20. Jawaid H., Ali M.M., Khan M.U., Sami S., Shaikh M.A.: Efficacy and safety of N-acetylcysteine for the treatment of nonacetaminophen-induced acute liver failure: an updated systematic review and meta-analysis. Clin Exp Hepatol 2021, 7, 156, doi: 10.5114/ceh.2021.107171. Jawaid H. Ali M.M. Khan M.U. Sami S. Shaikh M.A. : Efficacy and safety of N-acetylcysteine for the treatment of nonacetaminophen-induced acute liver failure: an updated systematic review and meta-analysis . Clin Exp Hepatol 2021 , 7 , 156 , doi: 10.5114/ceh.2021.107171 . Open DOISearch in Google Scholar

21. Jiang X., Wang J., Liu J., Zhu H., Hu J., Sun X., Zhou W.: Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae. Ecotoxicol Environ Saf 2023, 256, 114865, doi: 10.1016/j.ecoenv.2023.114865. Jiang X. Wang J. Liu J. Zhu H. Hu J. Sun X. Zhou W. : Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae . Ecotoxicol Environ Saf 2023 , 256 , 114865 , doi: 10.1016/j.ecoenv.2023.114865 . Open DOISearch in Google Scholar

22. Lu S.C.: Regulation of glutathione synthesis. Mol Aspects Med 2009, 30, 42–59, doi: 10.1016/j.mam.2008.05.005. Lu S.C. : Regulation of glutathione synthesis . Mol Aspects Med 2009 , 30 , 42 – 59 , doi: 10.1016/j.mam.2008.05.005 . Open DOISearch in Google Scholar

23. Mahmoud A.M., Hussein O.E., Abd El-Twab S.M., Hozayen W.G.: Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis. Food Funct 2019, 10, 4593–4607, doi: 10.1039/C9FO00114J. Mahmoud A.M. Hussein O.E. Abd El-Twab S.M. Hozayen W.G. : Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis . Food Funct 2019 , 10 , 4593 – 4607 , doi: 10.1039/C9FO00114J . Open DOISearch in Google Scholar

24. Meng Z., Liu L., Xi Y., Jia M., Yan S., Tian S., Sun W., Zhu W., Li X., Zhou Z.: Different effects of exposure to penconazole and its enantiomers on hepatic glycolipid metabolism of male mice. Environ Pollut 2020, 257, 113555, doi: 10.1016/j.envpol.2019.113555. Meng Z. Liu L. Xi Y. Jia M. Yan S. Tian S. Sun W. Zhu W. Li X. Zhou Z. : Different effects of exposure to penconazole and its enantiomers on hepatic glycolipid metabolism of male mice . Environ Pollut 2020 , 257 , 113555 , doi: 10.1016/j.envpol.2019.113555 . Open DOISearch in Google Scholar

25. Mercadante R., Polledri E., Scurati S., Moretto A., Fustinoni S.: Identification of metabolites of the fungicide penconazole in human urine. Chem Res Toxicol 2016, 29, 1179–1186, doi: 10.1021/acs.chemrestox.6b00149. Mercadante R. Polledri E. Scurati S. Moretto A. Fustinoni S. : Identification of metabolites of the fungicide penconazole in human urine . Chem Res Toxicol 2016 , 29 , 1179 – 1186 , doi: 10.1021/acs.chemrestox.6b00149 . Open DOISearch in Google Scholar

26. Morgan A.M., Hassanen E.I., Ogaly H.A., Al Dulmani S.A., Al-Zahrani F.A.M., Galal M.K., Kamel S., Rashad M.M., Ibrahim M.A., Hussien A.M.: The ameliorative effect of N-acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats. J Biochem Mol Toxicol 2021, 35, e22884, doi: 10.1002/jbt.22884. Morgan A.M. Hassanen E.I. Ogaly H.A. Al Dulmani S.A. Al-Zahrani F.A.M. Galal M.K. Kamel S. Rashad M.M. Ibrahim M.A. Hussien A.M. : The ameliorative effect of N-acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats . J Biochem Mol Toxicol 2021 , 35 , e22884 , doi: 10.1002/jbt.22884 . Open DOISearch in Google Scholar

27. Nguyen T., Nioi P., Pickett C.B.: The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009, 284, 13291–13295, doi: 10.1074/jbc.r900010200. Nguyen T. Nioi P. Pickett C.B. : The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress . J Biol Chem 2009 , 284 , 13291 – 13295 , doi: 10.1074/jbc.r900010200 . Open DOISearch in Google Scholar

28. Pan X., Wu X., Yan D., Peng C., Rao C., Yan H.: Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs. Toxicol Lett 2018, 288, 55–64, doi: 10.1016/j.toxlet.2018.02.002. Pan X. Wu X. Yan D. Peng C. Rao C. Yan H. : Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs . Toxicol Lett 2018 , 288 , 55 – 64 , doi: 10.1016/j.toxlet.2018.02.002 . Open DOISearch in Google Scholar

29. Pedre B., Barayeu U., Ezeriņa D., Dick T.P.: The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species. Pharmacol Ther 2021, 228, 107916, doi: 10.1016/j.pharmthera.2021.107916. Pedre B. Barayeu U. Ezeriņa D. Dick T.P. : The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species . Pharmacol Ther 2021 , 228 , 107916 , doi: 10.1016/j.pharmthera.2021.107916 . Open DOISearch in Google Scholar

30. Polledri E., Mercadante R., Fustinoni S.: Determination of tebuconazole and penconazole fungicides in rat and human hair by liquid chromatography/tandem mass spectrometry. Rapid Comm Mass Spectrom 2018, 32, 1243–1249, doi: 10.1002/rcm.8153. Polledri E. Mercadante R. Fustinoni S. : Determination of tebuconazole and penconazole fungicides in rat and human hair by liquid chromatography/tandem mass spectrometry . Rapid Comm Mass Spectrom 2018 , 32 , 1243 – 1249 , doi: 10.1002/rcm.8153 . Open DOISearch in Google Scholar

31. Roman D.L., Voiculescu D.I., Matica M.A., Baerle V., Filimon M.N., Ostafe V., Isvoran A.: Assessment of the Effects of Triticonazole on Soil and Human Health. Molecules 2022, 27, 6554, doi: 10.3390/molecules27196554. Roman D.L. Voiculescu D.I. Matica M.A. Baerle V. Filimon M.N. Ostafe V. Isvoran A. : Assessment of the Effects of Triticonazole on Soil and Human Health . Molecules 2022 , 27 , 6554 , doi: 10.3390/molecules27196554 . Open DOISearch in Google Scholar

32. Sies H., Berndt C., Jones D.P.: Oxidative stress. Annu Rev Biochem 2017, 86, 715–748, doi: 10.1146/annurev-biochem-061516-045037. Sies H. Berndt C. Jones D.P. : Oxidative stress . Annu Rev Biochem 2017 , 86 , 715 – 748 , doi: 10.1146/annurev-biochem-061516-045037 . Open DOISearch in Google Scholar

33. Sun S.C., Chang J.H., Jin J.: Regulation of nuclear factor-κB in autoimmunity. Trends Immunol 2013, 34, 282–289, doi: 10.1016/j.it.2013.01.004. Sun S.C. Chang J.H. Jin J. : Regulation of nuclear factor-κB in autoimmunity . Trends Immunol 2013 , 34 , 282 – 289 , doi: 10.1016/j.it.2013.01.004 . Open DOISearch in Google Scholar

34. Tanideh N., Sadeghi F., Amanat S., Firoozi D., Noorafshan A., Iraji A., Koohi-Hosseinabadi O.: Protection by pure and genistein fortified extra virgin olive oil, canola oil, and rice bran oil against acetic acid-induced ulcerative colitis in rats. Food Funct. 2020, 11, 860–870, doi: 10.1039/C9FO01951K. Tanideh N. Sadeghi F. Amanat S. Firoozi D. Noorafshan A. Iraji A. Koohi-Hosseinabadi O. : Protection by pure and genistein fortified extra virgin olive oil, canola oil, and rice bran oil against acetic acid-induced ulcerative colitis in rats . Food Funct . 2020 , 11 , 860 – 870 , doi: 10.1039/C9FO01951K . Open DOISearch in Google Scholar

35. Zhang L., Zhu Z., Liu J., Zhu Z., Hu Z.: Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway. J Recept Signal Transduct Res 2014, 34, 396–400, doi: 10.3109/10799893.2014.908916. Zhang L. Zhu Z. Liu J. Zhu Z. Hu Z. : Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway . J Recept Signal Transduct Res 2014 , 34 , 396 – 400 , doi: 10.3109/10799893.2014.908916 . Open DOISearch in Google Scholar

36. Zhang X., Wang X., Luo F., Sheng H., Zhou L., Zhong Q., Lou Z., Sun H., Yang M., Cui X., Chen Z.: Application and enantioselective residue determination of chiral pesticide penconazole in grape, tea, aquatic vegetables and soil by ultra performance liquid chromatography-tandem mass spectrometry. Ecotoxicol Environ Saf 2019, 172, 530–537, doi: 10.1016/j.ecoenv.2019.01.103. Zhang X. Wang X. Luo F. Sheng H. Zhou L. Zhong Q. Lou Z. Sun H. Yang M. Cui X. Chen Z. : Application and enantioselective residue determination of chiral pesticide penconazole in grape, tea, aquatic vegetables and soil by ultra performance liquid chromatography-tandem mass spectrometry . Ecotoxicol Environ Saf 2019 , 172 , 530 – 537 , doi: 10.1016/j.ecoenv.2019.01.103 . Open DOISearch in Google Scholar

37. Zhitkovich A.: N-acetylcysteine: antioxidant, aldehyde scavenger, and more. Chem Res Toxicol 2019, 32, 1318–1319, doi: 10.1021/acs.chemrestox.9b00152. Zhitkovich A. : N-acetylcysteine: antioxidant, aldehyde scavenger, and more . Chem Res Toxicol 2019 , 32 , 1318 – 1319 , doi: 10.1021/acs.chemrestox.9b00152 . Open DOISearch in Google Scholar