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Study of troponin, creatine kinase biomarkers, and histopathological lesions in experimental Nerium oleander toxicity in rats and mice

Monireh Khordadmehr
Monireh Khordadmehr
 und 
Saeed Nazifi
Saeed Nazifi
   | 30. März 2018
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Online veröffentlicht: 30. März 2018
Seitenbereich: 97 - 102
Eingereicht: 10. Nov. 2017
Akzeptiert: 09. März 2018
DOI: https://doi.org/10.2478/jvetres-2018-0013
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© 2018 M. Khordadmehr and S. Nazifi, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

Neruim oleander toxicity; Wistar rat; brain. Severe perivascular and perineuronal oedema (arrows) in group 3 which received 15 mg/kg b.w. of Nerium oleander extract. Scale bar = 60 μm, H&E
Neruim oleander toxicity; Wistar rat; brain. Severe perivascular and perineuronal oedema (arrows) in group 3 which received 15 mg/kg b.w. of Nerium oleander extract. Scale bar = 60 μm, H&E

Fig. 2

Neruim oleander toxicity; Wistar rat; brain. Focal haemorrhage (right arrows) and mild liqufactive necrosis (left arrow) were observed in group 4 which received 20 mg/kg b.w. of N. oleander extract. Scale bar = 60 μm, H&E
Neruim oleander toxicity; Wistar rat; brain. Focal haemorrhage (right arrows) and mild liqufactive necrosis (left arrow) were observed in group 4 which received 20 mg/kg b.w. of N. oleander extract. Scale bar = 60 μm, H&E

CK activity (u/L, mean ±SEM) on 1 to 4 days after the exposure to different doses of Nerium oleander extract in four experimental groups (Group 1, Group 2, Group 3, and Group 4 which received 10, 12.5, 15, and 20 mg/kg b.w. of the prepared extract of the plant respectively) and the control (group 5) which received only normal saline

Experimental groups First day Second day Third day Fourth day
10 mg/kg BALB/C 177.5 ± 34.7a

Different letters in the same column show significant differences between mice and rats (P < 0.05)

 171.7 ± 36.7c 175.8 ± 31.4e 164.3 ± 32.1g
Rat 1176 ± 89.4b 886 ± 82.4d 961 ± 78.1f 615.8 ± 61.9h
12.5 mg/kg BALB/C 219.7 ± 38.4a 207.9 ± 35.8c 204.9 ± 33.1e 171.7 ± 35.9g
Rat 965 ± 81.6b 966 ± 78.3d 934 ± 85.2f 733.5 ± 82.2h
15 mg/kg BALB/c 187.3 ± 32.8a 206.4 ± 34.2c 281.6 ± 24.2e 173.5 ± 33.6g
Rat 815 ± 88.4b 952 ± 72.6d 879 ± 79.6f 586.8 ± 69.4h
20 mg/kg BALB/C 217.8 ± 35.8a 237.5 ± 32.8c 231.4 ± 3.8e 169.4 ± 34.8g
Rat 973 ± 79.7b 986 ± 81.7d 981 ± 81.8f 694.7 ± 71.2h
control BALB/c 155.6 ± 9.4a 158.91 ± 10.3c 160.0 ± 11.9e 138.3 ± 3.8g
Rat 183.7 ± 11.6b 186.42 ± 12.3d 185.75 ± 13.6f 144.1 ± 11.4h

Troponin content (Ng/mL, mean ±SEM) on 1 to 4 days after the exposure to different doses of Nerium oleander extract in four experimental groups (Group 1, Group 2, Group 3, and Group 4 which received 10, 12.5, 15, and 20 mg/kg b.w. of the prepared extract of the plant, respectively) and the control (group 5) which received only normal saline

Experimental groups First day Second day Third day Fourth day
10 mg/kg BALB/C 183.3 ± 31.4a

Different letters in the same column show significant differences between mice and rats (P < 0.05)

 164.3 ± 32.1c 171.7 ± 39.3e 239.7 ± 38.5g
Rat 586.4 ± 69.2b 615.8 ± 61.9d 607.4 ± 54.6f 719.6 ± 92.3h
12.5 mg/kg BALB/C 192.4 ± 34.3a 171.7 ± 35.9c 188.4 ± 35.6e 214.6 ± 41.2g
Rat 609.8 ± 71.7b 733.5 ± 82.2d 664.7 ± 72.3f 687.8 ± 85.1h
15 mg/kg BALB/C 251.2 ± 41.9a 173.5 ± 33.6c 207.1 ± 38.7e 237.2 ± 39.1g
Rat 598.9 ± 75.8b 586.8 ± 69.4d 654.3 ± 75.8f 723.4 ± 78.2h
20 mg/kg BALB/C 234.8 ± 39.2a 169.4 ± 34.8c 211.4 ± 36.5e 266.7 ± 30.9g
Rat 643.6 ± 72.3b 694.7 ± 71.2d 677.8 ± 76.9f 768.7 ± 89.4h
control BALB/C 37.3 ± 3.4a 38.3 ± 3.8c 38.0 ± 3.2e 38.0 ± 3.6g
Rat 42.9 ± 10.1b 44.1 ± 11.4d 43.7 ± 10.8f 45.2 ± 12.7h
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