The effect of pre-existing sarcopenia on outcomes of critically ill patients treated for COVID-19

1. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16–31. Cruz-JentoftAJ BahatG BauerJ BoirieY BruyèreO CederholmT Sarcopenia: revised European consensus on definition and diagnosis Age Ageing 2019 Jan 1 48 1 16 31 Search in Google Scholar

2. Dhillon RJS, Hasni S. Pathogenesis and Management of Sarcopenia. Clin Geriatr Med. 2017 Feb;33(1):17–26. DhillonRJS HasniS Pathogenesis and Management of Sarcopenia Clin Geriatr Med 2017 Feb 33 1 17 26 Search in Google Scholar

3. Vanhorebeek I, Latronico N, Van Den Berghe G. ICU-acquired weakness. Intensive Care Med. 2020 Apr;46(4):637–53. VanhorebeekI LatronicoN Van Den BergheG ICU-acquired weakness Intensive Care Med 2020 Apr 46 4 637 53 Search in Google Scholar

4. Toptas M, Yalcin M, Akkoc İ, Demir E, Metin C, Savas Y, et al. The Relation between Sarcopenia and Mortality in Patients at Intensive Care Unit. BioMed Res Int. 2018;2018:1–9. ToptasM YalcinM Akkocİ DemirE MetinC SavasY The Relation between Sarcopenia and Mortality in Patients at Intensive Care Unit BioMed Res Int 2018 2018 1 9 Search in Google Scholar

5. Peterson SJ, Braunschweig CA. Prevalence of Sarcopenia and Associated Outcomes in the Clinical Setting. Nutr Clin Pract. 2016 Feb;31(1):40–8. PetersonSJ BraunschweigCA Prevalence of Sarcopenia and Associated Outcomes in the Clinical Setting Nutr Clin Pract 2016 Feb 31 1 40 8 Search in Google Scholar

6. Derstine BA, Holcombe SA, Ross BE, Wang NC, Su GL, Wang SC. Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population. Sci Rep. 2018 Jul 27;8(1):11369. DerstineBA HolcombeSA RossBE WangNC SuGL WangSC Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population Sci Rep 2018 Jul 27 8 1 11369 Search in Google Scholar

7. Shibahashi K, Sugiyama K, Kashiura M, Hamabe Y. Decreasing skeletal muscle as a risk factor for mortality in elderly patients with sepsis: a retrospective cohort study. J Intensive Care. 2017 Dec;5(1):8. ShibahashiK SugiyamaK KashiuraM HamabeY Decreasing skeletal muscle as a risk factor for mortality in elderly patients with sepsis: a retrospective cohort study J Intensive Care 2017 Dec 5 1 8 Search in Google Scholar

8. Andrade-Junior MCD, Salles ICDD, De Brito CMM, Pastore-Junior L, Righetti RF, Yamaguti WP. Skeletal Muscle Wasting and Function Impairment in Intensive Care Patients With Severe COVID-19. Front Physiol. 2021 Mar 11;12:640973. Andrade-JuniorMCD SallesICDD De BritoCMM Pastore-JuniorL RighettiRF YamagutiWP Skeletal Muscle Wasting and Function Impairment in Intensive Care Patients With Severe COVID-19 Front Physiol 2021 Mar 11 12 640973 Search in Google Scholar

9. Paneroni M, Simonelli C, Saleri M, Bertacchini L, Venturelli M, Troosters T, et al. Muscle Strength and Physical Performance in Patients Without Previous Disabilities Recovering From COVID-19 Pneumonia. Am J Phys Med Rehabil. 2021 Feb;100(2):105–9. PaneroniM SimonelliC SaleriM BertacchiniL VenturelliM TroostersT Muscle Strength and Physical Performance in Patients Without Previous Disabilities Recovering From COVID-19 Pneumonia Am J Phys Med Rehabil 2021 Feb 100 2 105 9 Search in Google Scholar

10. Van Der Meij BS, Ligthart-Melis GC, De Van Der Schueren MAE. Malnutrition in patients with COVID-19: assessment and consequences. Curr Opin Clin Nutr Metab Care. 2021 Nov;24(6):543–54. Van Der MeijBS Ligthart-MelisGC De Van Der SchuerenMAE Malnutrition in patients with COVID-19: assessment and consequences Curr Opin Clin Nutr Metab Care 2021 Nov 24 6 543 54 Search in Google Scholar

11. Tang Y, Liu J, Zhang D, Xu Z, Ji J, Wen C. Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies. Front Immunol. 2020 Jul 10;11:1708. TangY LiuJ ZhangD XuZ JiJ WenC Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies Front Immunol 2020 Jul 10 11 1708 Search in Google Scholar

12. Li YP, Reid MB. NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1165–1170. LiYP ReidMB NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes Am J Physiol Regul Integr Comp Physiol 2000 Oct 279 4 R1165 1170 Search in Google Scholar

13. Nicolau J, Ayala L, Sanchís P, Olivares J, Dotres K, Soler AG, et al. Influence of nutritional status on clinical outcomes among hospitalized patients with COVID-19. Clin Nutr ESPEN. 2021 Jun;43:223–9. NicolauJ AyalaL SanchísP OlivaresJ DotresK SolerAG Influence of nutritional status on clinical outcomes among hospitalized patients with COVID-19 Clin Nutr ESPEN 2021 Jun 43 223 9 Search in Google Scholar

14. Shen W, Punyanitya M, Wang Z, Gallagher D, St.-Onge MP, Albu J, et al. Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J Appl Physiol. 2004 Dec;97(6):2333–8. ShenW PunyanityaM WangZ GallagherD St.-OngeMP AlbuJ Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image J Appl Physiol 2004 Dec 97 6 2333 8 Search in Google Scholar

15. Prado CM, Birdsell LA, Baracos VE. The emerging role of computerized tomography in assessing cancer cachexia. Curr Opin Support Palliat Care. 2009 Dec;3(4):269–75. PradoCM BirdsellLA BaracosVE The emerging role of computerized tomography in assessing cancer cachexia Curr Opin Support Palliat Care 2009 Dec 3 4 269 75 Search in Google Scholar

16. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012 Jul;9(7):671–5. SchneiderCA RasbandWS EliceiriKW NIH Image to ImageJ: 25 years of image analysis Nat Methods 2012 Jul 9 7 671 5 Search in Google Scholar

17. Gomez-Perez S, McKeever L, Sheean P. Tutorial: A Step-by-Step Guide (Version 2.0) for Measuring Abdominal Circumference and Skeletal Muscle From a Single Cross-Sectional Computed-Tomography Image Using the National Institutes of Health ImageJ. J Parenter Enter Nutr. 2020 Mar;44(3):419–24. Gomez-PerezS McKeeverL SheeanP Tutorial: A Step-by-Step Guide (Version 2.0) for Measuring Abdominal Circumference and Skeletal Muscle From a Single Cross-Sectional Computed-Tomography Image Using the National Institutes of Health ImageJ J Parenter Enter Nutr 2020 Mar 44 3 419 24 Search in Google Scholar

18. Decazes P. Free macro for ImageJ to segment manually muscles, subcutaneous adipose tissue and visceral adipose tissue at level L3 on computed tomography. In 2019. DecazesP Free macro for ImageJ to segment manually muscles, subcutaneous adipose tissue and visceral adipose tissue at level L3 on computed tomography In 2019. Search in Google Scholar

19. Decazes P, Tonnelet D, Vera P, Gardin I. Anthropometer3D: Automatic Multi-Slice Segmentation Software for the Measurement of Anthropometric Parameters from CT of PET/CT. J Digit Imaging. 2019 Apr;32(2):241–50. DecazesP TonneletD VeraP GardinI Anthropometer3D: Automatic Multi-Slice Segmentation Software for the Measurement of Anthropometric Parameters from CT of PET/CT J Digit Imaging 2019 Apr 32 2 241 50 Search in Google Scholar

20. Kim JW, Yoon JS, Kim EJ, Hong HL, Kwon HH, Jung CY, et al. Prognostic Implication of Baseline Sarcopenia for Length of Hospital Stay and Survival in Patients with Coronavirus Disease 2019. J Gerontol A Biol Sci Med Sci. 2021 Mar 29;glab085. KimJW YoonJS KimEJ HongHL KwonHH JungCY Prognostic Implication of Baseline Sarcopenia for Length of Hospital Stay and Survival in Patients with Coronavirus Disease 2019 J Gerontol A Biol Sci Med Sci 2021 Mar 29 glab085 Search in Google Scholar

21. Moctezuma-Velázquez P, Miranda-Zazueta G, Ortiz-Brizuela E, González-Lara MF, Tamez-Torres KM, Román-Montes CM, et al. Low Thoracic Skeletal Muscle Area Is Not Associated With Negative Outcomes in Patients With COVID-19. Am J Phys Med Rehabil. 2021 May;100(5):413–8. Moctezuma-VelázquezP Miranda-ZazuetaG Ortiz-BrizuelaE González-LaraMF Tamez-TorresKM Román-MontesCM Low Thoracic Skeletal Muscle Area Is Not Associated With Negative Outcomes in Patients With COVID-19 Am J Phys Med Rehabil 2021 May 100 5 413 8 Search in Google Scholar

22. Damanti S, Cristel G, Ramirez GA, Bozzolo EP, Da Prat V, Gobbi A, et al. Influence of reduced muscle mass and quality on ventilator weaning and complications during intensive care unit stay in COVID-19 patients. Clin Nutr. 2022 Dec;41(12):2965–72. DamantiS CristelG RamirezGA BozzoloEP Da PratV GobbiA Influence of reduced muscle mass and quality on ventilator weaning and complications during intensive care unit stay in COVID-19 patients Clin Nutr 2022 Dec 41 12 2965 72 Search in Google Scholar

23. Oh HJ, Kim JH, Kim HR, Ahn JY, Jeong SJ, Ku NS, et al. The impact of sarcopenia on short-term and long-term mortality in patients with septic shock. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2054–63. OhHJ KimJH KimHR AhnJY JeongSJ KuNS The impact of sarcopenia on short-term and long-term mortality in patients with septic shock J Cachexia Sarcopenia Muscle 2022 Aug 13 4 2054 63 Search in Google Scholar

24. Yanagi N, Koike T, Kamiya K, Hamazaki N, Nozaki K, Ichikawa T, et al. Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness. Nutrients. 2021 Aug 8;13(8):2726. YanagiN KoikeT KamiyaK HamazakiN NozakiK IchikawaT Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness Nutrients 2021 Aug 8 13 8 2726 Search in Google Scholar

25. Kou HW, Yeh CH, Tsai HI, Hsu CC, Hsieh YC, Chen WT, et al. Sarcopenia is an effective predictor of difficult-to-wean and mortality among critically ill surgical patients. Lazzeri C, editor. PLOS ONE. 2019 Aug 8;14(8):e0220699. KouHW YehCH TsaiHI HsuCC HsiehYC ChenWT Sarcopenia is an effective predictor of difficult-to-wean and mortality among critically ill surgical patients LazzeriC editor. PLOS ONE 2019 Aug 8 14 8 e0220699 Search in Google Scholar

26. Siahaan YMT, Hartoyo V, Hariyanto TI, Kurniawan A. Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression. Clin Nutr ESPEN. 2022 Apr;48:158–66. SiahaanYMT HartoyoV HariyantoTI KurniawanA Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression Clin Nutr ESPEN 2022 Apr 48 158 66 Search in Google Scholar

27. Molwitz I, Ozga AK, Gerdes L, Ungerer A, Köhler D, Ristow I, et al. Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort. Sci Rep. 2022 Apr 19;12(1):6443. MolwitzI OzgaAK GerdesL UngererA KöhlerD RistowI Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort Sci Rep 2022 Apr 19 12 1 6443 Search in Google Scholar

28. Molfino A, Imbimbo G, Rizzo V, Muscaritoli M, Alampi D. The link between nutritional status and outcomes in COVID-19 patients in ICU: Is obesity or sarcopenia the real problem? Eur J Intern Med. 2021 Sep;91:93–5. MolfinoA ImbimboG RizzoV MuscaritoliM AlampiD The link between nutritional status and outcomes in COVID-19 patients in ICU: Is obesity or sarcopenia the real problem? Eur J Intern Med. 2021 Sep 91 93 5 Search in Google Scholar

29. Meyer HJ, Dermendzhiev T, Hetz M, Osterhoff G, Kleber C, Denecke T, et al. Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single-centre observational study. J Cachexia Sarcopenia Muscle. 2024 Aug 26; MeyerHJ DermendzhievT HetzM OsterhoffG KleberC DeneckeT Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single-centre observational study J Cachexia Sarcopenia Muscle 2024 Aug 26 Search in Google Scholar

30. Jiang T, Lin T, Shu X, Song Q, Dai M, Zhao Y, et al. Prevalence and prognostic value of pre-existing sarcopenia in patients with mechanical ventilation: a systematic review and meta-analysis. Crit Care Lond Engl. 2022 May 16;26(1):140. JiangT LinT ShuX SongQ DaiM ZhaoY Prevalence and prognostic value of pre-existing sarcopenia in patients with mechanical ventilation: a systematic review and meta-analysis Crit Care Lond Engl 2022 May 16 26 1 140 Search in Google Scholar

31. Ubachs J, Ziemons J, Minis-Rutten IJG, Kruitwagen RFPM, Kleijnen J, Lambrechts S, et al. Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1165–74. UbachsJ ZiemonsJ Minis-RuttenIJG KruitwagenRFPM KleijnenJ LambrechtsS Sarcopenia and ovarian cancer survival: a systematic review and meta-analysis J Cachexia Sarcopenia Muscle 2019 Dec 10 6 1165 74 Search in Google Scholar

32. Földi M, Farkas N, Kiss S, Dembrovszky F, Szakács Z, Balaskó M, et al. Visceral Adiposity Elevates the Risk of Critical Condition in COVID-19: A Systematic Review and Meta-Analysis. Obesity. 2021 Mar;29(3):521–8. FöldiM FarkasN KissS DembrovszkyF SzakácsZ BalaskóM Visceral Adiposity Elevates the Risk of Critical Condition in COVID-19: A Systematic Review and Meta-Analysis Obesity 2021 Mar 29 3 521 8 Search in Google Scholar

33. Petersen A, Bressem K, Albrecht J, Thieß HM, Vahldiek J, Hamm B, et al. The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectional pilot study in Germany. Metabolism. 2020 Sep;110:154317. PetersenA BressemK AlbrechtJ ThießHM VahldiekJ HammB The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectional pilot study in Germany Metabolism. 2020 Sep 110 154317 Search in Google Scholar

34. Battisti S, Pedone C, Napoli N, Russo E, Agnoletti V, Nigra SG, et al. Computed Tomography Highlights Increased Visceral Adiposity Associated With Critical Illness in COVID-19. Diabetes Care. 2020 Oct 1;43(10):e129–30. BattistiS PedoneC NapoliN RussoE AgnolettiV NigraSG Computed Tomography Highlights Increased Visceral Adiposity Associated With Critical Illness in COVID-19 Diabetes Care 2020 Oct 1 43 10 e129 30 Search in Google Scholar

35. Pranata R, Lim MA, Huang I, Yonas E, Henrina J, Vania R, et al. Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis. Clin Nutr ESPEN. 2021 Jun;43:163–8. PranataR LimMA HuangI YonasE HenrinaJ VaniaR Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis Clin Nutr ESPEN 2021 Jun 43 163 8 Search in Google Scholar

36. Yang J, Hu J, Zhu C. Obesity aggravates COVID-19: A systematic review and meta-analysis. J Med Virol. 2021 Jan;93(1):257–61. YangJ HuJ ZhuC Obesity aggravates COVID-19: A systematic review and meta-analysis J Med Virol 2021 Jan 93 1 257 61 Search in Google Scholar

37. Yang J, Tian C, Chen Y, Zhu C, Chi H, Li J. Obesity aggravates COVID-19: An updated systematic review and meta-analysis. J Med Virol. 2021 May;93(5):2662–74. YangJ TianC ChenY ZhuC ChiH LiJ Obesity aggravates COVID-19: An updated systematic review and meta-analysis J Med Virol 2021 May 93 5 2662 74 Search in Google Scholar

38. Yu W, Rohli KE, Yang S, Jia P. Impact of obesity on COVID-19 patients. J Diabetes Complications. 2021 Mar;35(3):107817. YuW RohliKE YangS JiaP Impact of obesity on COVID-19 patients J Diabetes Complications 2021 Mar 35 3 107817 Search in Google Scholar

39. Favre G, Legueult K, Pradier C, Raffaelli C, Ichai C, Iannelli A, et al. Visceral fat is associated to the severity of COVID-19. Metabolism. 2021 Feb;115:154440. FavreG LegueultK PradierC RaffaelliC IchaiC IannelliA Visceral fat is associated to the severity of COVID-19 Metabolism 2021 Feb 115 154440 Search in Google Scholar

40. Shi A, Hillege MMG, Wüst RCI, Wu G, Jaspers RT. Synergistic short-term and long-term effects of TGF-β1 and 3 on collagen production in differentiating myoblasts. Biochem Biophys Res Commun. 2021 Apr;547:176–82. ShiA HillegeMMG WüstRCI WuG JaspersRT Synergistic short-term and long-term effects of TGF-β1 and 3 on collagen production in differentiating myoblasts Biochem Biophys Res Commun 2021 Apr 547 176 82 Search in Google Scholar

41. Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017 May;35:200–21. KalinkovichA LivshitsG Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis Ageing Res Rev. 2017 May 35 200 21 Search in Google Scholar

42. Kalani C, Venigalla T, Bailey J, Udeani G, Surani S. Sepsis Patients in Critical Care Units with Obesity: Is Obesity Protective? Cureus. 2020 Feb 10;12(2):e6929. KalaniC VenigallaT BaileyJ UdeaniG SuraniS Sepsis Patients in Critical Care Units with Obesity: Is Obesity Protective? Cureus. 2020 Feb 10 12 2 e6929 Search in Google Scholar

43. Lennon H, Sperrin M, Badrick E, Renehan AG. The Obesity Paradox in Cancer: a Review. Curr Oncol Rep. 2016 Sep;18(9):56. LennonH SperrinM BadrickE RenehanAG The Obesity Paradox in Cancer: a Review Curr Oncol Rep 2016 Sep 18 9 56 Search in Google Scholar

44. Chang R, Elhusseiny KM, Yeh YC, Sun WZ. COVID-19 ICU and mechanical ventilation patient characteristics and outcomes—A systematic review and meta-analysis. PLOS ONE. 2021 Feb 11;16(2):e0246318. ChangR ElhusseinyKM YehYC SunWZ COVID-19 ICU and mechanical ventilation patient characteristics and outcomes—A systematic review and meta-analysis PLOS ONE 2021 Feb 11 16 2 e0246318 Search in Google Scholar