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Neutrophil-to-Lymphocyte Ratio and Thrombocyte-to-Lymphocyte Ratio as a Predictor of Severe and Moderate/Mild Acute Respiratory Distress Syndrome Patients: Preliminary Results

Mihai Claudiu Pui
Mihai Claudiu Pui
, 
Mihaela Butiulca
Mihaela Butiulca
, 
Vlad Cehan
Vlad Cehan
, 
Florin Stoica
Florin Stoica
 und 
Alexandra Lazar
Alexandra Lazar
   | 30. Jan. 2024
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Article Category: Research Article
Online veröffentlicht: 30. Jan. 2024
Seitenbereich: 49 - 55
Eingereicht: 01. Juli 2023
Akzeptiert: 08. Dez. 2023
DOI: https://doi.org/10.2478/jccm-2024-0005
Schlüsselwörter
© 2024 Mihai Claudiu Pui et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Fig. 1.

NLP differences between Severe ARDS and Mild/Moderate ARDS. NLR- Neutrophil-to-lymphocyte ratio; ARDS-acute respiratory distress syndrome; CI-confidence interval
NLP differences between Severe ARDS and Mild/Moderate ARDS. NLR- Neutrophil-to-lymphocyte ratio; ARDS-acute respiratory distress syndrome; CI-confidence interval

Fig. 2.

PLR differences between Severe ARDS and Moderate/Milld ARDS. PLR- Platelets-to-lymphocyte ratio; ARDS- acute respiratory distress syndrome; CI-confidence interval
PLR differences between Severe ARDS and Moderate/Milld ARDS. PLR- Platelets-to-lymphocyte ratio; ARDS- acute respiratory distress syndrome; CI-confidence interval

Fig. 3.

Comparison of NLR variations based on APACHE II score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation
Comparison of NLR variations based on APACHE II score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation

Fig. 4.

Comparison of NLR variations based on SOFA2 score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval
Comparison of NLR variations based on SOFA2 score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval

Fig. 5.

Comparison of PLR variations based on SOFA score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval
Comparison of PLR variations based on SOFA score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval

Fig. 6.

Comparison between PLR variations based on APACHE II score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation; CI – Confidence interval
Comparison between PLR variations based on APACHE II score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation; CI – Confidence interval

Fig. 7.

Investigation of NLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; NLR- Neutrophil-to-lymphocyte ratio; AUC-Area Under the Curve
Investigation of NLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; NLR- Neutrophil-to-lymphocyte ratio; AUC-Area Under the Curve

Fig. 8.

Investigation of PLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; PLR- Platelets-tolymphocyte ratio; AUC-Area Under the Curve
Investigation of PLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; PLR- Platelets-tolymphocyte ratio; AUC-Area Under the Curve

Baseline characteristics

All patients (n=33) Severe ARDS (n=11) Mild/Moderate ARDS (n=22) P
Age (years, mean±SD) 71.91±11.54 70.73±13.69 72.50±10.61 0.68*
GCS (median, min-max) 8(3–15) 6(3–15) 8(3–15) 0.69*
IOT-VM(n,%) 26(78.78) 9(81.81) 17(77.27) 0.76***
IOT-S(n,%) 1(3.03) 0(0) 1(4.54) 0.15***
NIV(n,%) 1(3.03) 0(0) 1(4.54) 0.15***
MF(n,%) 5(15.15) 2(18.18) 3(13.63) 0.73***
SpO2(%, mean±SD) 95.97±5.42 93.64±7.43 97.14±3.77 0.40**
FiO2(%, mean±SD) 68.94±20.61 76.36±23.78 65.23±18.29 0.16**
pH(mean±SD) 7.306±0.14 7.304±0.13 7.315±0.14 0.83*
pO2(mmHg, mean±SD) 91.68±40.42 59.61±15.27 107.7±39.63 <0.0001**
pCO2(mmHg, mean±SD) 50.65±20.50 46.05±16.47 52.95±22.25 0.44**
HCO3-(mEq/L, mean±SD) 25.16±6.35 22.12±5.28 26.68±6.40 0.0491**
Leukocytes (cells/µL, mean±SD) 15.91±7.50 16.52±5.66 15.60±8.38 0.7435*
Neutrophils (cells/µL, median, min-max) 10.93(3.47–84.70) 11.69(8.5–84.70) 10.69(3.47–40.45) 0.19**
Lymphocytes (cells/µL, median, min-max) 0.7(0.15–8.24) 0.6(0.15–8.24) 0.71(0.2–7.09) 0.55**
NLR(median, min-max) 16.90(1.13–96) 24.29(1.13–96) 15.67(1.69–49.71) 0.02*
PLR(median, min-max) 315.8(0–1427) 470.3(30.83–1427) 252.1(0–1253) 0.049**
APACHE II Score(mean±SD) 26.42±5.14 26.30±7.514 26.48±3.77 0.93*
SOFA (mean±SD) 10.33±3.22 10.55±3.446 10.23±3.19 0.79**
Outcome(n,%) 29(87.87) 10(90.90) 19(86.36) 0.70***
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