Effective Outcome of HBOT as an Adjuvant Therapy in Patients Diagnosed with COVID-19 in a Tertiary Care Hospital – A Preliminary Study
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12. Aug. 2022
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Artikel-Kategorie: Research Article
Online veröffentlicht: 12. Aug. 2022
Seitenbereich: 176 - 181
Eingereicht: 23. Aug. 2021
Akzeptiert: 23. Apr. 2022
DOI: https://doi.org/10.2478/jccm-2022-0008
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© 2022 Thiruppathy Palaniappan, Asif Shaikh, Navamani Kirthika, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Summary of oxygen requirement and PaO2 at day one and after three sittings of HBOT (N=50)
| Parameter | Summary |
|---|---|
| Oxygen Requirement (per minute) Day1 | |
| 4 liters | 2(4.00%) |
| 6 liters | 13(26.00%) |
| 8 liters | 6(12.00%) |
| 10 liters | 8(16.00%) |
| 15 liters | 18(36.00%) |
| 15 liters to HFNC | 3(6.00%) |
| Oxygen Requirement (per minute) After 3 Sittings of HBOT | |
| Room air | 45(90.00%) |
| 2 liters | 2(4.00%) |
| 4 liters | 2(4.00%) |
| 6 liters | 1(2.00%) |
| PaO2 (mm Hg) (At admission) | |
| ≤60 | 17(54.00%) |
| 61-70 | 29 (58%) |
| 71-80 | 3 (6%) |
| >80 | 1(2.00%) |
| PaO2 after three sittings (mm Hg) | |
| ≤60 | 0 (0%) |
| 61-70 | 0 (0%) |
| 71-80 | 0 (0%) |
| ≥90 | 50(100%) |
Summary of clinical and outcome parameter (N=50)
| Parameter | Summary |
|---|---|
| Comorbidities | |
| Diabetic mellitus | 35 (70%) |
| Hypertension | 30 (60%) |
| Obesity | 2 (4%) |
| Asthma | 1 (2%) |
| Dyslipidaemia | 1 (2%) |
| Hypothyroidism | 1 (2%) |
| Severity of pneumonia | |
| Moderate | 44 (88.00%) |
| Severe | 6(12.00%) |
| ATA Depth | 1.7 ± 0.11(ranged 1.50 to 1.80) |
| Tx Time (Minutes) | |
| 45 | 29 (58.00%) |
| 60 | 21 (42.00%) |
| Condition at discharge | |
| Breathing room air | 50 (100%) |
Comparison of oxygen requirement at day one and after three sittings (N=50)
| Oxygen Requirement (per minute) | Oxygen Requirement (per minute) after 3 Sittings |
|||
|---|---|---|---|---|
| Day one | 2 liters | 4 liters | 6 liters | Room air condition |
| 4 liters (N=2) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (100%) |
| 6 liters (N=13) | 0 (0%) | 0 (0%) | 0 (0%) | 13 (100%) |
| 8 liters (N=6) | 0 (0%) | 0 (0%) | 0 (0%) | 6 (100%) |
| 10 liters (N=8) | 0 (0%) | 0 (0%) | 0 (0%) | 8 (100%) |
| 15 liters (N=18) | 1 (5.56%) | 2 (11.11%) | 0 (0%) | 15 (83.33%) |
| 15 liters to HFNC (N=3) | 1 (33.33%) | 0 (0%) | 1 (33.33%) | 1 (33.33%) |
Summary of baseline parameter (N=50)
| Parameter | Summary |
|---|---|
| Age (in years) | 53.64 ± 13.26 (ranged 29 to 82) |
| Gender | |
| Male | 30 (60.00%) |
| Female | 20 (40.00%) |
| Lab parameter | |
| C-reactive protein levels (in mg/L) | 62.98 ± 23.12 (ranged 56.41 to 69.55) |
| D Dimer (in ng/mL) | 0.53 ± 0.1 (ranged 0.50 to 0.56) |
| IL-6 (in pg/mL) | 13.06 ± 9.07 (ranged 10.48 to 15.64) |
| Ferritin (normal) (in ng/mL) | 48 (96%) |
| Lactate dehydrogenase (normal) (in U/L) | 50 (100%) |
| CORAD Score | 5.18 ± 0.56 (ranged 5.02 to 5.34) |
| CORAD Score | |
| 4 (High- abnormalities suspicious of COVID) | 4 (8%) |
| 5 (very high- Typical COVID) | 33 (66%) |