<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Acute Motor Axonal Neuropathy (AMAN) is an immune-mediated disorder of the peripheral nervous system, part of the spectrum of the Guillain-Barre syndrome (GBS). An infectious event most often triggers it reported a few weeks before the onset. The reported case is of a 56 years-old woman who developed acute motor axonal neuropathy three weeks after respiratory infection with influenza A virus subtype H1N1. Despite early treatment with plasmapheresis and intravenous immunoglobulins, the patient remained tetraplegic, mechanically ventilated for five months, with repetitive unsuccessful weaning trails. The probable cause was considered to be phrenic nerve palsy in the context of acute motor axonal neuropathy. This case highlights that acute motor axonal neuropathy is a severe and life-threatening form of Guillain-Barre syndrome associated with significant mortality and morbidity. Neurological and physical recovery strongly depend on the inter-professional effort in an intensive care unit and neurology professionals.</p></abstract>

Acute Motor Axonal Neuropathy (AMAN) is an immune-mediated disorder of the peripheral nervous system, part of the spectrum of the Guillain-Barre syndrome (GBS). An infectious event most often triggers it reported a few weeks before the onset. The reported case is of a 56 years-old woman who developed acute motor axonal neuropathy three weeks after respiratory infection with influenza A virus subtype H1N1. Despite early treatment with plasmapheresis and intravenous immunoglobulins, the patient remained tetraplegic, mechanically ventilated for five months, with repetitive unsuccessful weaning trails. The probable cause was considered to be phrenic nerve palsy in the context of acute motor axonal neuropathy. This case highlights that acute motor axonal neuropathy is a severe and life-threatening form of Guillain-Barre syndrome associated with significant mortality and morbidity. Neurological and physical recovery strongly depend on the inter-professional effort in an intensive care unit and neurology professionals.

Severe Acute Motor Axonal Neuropathy Associated with Influenza-A (H1N1) Infection and Prolonged Respiratory Failure - A Case Report

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Acute Motor Axonal Neuropathy (AMAN) is an immune-mediated disorder of the peripheral nervous system, part of the spectrum of the Guillain-Barre syndrome...

Severe Acute Motor Axonal Neuropathy Associated with Influenza-A (H1N1) Infection and Prolonged Respiratory Failure - A Case Report

Article Category: Case Report

Online veröffentlicht: 06. Nov. 2021

Seitenbereich: 302 - 307

Eingereicht: 26. Feb. 2021

Akzeptiert: 29. Juli 2021

DOI: https://doi.org/10.2478/jccm-2021-0030

Schlüsselwörter
Guillain-Barre syndrome, acute motor axonal neuropathy, nodopathy, influenza virus A H1N1, tetraplegia, prolonged respiratory failure

© 2021 Oana Mosora, Laura Barcutean, Rodica Balasa, Raluca Fodor, Smaranda Maier, Zoltan Bajko, Adina Stoian, Anca Motataianu, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Severe Acute Motor Axonal Neuropathy Associated with Influenza-A (H1N1) Infection and Prolonged Respiratory Failure - A Case Report

Article Category: Case Report

Online veröffentlicht: 06. Nov. 2021

Seitenbereich: 302 - 307

Eingereicht: 26. Feb. 2021

Akzeptiert: 29. Juli 2021

DOI: https://doi.org/10.2478/jccm-2021-0030

SchlüsselwörterGuillain-Barre syndrome, acute motor axonal neuropathy, nodopathy, influenza virus A H1N1, tetraplegia, prolonged respiratory failure

© 2021 Oana Mosora, Laura Barcutean, Rodica Balasa, Raluca Fodor, Smaranda Maier, Zoltan Bajko, Adina Stoian, Anca Motataianu, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
Guillain-Barre syndrome, acute motor axonal neuropathy, nodopathy, influenza virus A H1N1, tetraplegia, prolonged respiratory failure