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Bilateral Ocular Exophthalmia – A Case of Atypical Acute Myeloblastic Leukemia in a Child

Réka Toth

Réka Toth

County Clinical Emergency Hospital Targu MuresTargu Mures, Romania
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Toth, Réka
, 
Alina Grama

Alina Grama

Department of Pediatrics I, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu MuresTargu Mures, Romania
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Grama, Alina
, 
Cristina Maki

Cristina Maki

Ophthalmology Clinic, Mures County Clinical HospitalTargu Mures, Romania
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Maki, Cristina
 und 
Mihaela Ioana Chinceșan

Mihaela Ioana Chinceșan

Department of Pediatrics I, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu MuresTargu Mures, Romania
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Chinceșan, Mihaela Ioana
  
07. Nov. 2020
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Artikel-Kategorie: Case Report
Online veröffentlicht: 07. Nov. 2020
Seitenbereich: 243 - 248
Eingereicht: 15. Mai 2020
Akzeptiert: 29. Aug. 2020
DOI: https://doi.org/10.2478/jccm-2020-0031
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© 2020 Réka Toth, Alina Grama, Cristina Maki, Mihaela Ioana Chinceșan, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Proptosis of the right eye in the first 24 hours after admission to the Paediatric Clinic
Proptosis of the right eye in the first 24 hours after admission to the Paediatric Clinic

Fig. 2

The non-contrast-enhanced cranial/cerebral CT of the head with coronal sections at the level of the orbits, shows two well-defined, soft-tissue density lesions in the supero-lateral aspect of the extraconal regions bilaterally, more pronounced on the right side, where downward displacement of the ocular globe is visible
The non-contrast-enhanced cranial/cerebral CT of the head with coronal sections at the level of the orbits, shows two well-defined, soft-tissue density lesions in the supero-lateral aspect of the extraconal regions bilaterally, more pronounced on the right side, where downward displacement of the ocular globe is visible

Fig. 3

Contrast-enhanced cranial CT axial view of the head and orbit, following intravenous iodinated contrast media administration. The lesions show mild, homogenous enhancement.
Contrast-enhanced cranial CT axial view of the head and orbit, following intravenous iodinated contrast media administration. The lesions show mild, homogenous enhancement.

Routine tests results performed on Day 1 post-admission to Paediatrics Clinic

CRPFgESRLDHASTALTCreatinineUrea
41.66 mg/l497 mg/dl93 mm/h601 U/l21 U/l8 U/l0,69 mg/dl26,1 mg/dl

Bone marrow immunophenotyping

CD34HLA-DRCD13CD33CD15CD117CD19CD3CD7CD10CD22CD11CD14CD64
80%80%78%75%70%60%62%negativenegativenegativenegativenegativenegativenegative

Supportive care of the induction phase_

Drug nameStrengthDosageRoute of administrationDates of administration
human immune globulin2,5g/25ml1 fl/dayintravenouslyDay 13
(CSL Behring GmbH, Marburg, Germany)
red blood cell10ml/kgintravenouslyDay 9,21
pooled platelets1unit/10kgintravenouslyDay 7-16, 21-25
trimethoprim-sulfamethoxazole(40mg/200mg)/5ml2x10ml/dayorallyDay 24-26
(E.I.P.I.Co., Tenth of Ramadan City, Egypt)
fluconazole2mg/ml100 mg onceintravenouslyDay 17-27
(Fareva Amboise, Pocé-Sur-Cisse, France)daily
granisetron1mg/ml1mg twice aIntravenouslyDay 4-11
(Fresenius Kabi Austria GmbH, Graz, Austria)day
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Englisch
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Fachgebiete der Zeitschrift:
Medizin, Klinische Medizin, Allgemeinmedizin, Innere Medizin, Innere Medizin, andere, Chirurgie, Chirurgie, andere, Anästhesiologie, Intensivmedizin und Notfallmedizin
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