<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Hepatobiliary sepsis and biliary septic shock are defined as a group of purulent-inflammatory diseases of the biliary tract which, in their progression, lead to sepsis in case of delayed diagnosis and treatment. The study aimed to analyse all the cases of hepatobiliary sepsis treated at the Clinic of Surgery, Dr G. Stranski University Hospital – Pleven, from 2016 to 2020 and create a reliable prognostic score for surveillance for patients with hepatobiliary sepsis. Retrospectively, we analysed the records of 697 patients (81%) with a hepatobiliary tract infection, including 79 (11.3%) diagnosed with hepatobiliary sepsis and six fatal cases (1.3%). We evaluated all statistically significant factors that affected mortality: immune deficiency comorbidity (р&lt;0.005), pathogenesis-related to trauma and ascending biliary tract infection (p&lt;0.005), positive hemoculture (p&lt;0.001), length of hospital stay, the need of treatment in intensive care unit and all septic complications. We designed four different prognostic indices based on calculated individual SOFA scores and factors that significantly affected mortality in the high SOFA score patients: immune deficiency, pathogenesis-related risks of sepsis or positive blood culture. The newly designed indices for the outcome are original and have 80% sensitivity and 87% specificity, compared with a simple SOFA score.</p>
</abstract>

Hepatobiliary sepsis and biliary septic shock are defined as a group of purulent-inflammatory diseases of the biliary tract which, in their progression, lead to sepsis in case of delayed diagnosis and treatment. The study aimed to analyse all the cases of hepatobiliary sepsis treated at the Clinic of Surgery, Dr G. Stranski University Hospital – Pleven, from 2016 to 2020 and create a reliable prognostic score for surveillance for patients with hepatobiliary sepsis. Retrospectively, we analysed the records of 697 patients (81%) with a hepatobiliary tract infection, including 79 (11.3%) diagnosed with hepatobiliary sepsis and six fatal cases (1.3%). We evaluated all statistically significant factors that affected mortality: immune deficiency comorbidity (р<0.005), pathogenesis-related to trauma and ascending biliary tract infection (p<0.005), positive hemoculture (p<0.001), length of hospital stay, the need of treatment in intensive care unit and all septic complications. We designed four different prognostic indices based on calculated individual SOFA scores and factors that significantly affected mortality in the high SOFA score patients: immune deficiency, pathogenesis-related risks of sepsis or positive blood culture. The newly designed indices for the outcome are original and have 80% sensitivity and 87% specificity, compared with a simple SOFA score.

Surgical Sepsis of Hepatobiliary Origin: Cоmplications and Prognosis

Faculty of Medicine Medical University Pleven

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Surgical Sepsis of Hepatobiliary Origin: Cоmplications and Prognosis"}

Hepatobiliary sepsis and biliary septic shock are defined as a group of purulent-inflammatory diseases of the biliary tract which, in their progression, lead...

Surgical Sepsis of Hepatobiliary Origin: Cоmplications and Prognosis

Online veröffentlicht: 11. Dez. 2023

Seitenbereich: 153 - 162

Eingereicht: 16. Dez. 2022

Akzeptiert: 09. Nov. 2023

DOI: https://doi.org/10.2478/jbcr-2023-0021

Schlüsselwörter
hepatobiliary sepsis, SOFA score

© 2023 Polina G. Marinova, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Surgical Sepsis of Hepatobiliary Origin: Cоmplications and Prognosis

Online veröffentlicht: 11. Dez. 2023

Seitenbereich: 153 - 162

Eingereicht: 16. Dez. 2022

Akzeptiert: 09. Nov. 2023

DOI: https://doi.org/10.2478/jbcr-2023-0021

Schlüsselwörterhepatobiliary sepsis, SOFA score

© 2023 Polina G. Marinova, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
hepatobiliary sepsis, SOFA score