1. bookVolumen 14 (2021): Heft 1 (June 2021)
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1313-9053
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08 Sep 2014
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Uneingeschränkter Zugang

Some of the Immunogenetics Aspects of Aging

Online veröffentlicht: 12 Jul 2021
Volumen & Heft: Volumen 14 (2021) - Heft 1 (June 2021)
Seitenbereich: 16 - 30
Eingereicht: 22 Jul 2020
Akzeptiert: 22 Apr 2021
Zeitschriftendaten
License
Format
Zeitschrift
eISSN
1313-9053
Erstveröffentlichung
08 Sep 2014
Erscheinungsweise
2 Hefte pro Jahr
Sprachen
Englisch

1. World health organization. Ageing and health. A review [online]. 2018 [cited 2018 Feb 5] Available from: URL: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.2018;2018. Search in Google Scholar

2. Naumova E, Ivanova M, Pawelec G. Immunogenetics of ageing. Int J Immunogenet. 2011;38(5):373–81.10.1111/j.1744-313X.2011.01022.x Search in Google Scholar

3. Choo SY. The HLA system: Genetics, immunology, clinical testing, and clinical implications. Yonsei Med. J. 2007;48:11-23. Search in Google Scholar

4. Pallavi P, Vijaya B, Rashmi B K. Recipient Hemovigilance Study in a University Teaching Hospital of South India: An Institutional Report for the Year 2014–2015. Glob J Transfus Med. 2017;2(2):124–9.10.4103/GJTM.GJTM_32_17 Search in Google Scholar

5. Soto-Vega E, Richaud-Patin Y, Llorente L. Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population. Immun Ageing. 2005;2:13.10.1186/1742-4933-2-13 Search in Google Scholar

6. Lagaay AM, D Amaro J, Ligthart GJ, Schreuder GM V, Rood JJ HW. Longevity and heredity in humans. Association with the human leucocyte antigen phenotype. Ann N Y Acad Sci. 1991;621:78–89.10.1111/j.1749-6632.1991.tb16970.x Search in Google Scholar

7. Listì F, Caruso C, Colonna-Romano G, Lio D, Nuzzo D, Candore G. HLA and KIR Frequencies in Sicilian Centenarians. Rejuvenation Res. 2010;13(2–3):314–8.10.1089/rej.2009.0984 Search in Google Scholar

8. Akisaka M, Suzuki M, Akisakal M, Suzuki M. Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. Tissue Antigens. 1997;50(5):489–93.10.1111/j.1399-0039.1997.tb02904.x Search in Google Scholar

9. Ivanova R, Hénon N, Lepage V, Charron D, Vicaut E, Schächter F. HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum Mol Genet. 1998;7(2):187–94.10.1093/hmg/7.2.187 Search in Google Scholar

10. Lio D, Motta M, Franceschi C, Malaguarnera M, Candore G, Caruso C. Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. Genes Immun. 2002;20–4.10.1038/sj.gene.6363823 Search in Google Scholar

11. Papasteriades C, Boki K, Pappa H AS, Papasteriadis E EJ. HLA phenotypes in healthy aged subjects. Gerontology. 1997;43:176–81.10.1159/000213847 Search in Google Scholar

12. Takata H, Ishii T, Suzuki M, Sekiguchi S, Iri H. Influence of Major Histocompatibility Complex Region Genes on Human Longevity Among Okinawan-Japanese Centenarians and Nonagenarians. Lancet. 1987;330(8563):824–6.10.1016/S0140-6736(87)91015-4 Search in Google Scholar

13. Yong-Xing M, Yue Z, Zan-Shun W, Chuan-Fu W, Su-Ying C, Mao-Tong Z, et al. HLA and longevity or aging among Shanghai Chinese. Mech Ageing Dev. 1997;94(1–3):191–8.10.1016/S0047-6374(96)01848-9 Search in Google Scholar

14. Naumova E, Mihaylova A, Ivanova M, Michailova S, Penkova K, Baltadjieva D. Immunological markers contributing to successful aging in Bulgarians. Exp Gerontol. 2004;39(4):637–44.10.1016/j.exger.2003.08.014 Search in Google Scholar

15. Ivanova M, Creary LE, Al Hadra B, Lukanov T, Mazzocco M, Sacchi N, et al. 17th IHIW component “Immunogenetics of Ageing” – New NGS data. Hum Immunol. 2019;(May 2018):1–11.10.1016/j.humimm.2019.07.287 Search in Google Scholar

16. Ferlazzo V, Lio D, Mario G, Carru C, Listı F, Candore G, et al. Association between the HLADR alleles and longevity : a study in Sardinian population. Exp Gerontol. 2003;38:313–8.10.1016/S0531-5565(02)00178-X Search in Google Scholar

17. Piazza A, Olivetti E, Rm G, Rendine S, Amoroso A, Barbanti M, et al. The distribution of HLA antigens in Italy. Gene Geogr. 1989;3(2–3):141–64. Search in Google Scholar

18. Bera O, Cabre P, Alizadeh M, Smadja D, Jugde F, Edan G, et al. Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLADR locus in the syndrome. Tissue Antigens. 2003;61:166–71.10.1046/j.0001-2815.2002.00008.x12694585 Search in Google Scholar

19. Scholz EM, Marcilla M, Daura X, Arribas-Layton D, James EA, Alvarez I. Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires. Front Immunol. 2017; 8(August):1–12.10.3389/fimmu.2017.00984556697828871256 Search in Google Scholar

20. Handunnetthi L, Ramagopalan S V, Ebers GC. Multiple sclerosis, vitamin D, and HLADRB1*15. Neurology. 2010;74:1905–10.10.1212/WNL.0b013e3181e24124288222220530326 Search in Google Scholar

21. Mosca L, Mantero V, Mantia L La, Marazzi MR. HLA-DRB1 * 15 association with multiple sclerosis is confirmed in a multigenerational Italian family. Funct Neurol. 2017;32(2):83–8.10.11138/FNeur/2017.32.2.083550715728676141 Search in Google Scholar

22. Wang C, Tang J, Song W, Lobashevsky E, Wilson CM, Kaslow RA. VIRAL HEPATITIS HLA and Cytokine Gene Polymorphisms Are Independently Associated With Responses to Hepatitis B Vaccination. Hepatology. 2004;39:978–88.10.1002/hep.2014215057902 Search in Google Scholar

23. Yang G, Liu J, Han S, Xie H, Du R, Yan Y, et al. Association between hepatitis B virus infection and HLA-DRB1 genotyping in Shaanxi Han patients in northwestern China. Tissue Antigens. 2007;69:170–5.10.1111/j.1399-0039.2006.00744.x17257320 Search in Google Scholar

24. Cheng YQ, Lin JS, Huang LH, Tian DY, Xiong P. The association of HLA-DRB1 allele polymorphism with the genetic susceptibility to liver cirrhosis due to hepatitis B virus. Chinese J Med Genet. 2003;20(3):247–9. Search in Google Scholar

25. Willcox BJ, Willcox DC, He Q, Curb JD, Suzuki M. Siblings of Okinawan Centenarians Share Lifelong Mortality Advantages. J Gerontol. 2006;61(4):345–54.10.1093/gerona/61.4.345 Search in Google Scholar

26. Ellis MC, Hetisimer AH, Ruddy DA, Hansen SL, Kronmal GS, McClelland E, et al. HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy. Immunogenetics. 1997;46(5):410–7.10.1007/s002510050295 Search in Google Scholar

27. Rea IM, Middleton D. Is the Phenotypic Combination A1B8Cw7DR3 a Marker for Male Longevity? J Am Geriatr Soc. 1994;42(9):978–83.10.1111/j.1532-5415.1994.tb06591.x Search in Google Scholar

28. Ross OA, Curran MD, Rea IM, Hyland P, Duggan O, Barnett CR, et al. HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. Mech Ageing Dev. 2003;124(4):563–7.10.1016/S0047-6374(03)00037-X Search in Google Scholar

29. Scola L, Lio D, Candore G, Forte GI, Crivello A, Colonna-Romano G, et al. Analysis of HLADRB1,DQA1,DQB1 haplotypes in Sardinian centenarians. Exp Gerontol. 2008;43(2):114–8.10.1016/j.exger.2007.06.007264569717714903 Search in Google Scholar

30. Naumova E, Pawelec G, Ivanova M, Constantinescu I, Bogunia-Kubik K, Lange A, et al. 14th International HLA and Immunogenetics Workshop: Report on the immunogenetics of aging. Tissue Antigens. 2007;69(SUPPL. 1):304–10.10.1111/j.1399-0039.2006.00783.x17445222 Search in Google Scholar

31. Proust J, Moulias R, Fumeron F, Bekkhoucha F, Busson M, Schmid M, et al. HLA and longevity. Tissue Antigens. 1982;19:168–73.10.1111/j.1399-0039.1982.tb01436.x7089955 Search in Google Scholar

32. Candore G, Balistreri CR, Colonna-Romano G, Lio D, Listì F, Vasto S, et al. Gender-Related Immune-Inflammatory Factors, Age-Related Diseases, and Longevity. Rejuvenation Res. 2010;13(2–3):292–7.10.1089/rej.2009.094220345280 Search in Google Scholar

33. Kraat YJ, Christiaans MHL, Nieman FHM, Berg-Loonen PM van den, Hooff JP van, Bruggeman CA. Risk factors for cytomegalovirus infection and disease in renal transplant recipients : HLA-DR7 and triple therapy. Transpl Int. 1994;7:362–7.10.1111/j.1432-2277.1994.tb01248.x Search in Google Scholar

34. Schrier RD, Freeman WR, Wiley CA, Mccutchan JA. Immune Predispositions for Cytomegalovirus Retinitis in AIDS. J Clin Invest. 1987;95:1741–6.10.1172/JCI1178512956947706482 Search in Google Scholar

35. Almarri A, Batchelor R. HLA and hepatitis B infection. Lancet. 1994;344:1194–5.10.1016/S0140-6736(94)90510-X Search in Google Scholar

36. Hill AVS. The immunogenetics of human infectious diseases. Annu Rev Immunol. 1998;16(593):593–617.10.1146/annurev.immunol.16.1.593 Search in Google Scholar

37. Fernandez-arquero M, Figueredo MA, Maluenda C, Concha EG De. HLA-Linked Genes Acting as Additive Susceptibility Factors in Celiac Disease. Hum Immunol. 1995;300:295–300.10.1016/0198-8859(94)00108-3 Search in Google Scholar

38. Zeliszewski D, Mougenot JF, Dormoy A, Gaudebout C, Tongio MM, Baudon JJ, et al. Reevaluation of the Relative Risk for Susceptibility to Celiac Disease of HLADRBl,-DQAl, -DQBl, -DPBl, and -TAP2 Alleles in a French Population. Hum Immunol. 1995;8859(95). Search in Google Scholar

39. Michalski JP, McCombs CC, Arai T, Elston RC, Cao T, McCarthf CF, et al. HLA-DR, DQ genotypes of celiac disease patients and healthy subjects from the West of Ireland. Tissue Antigens. 1996;47(9):127–33.10.1111/j.1399-0039.1996.tb02525.x8851726 Search in Google Scholar

40. Kummee P, Tangkijvanich P, Poovorawan Y, Hirankarn N. Association of HLA-DRB1 * 13 and TNF- a gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population. J Viral Hepat. 2007;14:841–8.10.1111/j.1365-2893.2007.00880.x18070287 Search in Google Scholar

41. Singh R, Kaul R, Kaul A, Khan K. A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol ISSN. 2007;13(12):1770–87.10.3748/wjg.v13.i12.1770414995217465466 Search in Google Scholar

42. 42. Bosi I, Ancora G, Mantovani W, Miniero R, Verucchi G, Attard L, et al. HLA DR13 and HCV Vertical Infection. Pediatr Res. 2002;51(6):746–9.10.1203/00006450-200206000-0001412032271 Search in Google Scholar

43. Yang F, Sun L, Zhu X, Han J, Zeng Y, Nie C, et al. Identification of new genetic variants of HLA - DQB1 associated with human longevity and lipid homeostasis — a cross - sectional study in a Chinese population. Aging (Albany NY). 2017;9(11):2316–33.10.18632/aging.101323572368929129831 Search in Google Scholar

44. Doganay L, Fejzullahu A, Katrinli S, Enc FY, Ozturk O, Colak Y. Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis b. World J Gastroenterol. 2014;20(25):8179–86.10.3748/wjg.v20.i25.8179408169025009391 Search in Google Scholar

45. Guoi XJ, Chen E, Zou HJ, Jin L, Mayes MD, Assassp S, et al. Association of HLA-DQBl * 0501 with scleroderma and its clinical features in chinese population. Int J Immunopathol Pharmacol. 2013;26(3):747–51.10.1177/039463201302600318388751324067471 Search in Google Scholar

46. Fourati H, Mahfoudh N, Abida O, Kammoun A, Mnif F, Haddouk S, et al. HLA-DRB1 / DQB1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia. Ann Endocrinol (Paris). 2011;72(3):232–8.10.1016/j.ando.2011.04.004 Search in Google Scholar

47. Fernandez CA, Smith C, Yang W, Dat M, Bashford D, Larsen E, et al. HLA-DRB1 * 07 : 01 is associated with a higher risk of asparaginase allergies. Clin TRIALS Obs. 2016;124(8):1266–77. Search in Google Scholar

48. Tashiro R, Id KN, Khor S, Tokunaga K, Fujimura M, Sakata H, et al. Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study. PLoS One. 2019;1–12.10.1371/journal.pone.0220858 Search in Google Scholar

49. Ricci G, Colombo C, Ghiazza B, Illeni MT. Association between longevity and allelic forms of human leukocyte antigens (HLA): Population study of aged Italian human subjects. Arch Immunol Ther Exp (Warsz). 1998;46(1):31–4. Search in Google Scholar

50. Lio D, Scola L, Crivello A, Candore G, Bonafè M, Cavallone L, et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alfa-308promoter SNP. J Med Genet. 2003;40:296–9.10.1136/jmg.40.4.296 Search in Google Scholar

51. Cavallone L, Lio D, Scola L, Crivello A, Candore G, Bonafe M, et al. Gender-specific association between −1082 IL-10 promoter polymorphism and longevity. Genes Immun. 2002;30–3.10.1038/sj.gene.6363827 Search in Google Scholar

52. Pes GM, Lio D, Carru C, Deiana L, Baggio G, Franceschi C, et al. Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians. Aging Clin Exp Res. 2004;16(3):244–8.10.1007/BF03327391 Search in Google Scholar

53. Ross OA, Curran MD, Meenagh A, Williams F, Barnett YA, Middleton D, et al. Study of age-association with cytokine gene polymorphisms in an aged Irish population. Mech Ageing Dev. 2003;124(2):199–206.10.1016/S0047-6374(02)00132-X Search in Google Scholar

54. Minciullo PL, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G, et al. Inflammaging and Anti-Inflammaging : The Role of Cytokines in Extreme Longevity. Arch Immunol Ther Exp (Warsz). 2016; 64(2):111-26.10.1007/s00005-015-0377-326658771 Search in Google Scholar

55. Khabour OF, Barnawi JM. Association of longevity with IL-10− 1082 G/A and TNF-α− 308 G/A polymorphisms. Int J Immunogenet. 2010;293–8.10.1111/j.1744-313X.2010.00925.x20518833 Search in Google Scholar

56. Ershler WB. Interleukin-6 : A Cytokine for Gerontolgists. J Am Geriatr Soc. 1993;41:176–81.10.1111/j.1532-5415.1993.tb02054.x8426042 Search in Google Scholar

57. Nishimichi N, Kawashima T, Hojyo S. Characterization and expression analysis of a chicken interleukin-6 receptor alpha. Dev Comp Immunol. 2006;30:419–29.10.1016/j.dci.2005.05.00716153708 Search in Google Scholar

58. Palmeri M, Misiano G, Malaguarnera M, Forte GI, Vaccarino L, Milano S, et al. Cytokine serum profile in a group of sicilian nonagenarians. J Immunoass Immunochem. 2012;33:82–90.10.1080/15321819.2011.601781 Search in Google Scholar

59. Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, et al. The origins of age-related proinflammatory state. Blood. 2005;105(6):2294–9.10.1182/blood-2004-07-2599 Search in Google Scholar

60. Giovannini S, Onder ÃG, Liperoti ÃR, Russo ÃA, Carter C, Capoluongo E, et al. Interleukin-6, C-Reactive Protein, and Tumor Necrosis Factor-Alpha as Predictors of Mortality in Frail, Community-Living Elderly Individuals. J Am Geriatr Soc. 2011;59:1679–85.10.1111/j.1532-5415.2011.03570.x Search in Google Scholar

61. Terry CF, Loukaci V, Green R, Terry CF, Loukaci V, Green FR. Genes : structure and regulation : Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation *. J Biol Chem. 2000;275:18138–44.10.1074/jbc.M000379200 Search in Google Scholar

62. Antonicelli R, Olivieri F, Bonafe M, Cavallone L, Spazzafumo L, Marchegiani F, et al. The interleukin-6 174 G>C promoter polymorpism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. Int J Cardiol. 2005;103:266–71.10.1016/j.ijcard.2004.08.064 Search in Google Scholar

63. Giacconi R, Cipriano C, Albanese F, Boccoli G, Saba V, Olivieri F, et al. The 2 174G / C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing. Exp Gerontol. 2004;39:621–8.10.1016/j.exger.2003.12.013 Search in Google Scholar

64. Tonet AC, Karnikowski M, Moraes CF, Gomes L, Karnikowski MGO. Association between the -174 G / C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women. Brazilian J Med Biol Res. 2008;41:47–53.10.1590/S0100-879X2006005000190 Search in Google Scholar

65. Pola R, Gaetani E, Flex A, Aloi F, Papaleo P, Gerardino L, et al. 2 174 G / C interleukin-6 gene polymorphism and increased risk of multi-infarct dementia : a case-control study. Exp Gerontol. 2002;37:949–55.10.1016/S0531-5565(02)00031-1 Search in Google Scholar

66. Cederholm T, Persson M, Andersson P, Stenvinkel P, Nordfors L, Madden J, et al. Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients. J Intern Med. 2007;262:215–23.10.1111/j.1365-2796.2007.01803.x Search in Google Scholar

67. Bonafè M, Olivieri F, Cavallone L, Giovagnetti S, Marchegiani F, Cardelli M, et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol. 2001;31(8):2357–61.10.1002/1521-4141(200108)31:8<2357::AID-IMMU2357>3.0.CO;2-X Search in Google Scholar

68. Di D, Vasto S, Capurso C, Christiansen L, Deiana L, Franceschi C, et al. Effect of interleukin-6 polymorphisms on human longevity : A systematic review and meta-analysis. Ageing Res Rev. 2009;8:36–42.10.1016/j.arr.2008.09.001 Search in Google Scholar

69. Levine SJ. Tumor Necrosis Factor Alpha (TNF-α). In G. J. Laurent, & S. D. Shapiro (Eds.). Encyclopedia of Respiratory Medicine. 2006:307–11.10.1016/B0-12-370879-6/00404-X Search in Google Scholar

70. Wilson AG, Symons JA, McDowell TL, McDevitt H, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci. 1997;94(April):3195–9.10.1073/pnas.94.7.3195 Search in Google Scholar

71. Tuglular S, Berthoux P. Polymorphisms of the tumour necrosis factor a gene at position À 308 and TNFd microsatellite in primary IgA nephropathy. Nephrol Dial Transplan. 2003;18:724–31.10.1093/ndt/gfg010 Search in Google Scholar

72. Biggelaar AHJ van den, Craen AJM de, Gussekloo J, Huizinga TWJ, Heijmans BT, Frölich M, et al. Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming. FASEB J. 2004;17(1):1–17. Search in Google Scholar

73. Mooradian AD, Reed RL, Osterweil D, Scuderi P. Detectable Serum Levels of Tumor Necrosis Elderlv Institutionalized Patients Factor Alpha May Predict Early Mortality in Elderlv Institutionalized Patients. JAGS. 1991;(39):891–4.10.1111/j.1532-5415.1991.tb04456.x Search in Google Scholar

74. Roubenoff R, Parise H, Agostino RD, Jacques PF, Wilson PWF, Dinarello CA, et al. Cytokines, Insulin-Like Growth Factor 1, Sarcopenia, and Mortality in VeryOld Community-Dwelling MenandWomen:The Framingham Heart Study. Am J Med. 2003;(11):429–35.10.1016/j.amjmed.2003.05.001 Search in Google Scholar

75. Yende S, Tuomanen EI, Wunderink R, Kanaya A, Newman AB, Harris T, et al. Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia. Am J Respir Crit Care Med. 2005;177(22):1440–6.10.1164/rccm.200506-888OC Search in Google Scholar

76. Bruunsgaard H, Andersen-ranberg K. Elevated Levels ofTumor Necrosis Factor Alpha and Mortality in Centenarians. Am J Med. 2003;115:278–283.10.1016/S0002-9343(03)00329-2 Search in Google Scholar

77. Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, et al. Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein . J Immunol. 1996;156(11):4274–9. Search in Google Scholar

78. Zanni F, Vescovini R, Biasini C, Fagnoni F, Zanlari L, Telera A, et al. Marked increase with age of type 1 cytokines within memory and effector / cytotoxic CD8+T cells in humans : a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol. 2003;38:981–7.10.1016/S0531-5565(03)00160-8 Search in Google Scholar

79. Alberti S, Cevenini E, Ostan R, Capri M, Salvioli S, Bucci L, et al. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4 + T cells in humans. Mech ageing Dev. 2006;127:560–6.10.1016/j.mad.2006.01.01416516272 Search in Google Scholar

80. Lio D, Scola L, Crivello A, Bonafe M. Allele frequencies of +874T -> A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. Exp Gerontol. 2002;37:315–9.10.1016/S0531-5565(01)00198-X Search in Google Scholar

81. 81. Chung HY, Lee EK, Choi YJ, Kim JM, Kim DH, Zou Y, et al. Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases. J Dent Res. 2011;90(7):830–40.10.1177/0022034510387794 Search in Google Scholar

82. Saraiva M, O’Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010;10(3):170–81.10.1038/nri2711 Search in Google Scholar

83. Naumova E, Ivanova M, Pawelec G, Constantinescu I, Bogunia-Kubik K, Lange A, et al. “Immunogenetics of Aging”: Report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. Tissue Antigens. 2011;77(3):187–92.10.1111/j.1399-0039.2010.01603.x Search in Google Scholar

84. Licastro F, Caldarera CM, Branzi A, Franceschi C, Caruso C. Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet. 2004;790–5.10.1136/jmg.2004.019885 Search in Google Scholar

85. Gm P, Lio D, Carru C, Deiana L, Baggio G, Franceschi C, et al. Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians. Aging Clin Exp Res. 2004;16(3):2004. Search in Google Scholar

86. Wang XY, Hurme M, Jylh M, Hervonen A. Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-α genes in Finnish nonagenarians. Mech Ageing Dev. 2001;123(1):29–38.10.1016/S0047-6374(01)00338-4 Search in Google Scholar

87. Yoshimura A, Wakabayashi Y, Mori T. Cellular and molecular basis for the regulation of inflammation by TGF- b. J Biochem. 2010;147(6):781–92.10.1093/jb/mvq043 Search in Google Scholar

88. Bierie B, Moses HL. Transforming growth factor beta (TGF-β) and inflammation in cancer. Cytokine Growth Factor Rev. 2011;21(1):49–59.10.1016/j.cytogfr.2009.11.008 Search in Google Scholar

89. Carrieri G, Marzi E, Olivieri F, Marchegiani F, Cavallone L, Cardelli M, et al. The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell. 2004;3(6):443–8.10.1111/j.1474-9728.2004.00129.x Search in Google Scholar

90. Forsey RJ, Thompson JM, Ernerudh J, Hurst TL, Strindhall J. Plasma cytokine profiles in elderly humans. Mech Ageing Dev. 2003;124:487–93.10.1016/S0047-6374(03)00025-3 Search in Google Scholar

91. Lin Y, Nakachi K, Ito Y, Kikuchi S, Tamakoshi A, Yagyu K. Variations in serum transforming growth factor- β 1 levels with gender, age and lifestyle factors of healthy Japanese adults. Dis Markers. 2009;27:23–8.10.1155/2009/529253 Search in Google Scholar

92. Okamoto Y, Gotoh Y, Uemura O, Tanaka S, Ando T. Age-dependent decrease in serum transforming growth factor (TGF) -beta 1 in healthy Japanese individuals; population study of serum TGF-beta 1 level in Japanese. Dis Markers. 2005;21:71–4.10.1155/2005/381215 Search in Google Scholar

93. Dunn-Walters DK. The ageing human B cell repertoire: A failure of selection? Clin Exp Immunol. 2016;183(1):50–6.10.1111/cei.12700 Search in Google Scholar

94. Cancro MP, Hao Y, Scholz JL, Riley RL, Frasca D, Dunn-Walters DK, et al. B cells and aging: molecules and mechanisms. Trends Immunol. 2009;30(7):313–8.10.1016/j.it.2009.04.005 Search in Google Scholar

95. Zharhary D. Age-related changes in the capability of the bone marrow to generate B cells. J Immunol. 1988;141(6):1863–9. Search in Google Scholar

96. Blanco E, Pérez-andrés M, Arriba-méndez S, Contreras-sanfeliciano T, Criado I, Pelak O, et al. Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood. J Allergy Clin Immunol. 2018;141(6):2208–19.10.1016/j.jaci.2018.02.017 Search in Google Scholar

97. Riley RL, Blomberg BB, Frasca D. B cells, E2A, and aging. Immunol Rev. 2005;205:30–47.10.1111/j.0105-2896.2005.00268.x Search in Google Scholar

98. Labrie JE, Sah AP, Allman DM, Cancro MP, Gerstein RM. Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice. J Exp Med. 2004;200(4):411–23.10.1084/jem.20040845 Search in Google Scholar

99. Weksler ME. Immune Senescence : Deficiency or Dysregulation. Nutr Rev. 1995;3–7.10.1111/j.1753-4887.1995.tb01513.x Search in Google Scholar

100. Sherwood EM, Blomberg BB, Xu W, Cynthia A, Riley RL, Sherwood EM, et al. Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ 5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment. J Immunol. 1998;161:4472–2275. Search in Google Scholar

101. Sherwood EM, Xu W, King AM, Blomberg BB, Riley RL. The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins. Mech Ageing Dev. 2000;118(1–2):45–59.10.1016/S0047-6374(00)00157-3 Search in Google Scholar

102. Gibson KL, Wu YC, Barnett Y, Duggan O, Vaughan R, Kondeatis E, et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell. 2009;8(1):18–25.10.1111/j.1474-9726.2008.00443.x266764718986373 Search in Google Scholar

103. Huang Y, Gauthey L, Michel M, Loreto M, Paccaud M, Pechere J, et al. The Relationship Between Influenza Vaccine-Induced Nonspecific Autoantibody Responses in Healthy Older Women. J Gerontol. 1992;47(2):50–5.10.1093/geronj/47.2.M50 Search in Google Scholar

104. Wang C, Liu Y, Xu LT, Jackson KJL, Roskin KM, Pham TD, et al. Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires. J Immunol. 2014;192(2):603–11.10.4049/jimmunol.1301384394712424337376 Search in Google Scholar

105. Jiang N, He J, Weinstein JA, Penland L, Sasaki S, He XS, et al. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013;5(171).10.1126/scitranslmed.3004794369934423390249 Search in Google Scholar

106. Ademokun A, Wu YC, Martin V, Mitra R, Sack U, Baxendale H, et al. Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell. 2011;10(6):922–30.10.1111/j.1474-9726.2011.00732.x326470421726404 Search in Google Scholar

107. Martin V, Wu YB, Kipling D, Dunn-walters D, Dunn-walters D. Ageing of the B-cell repertoire. Philos Trans R Soc L B Biol Sci. 2015;370(1676):20140237.10.1098/rstb.2014.0237452841426194751 Search in Google Scholar

108. Romero-steiner S, Musher DM, Cetron MS, Pais LB, Groover JE, Fiore AE, et al. Reduction in Functional Antibody Activity Against Streptococcus pneumoniae in Vaccinated Elderly Individuals Highly Correlates with Decreased IgG Antibody Avidity. Clin Infect Dis. 1999; 29:281–8.10.1086/52020010476727 Search in Google Scholar

109. Wardemann H. Predominant Autoantibody Production by Early Human B Cell Precursors. Science (80- ). 2003;301(5638):1374–7.10.1126/science.108690712920303 Search in Google Scholar

110. Larimore K, McCormick MW, Robins HS, Greenberg PD. Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing. J Immunol. 2012;189(6):3221–30.10.4049/jimmunol.120130322865917 Search in Google Scholar

111. Joshi PK et all. Genome-wide meta-analysis associates HLA- DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nat Commun. 2017;1–13. Search in Google Scholar

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