Altered Functions of Human Blood-Derived Vascular Endothelial Cells by Simulated Microgravity

Ali MH, Schumacker PT (2002) Endothelial responses to mechanical stress: where is the mechanosensor? Critical Care Medicine30(5 Suppl): S198–S206AliMHSchumackerPT2002Endothelial responses to mechanical stress: where is the mechanosensor?Critical Care Medicine305 SupplS198S20610.1097/00003246-200205001-00005Search in Google Scholar

Allen JB, Khan S, Lapidos KA, Ameer GA (2010) Toward engineering a human neoendothelium with circulating progenitor cells. Stem Cells28(2): 318–328AllenJBKhanSLapidosKAAmeerGA2010Toward engineering a human neoendothelium with circulating progenitor cellsStem Cells28231832810.1002/stem.275Search in Google Scholar

Allen JB, Khan S, Serrano MC, Ameer GA (2008) Characterization of porcine circulating progenitor cells: toward a functional endothelium. Tissue Engineering Part A14(1): 183–194AllenJBKhanSSerranoMCAmeerGA2008Characterization of porcine circulating progenitor cells: toward a functional endotheliumTissue Engineering Part A14118319410.1089/ten.a.2007.0265Search in Google Scholar

Antonutto G, di Prampero PE (2003) Cardiovascular deconditioning in microgravity: some possible countermeasures. European Journal of Applied Physiology90(3–4): 283–291AntonuttoGdi PramperoPE2003Cardiovascular deconditioning in microgravity: some possible countermeasuresEuropean Journal of Applied Physiology903–428329110.1007/s00421-003-0884-5Search in Google Scholar

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Isner JM (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science275(5302): 964–967AsaharaTMuroharaTSullivanASilverMvan der ZeeRLiTIsnerJM1997Isolation of putative progenitor endothelial cells for angiogenesisScience275530296496710.1126/science.275.5302.964Search in Google Scholar

Balistreri CR, Buffa S, Pisano C, Lio D, Ruvolo G, Mazzesi G (2015) Are endothelial progenitor cells the real solution for cardiovascular diseases? Focus on controversies and perspectives. BioMed Research International, 2015: 835934BalistreriCRBuffaSPisanoCLioDRuvoloGMazzesiG2015Are endothelial progenitor cells the real solution for cardiovascular diseases? Focus on controversies and perspectivesBioMed Research International201583593410.1155/2015/835934Search in Google Scholar

Beere HM, Green DR (2001) Stress management - heat shock protein-70 and the regulation of apoptosis. Trends in Cell Biology11(1): 6–10BeereHMGreenDR2001Stress management - heat shock protein-70 and the regulation of apoptosisTrends in Cell Biology11161010.1016/S0962-8924(00)01874-2Search in Google Scholar

Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M (2005) Key gravity-sensitive signaling pathways drive T cell activation. Federation of American Societies for Experimental Biology (FASEB) Journal19(14): 2020–2022BoonyaratanakornkitJBCogoliALiCFSchopperTPippiaPGalleriGMeloniMAHughes-FulfordM2005Key gravity-sensitive signaling pathways drive T cell activationFederation of American Societies for Experimental Biology (FASEB) Journal19142020202210.1096/fj.05-3778fje16210397Search in Google Scholar

Borges TJ, Wieten L, van Herwijnen MJC, Broere F, van der Zee R, Bonorino C, van Eden W (2012) The anti-inflammatory mechanisms of hsp70. Frontiers in Immunology3: 95BorgesTJWietenLvan HerwijnenMJCBroereFvan der ZeeRBonorinoCvan EdenW2012The anti-inflammatory mechanisms of hsp70Frontiers in Immunology39510.3389/fimmu.2012.00095334363022566973Search in Google Scholar

Carlsson SIM, Bertilaccio MTS, Ascari I, Bradamante S, Maier JAM (2002) Modulation of human endothelial cell behavior in simulated microgravity. Journal of Gravitational Physiology9(1): P273–P274CarlssonSIMBertilaccioMTSAscariIBradamanteSMaierJAM2002Modulation of human endothelial cell behavior in simulated microgravityJournal of Gravitational Physiology91P273P274Search in Google Scholar

Carlsson SIM, Bertilaccio MTS, Ballabio E, Maier JAM (2003) Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research1642(3): 173–179CarlssonSIMBertilaccioMTSBallabioEMaierJAM2003Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organizationBiochimica et Biophysica Acta (BBA) - Molecular Cell Research1642317317910.1016/j.bbamcr.2003.08.00314572900Search in Google Scholar

Cogoli A (1993) The effect of hypogravity and hypergravity on cells of the immune system. Journal of Leukocyte Biology54(3): 259–268CogoliA1993The effect of hypogravity and hypergravity on cells of the immune systemJournal of Leukocyte Biology54325926810.1002/jlb.54.3.2598371056Search in Google Scholar

Convertino VA (2009) Status of cardiovascular issues related to spaceflight: implications for future research directions. Respiratory Physiology & Neurobiology169(Suppl): S34–S37ConvertinoVA2009Status of cardiovascular issues related to spaceflight: implications for future research directionsRespiratory Physiology & Neurobiology169SupplS34S3710.1016/j.resp.2009.04.010Search in Google Scholar

Cotrupi S, Maier JAM (2004) Is HSP70 upregulation crucial for cellular proliferative response in simulated microgravity? Journal of Gravitational Physiology 11(2): P173–P176CotrupiSMaierJAM2004Is HSP70 upregulation crucial for cellular proliferative response in simulated microgravity?Journal of Gravitational Physiology112P173P176Search in Google Scholar

Cotrupi S, Ranzani D, Maier JAM (2005) Impact of modeled microgravity on microvascular endothelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research1746(2): 163–168CotrupiSRanzaniDMaierJAM2005Impact of modeled microgravity on microvascular endothelial cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research1746216316810.1016/j.bbamcr.2005.10.002Search in Google Scholar

Dai K, Wang Y, Yan R, Shi Q, Wang Z, Yuan Y, Cheng H, Li S, Fan Y, Zhuang F (2009) Effects of microgravity and hypergravity on platelet functions. Thrombosis and Haemostasis101(5): 902–910DaiKWangYYanRShiQWangZYuanYChengHLiSFanYZhuangF2009Effects of microgravity and hypergravity on platelet functionsThrombosis and Haemostasis101590291010.1160/TH08-11-0750Search in Google Scholar

Deakin AM, Payne AN, Whittle BJ, Moncada S (1995) The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gamma. Cytokine7(5): 408–416DeakinAMPayneANWhittleBJMoncadaS1995The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gammaCytokine7540841610.1006/cyto.1995.0056Search in Google Scholar

Douville EC, Kempczinski RF, Birinyi LK, Ramalanjaona GR (1987) Impact of endothelial cell seeding on long-term patency and subendothelial proliferation in a small-caliber highly porous polytetrafluoroethylene graft. Journal of Vascular Surgery5(4): 544–550DouvilleECKempczinskiRFBirinyiLKRamalanjaonaGR1987Impact of endothelial cell seeding on long-term patency and subendothelial proliferation in a small-caliber highly porous polytetrafluoroethylene graftJournal of Vascular Surgery5454455010.1016/0741-5214(87)90218-7Search in Google Scholar

Gamboa A, Okamoto LE, Raj SR, Diedrich A, Shibao CA, Robertson D, Biaggioni I (2013) Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects. Hypertension61(2): 376–381GamboaAOkamotoLERajSRDiedrichAShibaoCARobertsonDBiaggioniI2013Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjectsHypertension61237638110.1161/HYPERTENSIONAHA.111.00203362171723283362Search in Google Scholar

Gimbrone MA, Lelkes P (2003) Mechanical Forces and the Endothelium, The Netherlands: Hardwood Academic PublishersGimbroneMALelkesP2003Mechanical Forces and the EndotheliumThe NetherlandsHardwood Academic PublishersSearch in Google Scholar

Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M (2013) Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation, and adhesion molecules. Scientific Reports3: 1494GrenonSMJeanneMAguado-ZunigaJConteMSHughes-FulfordM2013Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation, and adhesion moleculesScientific Reports3149410.1038/srep01494360313323511048Search in Google Scholar

Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J (2014) Growing tissues in real and simulated microgravity: new methods for tissue engineering. Tissue Engineering Part B, Reviews20(6): 555–566GrimmDWehlandMPietschJAleshchevaGWisePvan LoonJUlbrichCMagnussonNEInfangerMBauerJ2014Growing tissues in real and simulated microgravity: new methods for tissue engineeringTissue Engineering Part B, Reviews20655556610.1089/ten.teb.2013.0704424197624597549Search in Google Scholar

Hammond TG, Hammond JM (2001) Optimized suspension culture: the rotating-wall vessel. American Journal of Physiology - Renal Physiology281(1): F12–F25HammondTGHammondJM2001Optimized suspension culture: the rotating-wall vesselAmerican Journal of Physiology - Renal Physiology2811F12F2510.1152/ajprenal.2001.281.1.F1211399642Search in Google Scholar

Hristov M, Erl W, Weber PC (2003) Endothelial progenitor cells: mobilization, differentiation, and homing. Arteriosclerosis, Thrombosis, and Vascular Biology23: 1185–1189HristovMErlWWeberPC2003Endothelial progenitor cells: mobilization, differentiation, and homingArteriosclerosis, Thrombosis, and Vascular Biology231185118910.1161/01.ATV.0000073832.49290.B512714439Search in Google Scholar

Hughes-Fulford M (2011). To infinity ... and beyond! Human spaceflight and life science. Federation of American Societies for Experimental Biology (FASEB) Journal25(9): 2858–2864Hughes-FulfordM2011To infinity ... and beyond! Human spaceflight and life scienceFederation of American Societies for Experimental Biology (FASEB) Journal2592858286410.1096/fj.11-0902ufmSearch in Google Scholar

Jacquier-Sarlin MR, Fuller K, Dinh-Xuan AT, Richard M-J, Polla BS (1994) Protective effects of hsp70 in inflammation. Experientia50(11): 1031–1038Jacquier-SarlinMRFullerKDinh-XuanATRichardM-JPollaBS1994Protective effects of hsp70 in inflammationExperientia50111031103810.1007/BF01923458Search in Google Scholar

Kiang J (1998) Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacology & Therapeutics80(2): 183–201KiangJ1998Heat shock protein 70 kDa: molecular biology, biochemistry, and physiologyPharmacology & Therapeutics80218320110.1016/S0163-7258(98)00028-XSearch in Google Scholar

Klaus DM (2001) Clinostats and bioreactors. Gravitational and Space Biology Bulletin14(2): 55–64KlausDM2001Clinostats and bioreactorsGravitational and Space Biology Bulletin1425564Search in Google Scholar

Kunz GA, Liang G, Cuculi F, Gregg D, Vata KC, Shaw LK, Goldschmidt-Clermont PJ, Dong C, Taylor DA, Peterson ED (2006) Circulating endothelial progenitor cells predict coronary artery disease severity. American Heart Journal152(1): 190–195KunzGALiangGCuculiFGreggDVataKCShawLKGoldschmidt-ClermontPJDongCTaylorDAPetersonED2006Circulating endothelial progenitor cells predict coronary artery disease severityAmerican Heart Journal152119019510.1016/j.ahj.2006.02.001Search in Google Scholar

Levin EG, Marzec U, Anderson J, Harker LA (1984) Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells. Journal of Clinical Investigation74(6): 1988–1995LevinEGMarzecUAndersonJHarkerLA1984Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cellsJournal of Clinical Investigation7461988199510.1172/JCI111620Search in Google Scholar

Luo X, Zuo X, Zhou Y, Zhang B, Shi Y, Liu M, Wang K, McMillian DR, Xiao X (2008) Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes. Arthritis Research & Therapy10: R41LuoXZuoXZhouYZhangBShiYLiuMWangKMcMillianDRXiaoX2008Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytesArthritis Research & Therapy10R4110.1186/ar2399Search in Google Scholar

Maiello M, Boeri D, Podesta F, Cagliero E, Vichi M, Odetti P, Adezati L, Lorenzi M (1992) Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose. Diabetes41(8): 1009–1015MaielloMBoeriDPodestaFCaglieroEVichiMOdettiPAdezatiLLorenziM1992Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucoseDiabetes4181009101510.2337/diab.41.8.1009Search in Google Scholar

Maier JAM, Cialdai F, Monici M, Morbidelli L (2015) The impact of microgravity and hypergravity on endothelial cells. BioMed Research InternationalVolume 2015: 434803MaierJAMCialdaiFMoniciMMorbidelliL2015The impact of microgravity and hypergravity on endothelial cellsBioMed Research International201543480310.1155/2015/434803Search in Google Scholar

Martinez EM, Yoshida MC, Candelario TLT, Hughes-Fulford M (2015) Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology308(6): R480–R488MartinezEMYoshidaMCCandelarioTLTHughes-FulfordM2015Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activationAmerican Journal of Physiology: Regulatory, Integrative, and Comparative Physiology3086R480R48810.1152/ajpregu.00449.2014Search in Google Scholar

May LT, Torcia G, Cozzolino F, Ray A, Tatter SB, Santhanam U, Sehgal PB, Stern D (1989) Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins, and inhibition of proliferation. Biochemical and Biophysical Research Communications159(3): 991–998MayLTTorciaGCozzolinoFRayATatterSBSanthanamUSehgalPBSternD1989Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins, and inhibition of proliferationBiochemical and Biophysical Research Communications159399199810.1016/0006-291X(89)92206-7Search in Google Scholar

Motlagh D, Allen J, Hoshi R, Yang J, Lui K, Ameer G (2007) Hemocompatibility evaluation of poly(diol citrate) in vitro for vascular tissue engineering. Journal of Biomedical Materials Research, Part A82(4): 907–916MotlaghDAllenJHoshiRYangJLuiKAmeerG2007Hemocompatibility evaluation of poly(diol citrate) in vitro for vascular tissue engineeringJournal of Biomedical Materials Research, Part A82490791610.1002/jbm.a.3121117335023Search in Google Scholar

Mukai CN, Lathers CM, Charles JB, Bennett BS (1994) Cardiovascular responses to repetitive exposure to hyper- and hypogravity states produced by parabolic flight. Journal of Clinical Pharmacology34(5): 472–479MukaiCNLathersCMCharlesJBBennettBS1994Cardiovascular responses to repetitive exposure to hyper- and hypogravity states produced by parabolic flightJournal of Clinical Pharmacology34547247910.1002/j.1552-4604.1994.tb04989.x8089258Search in Google Scholar

Murasawa S, Asahara T (2005) Endothelial progenitor cells for vasculogenesis. Physiology20: 36–42MurasawaSAsaharaT2005Endothelial progenitor cells for vasculogenesisPhysiology20364210.1152/physiol.00033.200415653838Search in Google Scholar

Orshal JM, Khalil RA (2004) Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension43(2): 434–444OrshalJMKhalilRA2004Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant ratsHypertension43243444410.1161/01.HYP.0000113044.46326.9814707155Search in Google Scholar

Piro M, Giubilato G, Pinnelli M, Giordano Sciacca P, Biasucci LM (2005) Endothelium and inflammation. Panminerva Medica47(2): 75–80PiroMGiubilatoGPinnelliMGiordano SciaccaPBiasucciLM2005Endothelium and inflammationPanminerva Medica4727580Search in Google Scholar

Radtke AL, Herbst-Kralovetz MM (2012) Culturing and applications of rotating wall vessel bioreactor derived 3D epithelial cell models. Journal of Visualized Experiments62: 3868RadtkeALHerbst-KralovetzMM2012Culturing and applications of rotating wall vessel bioreactor derived 3D epithelial cell modelsJournal of Visualized Experiments62386810.3791/3868356712522491366Search in Google Scholar

Ramaswamy V, Dirr EW, Allen JB (2015) The effect of simulated microgravity on differentiation of porcine blood-derived vascular stem cells. Stem Cells and Development25(4): 329–336RamaswamyVDirrEWAllenJB2015The effect of simulated microgravity on differentiation of porcine blood-derived vascular stem cellsStem Cells and Development25432933610.1089/scd.2015.029726649474Search in Google Scholar

Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger JM, Garrido C, Kroemer G (2001) Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nature Cell Biology3(9): 839–843RavagnanLGurbuxaniSSusinSAMaisseCDaugasEZamzamiNMakTJäätteläMPenningerJMGarridoCKroemerG2001Heat-shock protein 70 antagonizes apoptosis-inducing factorNature Cell Biology3983984310.1038/ncb0901-83911533664Search in Google Scholar

Ritz BW, Lelkes PI, Gardner EM (2006) Functional recovery of peripheral blood mononuclear cells in modeled microgravity. Federation of American Societies for Experimental Biology (FASEB) Journal20(2): 305–307RitzBWLelkesPIGardnerEM2006Functional recovery of peripheral blood mononuclear cells in modeled microgravityFederation of American Societies for Experimental Biology (FASEB) Journal20230530710.1096/fj.04-3122fje16371429Search in Google Scholar

Rubanyi GM (1993) The role of endothelium in cardiovascular homeostasis and diseases. Journal of Cardiovascular Pharmacology22(Suppl 4): S1–S14RubanyiGM1993The role of endothelium in cardiovascular homeostasis and diseasesJournal of Cardiovascular Pharmacology22Suppl 4S1S1410.1097/00005344-199322004-000027523767Search in Google Scholar

Spisni E, Bianco MC, Griffoni C, Toni M, D'Angelo R, Santi S, Riccio M, Tomasi V (2003) Mechanosensing role of caveolae and caveolar constituents in human endothelial cells. Journal of Cellular Physiology197(2): 198–204SpisniEBiancoMCGriffoniCToniMD'AngeloRSantiSRiccioMTomasiV2003Mechanosensing role of caveolae and caveolar constituents in human endothelial cellsJournal of Cellular Physiology197219820410.1002/jcp.1034414502559Search in Google Scholar

Spisni E, Toni M, Strillacci A, Galleri G, Santi S, Griffoni C, Tomasi V (2006) Caveolae and caveolae constituents in mechanosensing: effect of modeled microgravity on cultured human endothelial cells. Cell Biochemistry and Biophysics46(2): 155–164SpisniEToniMStrillacciAGalleriGSantiSGriffoniCTomasiV2006Caveolae and caveolae constituents in mechanosensing: effect of modeled microgravity on cultured human endothelial cellsCell Biochemistry and Biophysics46215516410.1385/CBB:46:2:155Search in Google Scholar

Stern DM, Esposito C, Gerlach H, Gerlach M, Ryan J, Handley D, Nawroth P (1991) Endothelium and regulation of coagulation. Diabetes Care14(2): 160–166SternDMEspositoCGerlachHGerlachMRyanJHandleyDNawrothP1991Endothelium and regulation of coagulationDiabetes Care14216016610.1007/978-1-4613-0937-6_13Search in Google Scholar

Trepels T, Zeiher AM, Fichtlscherer S (2009) The endothelium and inflammation. Endothelium: Journal of Endothelial Cell Research13(6): 423–429TrepelsTZeiherAMFichtlschererS2009The endothelium and inflammationEndothelium: Journal of Endothelial Cell Research13642342910.1080/10623320601061862Search in Google Scholar

Unsworth BR, Lelkes PI (1998) Growing tissues in microgravity. Nature Medicine4(8): 901–907UnsworthBRLelkesPI1998Growing tissues in microgravityNature Medicine4890190710.1038/nm0898-901Search in Google Scholar

Urbich C, Dimmeler S (2004) Endothelial progenitor cells: characterization and role in vascular biology. Circulation Research95(4): 343–353UrbichCDimmelerS2004Endothelial progenitor cells: characterization and role in vascular biologyCirculation Research95434335310.1161/01.RES.0000137877.89448.78Search in Google Scholar

Uva BM, Masini MA, Sturla M, Prato P, Passalacqua M, Giuliani M, Tagliafierro G, Strollo F (2002) Clinorotation-induced weightlessness influences the cytoskeleton of glial cells in culture. Brain Research934(2): 132–139UvaBMMasiniMASturlaMPratoPPassalacquaMGiulianiMTagliafierroGStrolloF2002Clinorotation-induced weightlessness influences the cytoskeleton of glial cells in cultureBrain Research934213213910.1016/S0006-8993(02)02415-0Search in Google Scholar

Van Guilder GP, Hoetzer GL, Smith DT, Irmiger HM, Greiner JJ, Stauffer BL, DeSouza CA (2005) Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise. American Journal of Physiology, Endocrinology, and Metabolism289(5): E807–E813Van GuilderGPHoetzerGLSmithDTIrmigerHMGreinerJJStaufferBLDeSouzaCA2005Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exerciseAmerican Journal of Physiology, Endocrinology, and Metabolism2895E807E81310.1152/ajpendo.00072.2005Search in Google Scholar

van Hinsbergh VWM (2012) Endothelium - role in regulation of coagulation and inflammation. Seminars in Immunopathology34(1): 93–106van HinsberghVWM2012Endothelium - role in regulation of coagulation and inflammationSeminars in Immunopathology3419310610.1007/s00281-011-0285-5Search in Google Scholar

Vaziri ND, Ding Y, Sangha DS, Purdy RE (2000) Upregulation of NOS by simulated microgravity, potential cause of orthostatic intolerance. Journal of Applied Physiology89(1): 338–344VaziriNDDingYSanghaDSPurdyRE2000Upregulation of NOS by simulated microgravity, potential cause of orthostatic intoleranceJournal of Applied Physiology89133834410.1152/jappl.2000.89.1.338Search in Google Scholar

Versari S, Longinotti G, Barenghi L, Maier JAM, Bradamante S (2013) The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment. Federation of American Societies for Experimental Biology (FASEB) Journal27(11): 4466–4475VersariSLonginottiGBarenghiLMaierJAMBradamanteS2013The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experimentFederation of American Societies for Experimental Biology (FASEB) Journal27114466447510.1096/fj.13-229195Search in Google Scholar

Versari S, Villa A, Bradamante S, Maier JAM (2007) Alterations of the actin cytoskeleton and increased nitric oxide synthesis are common features in human primary endothelial cell response to changes in gravity. Biochimica et Biophysica Acta1773(11): 1645–1652VersariSVillaABradamanteSMaierJAM2007Alterations of the actin cytoskeleton and increased nitric oxide synthesis are common features in human primary endothelial cell response to changes in gravityBiochimica et Biophysica Acta1773111645165210.1016/j.bbamcr.2007.05.014Search in Google Scholar

Villa A, Versari S, Maier JAM, Bradamante S (2005) Cell behavior in simulated microgravity: a comparison of results obtained with RWV and RPM. Gravitational and Space Biology Bulletin18(2): 89–90VillaAVersariSMaierJAMBradamanteS2005Cell behavior in simulated microgravity: a comparison of results obtained with RWV and RPMGravitational and Space Biology Bulletin1828990Search in Google Scholar

Wehland M, Ma X, Braun M, Hauslage J, Hemmersbach R, Bauer J, Grosse J, Infanger M, Grimm D (2013) The impact of altered gravity and vibration on endothelial cells during a parabolic flight. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology31(2–3): 432–451WehlandMMaXBraunMHauslageJHemmersbachRBauerJGrosseJInfangerMGrimmD2013The impact of altered gravity and vibration on endothelial cells during a parabolic flightCellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology312–343245110.1159/000343380Search in Google Scholar

Yamamoto K, Takahashi T, Asahara T, Ohura N, Sokabe T, Kamiya A, Ando J (2003) Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. Journal of Applied Physiology95(5): 2081–2088YamamotoKTakahashiTAsaharaTOhuraNSokabeTKamiyaAAndoJ2003Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stressJournal of Applied Physiology9552081208810.1152/japplphysiol.00232.2003Search in Google Scholar

Yates BJ, Kerman IA (1998) Post-spaceflight orthostatic intolerance: possible relationship to microgravity-induced plasticity in the vestibular system. Brain Research Reviews28(1–2): 73–82YatesBJKermanIA1998Post-spaceflight orthostatic intolerance: possible relationship to microgravity-induced plasticity in the vestibular systemBrain Research Reviews281–2738210.1016/S0165-0173(98)00028-9Search in Google Scholar

Zampetaki A, Kirton JP, Xu Q (2008) Vascular repair by endothelial progenitor cells. Cardiovascular Research78(3): 413–421ZampetakiAKirtonJPXuQ2008Vascular repair by endothelial progenitor cellsCardiovascular Research78341342110.1093/cvr/cvn08118349136Search in Google Scholar

Zhang Y, Sang C, Paulsen K, Arenz A, Zhao Z, Jia X, Ullrich O, Zhuang F (2010) ICAM-1 expression and organization in human endothelial cells is sensitive to gravity. Acta Astronautica67(9): 1073–1080ZhangYSangCPaulsenKArenzAZhaoZJiaXUllrichOZhuangF2010ICAM-1 expression and organization in human endothelial cells is sensitive to gravityActa Astronautica6791073108010.1016/j.actaastro.2010.06.027Search in Google Scholar