Oxygen and Silicon Ion Particles Induce Neoplastic Transformation in Human Colonic Epithelial Cells

Burns FJ, Jin Y, Koenig KL, Hosselet S (1993) The low carcinogenicity of electron radiation relative to argon ions in rat skin. Radiation Research 135: 178-188 Burns FJ Jin Y Koenig KL Hosselet S 1993 The low carcinogenicity of electron radiation relative to argon ions in rat skin Radiation Research 135 178 188 Search in Google Scholar

Burns FJ, Tang MS, Frenkel K, Nadas A, Wu F, Uddin A, Zhang R (2007) Induction and prevention of carcinogenesis in rat skin exposed to space radiation. Radiation Environmental Biophysics 46: 195-199 Burns FJ Tang MS Frenkel K Nadas A Wu F Uddin A Zhang R 2007 Induction and prevention of carcinogenesis in rat skin exposed to space radiation Radiation Environmental Biophysics 46 195 199 Search in Google Scholar

Chen GT, Castro JR, Quivey JM (1981) Heavy charged particle radiotherapy. Annual Review of Biophysics and Bioengineering 10: 499-529 Chen GT Castro JR Quivey JM 1981 Heavy charged particle radiotherapy Annual Review of Biophysics and Bioengineering 10 499 529 Search in Google Scholar

Clevers H, Nusse R (2012) Wnt/beta-catenin signaling and disease. Cell 149: 1192-1205 Clevers H Nusse R 2012 Wnt/beta-catenin signaling and disease Cell 149 1192 1205 Search in Google Scholar

Cucinotta FA, Kim MH, Chappell LJ, Huff JL (2013) How safe is safe enough? Radiation risk for a human mission to Mars. PLoS One 8: e74988 Cucinotta FA Kim MH Chappell LJ Huff JL 2013 How safe is safe enough? Radiation risk for a human mission to Mars PLoS One 8 e74988 Search in Google Scholar

Dicello JF, Christian A, Cucinotta FA, Gridley DS, Kathirithamby R, Mann J, Markham AR, Moyers MF, Novak GR, Piantadosi S, Ricart-Arbona R, Simonson DM, Strandberg JD, Vazquez M, Williams JR, Zhang Y, Zhou H, Huso D (2004) In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates. Physics in Medicine and Biology 49: 3817-3830 Dicello JF Christian A Cucinotta FA Gridley DS Kathirithamby R Mann J Markham AR Moyers MF Novak GR Piantadosi S Ricart-Arbona R Simonson DM Strandberg JD Vazquez M Williams JR Zhang Y Zhou H Huso D 2004 In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates Physics in Medicine and Biology 49 3817 3830 Search in Google Scholar

Eskiocak U, Kim SB, Roig AI, Kitten E, Batten K, Cornelius C, Zou YS, Wright WE, Shay JW (2010) CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells. Radiation Research 174: 27-36 Eskiocak U Kim SB Roig AI Kitten E Batten K Cornelius C Zou YS Wright WE Shay JW 2010 CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells Radiation Research 174 27 36 Search in Google Scholar

George K, Durante M, Willingham V, Wu H, Yang TC, Cucinotta FA (2003) Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes. Radiation Research 160: 425-435 George K Durante M Willingham V Wu H Yang TC Cucinotta FA 2003 Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes Radiation Research 160 425 435 Search in Google Scholar

George KA, Hada M, Chappell L, Cucinotta FA (2013) Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects. Radiation Research 180: 25-33 George KA Hada M Chappell L Cucinotta FA 2013 Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects Radiation Research 180 25 33 Search in Google Scholar

Habermann JK, Paulsen U, Roblick UJ, Upender MB, McShane LM, Korn EL, Wangsa D, Kruger S, Duchrow M, Bruch HP, Auer G, Ried T (2007) Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis. Genes Chromosomes and Cancer 46: 10-26 Habermann JK Paulsen U Roblick UJ Upender MB McShane LM Korn EL Wangsa D Kruger S Duchrow M Bruch HP Auer G Ried T 2007 Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis Genes Chromosomes and Cancer 46 10 26 Search in Google Scholar

Hellweg CE and Baumstark-Khan C (2007) Getting ready for the manned mission to Mars: the astronauts’ risk from space radiation. Naturwissenschaften 94: 517-526 Hellweg CE Baumstark-Khan C 2007 Getting ready for the manned mission to Mars: the astronauts’ risk from space radiation Naturwissenschaften 94 517 526 Search in Google Scholar

Horiguchi A, Oya M, Shimada T, Uchida A, Marumo K, Murai M (2002) Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: a study of incidence and its association with pathological features and clinical outcome. Journal of Urology 168: 762-765 Horiguchi A Oya M Shimada T Uchida A Marumo K Murai M 2002 Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: a study of incidence and its association with pathological features and clinical outcome Journal of Urology 168 762 765 Search in Google Scholar

Imaoka T, Nishimura M, Kakinuma S, Hatano Y, Ohmachi Y, Yoshinaga S, Kawano A, Maekawa A, Shimada Y (2007) High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations. International Journal of Radiation Oncology Biology Physics 69: 194-203 Imaoka T Nishimura M Kakinuma S Hatano Y Ohmachi Y Yoshinaga S Kawano A Maekawa A Shimada Y 2007 High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations International Journal of Radiation Oncology Biology Physics 69 194 203 Search in Google Scholar

Jin MJ, Chen K, Song L, Fan CH, Chen Q, Zhu YM, Ma XY, Yao KY (2005) The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. Cancer Genetics and Cytogenetics 163: 38-43 Jin MJ Chen K Song L Fan CH Chen Q Zhu YM Ma XY Yao KY 2005 The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population Cancer Genetics and Cytogenetics 163 38 43 Search in Google Scholar

Kim SB, Ly P, Kaisani A, Zhang L, Wright WE, Shay JW (2013) Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. Radiation Research 180: 259-267 Kim SB Ly P Kaisani A Zhang L Wright WE Shay JW 2013 Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells Radiation Research 180 259 267 Search in Google Scholar

Kim SB, Pandita RK, Eskiocak U, Ly P, Kaisani A, Kumar R, Cornelius C, Wright WE, Pandita TK, Shay JW (2012) Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proceedings of the National Academy of Sciences USA 109: E2949-2955 Kim SB Pandita RK Eskiocak U Ly P Kaisani A Kumar R Cornelius C Wright WE Pandita TK Shay JW 2012 Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation Proceedings of the National Academy of Sciences USA 109 E2949 2955 Search in Google Scholar

Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Nagayasu T, Sekine I (2005) Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. Journal of Clinical Pathology 58: 833-838 Kusaba T Nakayama T Yamazumi K Yakata Y Yoshizaki A Nagayasu T Sekine I 2005 Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors Journal of Clinical Pathology 58 833 838 Search in Google Scholar

Ly P, Eskiocak U, Kim SB, Roig AI, Hight SK, Lulla DR, Zou YS, Batten K, Wright WE, Shay JW (2011) Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells. Neoplasia 13: 348-357 Ly P Eskiocak U Kim SB Roig AI Hight SK Lulla DR Zou YS Batten K Wright WE Shay JW 2011 Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells Neoplasia 13 348 357 Search in Google Scholar

Musteanu M, Blaas L, Mair M, Schlederer M, Bilban M, Tauber S, Esterbauer H, Mueller M, Casanova E, Kenner L, Poli V, Eferl R (2010) Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology 138: 1003-1011, e1001-1005 Musteanu M Blaas L Mair M Schlederer M Bilban M Tauber S Esterbauer H Mueller M Casanova E Kenner L Poli V Eferl R 2010 Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice Gastroenterology 138 1003 1011 e1001-1005 Search in Google Scholar

Roig AI, Eskiocak U, Hight SK, Kim SB, Delgado O, Souza RF, Spechler SJ, Wright WE, Shay JW (2010) Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology 138: 1012-1021, e1011-1015 Roig AI Eskiocak U Hight SK Kim SB Delgado O Souza RF Spechler SJ Wright WE Shay JW 2010 Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro Gastroenterology 138 1012 1021 e1011-1015 Search in Google Scholar