Molecular Effects of Spaceflight in the Mouse Eye after Space Shuttle Mission STS-135

Figure 1.

Figure 2.

Figure 3.

Molecular Effects of Spaceflight in the Mouse Eye after Space Shuttle Mission STS-135 -- Supplemental Table 2

Gene Symbol	Gene Name	Fold Change	p Value	Probe Set ID	Entrez Gene ID
Dsp	Desmoplakin	4.01	0.045	1435493_at	109620
Ly6e	Lymphocyte antigen 6 complex, locus E	2.95	0.044	1453304_s_at	17069
Lcn2	Lipocalin 2	2.75	0.000	1427747_a_at	16819
Slc44a2	Solute carrier family 44, member 2	2.55	0.008	1438559_x_at	68682
Cirbp	Cold inducible RNA binding protein	2.48	0.000	1416332_at	12696
Pou4f1	POU class 4 homeobox 1	2.44	0.006	1429668_at	18996
Sgms2	Sphingomyelin synthase 2	2.36	0.025	1428663_at	74442
Defb9	Defensin beta 9	2.36	0.017	1427612_at	246079
Ripk4	Receptor-interacting serine-threonine kinase 4	2.32	0.045	1418488_s_at	72388
		2.24	0.002	1442025_a_at
Rprd2	Progestin and adipoQ receptor family member VIII	2.15	0.001	1434817_s_at	75137
		2.11	0.001	1447223_at
Paqr8	Progestin and adipoQ receptor family member VIII	2.04	0.006	1428958_at	74229
		-2.03	0.014	1418188_a_at
Tra2a	Transformer 2 alpha homolog (Drosophila)	-2.10	0.002	1454725_at	101214
Malat1	Metastasis associated lung adenocarcinoma transcript 1	-2.15	0.001	1418189_s_at	378938
S1pr3	Sphingosine-1-phosphate receptor 3	-2.26	0.016	1438658_a_at	13610
Sfpq	Splicing factor proline/glutamine-rich	-2.33	0.001	1423795_at	71514
	Solute carrier family 5 (sodium/myo-inositol cotransporter),
Slc5a3	member 3	-2.64	0.017	1435484_at	53881

Potential molecular pathways, processes, and diseases states triggered by spaceflight in the mouse retina_

PATHWAYS	PROCESSES	DISEASES
Endoplasmic Reticulum (ER) stress	RNA processing (mRNA splicing)	Molecular mechanisms of cancer
Pyrimidine metabolism RGC	Cell death of sensory neurons and nervous tissue	Neurodegeneration of nerves and
Cytokine production and signaling (IL-1, IL-6, IL17)	Apoptosis of microglia and neuronal cells	Degeneration of the optic nerve
Sphingosine-1-P signaling	Stabilization and assembly of desmosomes	Reactivation of herpes virus
Axonal guidance and actin cytoskeleton	Axon branching

Molecular Effects of Spaceflight in the Mouse Eye after Space Shuttle Mission STS-135 -- Supplemental Table 1

Gene Symbol	Gene Name	Fold Change	p Value	Probe Set ID	Entrez Gene ID
Dsp	Desmoplakin	4.01	0.045	1435493_at	109620
Ly6e	Lymphocyte antigen 6 complex, locus E	2.95	0.044	1453304_s_at	17069
Lcn2	Lipocalin 2	2.75	0.000	1427747_a_at	16819
Slc44a2	Solute carrier family 44, member 2	2.55	0.008	1438559_x_at	68682
Cirbp	Cold inducible RNA binding protein	2.48	0.000	1416332_at	12696
Pou4f1	POU class 4 homeobox 1	2.44	0.006	1429668_at	18996
Sgms2	Sphingomyelin synthase 2	2.36	0.025	1428663_at	74442
Defb9	Defensin beta 9	2.36	0.017	1427612_at	246079
Ripk4	Receptor-interacting serine-threonine kinase 4	2.32	0.045	1418488_s_at	72388
		2.24	0.002	1442025_a_at
Rprd2	Progestin and adipoQ receptor family member VIII	2.15	0.001	1434817_s_at	75137
		2.11	0.001	1447223_at
Paqr8	Progestin and adipoQ receptor family member VIII	2.04	0.006	1428958_at	74229
1700019G17Rik	Camello-like 2	1.99	0.021	1436669_at	75541
Cul2	Cullin 2	1.98	0.003	1419765_at	71745
Alcam	Activated leukocyte cell adhesion molecule	1.96	0.029	1437466_at	11658
Zbtb16	Zzinc finger and BTB domain containing 16	1.95	0.002	1419874_x_at	235320
Clvs1	Clavesin 1	1.93	0.020	1433906_at	74438
		1.93	0.003	1441430_at
Zc3h6	Zinc finger CCCH-type containing 6	1.92	0.011	1428682_at	78751
B4galnt1	Beta-1,4-N-acetyl-galactosaminyl transferase 1	1.92	0.006	1418655_at	14421
Gna13	Guanine nucleotide binding protein (G protein), alpha 13	1.89	0.000	1430295_at	14674
Ctsh	Cathepsin H	1.87	0.006	1443814_x_at	13036
Hnrpdl	Heterogeneous nuclear ribonucleoprotein D-like	1.84	0.001	1428224_at	50926
Wfs1	Wolfram syndrome 1	1.84	0.043	1448411_at	22393
Parp12	Poly (ADP-ribose) polymerase family, member 12	1.82	0.027	1426774_at	243771
Ehd4	EH-domain containing 4	1.82	0.020	1449852_a_at	98878
Acot9	Acyl-CoA thioesterase 9	1.81	0.023	1418073_at	56360
Sh3yl1	SH3 domain containing, Ysc84-like 1	1.80	0.011	1449579_at	24057
Agxt2l1	Alanine-glyoxylate aminotransferase 2-like 1	1.80	0.020	1452975_at	71760
Slc39a4	RIKEN cDNA 2210403K04 gene	1.79	0.032	1451139_at	72027
Inpp1	Inositol polyphosphate-1-phosphatase	1.79	0.016	1442073_at	16329
2210403K04Rik	RIKEN cDNA 2210403K04 gene	1.79	0.001	1428562_at	100042498
Zscan21	Zinc finger and SCAN domain containing 21	1.79	0.004	1449732_at	22697
		1.78	0.033	1449968_s_at
Cmas	Cytidine monophosphate N-acetylneuraminic acid synthetase	1.77	0.004	1426662_at	12764
Kalrn	Kalirin, RhoGEF kinase	1.76	0.016	1429796_at	545156
Rufy2	RUN and FYVE domain containing 2	1.76	0.030	1434347_s_at	70432
Trim25	Tripartite motif containing 25	1.75	0.016	1419879_s_at	217069
Angptl4	Angiopoietin-like 4	1.74	0.005	1417130_s_at	57875
Chst15	Carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	1.73	0.017	1452092_at	77590
Pex13	Peroxisomal biogenesis factor 13	1.72	0.012	1422472_at	72129
Mkrn1	Makorin ring finger protein 1	1.72	0.015	1451425_a_at	54484
A2m	Alpha-2-macroglobulin	1.72	0.019	1434719_at	232345
Mrpl15	Mitochondrial ribosomal protein L15	1.71	0.002	1430798_x_at	27395
Fabp4	Fatty acid binding protein 4, adipocyte	1.71	0.009	1417023_a_at	11770
AI451250	Expressed sequence AI451250	1.69	0.033	1447436_at	102524
Krt23	Keratin 23 (histone deacetylase inducible)	1.69	0.018	1418213_at	94179
Fkbp5	FK506 binding protein 5	1.68	0.000	1416125_at	14229
Fam194a	Family with sequence similarity 194, member A	1.66	0.046	1458320_at	545527
Mfsd6	Major facilitator superfamily domain containing 6	1.66	0.020	1424463_at	98682
Gm9776	Predicted gene 9776	1.66	0.010	1435723_at	328309
Sdr42e1	Short chain dehydrogenase/reductase family 42E, member 1	1.66	0.030	1427082_at	74032
A930041H05Rik	RIKEN cDNA A930041H05 gene	1.65	0.031	1442157_at	77834
Txnrd3	Thioredoxin reductase 3	1.65	0.006	1449623_at	232223
Pax6os1	Pax6 opposite strand transcript 1	1.65	0.014	1440445_at	402728
Slc1a1	Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1	1.64	0.046	1425415_a_at	20510
Col19a1	Collagen, type XIX, alpha 1	1.63	0.009	1421698_a_at	12823
Gpcpd1	Glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	1.62	0.004	1429144_at	74182
Lgi1	Leucine-rich, glioma inactivated 1	1.62	0.045	1423183_at	56839
Dcxr	Dicarbonyl/L-xylulose reductase	1.62	0.001	1419456_at	67880
Sbsn	Suprabasin	1.62	0.003	1459897_a_at	282619
Nipsnap1	Nipsnap homolog 1 (C. elegans)	1.61	0.021	1456748_a_at	18082
Ctsh	Cathepsin H	1.61	0.044	1418365_at	13036
Smc6	Structural maintenance of chromosomes 6	1.61	0.004	1448829_at	67241
Reps2	RALBP1 associated Eps domain containing 2	1.60	0.026	1435389_at	194590
		1.60	0.011	1438815_at
Crispld2	Cysteine-rich secretory protein LCCL domain containing 2	1.59	0.015	1434758_at	78892
Sorl1	Sortilin-related receptor	1.59	0.041	1453003_at	20660
Wwc1	WW and C2 domain containing 1	1.59	0.020	1420008_s_at	211652
Dhcr24	24-dehydrocholesterol reductase	1.59	0.029	1451895_a_at	74754
Acsl5	Acyl-CoA synthetase long-chain family member 5	1.58	0.008	1428082_at	433256
Chchd7	Coiled-coil-helix-coiled-coil-helix domain containing 7	1.58	0.029	1440158_x_at	66433
Smox	Spermine oxidase	1.58	0.022	1424268_at	228608
Nt5c2	5’-nucleotidase, cytosolic II	1.58	0.000	1425933_a_at	76952
Cpne8	Copine VIII	1.58	0.023	1431146_a_at	66871
Cpne8	Copine VIII	1.58	0.006	1430520_at	66871
Tcta	T-cell leukemia translocation altered gene	1.58	0.043	1420123_at	102791
Plekhh1	Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	1.57	0.039	1447807_s_at	211945
Ttll11	Tubulin tyrosine ligase-like family, member 11	1.57	0.038	1452964_at	74410
Rbpms	RNA binding protein gene with multiple splicing	1.57	0.038	1429359_s_at	19663
Fem1c	Fem-1 homolog c (C. elegans)	1.57	0.044	1438075_at	240263
Plin4	Perilipin 4	1.57	0.005	1418595_at	57435
Hnrpdl	Heterogeneous nuclear ribonucleoprotein D-like	1.57	0.008	1420093_s_at	50926
Cda	Cytidine deaminase	1.56	0.013	1427357_at	72269
Ifi35	Interferon-induced protein 35	1.56	0.029	1445897_s_at	70110
Ugt1a6	UDP glucuronosyltransferase 1 family, polypeptide A6	1.56	0.026	1426260_a_at
D130037M23Rik	RIKEN cDNA D130037M23 gene	1.56	0.006	1457321_at	328330
Slc7a1	Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	1.56	0.016	1454992_at	11987
Snrpd3	Small nuclear ribonucleoprotein D3 polypeptide 18kDa	1.55	0.016	1449629_s_at
Tsc22d3	TSC22 domain family, member 3	1.55	0.010	1425281_a_at	14605
Kazn	Kazrin, periplakin interacting protein	1.55	0.029	1434169_at	71529
Sh3bp5	SH3-domain binding protein 5 (BTK-associated)	1.54	0.004	1421923_at	24056
Hnrnpd	Heterogeneous nuclear ribonucleoprotein D	1.54	0.043	1457568_at	11991
Chl1	Cell adhesion molecule with homology to L1CAM	1.54	0.037	1435190_at	12661
Plin2	Perilipin 2	1.54	0.043	1448318_at	11520
Ptgis	Prostaglandin I2 (prostacyclin) synthase	1.53	0.034	1448816_at	19223
Armcx5	Armadillo repeat containing, X-linked 5	1.53	0.002	1424481_s_at	494468
Brd8	Bromodomain containing 8	1.53	0.005	1456351_at	78656
Tnfaip2	Tumor necrosis factor, alpha-induced protein 2	1.53	0.026	1438855_x_at	21928
Btbd11	BTB (POZ) domain containing 11	1.53	0.044	1428377_at	74007
Phyhip	Phytanoyl-CoA 2-hydroxylase interacting protein	1.53	0.030	1455463_at	105653
Btbd11	BTB (POZ) domain containing 11	1.53	0.022	1459838_s_at	74007
Hnrpdl	Heterogeneous nuclear ribonucleoprotein D-like	1.52	0.036	1449039_a_at	50926
Lgi1	Leucine-rich, glioma inactivated 1	1.52	0.030	1435851_at	56839
Rbm3	RNA binding motif (RNP1, RRM) protein 3	1.52	0.042	1422660_at	19652
Haghl	Hydroxyacylglutathione hydrolase-like	1.51	0.022	1428630_x_at	68977
Wwp2	WW domain containing E3 ubiquitin protein ligase 2	1.51	0.003	1448145_at	66894
Marveld2	MARVEL domain containing 2	1.51	0.002	1426914_at	218518
Dis3	DIS3 mitotic control homolog (S. cerevisiae)	1.51	0.005	1426609_at	72662
Cyb561	Cytochrome b-561	1.51	0.014	1417507_at	13056
Zbtb22	Zinc finger and BTB domain containing 22	1.51	0.011	1448705_at	81630
Rnf208	Ring finger protein 208	1.51	0.013	1435105_at	68846
Fam122b	Family with sequence similarity 122B	1.51	0.013	1452682_at	78755
Upk3b	Uroplakin 3B	1.51	0.014	1454881_s_at	100647
March7	Membrane-associated ring finger (C3HC4) 7	1.50	0.021	1420609_at	57438
3110003A17Rik	RIKEN cDNA 3110003A17 gene	1.50	0.008	1426964_at	73112
Sfpq	Splicing factor proline/glutamine-rich	-1.50	0.016	1423796_at	71514
Hsph1	Heat shock 105kDa/110kDa protein 1	-1.51	0.004	1423566_a_at	15505
Srsf10	Serine/arginine-rich splicing factor 10	-1.51	0.003	1449121_at	14105
Kdm2a	Lysine (K)-specific demethylase 2A	-1.53	0.036	1438890_at	225876
Lima1	LIM domain and actin binding 1	-1.53	0.013	1450629_at	65970
Crebzf	CREB/ATF bZIP transcription factor	-1.54	0.017	1434618_at	233490
Creld2	Cysteine-rich with EGF-like domains 2	-1.54	0.001	1452754_at	76737
Bcas2	Breast carcinoma amplified sequence 2	-1.54	0.013	1437262_x_at	68183
		-1.55	0.020	1417339_a_at
		-1.55	0.009	1456125_a_at
Cpsf6	Dynein, light chain, LC8-type 1	-1.55	0.006	1428232_at	432508
BB116930	Expressed sequence BB116930	-1.55	0.017	1440130_at	98740
Srsf6	Serine/arginine-rich splicing factor 6	-1.56	0.047	1448454_at	67996
Chordc1	Cysteine and histidine-rich domain (CHORD) containing 1	-1.57	0.001	1460645_at	66917
Xbp1	X-box binding protein 1	-1.59	0.007	1420011_s_at	22433
Pum2	Pumilio homolog 2 (Drosophila)	-1.59	0.004	1418017_at	80913
		-1.60	0.023	1422404_x_at
		-1.60	0.046	1424609_a_at
Hist3h2a	Histone cluster 3, H2a	-1.61	0.035	1435866_s_at	319162
Trpm1	Transient receptor potential cation channel, subfamily M, member 1	-1.62	0.025	1437445_at	17364
Trim47	Tripartite motif containing 47	-1.62	0.007	1426784_at	217333
4931428L18Rik	RIKEN cDNA 4931428L18 gene	-1.63	0.017	1430898_s_at	70988
Xbp1	X-box binding protein 1	-1.65	0.007	1437223_s_at	22433
Hist2h3c2-ps	Histone cluster 2, H3c	-1.65	0.006	1422155_at	97114
Hspa5	Heat shock 70kDa protein 5	-1.69	0.014	1427464_s_at	14828
6530402F18Rik	RIKEN cDNA 6530402F18 gene	-1.70	0.003	1441725_at	76220
Arsi	Arylsulfatase family, member I	-1.70	0.047	1427508_at	545260
Necab1	N-terminal EF-hand calcium binding protein 1	-1.73	0.046	1437156_at	69352
Cpsf6	Cleavage and polyadenylation specific factor 6, 68kDa	-1.73	0.006	1428233_at	432508
Btg1	B-cell translocation gene 1, anti-proliferative	-1.74	0.045	1426083_a_at	12226
S1pr3	Sphingosine-1-phosphate receptor 3	-1.78	0.019	1437173_at	13610
Hist2h3c1	Histone cluster 2, H3c	-1.79	0.002	1442051_at	15077
Car8	Carbonic anhydrase VIII	-1.79	0.019	1427482_a_at	12319
Rbm12b	RIKEN cDNA C430048L16 gene	-1.89	0.020	1435158_at	72397
		-2.03	0.014	1418188_a_at
Tra2a	Transformer 2 alpha homolog (Drosophila)	-2.10	0.002	1454725_at	101214
Malat1	Metastasis associated lung adenocarcinoma transcript 1	-2.15	0.001	1418189_s_at	378938
S1pr3	Sphingosine-1-phosphate receptor 3	-2.26	0.016	1438658_a_at	13610
Sfpq	Splicing factor proline/glutamine-rich	-2.33	0.001	1423795_at	71514
Slc5a3	Solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	-2.64	0.017	1435484_at	53881

Summary of the 139 differentially expressed genes in FLT compared to AEM ground controls_ Genes are listed according to fold change and its associated known molecular function_

Symbol: Name	Fold Change	Molecular Function
DSP: desmoplakin	4.01	other
LY6E: lymphocyte antigen 6 complex, locus E	2.95	other
LCN2: lipocalin 2	2.75	transporter
SLC44A2: solute carrier family 44, member 2	2.55	transporter
CIRBP: cold inducible RNA binding protein	2.48	translation regulator
POU4F1: POU class 4 homeobox 1	2.44	transcription regulator
SGMS2: sphingomyelin synthase 2	2.36	enzyme
Defb9: defensin beta 9	2.36	other
RIPK4: receptor-interacting serine-threonine kinase 4	2.32	kinase
RPRD2: regulation of nuclear pre-mRNA domain containing 2	2.15	other
PAQR8: progestin and adipoQ receptor family member VIII	2.04	other
1700019G17Rik/Cml2: camello-like 2	1.99	other
CUL2: cullin 2	1.98	enzyme
ALCAM: activated leukocyte cell adhesion molecule	1.96	other
ZBTB16: zinc finger and BTB domain containing 16	1.95	transcription regulator
CLVS1: clavesin 1	1.93	other
ZC3H6: zinc finger CCCH-type containing 6	1.92	other
B4GALNT1: beta-1,4-N-acetyl-galactosaminyl transferase 1	1.92	enzyme
GNA13: guanine nucleotide binding protein (G protein), alpha 13	1.89	enzyme
CTSH: cathepsin H	1.87	peptidase
WFS1: Wolfram syndrome 1	1.84	enzyme
HNRPDL: heterogeneous nuclear ribonucleoprotein D-like	1.84	other
PARP12: poly (ADP-ribose) polymerase family, member 12	1.83	other
EHD4: EH-domain containing 4	1.82	enzyme
ACOT9: acyl-CoA thioesterase 9	1.81	enzyme
AGXT2L1: alanine-glyoxylate aminotransferase 2-like 1	1.80	enzyme
SH3YL1: SH3 domain containing, Ysc84-like 1	1.80	other
2210403K04Rik: RIKEN cDNA 2210403K04 gene	1.79	other
INPP1: inositol polyphosphate-1-phosphatase	1.79	phosphatase
SLC39A4: solute carrier family 39 (zinc transporter), member 4	1.79	transporter
ZSCAN21: zinc finger and SCAN domain containing 21	1.79	transcription regulator
CMAS: cytidine monophosphate N-acetylneuraminic acid synthetase	1.77	enzyme
KALRN: kalirin, RhoGEF kinase	1.76	kinase
RUFY2: RUN and FYVE domain containing 2	1.76	other
TRIM25: tripartite motif containing 25	1.76	transcription regulator
ANGPTL4: angiopoietin-like 4	1.74	other
CHST15: carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	1.73	enzyme
PEX13: peroxisomal biogenesis factor 13	1.72	transporter
MKRN1: makorin ring finger protein 1	1.72	other
A2M: alpha-2-macroglobulin	1.72	transporter
MRPL15: mitochondrial ribosomal protein L15	1.71	other
FABP4: fatty acid binding protein 4, adipocyte	1.71	transporter
AI451250: expressed sequence AI451250	1.69	other
KRT23: keratin 23 (histone deacetylase inducible)	1.69	other
FKBP5: FK506 binding protein 5	1.69	enzyme
FAM194A: family with sequence similarity 194, member A	1.66	other
MFSD6: major facilitator superfamily domain containing 6	1.66	other
Gm9776: predicted gene 9776	1.66	other
SDR42E1: short chain dehydrogenase/reductase family 42E, member 1	1.66	enzyme
A930041H05Rik: RIKEN cDNA A930041H05 gene	1.65	other
TXNRD3: thioredoxin reductase 3	1.65	enzyme
Pax6os1: Pax6 opposite strand transcript 1	1.65	other
SLC1A1: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1	1.64	transporter
COL19A1 (includes EG:12823): collagen, type XIX, alpha 1	1.63	other
GPCPD1: glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	1.62	other
LGI1: leucine-rich, glioma inactivated 1	1.62	other
DCXR: dicarbonyl/L-xylulose reductase	1.62	enzyme
SBSN: suprabasin	1.62	other
NIPSNAP1: nipsnap homolog 1 (C. elegans)	1.61	enzyme
SMC6: structural maintenance of chromosomes 6	1.61	other
REPS2: RALBP1 associated Eps domain containing 2	1.60	other
HIST2H2AA3/HIST2H2AA4: histone cluster 2, H2aa3	1.60	other
CRISPLD2: cysteine-rich secretory protein LCCL domain containing 2	1.59	other
SORL1: sortilin-related receptor	1.59	transporter
WWC1: WW and C2 domain containing 1	1.59	transcription regulator
DHCR24: 24-dehydrocholesterol reductase	1.59	enzyme
ACSL5: acyl-CoA synthetase long-chain family member 5	1.59	enzyme
SMOX: spermine oxidase	1.58	enzyme
CHCHD7: coiled-coil-helix-coiled-coil-helix domain containing 7	1.58	other
NT5C2: 5’-nucleotidase, cytosolic II	1.58	phosphatase
CPNE8: copine VIII	1.58	other
TCTA: T-cell leukemia translocation altered gene	1.58	other
PLEKHH1: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	1.57	other
Rbpms: RNA binding protein gene with multiple splicing	1.57	transcription regulator
TTLL11: tubulin tyrosine ligase-like family, member 11	1.57	other
FEM1C: fem-1 homolog c (C. elegans)	1.57	transcription regulator
PLIN4: perilipin 4	1.57	other
CDA: cytidine deaminase	1.57	enzyme
IFI35: interferon-induced protein 35	1.56	other
UGT1A6: UDP glucuronosyltransferase 1 family, polypeptide A6	1.56	enzyme
D130037M23Rik: RIKEN cDNA D130037M23 gene	1.56	other
SLC7A1: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	1.56	transporter
SNRPD3: small nuclear ribonucleoprotein D3 polypeptide 18kDa	1.55	other
TSC22D3: TSC22 domain family, member 3	1.55	other
KAZN: kazrin, periplakin interacting protein	1.55	other
SH3BP5: SH3-domain binding protein 5 (BTK-associated)	1.55	other
CHL1: cell adhesion molecule with homology to L1CAM	1.54	other
HNRNPD: heterogeneous nuclear ribonucleoprotein D	1.54	transcription regulator
PLIN2: perilipin 2	1.54	other
PTGIS: prostaglandin I2 (prostacyclin) synthase	1.53	enzyme
ARMCX5: armadillo repeat containing, X-linked 5	1.53	other
TNFAIP2: tumor necrosis factor, alpha-induced protein 2	1.53	other
BRD8: bromodomain containing 8	1.53	transcription regulator
BTBD11: BTB (POZ) domain containing 11	1.53	transcription regulator
PHYHIP: phytanoyl-CoA 2-hydroxylase interacting protein	1.53	other
RBM3: RNA binding motif (RNP1, RRM) protein 3	1.52	other
HAGHL: hydroxyacylglutathione hydrolase-like	1.51	enzyme
MARVELD2: MARVEL domain containing 2	1.51	other
WWP2: WW domain containing E3 ubiquitin protein ligase 2	1.51	enzyme
DIS3: DIS3 mitotic control homolog (S. cerevisiae)	1.51	enzyme
ZBTB22: zinc finger and BTB domain containing 22	1.51	other
CYB561: cytochrome b-561	1.51	enzyme
RNF208: ring finger protein 208	1.51	other
FAM122B: family with sequence similarity 122B	1.51	other
UPK3B: uroplakin 3B	1.51	other
C6orf115: chromosome 6 open reading frame 115	1.50	other
MARCH7: membrane-associated ring finger (C3HC4) 7	1.50	other
HSPH1: heat shock 105kDa/110kDa protein 1	-1.51	other
LOC100505793/SRSF10: serine/arginine-rich splicing factor 10	-1.51	other
LIMA1: LIM domain and actin binding 1	-1.53	other
KDM2A: lysine (K)-specific demethylase 2A	-1.53	other
CREBZF: CREB/ATF bZIP transcription factor	-1.54	transcription regulator
CRELD2: cysteine-rich with EGF-like domains 2	-1.54	other
BCAS2: breast carcinoma amplified sequence 2	-1.54	other
DYNLL1: dynein, light chain, LC8-type 1	-1.55	other
BB116930: expressed sequence BB116930	-1.55	other
SRSF6: serine/arginine-rich splicing factor 6	-1.56	other
CHORDC1: cysteine and histidine-rich domain (CHORD) containing 1	-1.57	other
PUM2: pumilio homolog 2 (Drosophila)	-1.59	other
HIST3H2A: histone cluster 3, H2a	-1.61	other
TRPM1: transient receptor potential cation channel, subfamily M, member 1	-1.62	ion channel
TRIM47: tripartite motif containing 47	-1.62	other
4931428L18Rik: RIKEN cDNA 4931428L18 gene	-1.63	other
XBP1 (includes EG:140614): X-box binding protein 1	-1.65	transcription regulator
HIST1H3A: histone cluster 1, H3a	-1.66	other
HSPA5: heat shock 70kDa protein 5	-1.69	enzyme
6530402F18Rik: RIKEN cDNA 6530402F18 gene	-1.70	other
ARSI: arylsulfatase family, member I	-1.70	enzyme
NECAB1: N-terminal EF-hand calcium binding protein 1	-1.73	other
CPSF6: cleavage and polyadenylation specific factor 6, 68kDa	-1.73	other
BTG1: B-cell translocation gene 1, anti-proliferative	-1.74	transcription regulator
HIST2H3C (includes others): histone cluster 2, H3c	-1.79	other
CA8: carbonic anhydrase VIII	-1.79	enzyme
C430048L16Rik/Rbm12b: RIKEN cDNA C430048L16 gene	-1.89	other
TRA2A: transformer 2 alpha homolog (Drosophila)	-2.10	other
MALAT1: metastasis associated lung adenocarcinoma transcript 1	-2.15	other
S1PR3: sphingosine-1-phosphate receptor 3	-2.26	G-protein coupled receptor
SFPQ: splicing factor proline/glutamine-rich	-2.33	other
SLC5A3: solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	-2.64	transporter