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A rare case of medullary carcinoma of colon: Clinical implications and role of adjuvant therapy

Lakshmi Manogna Chintalacheruvu

Lakshmi Manogna Chintalacheruvu

Hematology/Oncology, Southern Illinois Health Cancer InstituteCarterville, United States of America
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Chintalacheruvu, Lakshmi Manogna
, 
Vamsi Krishna Chilluru

Vamsi Krishna Chilluru

Nephrology, Southern Illinois HealthCarbondale, United States of America
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Chilluru, Vamsi Krishna
, 
Narendra Babu Gutta

Narendra Babu Gutta

Interventional Radiology, Cape Radiology GroupCape Girardeau, United States of America
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Gutta, Narendra Babu
 und 
Heather Barrett

Heather Barrett

Pathology, Southern Illinois HealthCarbondale, United States of America
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Barrett, Heather
  
11. Juli 2025
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Artikel-Kategorie: Research Article
Online veröffentlicht: 11. Juli 2025
Eingereicht: 29. Nov. 2024
Akzeptiert: 26. Jan. 2025
DOI: https://doi.org/10.2478/fco-2024-0005
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© 2025 Lakshmi Manogna Chintalacheruvu et al., published by Sciendo
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Figure 1:

Circumferential thickening and heterogenous attenuation of the ascending colon just proximal to the level of the hepatic flexure.
Circumferential thickening and heterogenous attenuation of the ascending colon just proximal to the level of the hepatic flexure.

Figure 2:

Higher magnification reveals poorly differentiated cells with medium to large-sized vesicular nuclei, nucleoli, and moderate eosinophilic cytoplasm. The larger carcinomatous cells are interspersed by the smaller tumor infiltrating lymphocytes.
Higher magnification reveals poorly differentiated cells with medium to large-sized vesicular nuclei, nucleoli, and moderate eosinophilic cytoplasm. The larger carcinomatous cells are interspersed by the smaller tumor infiltrating lymphocytes.

Figure 3:

The medullary carcinoma is composed of poorly to undifferentiated cells in a vaguely trabecular to solid pattern. It lacks the typical glandular formation and mucin content seen in traditional colonic adenocarcinomas. The carcinoma has a circumscribed, pushing border, with a brisk intraepithelial and peritumoral lymphocytic infiltration.
The medullary carcinoma is composed of poorly to undifferentiated cells in a vaguely trabecular to solid pattern. It lacks the typical glandular formation and mucin content seen in traditional colonic adenocarcinomas. The carcinoma has a circumscribed, pushing border, with a brisk intraepithelial and peritumoral lymphocytic infiltration.
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