[
Abekawa T, Ito K, Nakagawa S, Nakato Y, Koyama T. Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex. Schizophr Res 101, 84–94, 2008.
]Search in Google Scholar
[
Centonze D, Usiello A, Costa C, Picconi B, Erbs E, Bernardi G, Borrelli E, Calabresi P. Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors. J Neurosci 24, 8214–8222, 2004.
]Search in Google Scholar
[
Chung JW, Seo JH, Baek SB, Kim CJ, Kim TW. Treadmill exercise inhibits hippocampal apoptosis through enhancing N-methyl-D-aspartate receptor expression in the MK-801-induced schizophrenic mice. J Exerc Rehabil 10, 218–224, 2014.
]Search in Google Scholar
[
Csernansky JG, Martin MV, Czeisler B, Meltzer MA, Ali Z, Dong H. Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury. Pharmacol Biochem Behav 83, 208–213, 2006.
]Search in Google Scholar
[
da Cruz Jung IE, Machado AK, da Cruz IB, Barbisan F, Azzolin VF, Duarte T, Duarte MM, do Prado-Lima PA, Bochi GV, Scola G, Moresco RN. Haloperidol and risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and 2016modification of cytokine levels. Psychopharmacology (Berl) 233, 1715–1723, 2016.
]Search in Google Scholar
[
Ding J, Zhou HH, Ma QR, He ZY, Ma JB, Liu YM, Zhang YW, He YQ, Liu J. Expression of NR1 and apoptosis levels in the hippocampal cells of mice treated with MK-801. Mol Med Rep 16, 8359–8364, 2017.
]Search in Google Scholar
[
Donohoe DR, Weeks K, Aamodt EJ, Dwyer DS. Antipsychotic drugs alter neuronal development including ALM neuroblast migration and PLM axonal outgrowth in Caenorhabditis elegans. Int J Dev Neurosci 26, 371–380, 2008.
]Search in Google Scholar
[
Gallagher MJ, Huang H, Lynch DR. Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions. J Neurochem 70, 2120–2128, 1998.
]Search in Google Scholar
[
Gasso P, Mas S, Molina O, Bernardo M, Lafuente A, Parellada E. Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry 36, 71–77, 2012.
]Search in Google Scholar
[
Genius J, Benninghoff J, Reuter N, Braun I, Giegling I, Hartmann A, Moller HJ, Rujescu D. Dysequilibrium of neuronal proliferation and apoptosis in a pharmacological animal model of psychosis. Methods 56, 519–527, 2012.
]Search in Google Scholar
[
He J, Xu H, Yang Y, Zhang X, Li XM. Neuroprotective effects of olanzapine on methamphetamine-induced neurotoxicity are associated with an inhibition of hyperthermia and prevention of Bcl-2 decrease in rats. Brain Res 1018, 186–192, 2004.
]Search in Google Scholar
[
Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE, Thotala D. GSK-3β: A bifunctional role in cell death pathways. Int J Cell Biol 2012, 930710, 2012.
]Search in Google Scholar
[
Jarskog LF, Glantz LA, Gilmore JH, Lieberman JA. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 29, 846–858, 2005.
]Search in Google Scholar
[
Jarskog LF. Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations. Curr Opin Psychiatry 19, 307–312, 2006.
]Search in Google Scholar
[
Jarskog LF, Gilmore JH, Glantz LA, Gable KL, German TT, Tong RI, Lieberman JA. Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics. Neuropsychopharmacology 32, 95–102, 2007.
]Search in Google Scholar
[
Jevtic G, Nikolic T, Mircic A, Stojkovic T, Velimirovic M, Trajkovic V, Markovic I, Trbovich AM, Radonjic NV, Petronijevic ND. Mitochondrial impairment, apoptosis and autophagy in a rat brain as immediate and long-term effects of perinatal phencyclidine treatment - influence of restraint stress. Prog Neuropsychopharmacol Biol Psychiatry 66, 87–96, 2016.
]Search in Google Scholar
[
Kim NR, Park SW, Lee JG, Kim YH. Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells. Prog Neuropsychopharmacol Biol Psychiatry 32, 633–642, 2008.
]Search in Google Scholar
[
Kondziella D, Brenner E, Eyjolfsson EM, Markinhuhta KR, Carlsson ML, Sonnewald U. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Neuropsychopharmacology 31, 1880–1887, 2006.
]Search in Google Scholar
[
Li P, Wang Y, Liu X, Zhou Z, Wang J, Zhou H, Zheng L, Yang L. Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling. BMC Pharmacol Toxicol 20, 10, 2019.
]Search in Google Scholar
[
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402–408, 2001.
]Search in Google Scholar
[
Meltzer HY, Matsubara S, Lee JC. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 251, 238–246, 1989.
]Search in Google Scholar
[
Ono T, Hashimoto E, Ukai W, Ishii T, Saito T. The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation. Schizophr Res 122, 239–247, 2010.
]Search in Google Scholar
[
O’Reilly KC, Levy ERJ, Patino AV, Perica MI, Fenton AA. Sub-circuit alterations in dorsal hippocampus structure and function after global neurodevelopmental insult. Brain Struct Funct 223, 3543–3556, 2018.
]Search in Google Scholar
[
Osacka J, Kiss A, Bacova Z, Tillinger A. Effect of haloperidol and olanzapine on hippocampal cells’ proliferation in animal model of schizophrenia. Int J Mol Sci 23, 7711, 2022.
]Search in Google Scholar
[
Palkovits M, Brownstein MJ. Maps and Guide to Microdissection of the Rat Brain. New York: Elsevier, 1988; pp. 1–223.
]Search in Google Scholar
[
Paxinos G, Watson C. The rat brain in stereotaxic coordinates, 3rd ed., Academic Press, Inc.: California, USA, 1997.
]Search in Google Scholar
[
Reus GZ, Abelaira HM, Agostinho FR, Ribeiro KF, Vitto MF, Luciano TF, Souza CT, Quevedo J. The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain. J Psychiatr Res 46, 1029–1035, 2012.
]Search in Google Scholar
[
Saldana M, Bonastre M, Aguilar E, Marin C. Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: role in neurotoxicity and stereotyped behavior. Exp Neurol 203, 302–308, 2007.
]Search in Google Scholar
[
Solek P, Mytych J, Tabecka-Lonczynska A, Sowa-Kucma M, Koziorowski M. Toxic effect of antidepressants on male reproductive system cells: evaluation of possible fertility reduction mechanism. J Physiol Pharmacol 72, 2021.
]Search in Google Scholar
[
Takahashi T, Suzuki M. Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention. Psychiatry Clin Neurosci 72, 556–571, 2018.
]Search in Google Scholar
[
Ukai W, Ozawa H, Tateno M, Hashimoto E, Saito T. Neurotoxic potential of haloperidol in comparison with risperi-done: implication of Akt-mediated signal changes by haloperidol. J Neural Transm (Vienna) 111, 667–681, 2004.
]Search in Google Scholar
[
Unal G, Dokumaci AH, Ozkartal CS, Yerer MB, Aricioglu F. Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3β/β-catenin signaling pathway in the SH-SY5Y cell line. Chem Biol Interact 314, 108823, 2019.
]Search in Google Scholar
[
Wang C, McInnis J, Ross-Sanchez M, Shinnick-Gallagher P, Wiley JL, Johnson KM. Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. Neuroscience 107, 535–550, 2001.
]Search in Google Scholar
[
Wang L, Zhu ZA. Nitric oxide show its survival role by NO-PKC pathway through cGMP-dependent or independent on the culture of cerebella granular neurons. Neurosci Lett 583, 165–169, 2014.
]Search in Google Scholar
[
Wasik A, Bialon M, Jantas D, Zarnowska M. The impact of the combined administration of 1MeTIQ and MK-801 on cell viability, oxidative stress markers, and glutamate release in the rat hippocampus. Neurotox Res 39, 1747–1761, 2021.
]Search in Google Scholar
[
Yoon WJ, Won SJ, Ryu BR, Gwag BJ. Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax-cytochrome C-caspase pathway: the causative role of Ca2+ deficiency. J Neurochem 85, 525–533, 2003.
]Search in Google Scholar
[
Yu W, Fang H, Zhang L, Hu M, He S, Li H, Zhu H. Reversible changes in BDNF expression in MK-801-induced hippocampal astrocytes through NMDAR/PI3K/ERK signaling. Front Cell Neurosci 15, 672136, 2021.
]Search in Google Scholar
