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Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE. The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling. Science 365, eaaw4144, 2019.10.1126/science.aaw414431273097Search in Google Scholar

Abu Aboud O, Chen CH, Senapedis W, Baloglu E, Argueta C, Weiss RH. Dual and specific inhibition of NAMPT and PAK4 by KPT-9274 decreases kidney cancer growth. Mol Cancer Ther 15, 2119–2129, 2016.10.1158/1535-7163.MCT-16-0197501093227390344Search in Google Scholar

Acunzo J, Katsogiannou M, Rocchi P. Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death. Int J Biochem Cell Biol 44, 1622–1631, 2012.10.1016/j.biocel.2012.04.00222521623Search in Google Scholar

Alaee M, Khaghani S, Behroozfar K, Hesari Z, Ghorbanhosseini SS, Nourbakhsh M. Inhibition of nicotinamide phosphoribosyltransferase induces apoptosis in estrogen receptor-positive MCF-7 breast cancer cells. J Breast Cancer 20, 20–26, 2017.10.4048/jbc.2017.20.1.20537857628382091Search in Google Scholar

Awais R, Spiller DG, White MR, Paraoan L. p63 is required beside p53 for PERP-Emediated apoptosis in uveal melanoma. Br J Cancer 115, 983–992, 2016.10.1038/bjc.2016.269506190427584665Search in Google Scholar

Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD. Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet 6, e1001168, 2010.10.1371/journal.pgen.1001168295881520975948Search in Google Scholar

Bochkov VN, Philippova M, Oskolkova O, Kadl A, Furnkranz A, Karabeg E, Breuss J, Minchenko OH, Mechtcheriakova D, Hohensinner P, Rychli K, Wojta J, Resink T, Binder BR, Leitinger N. Oxidized phospholipids stimulate angiogenesis via induction of VEGF, IL-8, COX-2 and ADAMTS-1 metalloprotease, implicating a novel role for lipid oxidation in progression and destabilization of atherosclerotic lesions. Circ Res 99, 900–908, 2006.10.1161/01.RES.0000245485.04489.ee16973904Search in Google Scholar

Bong IP, Ng CC, Fakiruddin SK, Lim MN, Zakaria Z. Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study. Bosn J Basic Med Sci 16, 268–275, 2016.Search in Google Scholar

Carra S, Boncoraglio A, Kanon B, Brunsting JF, Minoia M, Rana A, Vos MJ, Seidel K, Sibon OC, Kampinga HH. Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases. J Biol Chem 285, 37811–37822, 2010.10.1074/jbc.M110.127498298838520858900Search in Google Scholar

Cheleschi S, Giordano N, Volpi N, Tenti S, Gallo I, Di Meglio M, Giannotti S, Fioravanti A. A complex relationship between visfatin and resistin and microRNA: An in vitro study on human chondrocyte cultures. Int J Mol Sci 19, E3909, 2018.10.3390/ijms19123909632083230563239Search in Google Scholar

Chen J, Zhang S, Li Y, Tang Z, Kong W. Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma. Tumour Biol 35, 3743–3753, 2014.10.1007/s13277-013-1496-224363061Search in Google Scholar

Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, Xue C, Ren F, Ren Z, Li J, Liu L, Duan Z, Cui G, Sun R. Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. Mol Cancer 18, 33, 2019.10.1186/s12943-019-0947-9639774630825877Search in Google Scholar

Chiavarina B, Nokin MJ, Bellier J, Durieux F, Bletard N, Sherer F, Lovinfosse P, Peulen O, Verset L, Dehon R, Demetter P, Turtoi A, Uchida K, Goldman S, Hustinx R, Delvenne P, Castronovo V, Bellahcene A. Methylglyoxal-mediated stress correlates with high metabolic activity and promotes tumor growth in colorectal cancer. Int J Mol Sci 18, pii: E213, 2017.10.3390/ijms18010213529784228117708Search in Google Scholar

Crippa V, Carra S, Rusmini P, Sau D, Bolzoni E, Bendotti C, De Biasi S, Poletti A. A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases. Autophagy 6, 958–960, 2010a.10.4161/auto.6.7.1304220699640Search in Google Scholar

Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, Galbiati M, Fontana E, Marino M, Carra S, Bendotti C, De Biasi S, Poletti A. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum Mol Genet 19, 3440–3456, 2010b.10.1093/hmg/ddq25720570967Search in Google Scholar

Cui XY, Wang N, Yang BX, Gao WF, Lin YM, Yao XR, Ma XT. HSPB8 is methylated in hematopoietic malignancies and overexpression of HSPB8 exhibits antileukemia effect. Exp Hematol 40, 14–21, 2012.10.1016/j.exphem.2011.09.00421914495Search in Google Scholar

Cui D, Sajan P, Shi J, Shen Y, Wang K, Deng X, Zhou L, Hu P, Gao L. MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations. Oncotarget 8, 25345–25361, 2017.10.18632/oncotarget.15867542193528445981Search in Google Scholar

Feng J, Yan PF, Zhao HY, Zhang FC, Zhao WH, Feng M. Inhibitor of nicotinamide phosphoribosyltransferase sensitizes glioblastoma cells to temozolomide via activating ROS/JNK signaling pathway. Biomed Res Int 2016, 1450843, 2016.10.1155/2016/1450843520641128097126Search in Google Scholar

Guilbert SM, Lambert H, Rodrigue MA, Fuchs M, Landry J, Lavoie JN. HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency. FASEB J 32, 3518–3535, 2018.10.1096/fj.201700558RR29405094Search in Google Scholar

Guo Y, Zhang Y, Yang X, Lu P, Yan X, Xiao F, Zhou H, Wen C, Shi M, Lu J, Meng QH. Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2. Cancer Biol Ther 17, 169–180, 2016.10.1080/15384047.2015.1121346484800026618552Search in Google Scholar

Hacker KE, Bolland DE, Tan L, Saha AK, Niknafs YS, Markovitz DM, McLean K. The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival. Neoplasia 20, 1209–1218, 2018.10.1016/j.neo.2018.10.005622662530412857Search in Google Scholar

Hesari Z, Nourbakhsh M, Hosseinkhani S, Abdolvahabi Z, Alipour M, Tavakoli-Yaraki M, Ghorbanhosseini SS, Yousefi Z, Jafarzadeh M, Yarahmadi S. Down-regulation of NAMPT expression by mir-206 reduces cell survival of breast cancer cells. Gene 673, 149–158, 2018.10.1016/j.gene.2018.06.02129886033Search in Google Scholar

Hu Y, Jin R, Gao M, Xu H, Zou S, Li X, Xing C, Wang Q, Wang H, Feng J, Hu M, Song L. Transcriptional repression of IKKbeta by p53 in arsenite-induced GADD45alpha accumulation and apoptosis. Oncogene 38, 731–746, 2019.10.1038/s41388-018-0478-7635565030177839Search in Google Scholar

Huang YQ, Han ZD, Liang YX, Lin ZY, Ling XH, Fu X, Cai C, Bi XC, Dai QS, Chen JH, He HC, Chen YR, Jiang FN, Zhong WD. Decreased expression of myosin light chain MYL9 in stroma predicts malignant progression and poor biochemical recurrence-free survival in prostate cancer. Med Oncol 31, 820, 2014.10.1007/s12032-013-0820-424338276Search in Google Scholar

Hutschenreuther A, Bigl M, Hemdan NY, Debebe T, Gaunitz F, Birkenmeier G. Modulation of GLO1 expression affects malignant properties of cells. Int J Mol Sci 17, pii: E2133, 2016.10.3390/ijms17122133518793327999356Search in Google Scholar

Kim HG, Woo SU, Kim HY, Son GS, Lee JB, Bae JW, Woo OH, Yang DS, Seo JH, Kim AR. The expression of insulin receptor substrate 1 and estrogen receptor as prognostic factor on breast cancer patient. J Cancer Res Ther 14 (Supplement), S494–S498, 2018.10.4103/0973-1482.18118029970713Search in Google Scholar

Kruthika BS, Sugur H, Nandaki K, Arimappamagan A, Paturu K, Santosh V. Expression pattern and prognostic significance of myosin light chain 9 (MYL9): a novel biomarker in glioblastoma. J Clin Pathol 72, 677–681, 2019.10.1136/jclinpath-2019-20583431270134Search in Google Scholar

Lee BC, Song J, Lee A, Cho D, Kim TS. Visfatin promotes wound healing through the activation of ERK1/2 and JNK1/2 pathway. Int J Mol Sci 19, E3642, 2018.10.3390/ijms19113642627480930463229Search in Google Scholar

Li XS, Xu Q, Fu XY, Luo WS. Heat shock protein 22 overexpression is associated with the progression and prognosis in gastric cancer. J Cancer Res Clin Oncol 140, 1305–1313, 2014.10.1007/s00432-014-1698-z24804817Search in Google Scholar

Li Z, Qiu HY, Jiao Y, Cen JN, Fu CM, Hu SY, Zhu MQ, Wu DP, Qi XF. Growth and differentiation effects of Homer3 on a leukemia cell line. Asian Pac J Cancer Prev 14, 2525–2528, 2013.10.7314/APJCP.2013.14.4.2525Search in Google Scholar

Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV. Upregulation of IRS1 enhances IGF1 response in Y537S and D538G ESR1 mutant breast cancer cells. Endocrinology 159, 285–296, 2018.10.1210/en.2017-00693576160229029116Search in Google Scholar

Liang N, Chen Y, Yang L, He S, Liu T. Visfatin increases miR-21 to promote migration in HCC. Cell Mol Biol (Noisy-le-grand) 64, 48–52, 2018.10.14715/cmb/2018.64.6.9Search in Google Scholar

Meram AT, Alzubaidi Y, Cotelingam J, Ghali G, Lopez L, Coppola D, Shackelford R. Nicotinamide phosphoribosyl transferase is increased in osteosarcomas and chondrosarcomas compared to benign bone and cartilage. Anticancer Res 39, 1761–1765, 2019.10.21873/anticanres.13282777130830952715Search in Google Scholar

Minchenko DO, Kharkova AP, Hubenia OV, Minchenko OH. Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and gluta-mine or glucose deprivation. Endocr Reg 47, 15–26, 2013.10.4149/endo_2013_01_1523363253Search in Google Scholar

Minchenko OH, Tsymbal DO, Minchenko DO, Moenner M, Kovalevska OV, Lypova NM. Inhibition of kinase and endoribonuclease activity of ERN1/IRE1 affects expression of proliferation-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 2, 18–29, 2015.10.1515/ersc-2015-0002Search in Google Scholar

Minchenko DO, Kharkova AP, Halkin OV, Karbovskyi LL, Minchenko OH. Effect of hypoxia on the expression of genes encoded insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function. Endocr Reg 50, 43–54, 2016a.10.1515/enr-2016-000827560636Search in Google Scholar

Minchenko DO, Riabovol OO, Tsymbal DO, Ratushna OO, Minchenko OH. Inhibition of IRE1 affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells. Endocr Reg 50, 127–136, 2016b.10.1515/enr-2016-001427560795Search in Google Scholar

Minchenko DO, Riabovol OO, Ratushna OO, Minchenko OH. Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: effect of IRE1 inhibition. Endocr Reg 51, 8–19, 2017.10.1515/enr-2017-000228222026Search in Google Scholar

Minchenko DO, Tsymbal DO, Luzina OY, Riabovol OO, Danilovskyi SV, Minchenko OH. Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells. Endocr Reg 54, 31–42, 2020.10.2478/enr-2020-000532597148Search in Google Scholar

Modem S, Chinnakannu K, Bai U, Reddy GP, Reddy TR. Hsp22 (HspB/H11) knockdown induces Sam68 expression and stimulates proliferation of glioblastoma cells. J Cell Physiol 226, 2747–2751, 2011.10.1002/jcp.22868317871521678403Search in Google Scholar

Nielsen KN, Peics J, Ma T, Karavaeva I, Dall M, Chubanava S, Basse AL, Dmytriyeva O, Treebak JT, Gerhart-Hines Z. NAMPT-mediated NAD+ biosynthesis is indispensable for adipose tissue plasticity and development of obesity. Mol Metab 11, 178–188, 2018.10.1016/j.molmet.2018.02.014600135529551635Search in Google Scholar

Nishiyama M, Wands JR. Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun 183, 280–285, 1992.10.1016/0006-291X(92)91640-CSearch in Google Scholar

Nivon M, Abou-Samra M, Richet E, Guyot B, Arrigo AP and Kretz-Remy C. NF-kappaB regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex. J Cell Sci 125, 1141–1151, 2012.10.1242/jcs.09104122302993Search in Google Scholar

Piccolella M, Crippa V, Cristofani R, Rusmini P, Galbiati M, Cicardi ME, Meroni M, Ferri N, Morelli FF, Carra S, Messi E, Poletti A. The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells. Oncotarget 8, 10400–10415, 2017.10.18632/oncotarget.14422535466728060751Search in Google Scholar

Qu M, Duffy T, Hirota T, Kay SA. Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Proc Natl Acad Sci USA 115, E12305–E12312, 2018.10.1073/pnas.1816411115631082130530698Search in Google Scholar

Rahman S, Kraljevic Pavelic S, Markova-Car E. Circadian (De)regulation in head and neck squamous cell carcinoma. Int J Mol Sci 20, pii: E2662, 2019.10.3390/ijms20112662660014331151182Search in Google Scholar

Shen J, Li M, Min L. HSPB8 promotes cancer cell growth by activating the ERKCREB pathway and is indicative of a poor prognosis in gastric cancer patients. Oncol Rep 39, 2978–2986, 2018.10.3892/or.2018.637629693129Search in Google Scholar

Shen TY, Mei LL, Qiu YT, Shi ZZ. Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma. Oncol Lett 12, 2956–2961, 2016.10.3892/ol.2016.4947503843927698883Search in Google Scholar

Shi C, Wu H, Du D, Im HJ, Zhang Y, Hu B, Chen H, Wang X, Liu Y, Cao P, Tian Y, Shen X, Gao R, van Wijnen AJ, Ye X, Yuan W. Nicotinamide phosphoribosyltransferase inhibitor APO866 prevents IL-1beta-induced human nucleus pulposus cell degeneration via autophagy. Cell Physiol Biochem 49, 2463–2482, 2018.10.1159/00049384330261504Search in Google Scholar

Smith CC, Lee KS, Li B, Laing JM, Hersl J, Shvartsbeyn M, Aurelian L. Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways. Cell Death Dis 3, E371, 2012.10.1038/cddis.2012.108343466622898869Search in Google Scholar

Sun Y, Zhou J, Shi L, Li J, Chen J. MicroRNA-466 inhibits cell proliferation and invasion in osteosarcoma by directly targeting insulin receptor substrate 1. Mol Med Rep 19, 3345–3352, 2019.10.3892/mmr.2019.995630816452Search in Google Scholar

Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui T, Yoshimi N, Kozawa O, Morishige K. Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration. Arch Biochem Biophys 571, 40–49, 2015.10.1016/j.abb.2015.02.03025731856Search in Google Scholar

Varlet AA, Fuchs M, Luthold C, Lambert H, Landry J, Lavoie JN. Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division. Cell Stress Chaperones 22, 553–567, 2017.10.1007/s12192-017-0780-2546503228275944Search in Google Scholar

Wang JH, Zhang L, Huang ST, Xu J, Zhou Y, Yu XJ, Luo RZ, Wen ZS, Jia WH, Zheng M. Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma. PLoS ONE 12, E0175280, 2017.10.1371/journal.pone.0175280538475428388691Search in Google Scholar

Wu L, Li Y, Li J, Ma D. MicroRNA-664 targets insulin receptor substrate 1 to suppress cell proliferation and invasion in breast cancer. Oncol Res 27, 459–467, 2019.10.3727/096504018X15193500663936784846729495974Search in Google Scholar

Xiang R, Cui Y, Wang Y, Xie T, Yang X, Wang Z, Li J, Li Q. Circadian clock gene Per2 downregulation in nonsmall cell lung cancer is associated with tumour progression and metastasis. Oncol Rep 40, 3040–3048, 2018.10.3892/or.2018.670430226549Search in Google Scholar

Xie Z, Chooi JY, Toh SHM, Yang D, Basri NB, Ho YS, Chng WJ. MMSET I acts as an oncoprotein and regulates GLO1 expression in t(4;14) multiple myeloma cells. Leukemia 33, 739–748, 2019.10.1038/s41375-018-0300-030470837Search in Google Scholar

Xiong H, Yang Y, Yang K, Zhao D, Tang H, Ran X. Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer. Int J Oncol 52, 279–287, 2018.10.3892/ijo.2017.418029115399Search in Google Scholar

Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. Proc Natl Acad Sci USA 115, 4228–4233, 2018.10.1073/pnas.1718414115591083729610318Search in Google Scholar

Xu R, Yuan Z, Yang L, Li L, Li D, Lv C. Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress. Oncol Rep 38, 1767–1773, 2017.10.3892/or.2017.579328714034Search in Google Scholar

Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI. IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. Elife 7, pii: e32893, 2018.10.7554/eLife.32893590386629661273Search in Google Scholar

Yoo JJ, Yu SJ, Na J, Kim K, Cho YY, Lee YB, Cho EJ, Lee JH, Kim YJ, Youn H, Yoon JH. Hexokinase-II inhibition synergistically augments the anti-tumor efficacy of sorafenib in hepatocellular carcinoma Int J Mol Sci 20, E1292, 2019.10.3390/ijms20061292647130230875800Search in Google Scholar

You S, Guan Y, Li W. Epithelialmesenchymal transition in colorectal carcinoma cells is mediated by DEK/IMP3. Mol Med Rep 17, 1065–1070, 2018.10.3892/mmr.2017.794329115492Search in Google Scholar

Zhao H, Tang W, Chen X, Wang S, Wang X, Xu H, Li L. The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells. Biochem Biophys Res Commun 493, 77–84, 2017.10.1016/j.bbrc.2017.09.07128919418Search in Google Scholar

Zhou Y, Leng X, He Y, Li Y, Liu Y, Liu Y, Zou Q, Shi G, Wang Y. Loss of Perp in T cells promotes resistance to apoptosis of T helper 17 cells and exacerbates the development of experimental autoimmune encephalomyelitis in mice. Front Immunol 9, 842, 2018.10.3389/fimmu.2018.00842592596029740445Search in Google Scholar

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