Gene 1 | Gene 2 | Weight | Network group |
---|---|---|---|
AP3S1 | HSP90AA1 | 0.013259681 | Co-expression |
CTR9 | CDC73 | 0.008208696 | Co-expression |
CTR9 | LEO1 | 0.003100712 | Co-expression |
WDR61 | LEO1 | 0.007506342 | Co-expression |
WDR61 | CTR9 | 0.003934787 | Co-expression |
KMT2C | BCL9L | 0.01605392 | Co-expression |
CDK9 | CPSF4 | 0.007431932 | Co-expression |
GTF2F1 | PAF1 | 0.004063675 | Co-expression |
GTF2F1 | KMT2C | 0.008976047 | Co-expression |
AURKB | TKT | 0.011608324 | Co-expression |
NUP98 | CTR9 | 0.014227687 | Co-expression |
CPSF4 | TKT | 0.00430011 | Co-expression |
CPSF4 | AURKB | 0.006637127 | Co-expression |
CHUK | CSTF3 | 0.016616315 | Co-expression |
CSTF2 | AURKB | 0.004579851 | Co-expression |
CHUK | CDC73 | 0.001583963 | Co-expression |
CHUK | NUP98 | 0.004846978 | Co-expression |
GTF2F1 | TKT | 0.009125041 | Co-expression |
CPSF4 | CSTF3 | 0.014529244 | Co-expression |
CHUK | NUP98 | 0.008912819 | Co-expression |
NUP98 | CDC73 | 0.00588025 | Co-expression |
CHUK | CDC73 | 0.001885684 | Co-expression |
CSTF2 | LEO1 | 0.006971632 | Co-expression |
CSTF3 | CTR9 | 0.006781118 | Co-expression |
CHUK | CDC73 | 0.011535326 | Co-expression |
CHUK | CTR9 | 0.00340099 | Co-expression |
AP3S1 | CTR9 | 0.004597292 | Co-expression |
GTF2F1 | PAF1 | 0.010657921 | Co-expression |
GTF2F1 | CPSF4 | 0.011196721 | Co-expression |
CSTF2 | CTR9 | 0.011377413 | Co-expression |
CDK9 | CPSF4 | 0.009146069 | Co-expression |
AURKB | CSTF3 | 0.006553773 | Co-expression |
SPCS3 | CHUK | 0.00718225 | Co-expression |
AURKB | NUP98 | 0.004425747 | Pathway |
CPSF4 | CSTF3 | 0.11179613 | Pathway |
CHUK | HSP90AA1 | 0.006348364 | Pathway |
CSTF2 | CSTF3 | 0.009734826 | Pathway |
CSTF2 | CPSF4 | 0.11179613 | Pathway |
GTF2F1 | CSTF3 | 0.005905584 | Pathway |
GTF2F1 | CSTF2 | 0.005905584 | Pathway |
GTF2F1 | CDK9 | 0.011108032 | Pathway |
CSTF2 | CSTF3 | 0.011789562 | Pathway |
GTF2F1 | CSTF3 | 0.008021638 | Pathway |
GTF2F1 | CSTF2 | 0.007878398 | Pathway |
GTF2F1 | CDK9 | 0.014240757 | Pathway |
CHUK | HSP90AA1 | 0.088913664 | Pathway |
LEO1 | CDC73 | 0.122442566 | Physical Interactions |
PAF1 | CDC73 | 0.21769759 | Physical Interactions |
PAF1 | LEO1 | 0.15407903 | Physical Interactions |
CTR9 | CDC73 | 0.21769759 | Physical Interactions |
CTR9 | LEO1 | 0.15407903 | Physical Interactions |
CTR9 | PAF1 | 0.27394587 | Physical Interactions |
WDR61 | CDC73 | 0.21769759 | Physical Interactions |
WDR61 | LEO1 | 0.15407903 | Physical Interactions |
WDR61 | PAF1 | 0.27394587 | Physical Interactions |
WDR61 | CTR9 | 0.27394587 | Physical Interactions |
HSP90AA1 | CDC73 | 0.3958806 | Physical Interactions |
CDK9 | HSP90AA1 | 0.20299108 | Physical Interactions |
CDK9 | CDC73 | 0.119673245 | Physical Interactions |
AURKB | CDC73 | 0.1827706 | Physical Interactions |
AURKB | HSP90AA1 | 0.042777777 | Physical Interactions |
PAF1 | CDC73 | 0.13507365 | Physical Interactions |
CTR9 | CDC73 | 0.18643428 | Physical Interactions |
NUP98 | CDC73 | 0.203537 | Physical Interactions |
NUP98 | PAF1 | 0.31207067 | Physical Interactions |
CHUK | CDC73 | 0.1774874 | Physical Interactions |
CHUK | PAF1 | 0.2721304 | Physical Interactions |
CDK9 | HSP90AA1 | 0.040214784 | Physical Interactions |
LEO1 | CDC73 | 0.20954604 | Physical Interactions |
PAF1 | CDC73 | 0.16041815 | Physical Interactions |
PAF1 | LEO1 | 0.08672058 | Physical Interactions |
CTR9 | CDC73 | 0.24223034 | Physical Interactions |
CTR9 | LEO1 | 0.1309475 | Physical Interactions |
CTR9 | PAF1 | 0.10024697 | Physical Interactions |
CSTF2 | CSTF3 | 0.24596581 | Physical Interactions |
GTF2F1 | CDC73 | 0.1822143 | Physical Interactions |
GTF2F1 | CDK9 | 0.077137925 | Physical Interactions |
LEO1 | CDC73 | 0.3225924 | Physical Interactions |
PAF1 | CDC73 | 0.3225924 | Physical Interactions |
CTR9 | CDC73 | 0.3225924 | Physical Interactions |
WDR61 | CDC73 | 0.17647609 | Physical Interactions |
CSTF3 | CDC73 | 0.3225924 | Physical Interactions |
FIP1L1 | CDC73 | 0.3225924 | Physical Interactions |
CPSF4 | CDC73 | 0.17647609 | Physical Interactions |
CHUK | HSP90AA1 | 0.02887361 | Physical Interactions |
KMT2C | CDC73 | 0.15483053 | Physical Interactions |
CSTF2 | CDC73 | 0.16203262 | Physical Interactions |
LEO1 | CDC73 | 0.09317254 | Physical Interactions |
PAF1 | CDC73 | 0.08377836 | Physical Interactions |
PAF1 | LEO1 | 0.07275753 | Physical Interactions |
CTR9 | CDC73 | 0.09010142 | Physical Interactions |
CTR9 | LEO1 | 0.078248814 | Physical Interactions |
CTR9 | PAF1 | 0.07035932 | Physical Interactions |
WDR61 | CDC73 | 0.114276804 | Physical Interactions |
WDR61 | LEO1 | 0.09924398 | Physical Interactions |
WDR61 | PAF1 | 0.089237645 | Physical Interactions |
WDR61 | CTR9 | 0.09597274 | Physical Interactions |
AP3S1 | CDC73 | 0.2352175 | Physical Interactions |
CSTF2 | CSTF3 | 0.077111326 | Physical Interactions |
LEO1 | CDC73 | 0.049589828 | Physical Interactions |
PAF1 | CDC73 | 0.10079521 | Physical Interactions |
PAF1 | LEO1 | 0.11382505 | Physical Interactions |
CTR9 | CDC73 | 0.01533186 | Physical Interactions |
CTR9 | LEO1 | 0.017313818 | Physical Interactions |
CTR9 | PAF1 | 0.035191692 | Physical Interactions |
WDR61 | CDC73 | 0.041940387 | Physical Interactions |
WDR61 | LEO1 | 0.047362044 | Physical Interactions |
WDR61 | PAF1 | 0.09626707 | Physical Interactions |
WDR61 | CTR9 | 0.014643089 | Physical Interactions |
FIP1L1 | CSTF3 | 0.113308094 | Physical Interactions |
CPSF4 | FIP1L1 | 0.14965165 | Physical Interactions |
CSTF2 | FIP1L1 | 0.10615889 | Physical Interactions |
CDK9 | CTR9 | 0.0411037 | Physical Interactions |
LEO1 | CDC73 | 0.05172406 | Physical Interactions |
PAF1 | CDC73 | 0.028004196 | Physical Interactions |
PAF1 | LEO1 | 0.054951686 | Physical Interactions |
CTR9 | CDC73 | 0.04297603 | Physical Interactions |
CTR9 | LEO1 | 0.08433042 | Physical Interactions |
CTR9 | PAF1 | 0.045657773 | Physical Interactions |
WDR61 | CDC73 | 0.04966663 | Physical Interactions |
WDR61 | LEO1 | 0.09745915 | Physical Interactions |
WDR61 | PAF1 | 0.05276587 | Physical Interactions |
WDR61 | CTR9 | 0.080975994 | Physical Interactions |
CSTF3 | CDC73 | 0.06669109 | Physical Interactions |
FIP1L1 | CSTF3 | 0.14174445 | Physical Interactions |
AURKB | HSP90AA1 | 0.002030884 | Physical Interactions |
CPSF4 | CDC73 | 0.09574746 | Physical Interactions |
CPSF4 | FIP1L1 | 0.20350051 | Physical Interactions |
CHUK | HSP90AA1 | 0.001720827 | Physical Interactions |
BCL9L | CDC73 | 0.2791709 | Physical Interactions |
KMT2C | CDC73 | 0.04642578 | Physical Interactions |
CSTF2 | CDC73 | 0.0463337 | Physical Interactions |
CSTF2 | CSTF3 | 0.11722768 | Physical Interactions |
CDK9 | PAF1 | 0.01438359 | Physical Interactions |
GTF2F1 | CDK9 | 0.013446528 | Physical Interactions |
AURKB | HSP90AA1 | 0.03819712 | Physical Interactions |
CDK9 | HSP90AA1 | 0.03819712 | Physical Interactions |
LEO1 | CDC73 | 0.5193767 | Physical Interactions |
PAF1 | CDC73 | 0.5193767 | Physical Interactions |
CTR9 | CDC73 | 0.37205398 | Physical Interactions |
WDR61 | CDC73 | 0.5193767 | Physical Interactions |
AURKB | HSP90AA1 | 0.080966905 | Physical Interactions |
CDK9 | HSP90AA1 | 0.036444858 | Physical Interactions |
LEO1 | CDC73 | 0.0771831 | Physical Interactions |
PAF1 | CDC73 | 0.031383026 | Physical Interactions |
PAF1 | LEO1 | 0.14005615 | Physical Interactions |
CTR9 | CDC73 | 0.058806863 | Physical Interactions |
CTR9 | PAF1 | 0.10671071 | Physical Interactions |
WDR61 | CTR9 | 0.34459004 | Physical Interactions |
CPSF4 | FIP1L1 | 0.44817418 | Physical Interactions |
CHUK | HSP90AA1 | 0.0081622 | Physical Interactions |
HSF2BP | CDC73 | 0.31519976 | Physical Interactions |
CDK9 | HSP90AA1 | 0.010792454 | Physical Interactions |
HSF2BP | CDC73 | 0.58701295 | Physical Interactions |
CPSF4 | FIP1L1 | 0.6677753 | Physical Interactions |
CHUK | HSP90AA1 | 0.007963367 | Physical Interactions |
CSTF2 | CSTF3 | 0.2417784 | Physical Interactions |
CTR9 | LEO1 | 0.09094542 | Predicted |
CTR9 | LEO1 | 0.0869592 | Predicted |
LEO1 | CDC73 | 1 | Predicted |
CPSF4 | FIP1L1 | 1 | Predicted |
CSTF3 | LEO1 | 0.020077549 | Predicted |
FIP1L1 | CSTF3 | 0.015798066 | Predicted |
NUP98 | CTR9 | 0.047920566 | Predicted |
SPCS3 | CDC73 | 0.25866398 | Predicted |
CTR9 | LEO1 | 0.34126943 | Predicted |
TKT | CDC73 | 1 | Predicted |
TKT | CDC73 | 1 | Predicted |
CHUK | AURKB | 0.006874138 | Shared protein domains |
CDK9 | AURKB | 0.003942981 | Shared protein domains |
CDK9 | CHUK | 0.006889931 | Shared protein domains |
CHUK | AURKB | 0.003882364 | Shared protein domains |
CDK9 | AURKB | 0.002896895 | Shared protein domains |
CDK9 | CHUK | 0.004389529 | Shared protein domains |
dbSNP rs#* | Sub* | SNPandGO Prediction | RI* | snp and go score | PHD Prediction | RI | PHD probability | PMut prediction | PMut score |
---|---|---|---|---|---|---|---|---|---|
rs200806263 | G49C | Disease | 7 | 0.829 | Disease | 8 | 0.893 | Disease | 0.54 (80%) |
rs1060500015 | L63P | Disease | 3 | 0.657 | Disease | 7 | 0.861 | Disease | 0.68 (85%) |
rs121434264 | L64P | Disease | 5 | 0.729 | Disease | 8 | 0.875 | Disease | 0.75 (87%) |
rs778467088 | D90H | Disease | 4 | 0.708 | Disease | 7 | 0.867 | Disease | 0.70 (86%) |
rs770439843 | R222G | Disease | 1 | 0.553 | Disease | 6 | 0.782 | Disease | 0.53 (80%) |
rs1060500022 | W231R | Disease | 1 | 0.544 | Disease | 1 | 0.56 | Disease | 0.64 (84%) |
rs770734388 | P360S | Disease | 3 | 0.65 | Disease | 0 | 0.503 | Disease | 0.84 (90%) |
rs754454928 | R441C | Disease | 5 | 0.743 | Disease | 5 | 0.775 | Disease | 0.61 (83%) |
rs778432682 | R441H | Disease | 3 | 0.669 | Disease | 5 | 0.753 | Disease | 0.70 (86%) |
rs1292596060 | R504S | Disease | 6 | 0.823 | Disease | 7 | 0.867 | Disease | 0.86 (91%) |
rs759222387 | R504H | Disease | 6 | 0.811 | Disease | 7 | 0.857 | Disease | 0.72 (86%) |
dbSNP rs# | sub | I-MUTANT prediction | SCORE | RI | COSMIC Mutation type | Frequency alleles |
---|---|---|---|---|---|---|
rs200806263 | G49C | Decrease | -0.91 | 5 | N/A | 0.00000 |
rs1060500015 | L63P | Decrease | -1.61 | 2 | Deletion - Frameshift | N/A* |
rs121434264 | L64P | Decrease | -1.58 | 2 | N/A | 0.0000 |
rs778467088 | D90H | Decrease | -1.19 | 9 | N/A | 0.00001 |
rs770439843 | R222G | Decrease | -1.23 | 6 | Substitution - Nonsense | 0.00001 |
rs1060500022 | W231R | Decrease | -1.07 | 8 | Substitution - Nonsense | N/A |
rs770734388 | P360S | Decrease | -1.45 | 8 | N/A | 0.00001 |
rs754454928 | R441C | Decrease | -0.91 | 7 | Substitution - Missense | 0.00001 |
rs778432682 | R441H | Decrease | -1.31 | 9 | N/A | 0.00001 |
rs1292596060 | R504S | Decrease | -1.3 | 9 | N/A | N/A |
rs759222387 | R504H | Decrease | -1.52 | 9 | N/A | 0.00004 |
dbSNP rs#* | Sub* | Sift prediction | Sift score | Provean prediction | PROVEAN score | Polyphen2 prediction | Polyphen2 score | Snap2 prediction | Snap2 Score |
---|---|---|---|---|---|---|---|---|---|
rs28942098 | M1I | afect | 0 | Deleterious | -2.586 | probably damaging | 0.999 | effect | 41 |
rs1296841626 | L5F | afect | 0 | Deleterious | 2.676 | probably damaging | 1 | efect | 43 |
rs770544416 | S6G | afect | 0 | Deleterious | -2.539 | possibly damaging | 0.567 | efect | 8 |
rs1054465259 | G28A | afect | 0 | Deleterious | -3.745 | possibly damaging | 0.816 | efect | 47 |
rs777541949 | T38S | afect | 0 | Deleterious | -2.785 | probably damaging | 1 | efect | 49 |
rs1019931450 | Y40C | afect | 0 | Deleterious | -5.114 | probably damaging | 1 | efect | 56 |
rs200806263 | G49C | afect | 0 | Deleterious | -5.363 | probably damaging | 1 | efect | 14 |
rs1454615241 | T56I | afect | 0 | Deleterious | -4.102 | probably damaging | 1 | efect | 48 |
rs1060500015 | L63P | afect | 0 | Deleterious | -4.277 | probably damaging | 1 | efect | 25 |
rs121434264 | L64P | afect | 0 | Deleterious | -4.435 | probably damaging | 0.999 | efect | 60 |
rs778467088 | D90H | afect | 0 | Deleterious | -5.36 | probably damaging | 1 | efect | 17 |
rs1186176634 | S174P | afect | 0 | Deleterious | -2.64 | probably damaging | 1 | efect | 23 |
rs770439843 | R222G | afect | 0 | Deleterious | -3.272 | possibly damaging | 0.955 | efect | 49 |
rs776394390 | D223G | afect | 0 | Deleterious | -3.71 | probably damaging | 0.994 | efect | 25 |
rs1330160847 | I224T | afect | 0 | Deleterious | -3.072 | probably damaging | 0.991 | efect | 25 |
rs1060500022 | W231R | afect | 0 | Deleterious | -7.888 | probably damaging | 0.996 | efect | 64 |
rs1452051467 | R234Q | afect | 0 | Deleterious | -3.063 | probably damaging | 1 | efect | 72 |
rs973863694 | I249T | afect | 0 | Deleterious | -3.648 | probably damaging | 0.999 | efect | 33 |
rs878855091 | R263C | afect | 0 | Deleterious | -3.402 | probably damaging | 1 | efect | 17 |
rs1244272523 | R330W | afect | 0 | Deleterious | -3.789 | probably damaging | 0.996 | efect | 56 |
rs770734388 | P360S | afect | 0 | Deleterious | -6.86 | probably damaging | 1 | efect | 59 |
rs769288212 | P365L | afect | 0.04 | Deleterious | -8.661 | probably damaging | 1 | efect | 75 |
rs113200235 | A367V | afect | 0.05 | Deleterious | -3.178 | probably damaging | 0.996 | efect | 66 |
rs866465727 | V387A | afect | 0 | Deleterious | -3.326 | possibly damaging | 0.656 | efect | 48 |
rs866793539 | G396C | afect | 0.02 | Deleterious | -7.128 | probably damaging | 1 | efect | 25 |
rs754454928 | R441C | afect | 0 | Deleterious | -7.186 | probably damaging | 1 | efect | 58 |
rs778432682 | R441H | afect | 0 | Deleterious | -4.441 | probably damaging | 1 | efect | 64 |
rs1225502334 | R484C | afect | 0.05 | Deleterious | -3.972 | probably damaging | 0.994 | efect | 32 |
rs1292596060 | R504S | afect | 0 | Deleterious | -5.296 | probably damaging | 1 | efect | 74 |
rs759222387 | R504H | afect | 0 | Deleterious | -4.43 | probably damaging | 1 | efect | 73 |
rs1060500011 | R513W | afect | 0.04 | Deleterious | -3.834 | probably damaging | 0.977 | efect | 59 |
Function | FDR | Genes in network | Genes in genome |
---|---|---|---|
transcription elongation factor complex | 2.52E-09 | 6 | 28 |
regulation of transcription elongation from RNA polymerase II promoter | 2.52E-09 | 5 | 10 |
transcription elongation from RNA polymerase II promoter | 6.60E-09 | 7 | 75 |
DNA-templated transcription, elongation | 5.45E-08 | 7 | 108 |
positive regulation of DNA-templated transcription, elongation | 5.45E-08 | 5 | 20 |
mRNA polyadenylation | 7.21E-08 | 5 | 22 |
RNA polyadenylation | 9.97E-08 | 5 | 24 |
regulation of DNA-templated transcription, elongation | 2.01E-07 | 5 | 28 |
histone modification | 3.31E-07 | 8 | 260 |
covalent chromatin modification | 3.47E-07 | 8 | 265 |
DNA-directed RNA polymerase II, holoenzyme | 3.50E-07 | 6 | 81 |
endodermal cell fate commitment | 3.50E-07 | 4 | 10 |
RNA polymerase complex | 7.92E-07 | 6 | 96 |
DNA-directed RNA polymerase complex | 7.92E-07 | 6 | 95 |
nuclear DNA-directed RNA polymerase complex | 7.92E-07 | 6 | 95 |
endodermal cell differentiation | 8.50E-07 | 4 | 13 |
negative regulation of myeloid cell differentiation | 1.03424E-06 | 5 | 44 |
cell fate commitment involved in formation of primary germ layer | 2.50852E-06 | 4 | 17 |
histone monoubiquitination | 3.86491E-06 | 4 | 19 |
endoderm formation | 5.6616E-06 | 4 | 21 |
mRNA processing | 1.22928E-05 | 7 | 287 |
endoderm development | 1.28119E-05 | 4 | 26 |
histone ubiquitination | 2.24022E-05 | 4 | 30 |
mRNA 3’-end processing | 2.5645E-05 | 5 | 88 |
regulation of myeloid cell differentiation | 4.02517E-05 | 5 | 97 |
protein monoubiquitination | 4.41323E-05 | 4 | 37 |
formation of primary germ layer | 4.41323E-05 | 4 | 37 |
RNA 3’-end processing | 4.41323E-05 | 5 | 101 |
regulation of mRNA processing | 0.000289177 | 4 | 59 |
positive regulation of mRNA 3’-end processing | 0.000313172 | 3 | 15 |
regulation of mRNA 3’-end processing | 0.000372752 | 3 | 16 |
myeloid cell diferentiation | 0.000446549 | 5 | 165 |
Gastrulation | 0.000451884 | 4 | 68 |
positive regulation of mRNA processing | 0.000804394 | 3 | 21 |
histone H3-K4 methylation | 0.001915467 | 3 | 28 |
cell fate commitment | 0.002956445 | 4 | 111 |
negative regulation of cell differentiation | 0.004090933 | 5 | 267 |
stem cell maintenance | 0.005276884 | 3 | 40 |
histone lysine methylation | 0.006873226 | 3 | 44 |
regulation of histone modification | 0.011780086 | 3 | 53 |
histone methylation | 0.01357129 | 3 | 56 |
stem cell diferentiation | 0.013955822 | 4 | 171 |
cellular response to lipopolysaccharide | 0.01758198 | 3 | 62 |
regulation of chromatin organization | 0.018029071 | 3 | 63 |
cellular response to molecule of bacterial origin | 0.020035617 | 3 | 66 |
embryonic morphogenesis | 0.020035617 | 4 | 192 |
RNA polymerase II core binding | 0.020433712 | 2 | 10 |
peptidyl-lysine trimethylation | 0.022132906 | 2 | 11 |
basal transcription machinery binding | 0.022132906 | 2 | 11 |
basal RNA polymerase II transcription machinery binding | 0.022132906 | 2 | 11 |
mRNA cleavage | 0.022132906 | 2 | 11 |
transcriptionally active chromatin | 0.022132906 | 2 | 11 |
regulation of histone H3-K4 methylation | 0.022132906 | 2 | 11 |
protein alkylation | 0.022434688 | 3 | 73 |
protein methylation | 0.022434688 | 3 | 73 |
cellular response to biotic stimulus | 0.022949254 | 3 | 74 |
mRNA cleavage factor complex | 0.024254179 | 2 | 12 |
RNA polymerase core enzyme binding | 0.024254179 | 2 | 12 |
positive regulation of histone methylation | 0.028159975 | 2 | 13 |
response to lipopolysaccharide | 0.037153654 | 3 | 90 |
stem cell development | 0.037153654 | 3 | 90 |
regulation of chromosome organization | 0.037153654 | 3 | 90 |
RNA polymerase binding | 0.040493707 | 2 | 16 |
regulation of histone methylation | 0.04514658 | 2 | 17 |
response to molecule of bacterial origin | 0.049891593 | 3 | 101 |
peptidyl-lysine methylation | 0.054973868 | 2 | 19 |
macromolecule methylation | 0.080506456 | 3 | 120 |